Dopaminergic Medications in Treatment-Resistant Depression

Dopaminergic Medications in Treatment-Resistant Depression - Meet the Scientist Webinar

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Brain & Behavior Research Foundation

Күн бұрын

Join in the conversation with #BBRFWebinar!
Learn more about this webinar at: www.bbrfoundation.org/event/d...
Each month The Brain & Behavior Research Foundation (BBRF) hosts a Meet the Scientist Webinar featuring a researcher discussing the latest findings related to mental illness.
In August 2014, BBRF featured the research of Dr. Jan A. Fawcett of the University of New Mexico School of Medicine. He presented DOPAMINERGIC MEDICATIONS IN TREATMENT-RESISTANT DEPRESSION.
Dr. Fawcett’s career has been devoted to research on and treatment of affective disorders and suicide prevention. He is a principal investigator of the Recurrent Depression Prevention with Medication and Cognitive Behavioral Therapy project, a five-year NIMH study which is being conducted at Rush Medical College in collaboration with investigators at Vanderbilt University and the University of Pennsylvania. Dr. Fawcett helped found the National Depressive and Manic-Depressive Association (now the Depression and Bipolar Support Alliance), which created and presented him with the Dr. Jan Fawcett Humanitarian Award. Among his efforts to help educate the public on mental illness, he is a co-author of the book “New Hope for People with Bipolar Disorder.” He is also the Chair of the Mood Disorders Workgroup and a member of the Task Force for DSM-V.
Before assuming his current post, Dr. Fawcett worked for 30 years at Rush Medical College in Chicago, where he was Stanley Harris, Sr. Chairman of the Department of Psychiatry.
Find recordings of past BBRF Webinars and register for upcoming Meet the Scientist Webinars here: www.bbrfoundation.org/events
Learn more about BBRF and donate to support mental health research: www.bbrfoundation.org
Remember 100% of your donation for research is invested in research grants thanks to the generosity of two family foundations that cover Foundation operating expenses.
We encourage you to share this presentation! #BBRFWebinar

Пікірлер: 164

@johns966 3 жыл бұрын

This absolutely needs a follow up. Dr. Fawcet is brilliant.

@brucephillips1736 3 жыл бұрын

I 100% agree! I've been reading Dr. Fawcett's research for decades - he's a huge ally for the progression of depression treatments!

@scottvk4129 4 ай бұрын

I have been on pramipexole (as discussed in this video at 45:32) for about 6 weeks now. I have severe TRD and I would say I am about 25-33% better since starting pramipexole. I have cut back to 2mg (from 4mg) . This is the first med out of several in the last three years that has done anything at all for me.

@ddg227 3 жыл бұрын

Starts at 14:00

@be5333 9 жыл бұрын

Thank you to Dr Jan Fawcett and the Brain & Behavior Research Foundation for posting this webinar to KZfaq. It disseminates this information more widely which is desperately needed for people suffering from Treatment Resistant Depression.

@amnazubair73 8 жыл бұрын

Thanks so much for sharing the video. Excellent presentation. I learnt so many things.

@yogi9631 Жыл бұрын

Great video Dr hits the nail on the head @26:09sec!! Each Maoi is unique even though they are same class. One is excitatory (parnate) vs inhibitory (Nardil). This is a brilliant dr that thinks outside the square!! I just wish more so called psychiatrist n dr were like him.

@missadventuresmotorcycledi2773 Жыл бұрын

Excellent video, my Mother suffered from Dementia and Provigil helped lift her mood dramatically.

@NickArcade Жыл бұрын

RIP Dr. Fawcett

@gustavpace9858 7 жыл бұрын

Great webinar!

@NekoSoKawaii221 2 жыл бұрын

I wish studies like this were done for people like me who are 18-30. I’m about to be 26, been on meds since I was 14 nothing has worked and my doctors have given up.

@metalwarrior6657 5 ай бұрын

This is amazing. I have to try these drugs, will update you.

@KhalidFarooq786 2 ай бұрын

brilliant presentation

@BillyG563 Жыл бұрын

I just started pramipexole a few days ago after 30+ failed medications for refractory MDD and ADHD. I've tried everything from 12 sessions of ECT to macro and micro dosing of psilocybin from homegrown mushrooms, all with no help whatsoever. Fingers crossed.

@maikedasilvasantos7461 Жыл бұрын

Você toma para depressao ? Quantas mg você toma ?

@BillyG563 Жыл бұрын

@@maikedasilvasantos7461 It's working great!! I'm now taking 3mg each day: 1.5mg in the morning and 1.5mg at night. It has CURED my depression. Seriously. It is saving my life.

@ivannenchev6181 Жыл бұрын

@BillGreenfield how long did you wait to see a result?

