@@jackhannon4322 Thank you! Really appreciate the feedback.

Excellent video! Very informative and editing very much compliments it. 👍

@@everready2903 Thank you for your feedback! :)

Has Neropharmacist ever partaken of DMT, outside of normal Pineal production?

@@Khaymen223 I'm sure he's an expert from all perspectives.

I think about this almost everyday. Even had a heated discussion with someone regarding how old dinosaurs were, he kept mentioning a machine that could tell the year. Like come on now, were you or the machine actually there with the dinosaurs? Nobody truly knows anything, we only know what we see and are taught.

@@jaylapearson3256 It's this. It'a all related, every single thing. Let's start with this, christanity. Jesus was a central figure in bringing the enlighthment that people should try to be nicer to each other cause spiritually it is neccesary, when you die if you live your life in an incorrect and hellish manner that involves things like lying stealing cheating and all the things that are inherently bad thats present in all these religions. Dmt when you go off will remind you of those actions and it won't be fifteen min this time, it might feel like an eternity, depending on who you are as a person. In christanity it introduced that figure and then, there was this person. In the times of christ there was wine and adultry and those are things they took from jesus as holy tho it wasn't what jesus represented, jesus preached what every prophet preached, the common good of man. In Deuteronomy 18:17-19, Moses(as) prophesied: “And the Lord said unto me. They have well spoken that which they have spoken, I will raise them up a prophet from among their brethren like unto thee, and will put my words in his mouth; and he shall speak unto them all that I shall command him. And it shall come to pass, that whosoever will not hearken unto my words which he shall speak in my name, I will require it of him.” when the prophet mohammed came he seperated the men and women then, he banned alochol as he seen that it made people stray away from their religion and commit acts of adultry, as well as provide a way to maintain cleanness of body, when muslims pray they cleanse their body with water before that. As they pray it affects the pinal gland, INMT which is thought to be the pivotal enzyme in the DMT production from the biogenic amine tryptamine, and therefore can indicate the sources of DMT. However, INMT methylates other substrates, and therefore its presence can only imply DMT production. Now lets keep going, in islam there is a term for the black spot present from said spot that produces dmt. The zebibah, Arabic for raisin, is a dark circle of callused skin, or in some cases a protruding bump, between the hairline and the eyebrows. It emerges on the spot where worshipers press their foreheads into the ground during daily prayers. It marks them as devout muslims in belief and mannerisms with people. That is also present in hinduism a completely alien culture to the muslims. People who are said to have the capacity to utilize their third eyes are sometimes known as seers. In Hinduism and Buddhism, the third eye is said to be located around the middle of the forehead, slightly above the junction of the eyebrows, representing the enlightenment one achieves through meditation.

@@jaylapearson3256we can measure the time by the earth surface back then… we can measure the time that passed quite good, but yea there’s many weird stuff in our unknown history

@@TheMohammedAlmashaqbeh No, wrong. Let's not start with Christianity. Why are people so obsessed with continuing this delusion? Christianity is a massive fraud perpetrated by Rome in the fourth century, and had nearly nothing to do with the teachings of Ye'shua. The bible is historically invalid. That you believe this crap shows clearly that you have not studied the beginnings of your religion, the precedents, the history of the bible, the wider social and political issues of Roman Palestine, anything relevant. Islam is just as bad. DMT is one of the best methods of acquiring the awareness that transcends religion and renounces deluded beliefs.

Holy shit cringe thread detected.

I've had ketamine infusions for my bipolar disorder. Been amazing! Has come back but the longest remission period I've had ever. Shrooms are also great. Jessika

Thanks!

Yes

Thank you! Might look into it at some point.

Maybe in the near future!

He was an intriguing character for sure! I know some of his hypotheses and find them interesting, but perhaps not so scientifically thorough. He had a brilliant way with words in reporting his experiences.

There is no evidence of endogenous DMT playing any role in nervous system signaling.

So you only smoked weed but had a psychedelic experience?

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What you are describing sounds like "Alice in Wonderland Syndrome" in which it is common for people to experience at occasional points in life, especially during childhood and before sleep. The DMT experience is very different as it breaks down what makes you "you" and not just geometric visuals and such. It's a much more profound experience that cannot be fathomed into words.

@@enlightenedhermes I had ego deaths too, visions in which I couldn't remember or describe what is "me", where even the concept of "me" didn't exist

I had the same thing and learned to induce it before sleep. Its beautiful but can't seem to control it. Only difference is what i see is closer to visuals from a mushroom trip, not dmt. Ive done both thereafter having it. Wiki calls it closed eye visualisations?

