Im waiting for CRISPR antidepressants :D

Ikr!!!!!!!(the original comment)

Waiting for CRISPR to cure Herpes and HPV, eventually HIV. Everybody deserves a second chance in life!

@@leeleitanmonica7128 so you never go to doctor or take medicines? And I’m sure in a life threatening situation you will not call ambulance and spoil gods plan.

@Ortu Solis I'm not sure about those conspiracy theories but now as we have a potential for a cure for these viruses, I am optimistic that someday these diseases would be able to be considered ''mild''

I have it in 8 lolllll

@@NO-tf1mj all the best man

hey, do u go to med school?

How was it?

James Hopkins, You probably wouldn't support it if you were a potential target. What if we don't want to be 'cured'? That's why we started The Neurodiversity Movement, clinics and other people don't have the right to eradicate us from existence just because we're different, it is racism and discrimination. There's no doubt in my mind they are going to use it as an eugenics tool just like abortion. Just because you can do something doesn't mean you should.

hi

For sure he has explained it well.

Good luck on your thesis. Curious, what level and major?

1q1

The question that needs answering is "how do we discern a disease?" Autistic people, ADHD, Down Syndrome, Bipolar etc... the vast majority of people diagnosed including myself don't want to be cured and it's our life. This is basically the completion of the first step of the discriminatory racist eugenics movement, they have already casted us out, the "artificial selection" is completed. All they have to do now is rub us out of existence. It's hard to believe the public can't see things as what they actually are. If you look up when all these disabilities became perceived as disabilities, it was in the eugenics after Francis Galton coined the term "eugenics" even though they trace back 100,000s of years. Intellectual disability was created by eugeneticists by their bias IQ, autistic people tend to complete the RPMT 40% faster than nonautistic people. CRISPR-Cas9 is actually acting upon false assumptions known as neo-Darwinism. Mutations are not random and they are essential to adaptation as well as diversity. Evelyn Fox Keller explains: "We now know that mechanisms for enduring genetic stability are a product of evolution. Yet a surprising number of mutations in which at least some of these mechanisms are disabled have been found in bacteria living under natural conditions. Why do these mutants persist? Is it possible that they provide some selective advantage to the population as a whole? Might the persistence of some mutator genes in a population enhance the adaptability of that population? Apparently so. New mathematical models of bacterial populations in variable environments confirm that, under such conditions, selection favors the fixation of some mutator alleles and furthermore, that their presence accelerates the pace of evolution."

Swears! Been reading several journals only to end up with headache

​@@danielmoore4024y69uk fcigf

@@danielmoore4024 Nobody wants to treat Aspergers with CRISPR/Cas9 but rather debilitating metabolic dieseases that cause intense suffering or death. Genetic engineering laws here in Germany are very strict.

@@Mulmgott I make my own videos under a separate account and have spoken much on eugenics and CRISPR, on them you’ll hear me say I approve and agree with using biotechnology to cure things like sickle-cell anemia. I point out my overall argument is the science community can’t keep equating uncommon differences as disorders, that we need a legitimate definition of what is a disease. According to today’s scientists, statistical deviation = disease which is plain thick and stupid of them, normativity is an ideology, the fact the whole field about disease is a cultural value judgement and not legitimate science people can’t be trusted to not start another Holocaust on disabled people. As I point out in my videos, there’s clinical websites saying CRISPR is a great hope to eradicate autism, ADHD, down syndrome, dyslexia, and other disabled people. They already approve genocide on individuals who test positive for down syndrome, they don’t allow disabled people to donate embryos, the fact they already approve of genocide, using abortion as an eugenics tool, there’s the evidence they will abuse it.

When u turn a compliment into a self-compliment hahaha

@@aaronwewer1701 wait that's true 😳

Hah, thank the algorithm

@@sanaltdelete always

Genuinely curious about this suggestion. Are you saying that you would modify Tregs using Crispr to keep them away from the tumour site? How would you accomplish that? Especially considering the possible autoimmune costs to the patient. Or did you mean that antibody blockades would be applied?