@johns966 8 ай бұрын

Happy for you my king! 👑

@scottvk4129 6 ай бұрын

@@BillyG563 still taking pramipexole for depression? How is it going? What doseage did you first start seeing results?

@anlace3447 3 жыл бұрын

I find MAOIs, particular Phenelzine (Nardil) tremendously helpful.

@gregorymalchuk272 3 жыл бұрын

How long did it take you to notice a difference on nardil? What dose were you on? Does it give you back the energy and motivation to get back to work/school/hobbies/social life?

@TSCarmenMelbourne 2 жыл бұрын

I'd agree with you and Tranycypromine (Parnate) is good too but a little more stimulating than Nardil

@vikasgupta1828 Жыл бұрын

Thanks

@georgeschiraga5725 2 ай бұрын

Great news.

@gabrielaponte6403 5 жыл бұрын

For the old guy with treatment resistant it is possible he may be getting early symptoms of Parkinson’s since early symptoms are usually depression and since it is primarily dopamine related symptoms

@audreyheart2180 Жыл бұрын

🙏❤ "Keep away from people who try to belittle your ambitions and /(or your trauma). Small people always do that. But the really great ones, they make you believe that you too can become great/ (or overcome your trauma)." -Mark Twain

@Kingboo1081 2 жыл бұрын

Anyone using Selegiline with Pramipexole?

@bill9923 4 жыл бұрын

I failed TMS. Forty consecutive sessions. It made my anxiety worse😭

@raylee2476 3 жыл бұрын

I failed too :(

@JB-yh8so 9 жыл бұрын

The patient you spoke about 26 min into the video. You mentioned he had prostate cancer. Was he being treated with finasteride prior to getting surgery? Robin Williams was on that medication for hair loss treatment. I fear it contributed to his suicide. I can tell you first hand it causes VERY serious depression. That medication breaks something in the brain and it stays that way well after stopping the medication. There is research underway in Italy that shows the drug greatly impacting neurosteroids levels well after stopping as well. Some of the same neurosteroids deficiencies recently found in MS. The stuff is pure evil in a pill. I would rather die from cancer then take that medication. I really wish more doctors were aware of the power that medication has to induce these problems.

@gabrielaponte6403 5 жыл бұрын

Yeah it’s very bad for neurosteroids which are very important for cognition and mood and drive

@ginzo666 Жыл бұрын

Just take some proviron. You'll be fine.

@kalliaslands9938 5 ай бұрын

Yes. Finasteride anxiety is quick and pretty bad. It’s a real shame that they have not developed an analogue without BBB penetration. There is very little benefit to having it active in the CNS

@lukeraynor3704 4 жыл бұрын

What about Parnate ?

@gregorymalchuk272 3 жыл бұрын

Have you had any success with MAOIs?

@alainsibler9135 4 жыл бұрын

With such a high dosage target and only once daily dosing, wouldn't it be wiser to use an Extended Release formulation of pramipexole to avoid substantial daily blood level fluctuations ? Dr Fawcett never mentions the subject, so I guess he's using the Immediate Release formulation.

@alainsibler9135 4 жыл бұрын

@Katie R Hi Katie, Did you try pramipexole? Got any results with it?

@alainsibler9135 4 жыл бұрын

@Katie R Yes I have, for approximately one month, but I couldn't ramp up the dosage very high (1mg is the highest I could get). After a while it gave me intolerable insomnia that didn't abate even with a dose reduction, so I had to stop. I didn't feel much of a positive effect, just some sort of unpleasant stimulation and a buying compulsion that I had to repress.

@gregorymalchuk272 3 жыл бұрын

@@alainsibler9135 Did it help much for motivation and cognition?

@alainsibler9135 3 жыл бұрын

@@gregorymalchuk272 As for me I would say no, but again, I didn't tolerate it, so I couldn't take it for long enough on a dosage high enough. By the way, I read somewhere that intolerance was rather high (around 20%). That's a fact that Dr Fawcett doesn't emphasize so much about his wonder drug...

@mauriciojr.4428 5 ай бұрын

@@alainsibler9135Shut up...

@toddbedusek2780 6 жыл бұрын

I don't think have dopamine drugs only seratonin

@gildedgatsby 4 жыл бұрын

Do you think RD Lang and Thomas Szasz are worth considering?

@shawnrobertson9901 3 жыл бұрын

Case 4 sounds like me to a T. I am trying to get my Dr to listen to me and treat me for low dopamine. I can't make myself do anything and I am miserable

@kibnob 3 жыл бұрын

Try contacting Dr. Fawcett and see if he'll write a letter to your psychiatrist describing his strategies for treating anhedonia. Dr. Ken Gillman is another eminent psychiatrist who understands the importance of dopamine, he responds to emails and has an open letter on his site you can bring to your doctor ( psychotropical.com/open-letter-using-monoamine-oxidase-inhibitor-maoi-drugs/ ). You could also print out the studies mentioned in the video on pramipexole and MAOI treatment and bring them to your next appointment.