Alice in wonderland syndrome is just another cop out diagnosis

@@camiel61 I wasn’t saying it was indeed the case of Alice in Wonderland Syndrome, I was just saying that it very well could be, due to the fact that all the things he describes perfectly fit the terms of an Alice in Wonderland Syndrome experiences. Besides that, the guy hasn’t even tried DMT, so how would he know what’s similar or not to a trip? As someone who has had the same experienced as said in the op, and done DMT, they are vastly different.

Man's on telegram

@@Nathankruse-do3tz thanks but i don't buy illegal shit online, lolol

Very interesting I was wondering how this differed. Things sure have changed since the 90's. 🤔

The video states that there is no way of measuring that

@@XenoTravis yet...

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Some chemicals like DMT can elicit piezoluminescence under the right conditions. However, it does not happen in the wetness of the brain.

dr joe dispenza look it up he actually can answer ur Q

@@travissimpson1353 👍 Thank you.

No evidence for that.

I'm sure there are some people interested in pursuing this line of work.

wow 😮 i wouldn’t doubt it

Are you sure you had an overdose and it wasn’t just you having a breakthrough on the drug?

@@markomclane475 I'm sure I overdosed. I was on all kinds of shit and had a seizure and was turning blue from the lack of oxygen I had. If my friend weren't there, I'd be dead.

@@markomclane475I agree - you cannot overdose on DMT itself. You may have ego death though. If combining with other stuff? Yeah, for sure.

Thanks, man.

DMT: 4.00 5ht7, 3.97 5ht1d, 3.91 5ht2b, 3.53 Alpha2B, 3.53 Alpha2C, 3.51 D1, 3.42 5ht2c, 3.28 5ht1e, 3.25 5ht6, 3.16 5ht5a, 3.13 Imidazoline1, 2.95 Alpha1B, 2.75 Alpha2A, 2.70 Alpha1A, 2.58 5ht2a, 2.37 SERT, 2.23 Sigma1; 0.00: 5ht1a, D4, D5, Beta1, D2, D3, DAT, NET, 5ht1b, Beta2, Sigma2, CB2, KOR, Ca+Channel, M1, M2, M3, M4, M5, H2, CB1; ND: H1, DOR, MOR, NMDA journals.plos.org/plosone/article?id=10.1371/journal.pone.0009019 A good start

DMT binds to the Sigma 1 receptor which is responsible for the synthesis of over 900 mammalian proteins 👍

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Try what?

@@Neuropharmacist DMT

​@@Neuropharmacist dmt obviously

Why would you assume that I haven't or that it would make a difference?

@@Neuropharmacist Because I am curious

@jenny_jane6 do one

I've seen one very small study, and a lot of speculation. I don't find it too convincing.

@@Neuropharmacist I found this one today: www.ncbi.nlm.nih.gov/pmc/articles/PMC6370651/ that suggests altered MAO-A functioning is involved. maybe not convincing but still interesting research.

No real evidence to support either.

What a silly ass question

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Just continue to study and go for science!

Accepting life, I started with a B.Pharm. Just do a bit of recon and find a uni that has a neuropharm unit (preferably part of their School of Medicine or a pharmacy school that is more than 50y.o. - the type where you learn proper compounding and has a pharmacology, chemistry and biology - 3 prong focus). Then do the unit (beat all the med students), befriend the lecturer and ask if there are any volunteer positions available and go from there (at least that's what I did - I was running the tutes for the elective "Neuropharmacolgy 551/552" for final year B.Med/Surg students the following year. I would also recommend not coming at it as in interest in hallucinogenics, bro the fun is in learning new and beautiful cascades that ultimately dictate how the rest of the flesh bag works. Psychonautics is fun but narrow and limiting.

The why can be speculated - that DMT is a tryptamine closely associated with many other biologically active molecules and pathways, and thus it may just exist as a side product of those machineries. The function of endogenous DMT is unknown as far as I know, suggesting it may not be relevant for any major function. But as I mention in the video, it could still have some physiological role waiting to be discovered.

DMT is not just endogenous in mammals, it is present in almost all lifeforms. I suspect you meant to ask 'what really is the function OF DMT in mammals'. The 'function of mammals' is a huge, vague, irrelevant issue.

​@@Neuropharmacistand thus

@@tracemagace8434 yes

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Your beliefs are wrong!

