Even more important to understanding the importance of the CYP enzymes are two other factors. Most important: many of use either completely lack function of some CYP enzymes, or have hyper function of the enzymes. This is vastly more important to know than is the inducer or inhibitor character. Second and also far more important tied the the first is that some drugs are in their active form as ingested (e.g. benzodiazepines). The enzyme (if functional) converts the enzyme into a less or non-functional form. For people lacking the functioning enzyme, these drugs either need to be avoided entirely, or downward dose adjustments are essential. For other drugs, the CYP enzymes (e.g. 2D6 for some opiates like codeine, Vicodin, or tramadol) convert the ingested drug into its active form (e.g. codeine converts to morphine). People lacking a functional 2D6 enzyme gain no benefit at all from these drugs. Testing should be widespread for these gene functions either through genotyping of phenotypic, but is still rare. Even with full genome sequencing, determining the precise gene variants and there effect on functionality is difficult. It is not uncommon for a person to be missing functional forms of many of these enzymes. And this much more so than the competition for function by inducers or suppressors leads to a lot of drug dangers, injuries and deaths. There are also broad differences in the likelihood of having hypo, non, or hyper functional CYP variants based on country, region, or ethnic group origin. This too can be critical for patient health. Common references focus on substrates, inducers, and suppressors and entirely omit these vitally important ideas.

thank you so much. was finding it so hard to understand this, until i found this video!!

Thank-you for sharing. Watching your video was the first time I understood this

Thank you for making it easy! -PA student

I have had no education except for some years in primary school. I'm currently teaching myself to gain some more knowledge. Just wanted to let you know that although this is difficult study material, I understood more or less or let's say most of it. This thanks to your way of teaching. I love your explanations so much. Thank you kindly.

This is the best explanation of this ive ever found. THANKS SM!!!

WOW! thank you, I have my A&P exam next month and it includes Pharmacology and this just made it easier to understand.

Such a good explanation thank you sooo much

Thank you so much for the making the concept more understandable.

Thanks friend. It helped me a lot!

Thank you! Loved it

Thank you straight forward and good❤

Its mind blowing ❤❤

thank youuuuuuuuu so muchhhhh - شكرا جدددددنن استفدتتت god bless u

You really dumbed this down to the T! Thank you !!!

Thank you for this!

Literally an entire semester of APRN Pharmacology... and reviewing for the final and decided to search for an easier way of understanding this content... THANK YOU For this. 5 minutes and i understood it so much better than a whole semester of pharmacology....

Thank you for this video. It helped me understand how inducers and inhibitors affect drug concentration. I appreciate it

This was a big video for me. I love grapefruit juice and i take st John's wort over the counter. I'm glad I'm not prescribed anything right now

That was amazing 👌

Thank you so much for sharing your wisdom! I personally really liked the graphics of the enzyme inducer.

Can you do more NYS compounding videos? The 2021 exam is coming up soon and I would appreciate it!

Great explanation.

Excellent !

Thank you this was very helpful and informative!!

incredible!

Brilliant video, thanks for mentioning the St John's wort

This is amazing! Thank you!

thanks, very helpful

beautiful!

I am currently studying for Naplex, this was a great explanation! Thank you for posting! 😃😃

Great explanation! At 2:52 of the video, why is Drug A causes reduces of CYP enzymes for Drug B? From my understanding, reduction and increase of CYP enzymes does not depend on the drug itself, but rather than the the production in the liver (perhaps) or addtional enzymes that the person is taking.

and what path follows this enzime? cytosolic or secretory? and pdt: the video is amazing

Yo bro love the video I have a rly important question that would rly help me in my daily life if it’s possible for me to reach out to you? Ofc it’s about the same topic in the video. Amazing video greetings from the Netherlands

Loved this video and your teaching! I am researching content for a video on Azole Antifungals for nurses and the CYP450 is an important element to include .. I will be sharing your video with my students

easy to understand thank you!!

amazing explanation thank you!

Thank you

A 2nd year pharmacy students here. I just got scolded in class because I don't know an answer regarding the CYP. This video is really helpful :) Initially I thought CYP (along with random number and letter after it) is just a random specific things that I don't need to understand deeply yet. Turns out it just an enzyme. Thank you so much.

Main Question, Does processing Drug A, speed up the proccessing of drug B when multiple drugs are involed. does the production of enzymes for drug A speed up the whole proccess for drug B????? this seems to be true in my experience.

Thank you!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

I don't know why I'm struggling so much with this concept 🤦🏾‍♀️. For instance, when drug A acts as an inducer on an enzyme that normally metabolizes drug B, in the presence of drug A what happens to drug B. Does it bind to proteins? Is it free in serum? Or excreted? What does it mean for serum concentrations?

Thanks

Thank you! 🙌🏾

thanks :D

👏👏👏👏👏

Thank you wow

❤❤

So I'm an ultra rapid metabolizer. Found out after liver donation. Means alcohol doesn't make me drunk, weed doesn't make me high, acid does very little, molly is weak and lasts 1 minutes, I can drink red bull and a five hour energy and fall asleep, and anti-depressants don't do much.

Drug metabolism means the drug is degraded before it has a chance to exert its effect?

Grapefruit juice seems to be a big issue with a lot of drugs.

You have my maximum respect Dr Igudia, I am now negative from Hepatitis b Virus after I did the test, I wonder what might have become of me it I didn't get the herbal cure From your KZfaq channel. God bless you sir.

CBD is a P450 enzyme inducer.

I really do appreciate you Dr Igudia youtube,your commitment towards saving human lives is steadfast ,all the knowledge I got from you and,the help with the herbal meds, I was recently tested negative of my type 2 Diabetes,I’m so happy thanks doc

5:07 i don't think that the job of cyp enzymes is to activate drugs; cyp enzymes metabolize drugs; and metabolism of a drug means inactivating it

great video. lol but I swear I can hear a NYC accent.

Black Professionals!! Love To See It!!!!! 🤎🤎🤎