Does naltrexone impact your mood or block healthy endorphins?

Does naltrexone impact your mood or block healthy endorphins? | The Sinclair Method

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5 жыл бұрын

Dr. Mendelson discusses whether taking naltrexone as a treatment for alcohol addiction can block your bodies natural endorphins and affect your mood.
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People often wonder if naltrexone blocks all the pleasure activities that produce endorphins - and not only alcohol related endorphins. In this video, Dr. Mendelson speaks about naltrexone and how it impacts endorphins, serotonin, and mood when someone is using the medication for alcohol addiction, or alcohol use disorder (AUD). Dr. Mendelson explains how endorphins from alcohol are different than endorphins from other activities.
Ria Health delivers evidence-based care that includes medications, one on one support, a digital app, and progress tools. We support people who want to either reduce or stop drinking with the care of an expert medical team and community support.
We use safe and FDA approved medications such as naltrexone, which is the cornerstone of the Sinclair Method. We also support not for profit advocates that promote awareness of options for people who want to change their relationship with alcohol. We are proud sponsors of Claudia Christian's CThree Foundation and Moderation Management.
Learn more about the Sinclair Method: riahealth.com/sinclair-method/
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Пікірлер: 108

@RiaHealth 4 жыл бұрын

Find out how Ria Health's program can help you drink less from home at riahealth.com/how-it-works/ or schedule a call with a team member at member.riahealth.com/signup/sched?showTimes=true

@missylove5303 Жыл бұрын

Naltrexsone definitely works for me. I have become so disinterested in drinking since no buzz. No, it does not change my mood whatsoever. I work out, eat super healthy, meditate, and stay super active. You have to work it to make it work just like everything. There is no ONE cure-all folks. You have to do the work.

@Lee-jo7lp 3 ай бұрын

This is a fake response because naltrexone does not stop the buzz from alcohol. It's designed to take away the release of serotonin (the feel good) pleasure feeling in your brain from drinking. Visit the naltroxone site to confirm this. Either you're paid to say this or your full of bs.

@theproductivebabe 19 күн бұрын

What is your dosage?

@andrewkapaldo5131 4 ай бұрын

Stuff seriously works, no joke. Almost 2 months sober from drinking myself to "sleep" every night for the past 10 years. Ended up in hospital with pancreatitis. Primary care physician prescribed me Naltrexone. Pretty sure it saved my life. Lost like 10lbs already too. Be that as it may there we periods where I wouldve been fine if I didnt wake up. Lost sense of purpose in life from losing the pleasure in things. Took me a little bit to get over. You have to look at things differently. Part of the journey to changing anyhow. It also gave me the patience to sit and think things through rather than giving into the gratification of jumping straight to anger. Now I feel very uncomfortable without it (the meds). It is the very first thing I reach for in the morning. Its going to be hell getting off it.

@Tuck-xr6zh 10 ай бұрын

I’m a recovering opioid user that has been on vivitrol for about 6months I can only say from personal experience I do experience pleasure in doing things but it does block all endorphins. For example I feel good after working out but no “runners high” after.

@oceanark77 2 жыл бұрын

So I just got my 2nd Naltrexone (2 month) yesterday. I just wanna be able to sleep!!!! 😭

@oceanark77 2 жыл бұрын

So I just had the 2month implant put in this March 28th. Question, I plan to go back in 2 months to get another, then one more time 2 months later. What happens after my last 2month implant runs out? With I feel any type of withdrawal?

@donaldgodwin6876 3 жыл бұрын

Plss i was once addicted to tramaldol and it has been 3 years i manage to stop it by drinking alchohol ever since then ive been having somany problems itching sneazing serious cold dizzyness chest pain also pain on my testics can i still take naltrexone or wat should i do plss help me thank you🖤

@electrictofumuffins6384 3 ай бұрын

High shutter speed is used to make the viewer feel anxious.

@reallycoolguy121 5 жыл бұрын

Thank you very much for this video. I'm on antabuse at the moment and stopped trying the sinclair method out of this precise fear.

@RiaHealth 5 жыл бұрын

Wishing you the best! If we can be of help, do let us know.