​@@NeuropharmacistLol so direct and to the point

I experienced it 30 years ago when i was 21, and it happened upon entering the sleep-state, in a state called the hypnagogic state. It is believed to be an optimal state for problem solving/higher thinking and creativity, and can give/produce, some trippy psychedelic like experiences. Its a state that happen upon entering sleep, and when coming out of sleep, (the state when coming out of sleep is called the hypnapompic state). The brain waves activity measured in this state, is of equal high activity between Alpha and Theta. And it is usually also in relation to this state, that people will suddently wake up, with a solution, to a problem they have recently been pondering on. Usually illustrated by a person sitting upright in the bed, while saying: Heurica! i got it.

look into astral projection :)

Thank you for your comment. I'm aware of that paper, but I also didn't find it to change my opinion much. Did you read this excellent critique of that study by the Nichols: www.aliusresearch.org/nichols-nichols-endogenous-dmt.html

@@Neuropharmacist That critique is simply saying there are other possibilities besides DMT which is... obvious? With the lack of the criticizers own empirical data to counter anything, only conjecturing that a bunch of other factors may be more important, or solely responsible for the effects, the critique is simply stating obviousness that goes without saying. Neither do they recognize that despite the amount of other variables at play, the endogenous production of DMT may still be necessary but not sufficient regardless of comparable quantity?

@@Neuropharmacist Wow, you have sadly ignored science that disproves a lot of your arguments which are pulled from the Nichols paper. Steven Barker wrote an excellent rebuttal as well. www.frontiersin.org/articles/10.3389/fnins.2018.00536/full

I respect both scientist, but I have to note that I don't think Dr. Gallimore has published any studies concerning DMT in the brain, and neither have I. I'm merely a neuropharmacologist interested in the subject matter. I certainly don't think I'm an authority on most of the topics I talk about, but I do hope that presenting my perspective may be insightful to some people. I sincerely hope that people would not evaluate anyones authority on any subject based on the tone of their voice.

@@Neuropharmacist apologies for coming off harsh

@@riseofmerlin3111 No worries!

I’d appreciate your comment

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It's called science.

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That why you should micro dose

I think David Nichols scientific writings are a more trustworthy source of information on chemistry and pharmacology than Strassman's Rogan interview.

@@Neuropharmacist I'm not concerned with Rogan...Im specifically talking about Strassman and his quotes. I'm going to assume because of DMT being his life's work, he is studying the same papers you are reading and probably even more. I'm going to also assume he has access and connections to people currently studying DMT that you don't have. Therefore I'm going to assume Strassmans quotes to be accurate. Even more accurate than your quotes? Alot of assumptions sure, but am I completely off base that you holding one man's papers as the absolute final word on the subject as being the final truth?

@@Khaymen223 There is no final truth, I have never claimed that. What I explicitly state, is that there is no clear evidence for endogenous DMT playing any significant role in generation of any subjective experience! Until someone provides me evidence proving otherwise, in the form of peer-reviewed scientific studies, I will not be changing my opinion.

@@Neuropharmacist I got that....And that is what I'd call a 'typical' way for a scientist to respond. However a more honest video would have stated or led to the conclusion - *We have no idea what role DMT plays because it has never been measured at its source, let alone what the source even is. You , and most scientists lead the viewer into the belief there most likely isn't any role because of the small amounts measured. That in my opinion (while you are currently correct there isn't any current evidence) is disingenuous at least and in a way misleading the viewer. You never said in your video, 'DMT has never been measured at its source, so we don't know.' I do thank you for taking the subject on however.......kudos.

@@Khaymen223 There's a good chance it is a side product of INMT, without any further source, release and storage mechanisms. Rodent studies certainly give some insight into the levels of endogenous DMT, and even during asphyxiation, the levels seem to be upregulated less than those of serotonin, which has a higher affinity for 5HT2A receptors than DMT.

I fail to see the logic.

@@Neuropharmacist I have done DMT and mushrooms and I have seen things that I did not learn in school, my mind is not that complex to come up with, for example, I am not any good at math or understanding geometry, that is what I see , one time I felt like I was in a clock with moving parts and wheels , I could focus on different parts of this clock, I was in a different world.

20-30 micrograms of DMT? Great advice.

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Also! If DMT and melatonin are both produced in the pineal gland, I’ll bet that is not a coincidence. I’ll bet they work together for dreams.

Increasing levels would be futile since we metabolize and destroy it so fast. I'm sure our bodies have a naturally evolved method of balancing and producing to immediate need. Any attempt at associating bible study with spiritual evolution or DMT results is absurdly futile. The bible is not a historically valid document, and none of the Abrahamic religions promote actual healthy spirituality. Christianity specifically is a massive fraud perpetrated by Rome, in the fourth century. It has nearly nothing to do with Ye'shua. DMT is one of the best methods of acquiring the awareness that transcends religion and renounces delusions like biblical relevance.

Why would anyone want to base their life and worldview on a bunch of lies that hurt people?

​@@godisincontrol7407Check out the ecstatic states of St. Teresa of Avila

​@@shepberryhill4912The common drug user should also ask those questions.

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Can you clarify your point?

mycotripper1

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@@CamilleSwisher never had it.