Cytotoxic T cells | Immune system physiology | NCLEX-RN

Cytotoxic T cells | Immune system physiology | NCLEX-RN | Khan Academy

Рет қаралды 690,883

14 жыл бұрын

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How cytotoxic T cells get activated by MHC-I/antigen complexes and then proceed to kill infected cells. Created by Sal Khan.
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Пікірлер: 184

@themexiranian 13 жыл бұрын

i just like that you are drawing things out and explaining them, rather than pointing to an unmoving ppt presentation thats been molding around for years and years

@scramblesk8 10 жыл бұрын

Love your videos. great idea using different colors and breaking it down with imagines. So much easier than reading a definition. Thanks!

@shaynabourgeois7241 12 жыл бұрын

" I am a virus, I am a virus making maching, you better kill me!" This is great! If only my instructor made her lectures like this! Thanks for being a lifesaver!!

@Marvel.Ak1917 Жыл бұрын

Been 10 yrs since you commented

@devidrsr 11 жыл бұрын

THIS IS THE BEST WAY OF TEACHING AS MY HEART SAYS

@DisKeda 3 жыл бұрын

What this guy does can't be done better. Unbelievable videos. The best! Thank you so much!

@nappingracez 7 жыл бұрын

"So the big picture is, if you want to just take 20000 feet." HAHAHAHAHAHAHAHAHAHA gotta love this guy! He always makes me day studying MCAT less shitty

@cherrytehhladyy 13 жыл бұрын

i'm so slow at understanding processes like this, thank you ! it was so easy for me to connect with this .

@LadyD0113 6 жыл бұрын

I just learned everything I need to know in an hour....than in 5 lectures...Thank you! Now to answer the professors ridiculous reaching questions!

@zuay9016 12 жыл бұрын

so these are what i've been learning in my lectures all this while!!thank you! u make my revision more enjoyable :))

@jessicasingh1286 9 жыл бұрын

you have made my life so much easier.. thank you. You are a legend!

@in2ennui 13 жыл бұрын

Your teaching skills are AMAZING!! Very unlike my own professor... I seriously learn better from you than from sitting in class where a teacher reads slides! Step by Step drawings and words are an enormously effective technique!

@PurposefulPawn 11 жыл бұрын

dude you have the best video about the lymphocytes on youtube! thanks!

@jerryliao5299 10 жыл бұрын

much nice visuals, many help. so thank you

@xforestberryx 14 жыл бұрын

this is so brilliant! ty for the upload!

@Ddelke 12 жыл бұрын

Thank you so much!!!! You helped me to get ready for the exam, keep the good work! Greetings from Serbia!! Pozdrav iz Srbije!

@qteshorty634 14 жыл бұрын

sweet!!! this helped a lot for my microbiology class I wish all the teachers were like you !

@dulee101 12 жыл бұрын

This is absolutely amazing! you saved another medical student trying to connect the dots of the immune system! Good luck with everything, these videos are so so helpful :)

@andrewmontoya8511 4 ай бұрын

you doctor yet

@Nirvana87 12 жыл бұрын

How can someone possibly dislike this?? Awesome teacher!

@lamishaahmed6094 Жыл бұрын

I have been following your videos for a while, and omg every time I am in a topic, I am so amazed by you detailing and explaining skills. Khan academy is undoubtedly doing a great job of teaching people the basics of science.

@illumineat_nutritionist 7 жыл бұрын

This guy explains stuff SO well

@theprophetez1357 3 жыл бұрын

Thanks Kahn you do a great job and have a new sub here. I need a break after watching two of your videos, but I certainly look forward to coming back and learning more. Thanks again.

@lloplop 14 жыл бұрын

I second the grammar video! I really really love these videos. they help me tremendously.

@JoseHernandez-zh5tu 9 жыл бұрын

LOVE IT! GOD BLESS YOU!

@CRUZifyre 12 жыл бұрын

Incredible videos on cytotoxic and helper t cells, B cells.... These helped me understand more than the college classroom! Thank you!!!

@Elnora4ka 12 жыл бұрын

Thank you very much for your helpful lessons! God bless you!

@jimsperlakis5634 Жыл бұрын

Great audio presentation! Best I've watched. But, You should start with a page that already has the cells drawn. Then, as you describe or define, you can label that specific cell and draw the specific receptor involved.

@n3r0z3r0 9 жыл бұрын

This is better then Science Fiction!!!! Amazing! Thank you so much!

@ghoshsurajit85 13 жыл бұрын

This is an amazing video and exactly what i wanted to know regarding the T cells. so thanks a lot for the pleasent lecture.

@MrPyrhana25 13 жыл бұрын

Best life sciences videos on you tube. Great logic of sequence!

@04imran 11 жыл бұрын

was never so clear about this before... thank u osm videao to learn

@wendyQR 9 жыл бұрын

thank you so much～now I manage to understand the whole process~~

@MrPeperonio Жыл бұрын

amazing video thank you so much!