@mazklassa9338 2 жыл бұрын

Same. I've told more than one Doctor several times that I wanted to abstain from masturbation and porn addiction, which I have done through sheer will power, but after conditioning my brain with that GARBAGE has left me with anhedonia and insomnia, erectile dysfunction, short term memory loss and poor focus, and subsequently acute depression, suicidal ideation. Most Doctors do not give a shit about their patients. That's what I'm begining to think.

@possumprince 2 жыл бұрын

ask about trying wellbutrin, it helps low dopamine, and doctors generally aren't too hesitant to try it. sometimes they might wanna try an ssri first but if that doesn't work, wellbutrin is a pretty common second attempt

@dpalmer1557 Жыл бұрын

@@mazklassa9338 Dr.Trish Leigh. KZfaq porn addicted? Porn kills love!

@aphysique Жыл бұрын

@@mazklassa9338 did ya get help? What did ya use?

@adimalaviya Жыл бұрын

What about low dose Amisulpride ? Worked wonders for me

@ivannenchev6181 Жыл бұрын

@adimalaviya,how long did you take it and in what dose?

@adimalaviya Жыл бұрын

@@ivannenchev6181 I took 25-50 mg, never more than 50 mg and I took it for quite some time, a few years, but yes it does work really well. Unfortunately I hear that it's not available in the USA

@ivannenchev6181 Жыл бұрын

@adimalaviya, thank you for the response and how long did you take it before it started working?

@adimalaviya Жыл бұрын

@@ivannenchev6181 within a month, but I must warn you that this medicine does have bad sexual side effects.

@tayyebafridi 2 жыл бұрын

I've treatment-resistant depression and was looking for solution. After finding this one, I immediately discussed pramipexol with doctor this morning (March31,2021). His response was not positive as he was of the view that few successful cases couldn't be the benchmark. So he doesn't advise it. I desperately wanted to try it as I have been testing SSRI, SNRI, and TCA, for 20 years. Nothing helped. Still down and restless with mental fatigue and low energy, low self esteem, sleep problems, anhedonia and many more issues. What should I do? Should I discuss this with another doc or this medicine is no longer relevant as this video is 7 years old. Response from Brain and Behaviour research foundation would be appreciated. Thanks.

@mnkwazi 2 жыл бұрын

@Muhammad Tayyeb Afridi I am in the same situation. They won't let me try pramipexole

@johns966 2 жыл бұрын

order it online

@tayyebafridi 2 жыл бұрын

@@mnkwazi I'm sorry to know that you are also going through this situation. Sending you strength.

@tayyebafridi 2 жыл бұрын

@@johns966 Can I try it without doctor? Not sure of side affects.

@johns966 2 жыл бұрын

@@tayyebafridi I ordered it from overseas. The side effects can be pretty bad but go away with time. The one side effect to watch out for is compulsive behavior. That can be VERY dangerous.

@shonasaror90 3 жыл бұрын

Can use t.pramipex.125mg for my daughter is having MDD with annehodia with loss of interest in studying.?

@matthewmccarty9991 4 жыл бұрын

42:00

@capitalist4life 8 жыл бұрын

D2 receptors have got to be involved in depression. Abilify, a D2 agonist, works incredibly well for me.

@jammysivile4378 7 жыл бұрын

How long did it take to kick in? Did you try other meds before you had a breakthrough with Abilify?

@capitalist4life 7 жыл бұрын

overnight typically (2 mg)

@_Trakman 6 жыл бұрын

capitalist4life what medication?

@gabrielaponte6403 5 жыл бұрын

capitalist4life it’s partial d2 agonist meaning it blocks excessive d2 stimulation but slightly stimulates it , abilify (aripriprozole) is also of serotonin receptors 2 antagonist which has antidepressant quality and a serotonin 1 receptor agonist which also has antidepressant quality

@toddbedusek6263 5 жыл бұрын

@@capitalist4life does it cause weight gain. Though

@matthewmccarty9991 4 жыл бұрын

59:30

@maiberlinhernandez3008 4 жыл бұрын

Not certain about the points made but ,if anyone else wants to discover getting over depression try Elumpa Depression Cure Alchemist (do a google search ) ? Ive heard some interesting things about it and my mate got excellent success with it.

@diksonh 4 ай бұрын

Low dosage of flupentixol helps with dopamine related depression for me. I guess it is not mentioned here because US does not approve this drug.