@joshgreer3527 11 ай бұрын

I take vivatrol it kinda helped me but relapsed 30 days after taking it even tried taking it at night I would get like drunk feeling and hadn't drank any thing

@vonaldautterback8831 Жыл бұрын

Thanks for this info. Can you please address the difference between taking Naltrexone once a day (as usually prescribed) vs. the Sinclair method of taking it one hour before you plan on drinking and why you support the Sinclair method of taking Naltrexone?

@RiaHealth Жыл бұрын

Our studies show that the Sinclair Method (coupled with counseling, which is very important) works for most people. And also for most people, taking naltrexone before drinking would happen just once a day. But all of this should be discussed with your doctor. We hope we answered your question, and appreciate your writing.

@gymnasmic7425 Жыл бұрын

Consistent use of naltrexone is better studied but both types of uses are proven to be similarly effective.

@keitheepoo7253 Жыл бұрын

When the high is no longer worth the low. Its so hard to make a netting with a therapist a month from now when you need the help now.

@nuladee787 2 ай бұрын

Oh mate I feel for you this is exactly my situation. Just keep trying. The practitioner may have a cancellation

@Moogles1982 2 жыл бұрын

I took 50mg for just 2 days and experiences severe irritability, muscle aches, extreme drowsiness, yet difficulty sleeping with very vivid and disturbing dreams. I also lost my appetite for food or any close connection with my wife, even holding hands felt undesirable. For me, these side effects were just too much to cope with and I ended the program. Two days later, I started returning to normal

@Uvvibes 2 жыл бұрын

Sorry to hear, are you still trying to quit via another method?

@onebadhombre7158 2 жыл бұрын

Start off lower 12.5Mg

@Moogles1982 2 жыл бұрын

@@Uvvibes yes. AA, but it’s not helping so far

@RiaHealth 2 жыл бұрын

We are sorry to hear about your side effects! For a small percentage of people, they become intolerable. There are other medications you can look into, we have information on our website if you'd like to learn more: riahealth.com/medication-for-alcoholism/

@reneeellison6877 2 жыл бұрын

I don't think you really aloud the process to work long enough... The irritability goes away and allows you to work on your relationship....

@kamilKos20 11 ай бұрын

I changed my mind. Naltrexone only in case of emergency 🚨

@thomashenner3400 8 ай бұрын

What about stimulant

@acgdlov3325 2 жыл бұрын

Interesting. In another video with Claudia, she made it seem like if you took it in the morning as a doctor might prescribe, you would be blocking good endorphins from everyday things like food, sex, exercise etc. So, that is not the case?

@trias418 2 жыл бұрын

I certainly enjoyed food while on naltrexone, but I am more skeptical about their claims regarding sex and exercise. However, I would also be concerned about taking naltrexone in the morning because if you are a late night drinker, the half-life of the drug in your system means it may not be effective enough at night time if you take it too early.

@adrianchavez7183 Жыл бұрын

How can I get LDN doses 25mg and 50mg side effects are really weird with me .. I just completed my first week on TSM?

@RiaHealth Жыл бұрын

Hi, definitely ask your doctor about this. You'll probably have to go through a compounding pharmacy. Hope that helps and that the side effects improve.

@paradoxinmotion 3 жыл бұрын

if Naltrexone blocks opioids, are we considering GABA an opioid then? // ie. would this be effective for treatment of those addicted to benzodiazepines?

@ScottDieken Жыл бұрын

i was prescribed naltrexone and gabapentin by the same provider at the same time.

@drrachelblackie2976 2 ай бұрын

GABA is different. Alcohol use takes over our gaba system apparently….and then gaba system has to reestablish itself after alcohol cessation I believe.

@big_hat_logan 2 ай бұрын

GABA is related to the withdrawal syndrome and acute effects. Evidence suggests that the dopaminergic reward system is more responsible and involved with addictive, compulsive, harmful behavior loops ppl get caught in, even with alcohol

@jasonmadello7345 11 ай бұрын

This is to you. Can you get me put on this medication so that i can eat lesser and exercisse more so that i can weight lesser than 75 pounds.

@ThreeCrowns 9 ай бұрын

Naltrexone gave me anhedonia :(

@SavagePrisonerSP 3 ай бұрын

are you sure it was Naltrexone and not the alcohol withdrawal or depression? Most people experience disinterest in life after they first quit drinking.

@TheNewOriginals450 Ай бұрын

How are you know?