@x3baybeee 9 жыл бұрын

i think i learn better watching these videos at 2x the speed lol

@tonyakriba6836 3 жыл бұрын

Same

@pickle_256 2 жыл бұрын

Keeps you focused.

@boonlorify 13 жыл бұрын

Extreamly helpful!!!! I'm in med school and he explains it better than the book and/or the professors!!!!

@joshgilbo 9 жыл бұрын

fantastic video, finally understand, you're a legend

@ajiboyewilliam 11 жыл бұрын

You really solved my problem with mhc1 and mhc11. Thanks.

@Pangjunmin 13 жыл бұрын

i can finally understand! my group spent so many hours trying to understand what the heck was going on, this simplifies it so much that i can teach it to them now :D

@toriroe8401 12 жыл бұрын

ah thankyou so much, so helpful you explain things so well! you're amazing :)

@pokuneff 14 жыл бұрын

You are a gifted and brilliant teacher. thank you so much!!

@xwhiterabbitx420 12 жыл бұрын

excellent! thank you!

@cherrycoke8464 13 жыл бұрын

Thank you so much for these videos Sal, you made me just a little bit smarter today. And you didn't bore me in the process. Big ups for that!! :D

@alimukhtar4759 Жыл бұрын

Thank u so much for such helpful content

@jahu198 13 жыл бұрын

Thank you so so so much! I didn't understand a word of what they talked about at uni and now I get it. Well, at least the basics, but that's more than I ever thought I'd understand. (Especially with a teacher with a strong accent). Thank you! You're awesome! :)

@msthekissable 9 жыл бұрын

Thanks so much

@iamchill702 7 жыл бұрын

WOW. Great explanation. Now to time to youtube other things completely not about my final tomorrow.

@xenon8117 4 жыл бұрын

4:58 In my immunology test tomorrow.

@mizmoe81 13 жыл бұрын

I am SUCH a visual learner! Thank you thank you thank you!!!

@khansafi5583 3 жыл бұрын

Hi how are you dear

@TheHishamable 10 жыл бұрын

thank you so much !!!!

@ninjanerdstudent6937 9 жыл бұрын

Lesson learned: Shady characters need to die.

@backstreetfan2887 3 жыл бұрын

thank you so much Khan Academy

@saskiakuik99 8 жыл бұрын

really helpful! thanks :)

@agarwalsurbhi221 11 жыл бұрын

thank u so much u have made my problem in mhc1 simpler.

@kareemapollo 13 жыл бұрын

great job khan sahad

@kareemapollo 13 жыл бұрын

great job khan sahad kindly expand u r area of teaching by including medical sciences

@lronbutters5688 5 жыл бұрын

Love the T cells!!!

@cynthiad_ 2 жыл бұрын

This Video helped me So So Much 💯💯🙏I love your Videos because I always learn so much!!! Thank You🤗❤

@ghost2me 12 жыл бұрын

hey shady guy!! love these videos so much!! thanx a lot!! :D

@YaMahaWorld 12 жыл бұрын

Mr. Salman I wish if you were my teacher, i'm currently in basic immunity course at collage and the doc make it boring and not understandable I'm glad that i found your channel, you helped me a lot and made it more interesting to study :) Thank you so much for your efforts

@bl3owns3all 13 жыл бұрын

Seriously, good stuff. Now i have more hope for my finals. :)

@abdulandschool2266 8 жыл бұрын

Shot, this is on the MCAT, I have to study good, I might need it later.

@EvelynNLB 12 жыл бұрын

your the best!!

@mcatpdf2248 8 жыл бұрын

this is extremely helpful for MCAT

@AznsrAwesome 12 жыл бұрын

10 minutes before my test and I finally understand this material

@amenamahmood6402 11 жыл бұрын

awesomeeeee...i learn alot.

@rachellouisejoyce8482 11 жыл бұрын

Thankyou so much for your video's they are amazing and really helping me revise:) Keep it up x

@yousifradhy2148 6 жыл бұрын

عاشت ايدكم

@chadsmith7203 6 ай бұрын

Entire semester of microbiology and came nowhere close to grasping it like I just did. Thank you

@andrewmontoya8511 4 ай бұрын

lol

@BloxyFliks Жыл бұрын

i dream of becoming a doctor one day this helps so much and also i just saw this video

@pranabnirmal5597 4 жыл бұрын

After 20 years into medicine.. I start understanding immunity after watching your videos

@mustafaal-ghezi1757 3 жыл бұрын

I feel sorry for your patients

@xinahicks13 Жыл бұрын

@@mustafaal-ghezi1757 😳

@Bodyskillz2011 12 жыл бұрын

thank you very much man its really easy and important better than our books

@trustjess 14 жыл бұрын

You are the best thing that has ever happened to me! Maybe now I'll pas A+P II

@wlsgh50 13 жыл бұрын

Thanks alot ^^

@ShimmyMD 14 жыл бұрын

@Zturn RBCs don't have nuclei nor any organelles like ER or mitochondria. So they don't have an MHC I. But they get degraded in the spleen every ~120 days

@Arilaynne 13 жыл бұрын

Your vids are truly great. But i'd like to add that thrombocytes are also not nucleated

@DomedOutBullyz 12 жыл бұрын

Man !!!You are tha MAN!!!!

