This is a summary of the CPIC guideline for serotonin reuptake inhibitors and variation in the genes CYP2D6, CYP2C19, CYP2B6, HTR2A and SLC6A4.
This video will focus on the recommendations for sertraline. Videos covering the recommendations for other gene-drug pairs as well as a video about the gene-drug pairs with no recommendation in the guideline can be found at the following links:
Citalopram and escitalopram and CYP2C19 - • CPIC guideline for cit...
Fluvoxamine and CYP2D6 - • CPIC guideline for flu...
Paroxetine and CYP2D6 - • CPIC guideline for par...
Venlafaxine and CYP2D6 - • CPIC guideline for ven...
Vortioxetine and CYP2D6 - • CPIC guideline for vor...
Serotonin reuptake inhibitors and CYP2D6, HTR2A and SLC6A4 (no recommendations) - • CPIC guideline for ser...
Guideline and supplemental information - cpicpgx.org/guidelines/cpic-g...
Annotated guideline and genotype picker - www.pharmgkb.org/guidelineAnn...
PharmGKB sertraline pathway - www.pharmgkb.org/pathway/PA16...
CYP2C19 Gene Information Tables - www.pharmgkb.org/page/cyp2c19...
CYP2B6 Gene Information Tables - www.pharmgkb.org/page/cyp2b6R...
PharmVar - www.pharmvar.org/