What is defined as a disease is my concern, can you recall homosexuality defined as a pathological disorder? Hitler and racial hygiene? Why were alternative races defined as diseases? Humans clearly cannot be trusted, they will no doubt abuse people with it with selfish motives. I am autistic and I don't want to be cured of the gifts that come with it, they should not have the right to change people without our consent, it is racism and discrimination. Molecular biologist Miroslav Radman writes, "Mutagenesis has traditionally been viewed as an unavoidable consequence of imperfections in the process of DNA replication and repair. But if diversity is essential to survival, and if mutagenesis is required to generate such diversity, perhaps mutagenesis has been positively selected for throughout evolution." Evelyn Fox Keller explains: "We now know that mechanisms for enduring genetic stability are a product of evolution. Yet a surprising number of mutations in which at least some of these mechanisms are disabled have been found in bacteria living under natural conditions. Why do these mutants persist? Is it possible that they provide some selective advantage to the population as a whole? Might the persistence of some mutator genes in a population enhance the adaptability of that population? Apparently so. New mathematical models of bacterial populations in variable environments confirm that, under such conditions, selection favors the fixation of some mutator alleles and furthermore, that their presence accelerates the pace of evolution." The mutants behind autism offer some great advantages to the human race, diminishing the genes is a great risk because without those mechanisms there is no asurety of genetic stability pushing us in the direction of extinction. Psychologist Howard Gardner warns: "With the coming of age of genetics, the danger magnifies. Beyond doubt we will discover genes that are important for reading alphabetical scripts; and there is already evidence that a small set of genes may be related to reading problems. As with the brain evidence, such information can be helpful for early intervention; but it could easily be used for stigmatising purposes. Indeed, it might become relevant for marriage prospects, holding a job, securing insurance, or even eugenic purposes. And no doubt, especially in our interventionist society, individuals with a genetic predisposition for reading problems will look into different kinds of genetic engineering or therapy. It is possible that such interventions will work and have no negative side effects, but it is perhaps more likely that they will have unanticipated effects. And we might even want to consider which valued human abilities - eg. spatial or pattern recognition skills - might be placed at risk were we to target our interventions specifically at reading disorders." We can see the vast majority of so called diseases for what they are; they are discriminatory social constructions, not an intention to objectively understand human biology. Were global warming, warmer oceans, production of epidemic diseases, climate change, increased natural hazards and more anticipated. I doubt it so I would say Howard Gardner has a good point, every time humans have tried to play God and control nature nature struck humans back with greater problems, the people trying to solve the problems are the people who caused the problems and are trying to solve those problems repeating the same mistake to cause more problems.

@@danielmoore4024 You make some very good points, Daniel. Having been around biopharmaceutical development for quite some time, I might take exception to the notion that the "vast majority" of diseases are social constructions. While there are some "diseases" that might be classified in this way, I'd offer that the "vast majority" of diseases are so classified because they actually conform with all of Koch's Postulates. For example, homosexuality is not a disease because there is no known organism or virus that can isolated in someone who is (or claims to be) homosexual, reproduced, then transferred to a heterosexual host whom we observe to then become homosexual. It is understandable to be fearful of flawed human intentions, but science is sufficiently rigorous to be dispassionate. Also, despite what you may witness through lens of media, the vast majority of people who work on the development of genetic breakthroughs, like CRISPR, are extremely concerned about how these technologies could be leveraged by amoral ne'er-do-wells.

@@glennpearson9348 To be more specific when I say diseases, I'm referring mainly to neurological differences and genes that make a brain function more differently like autism, ADHD, learning disabilities, dyslexia, intellectual disability, Down Syndrome etc... I assume you've heard of "The Neurodiversity Movement". In the 19th century pathology was corrupted by Francis Galton basing everything on the concept of "normal", pathology was no longer defined by pathology, it became "difference = pathological" like: "homosexuality = difference = pathological" proven by the fact they were trying to cure LGBTQ+ as recently as 50 years ago, and that they're in the DSM 1st edition. Those of us autistic are only defined as pathological because of differences to the social norm. There's no doubt in my mind that as evolution continues more minorities will be identified and automatically labelled pathological and don't deserve to live, abortion is already been used as an eugenics tool which is why I'm against screening and know we are going to be abused. The disabilities I listed bring abilities that nondisabled people are incapable of, which raises the question why isn't the majority that can't do what disabled people can do defined as disabled as well? I don't see why our difficulties must be cured if the difficulties of nondisabled people don't need to be cured. What I see being overlooked is "proportion". Things need to be kept proportional, enhancing everything to the maximum will take things out of proportion, and why do they feel the need of enhancement if there's nothing wrong with them? They clearly recognise their dichotomy and false sense of superiority over minorities, and who decides what's desirable as desirable is an opinion, like in order for The Neurodiversity Movement to be persisting there must be people who find these genes desirable and others undesirable.

Hello from Penn! I am also using CRISPR-derived platforms to induce a CCR5 KO for HIV-1 resistance. Personally, I'm a bigger fan of neutralizing the provirus, but I have to accept that the CCR5 edit is immensely more practical. I love the work ya'll are doing - I think of Temple as the tip of the spear when it comes to CRISPR/HIV-1 work (and Dr. Khalili's lab sure is something!). Keep it up!

@@kevinnewcombe7682 that's awesome! Is your lab part of the Delaney Collaboratory? I know we have collaborators at a bunch of different schools all working on that project, a big part of which is CCR5 KO

@@Bigboibeven My last two labs were both part of the Delaney Collab, but I've just begun my PhD and am currently rotating in a lab outside of the Collaboratory. Though I've been involved in other HIV-1 cure research efforts for several years (high-fidelity disease modeling, metabolomics, and CAR T stuff), it's wonderful to be doing work even closer to my long-term interests!

@Kevin Newcombe that's great! I'm currently just a tech, but plan on entering a PhD program Fall of 2024. I personally don't do any of the CRISPR for the Delaney, but I do all the PBMC isolations for all monkey blood draws and process and store all monkey samples for the study

@@Bigboibeven I was also a tech before starting grad school! It's a phenomenal way to build relevant experience. I have fond memories of doing my ficoll isolations for PBMC, lol. The monkey stuff sounds very cool, I haven't done much simian research other than brain cryosectioning for HAND-adjacent studies. They're super important for sure!