In this video, we will be exploring the topic of Multi-Cancer Early Detection tests (MCED). MCED tests are a type of liquid biopsy test that uses a sample of blood to detect cancer cells before symptoms may begin to appear. Throughout the video, we will explore what MCED Tests are, the various types and their mechanisms, the reliability/risks of MCED tests, and finally the current research studies ongoing on this topic.
This video was made by McMaster University students Jananey Rajagopalan, MD Tamim Adnan, Myra Bhatti and Ritika Khetarpal in collaboration with the Demystifying Research McMaster Program.
Timestamps: 
0:00 -1:06: Introduction to MCED Tests
1:06 - 3:48 Mechanism of MCED Tests
3:48 - 4:49 Risks and Reliability of MCED Tests
4:49 - 6:52 Current Research Studies
This video is provided for general and educational information only.
Copyright McMaster University 2023
#cancer #diagnostics #research
References:
Brito-Rocha, T., Constâncio, V., Henrique, R., & Jerónimo, C. (2023). Shifting the Cancer Screening Paradigm: The Rising Potential of Blood-Based Multi-Cancer Early Detection Tests. Cells, 12(6), 935. doi.org/10.339...
Hackshaw, A., Clarke, C. A., & Hartman, A.-R. (2022). New genomic technologies for multi-cancer early detection: Rethinking the scope of cancer screening. Cancer Cell, 40(2), 109-113. doi.org/10.101...
Jamshidi, A., Liu, M. C., Klein, E. A., Venn, O., Hubbell, E., Beausang, J. F., Gross, S., Melton, C., Fields, A. P., Liu, Q., Zhang, N., Fung, E. T., Kurtzman, K. N., Amini, H., Betts, C., Civello, D., Freese, P., Calef, R., Davydov, K., Fayzullina, S., … Swanton, C. (2022). Evaluation of cell-free DNA approaches for multi-cancer early detection. Cancer cell, 40(12), 1537-1549.e12. doi.org/10.101...
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Lawrence, R., Watters, M., Davies, C. R., Pantel, K., & Lu, Y.-J. (2023). Circulating tumour cells for early detection of clinically relevant cancer. Nature Reviews Clinical Oncology, 20(7), Article 7. doi.org/10.103...
Mauracher, J. (2023, August 25). What are multi-cancer early detection (MCED) tests, and should you get one? MD Anderson Cancer Center. www.mdanderson...
Multi-cancer Early Detection Tests. (2022, June 30). American Cancer Society. www.cancer.org...
Patel, J. (2022, October 25). What are Multi-Cancer Early Detection tests and how might they impact the future of cancer screening? Cancer.Net. www.cancer.net...
Ruder, K. (2023, January 12). Liquid biopsies for cancer: what to know and what to expect. Cancer.Net. www.cancer.net...
Symplify. Oxford Cancer. (2022, July 19). www.cancer.ox....