@sciencenerd7639 2 жыл бұрын

Amazing

@alphaveteducation6782 11 жыл бұрын

perfect

@ronzaarraf 12 жыл бұрын

God bless u

@Mindful2222 10 жыл бұрын

amazing

@nystagmus 4 жыл бұрын

Along with MHC IIs, Dendritic cells also have MHC I Same with macrophages and B cells

@akmi1717 7 жыл бұрын

good video.

@GoodTunesFtw 14 жыл бұрын

I've never seen ads on his videos.

@ShimmyMD 14 жыл бұрын

I have a question...when you say the DNA gets shuffled around...do you refer to the post transcriptional modifications of pre-mRNA (exon splicing combination's)? Because I don't think DNA can do that. THANKS Great video btw!!

@maram5102 5 жыл бұрын

Science legend .

@sameenaz2006 14 жыл бұрын

@stardanny33 He is referring to alternative splicing. Different ways to splice out introns creating different sets of mature mRNA to be translated, thus giving off different proteins. Also, it gains more variance through post-translation modification, such as different forms of sorting and glycosylation at the golgi before being presented on the surface. Hope that helps.

@khanacademy 14 жыл бұрын

KZfaq just started doing that. It should be off now.

@chrisjay7750 9 жыл бұрын

Im trying to find in your video a reference to APC licensing but can't :( Its where T helper cells bind to a dendritic cell via the mhc class 2 and cd4+, (as well as cd40-40L) and then allow the dendritic cell to express the processed peptides on the surface of their MHC 1, to allow the recruitment of cytotoxic cd8+ t cells?

@tombiddles 12 жыл бұрын

I have exams coming up, You have saved my ass!! (a grateful medical student)

@wonkeyleggs 11 жыл бұрын

I totally agree, there needs to be a Khan-uni degree

@abdullahyusuf190 8 жыл бұрын

This guy knows everything, he's the voice for organic chemistry and differential equations

@Nicole-em7iv 7 жыл бұрын

this is pretty basic undergrad stuff. almost everyone with a bachelor's degree knows as much..

@basicallydelpan8768 7 жыл бұрын

yes probably really simple stuff. Studying it in yr 11

@bjerryy 6 жыл бұрын

Pro!

@rajkaur17 11 жыл бұрын

Also, Thelper cell only recognize 12-18 peptide and has complemenatry receptor for Mhc2 only and they can't bind to Mhc 1 unless and untill there is a mutatio

@DavidTSaad 3 жыл бұрын

7:29 Doesn't the T- cytotoxic cell need some kind of a second signal as the T-Helper cells do? The CD28 with B7? My point is: is it normal for T-cytotoxic cells to be activated from normal cells, or do they have to be activated from professional antigen presenting cells?

@babyshamblez 13 жыл бұрын

@addycastro @addycastro B cells display both MHC 1 and MHC 2. the antigens are presented on MHC 2 because the antibodies coating the membrane of the Bcell have attached to a foreign particle. this particle is then engulfed, lysed and some of the protein debris is presented on the MHC2 on the outside of the cell so the Helper T cells can come and help produce antibodies. MHC1 complexes only have antigens presented on them when a foreign body enters the cell without being engulfed...

@BMTaher 11 жыл бұрын

Is there anyway we can thank you enough?

@paulhetherington3854 4 жыл бұрын

Sphere--XL or KL-- for cell. SIDZPHERO= Sip this, carried drink-- cells and receptors-- nodes-- arteries-- vents-- caps. Rapido-- shaped organelles.

@iamanubertuber 10 жыл бұрын

In the case of HIV infection, where CD4 T helper cell is infected with virus, do the MHC I of CD4 present HIV fragments, and consequently get destroyed by CD8 cytotoxic effector cells?

@Donau005 13 жыл бұрын

Thanks alot...This is great :) Although.. Neurons (Nerve cells) doesn't have MHC-I receptors on them. (?) Isn't that correct? But except for that one type of cells, all nucleated cells DO have MHC-I receptors..

@howardxing5885 6 жыл бұрын

4:54 "nuts" and sacrifice lol

@kendramartin6103 8 жыл бұрын

You do an amazing job explaining this system! When I'm looking at my lecture notes it's harder to make these connections. Now I have a question... My professor has on his notes that the dendritic cells are the only cells that carry both MHC II and MHC I. You are also saying B cells have this quality?

@joszaynka 8 жыл бұрын

+Kendra Martin All nucleated cells (essentially all cells minus erytrocites) have MHC I proteins; while only APCs have MHC II proteins, however since they are also nucleated cells they carry MHC I as well.