@SavagePrisonerSP Ай бұрын

@@TheNewOriginals450 I'm not the person you're askin, but I started taking Naltrexone and the same thing kinda happened to me. When I drank, I felt no pleasure in it, alongside other things. It was a weird feeling. I was still able to feel contentment and happinnes, but super pleasurable things weren't so pleasurable. BUT things like socializing and hanging out with friends felt WAY better! I enjoyed it more than when I wasn't taking Naltrexone, and maybe even more than when I was drinking! Thing is, I started getting some upper-right abdominal pain/discomfort (which is ur liver) and I hated not having my life without my pleasure response so I stopped taking it. I am now more thankful and grateful for going sober the OG way, even if it may be harder.

@TheNewOriginals450 Ай бұрын

@@SavagePrisonerSP Thanks for the insights 🙂.

@Uvvibes 2 жыл бұрын

Starting soon im nervous because i already have depression and anxiety

@hearme4581 Жыл бұрын

What happened?

@yennyjen5742 5 күн бұрын

How did you do on the medication?

@pattidean-jucha9694 3 жыл бұрын

What about if your taking an antidepressant, does it interfere with that in anyway/

@RiaHealth 3 жыл бұрын

That is a great question. Since everyone is on different medications, and responds differently to medications, this is something you'd have to ask your doctor specifically.

@monsecko4792 3 жыл бұрын

Probably not if you’re on ssri antidepressants since they affect serotonin levels and naltrexone is not known to affect them as mentioned

@ritabrito5040 3 жыл бұрын

@@RiaHealth I take lexapro and clonazepan, and I'm concerned about that.

@waydirtysanchez 2 жыл бұрын

@@ritabrito5040 I would also like to know this

@vagabond_trader 2 жыл бұрын

I take Wellbutrin (buproprion) and its fine. In fact there is a weight loss pill called contrave that is ntx and buproprion.

@Koorek1337 2 жыл бұрын

So does it block endorphins effects from other sources than alcohol, or not?

@marysia5049 Жыл бұрын

Z tego co zrozumiałam to nie, a u Ciebie jak? Pigułka działa? Pozdrawiam

@RiaHealth Жыл бұрын

We just made another video about that which is coming out soon! It *can* but typically not in a significant way if it is taken in a targeted dose before drinking. But it also depends on the individual and how much and how frequently they are taking it.

@conahema Жыл бұрын

@@RiaHealth Has this video come out yet? I am an avid cyclist and work out everyday. I just started Naltrexone trying the Sinclair method and want to be sure this won't impact desire to train.

@electrictofumuffins6384 3 ай бұрын

Off label use for hashimotos 8mg naltrexone for two months; there has been no benefit but I do notice a decrease in creativity. Head been buzzing. Weaning off today.

@MissCookie8260 10 ай бұрын

I took it and had a severe crying fit for the next 12 hours. It was horribly depressive for me.

@brandy61 10 ай бұрын

Yikes I’m not taking that shit

@christinascibetta1043 23 күн бұрын

I noticed a change in my mood i only take when i am going to drink. My doc wanted me to take daily but it upset my stomach. If i do drink on it i get sick too...but i still incorporate it into my life and my drinking has lessened from 3 nights per week with 2 or 3 drinks to once a week 1 or 2 drinks.....my mood overall while off it and not drinking has improved. My skin too !

@Stewpadaso4661 Жыл бұрын

50mg a day and still drinking, just want to go to bed about 4 hours earlier

@MJ-om5go 2 жыл бұрын

I heard this can help with sex addiction, is this true?

@RiaHealth Жыл бұрын

Yes, there is some evidence that the medication works with many different types of addictions.

@erimozata5120 Жыл бұрын

@@RiaHealth good to hear

@andrewkapaldo5131 4 ай бұрын

bro i feel pretty much castrated. i was like a 3 times a day dude. now maybe once every 3 days. its like i got married to myself

@Alex-Music639 9 ай бұрын

0:51 he says Naltrexone doesn't affect neurotransmitters, but we know and as he said after, it works on the endorphins .... endorphins ARE neurotransmitters 😬

@Pine_bluffs 8 ай бұрын

You also get plenty of doctors from for example The LDN research trust claiming Naltrexone indeed does help regulate dopamine too…

@drrachelblackie2976 2 ай бұрын

LDN does different things to Normal dose N. Weirdly.