@mangos2888 Жыл бұрын

I'd be curious how he feels about dopamine-genetic medications now that Tardive Dyskinesia has gained awareness. 🤔

@johns966 Жыл бұрын

tardive dyskinesia is caused by anti-dopaminergic drugs (risperidone, haloperidol, etc.) not dopaminergic drugs like pramipexole

@beckyweaver5981 4 жыл бұрын

Pramipexole treats anhedonia. TMS treats MDD.

@toddbedusek6263 5 жыл бұрын

Can provgil help with dopamine

@levtrot3041 4 жыл бұрын

just try meth dude

@j.d.2703 4 жыл бұрын

Provigil sucks...$40 for the worst headache EVER

@Nitroblast 4 жыл бұрын

@@j.d.2703 i didn't get headaches, i found it very useful for when i was exhausted but it didn't help my anxiety at all

@j.d.2703 4 жыл бұрын

I will be asking for ritalin and dropping my depression meds to counter my percocet and gabapentin

@Nitroblast 4 жыл бұрын

@@j.d.2703 ritalin for adhd or depression? and interesting, i take pregabalin (which is metabolised into gabapentin) for ibs pain/anxiety and low dose quetiapine which only helps me to sleep but have tried 3 antidepressants with no success.

@toddbedusek2780 5 жыл бұрын

The fisher wallace device ..

@bobmalone4519 8 жыл бұрын

I have had major treatment resistant depression for twenty five years.tried all the antidepressants with little help.I saw this video and asked my doctor for pramipexole.the doctor said no.any one know a legit online pharmacy where i can get it.doctors should be willing to try things till something works.

@jakeofjoy6818 8 жыл бұрын

+bob malone i've ordered from buy-pharma. co, they have pramipexole, i believe its made in india. The meds ive gotten from them have been legit.

@capitalist4life 7 жыл бұрын

Find a successful clinical trial on pubmed, print out the abstract, and show it to your doctor. onlinelibrary.wiley.com/doi/10.1034/j.1399-5618.2002.01171.x/full

@Nitroblast 4 жыл бұрын

@@capitalist4life i appreciate that but unfortunately i'm in the uk where we have a formulary based prescribing system and so it's very hard to get even a psychiatrist to prescribe something not on the formulary

@beckyweaver5981 4 жыл бұрын

Nitroblast have you tried a TMS? Look into Fisher Wallace stimulator and of course the pramipexole, which will help give u back some ambition and drive. (Treats anhedonia)

@beckyweaver5981 4 жыл бұрын

Jakeofjoy that website is not there now

@toddbedusek2780 5 жыл бұрын

This was filmed 2014 ..

@toddbedusek2780 5 жыл бұрын

Wellbutrin is very week

@ligeskityler 4 жыл бұрын

Todd Bedusek Made me sick

@johnmoore1495 Жыл бұрын

Yeah it’s weak and has a high side effect profile. I get horrible tremors on 450mg/day and my vision blurs really bad.

@dash9746 Жыл бұрын

It mostly raises noradrenaline which is probably what the side effects are from. Noradrenaline is similar to adrenaline. Insomnia, sweating, overstimulation etc

@andreyaksyonov Жыл бұрын

From all of these only ppx and 4 amphetamine stimulants work.

@clausmehl8731 2 жыл бұрын

Ssri causes this disorder

@toddbedusek2780 6 жыл бұрын

unless you live in wisconsin Dr here's suck

@johnmoore1495 Жыл бұрын

Agreed lol. Only had one good doctor and he was a psychologist, if only he was a psychiatrist and he could’ve prescribed my meds too.

@garimapandey4800 3 жыл бұрын

But it's withradwal are similar to cocaine Why would we take it ?

@toddbedusek2780 5 жыл бұрын

Robin Williams wasn't given the right medication apparently

@laurieb9053 4 жыл бұрын

He knew he was getting Parkinson's and didn't want to go through that...he was on mirtazipine.

@toddbedusek2780 5 жыл бұрын

My doctor sucks

@dpalmer1557 Жыл бұрын

Amino acids... Try this, it will take couple days to get in your system. Adjust as needed. Vit.C 200mg Vit B6 75mg Magnesium 80mg Zinc 30mg LTyrosine 900mg free form LGlutamine 900mg. Free form Taurine 750 mg. Good luck. That was a formula used by natural herbal co. Big pharma bought it...that formula got my dad off zoloft and a sibling off prozac.

@chenashohor 9 жыл бұрын

Hey! Have you tried Depzap Total Depression Domination (should be on google, have a look)? Ive heard some awesome things about it and my m8 managed to end depression once and for all.

@danielandrespat 23 күн бұрын

Hi, i googled it, and didnt found anything. Do you have a link? thanks