Anesthesiologist Dr. Steve Shafer testifies that he wants to dispel the stigma that Propofol is a bad drug.
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@Kings_1K11 жыл бұрын
Awh, he's so nervous. But seems like a great doctor.
@kkdesignservices1834 жыл бұрын
"Treating" insomnia with propofol is like "treating" a hangnail with a chainsaw.
@michaelh50553 жыл бұрын
Or like using chemotherapy to go bald rather than a razor
@RadagonTheRed10 ай бұрын
Jackson’s tolerance to benzodiazepines must have been colossal if his daily regimen of midazolam, lorazepam, diazepam and (non-benzodiazepine) trazadone wasn’t allowing him to sleep, leading to him asking for propofol.
@creativeself71478 ай бұрын
Oh yes, you're 100% right. Before I became an anesthesiologist and later Psychiatrist, I had a massive Sedative issue myself, regularly taking 10mg Diazepam (or. or i.m.) / 25mg Oxazepam (or.) + 1,0mg - 1,5mg Lorazepam (or./sublingual) and 5mg Midazolam (i.m. or rectally) to fall asleep relatively comfortably and quick. It's already a massive amount of sedatives and my tolerance was extremely high. But what Michael Jackson was given is on a whole other level. At that point, I have no doubt that the man was absolutely desperate for something along the lines of Propofol. However, this doesn't change the fact that he should have never been given Propofol. Especially not considering that there are MANY options that could have been tried before taking the Propofol route... which is the absolute last option that should ever be taken. Especially considering that Propofol-induced unconsciousness is NOT sleep. Sleep is mandatory for the human brain to build nerves and repolarize certain Neurotransmitters. During Propofol-"Sleep" none of that happens. Michael Jackson's brain had essentially been going without sleep for weeks... which is incredible to even imagine and further explains why he's been so resistant to Benzodiazepines (but that's a whole other topic). There are quite a few drugs that can assist people with major Benzodiazepine dependence to fall asleep since they affect different Neurotransmitters and different areas in the brain. Murray should have tried a variety of anti-psychotics/neuroleptics (typical and atypical) like Quetiapine, Promethazine, Olanzapine, Risperidone, Haloperidol, Aripiprazole, etc. These drugs might not be primarily indicated for the treatment of insomnia, but of-label use for insomnia is allowed, effective, and perfectly safe. If that didn't help, he could have additionally given antihistamines like Doxylamine and/or Diphenhydramine. In combination with the Benzodiazepines, this would combine three different routes of sedation that each work in different ways. You have the Benzos to affect the GABA-System and reduce catecholaminergic activity (such as adrenaline and noradrenaline) and overall stimuli-sensitivity; you have the antipsychotics act on dopamine-neurotransmitters and severely reduce dopamine activity, causing a major decrease in activity-inducing motivation, a reduction of focus and concentration and a feeling of major tiredness; and you have the antihistamines that reduce histamine activity in communicating nerves inside the brain and CNS, further reducing overall nerve-activity and causing an urge to lay down and close your eyes as the body is essentially being tricked into thinking that it's suffering an infection. These drugs might not be as 'comfortable' to fall asleep to as Benzodiazepines and often cause quite a bit of fuzziness in the 2 - 3 hours after waking up the next day, but they are surprisingly effective at inducing a strong feeling of tiredness even at low doses. I can confirm it myself. Back when I was taking the Benzodiazepines, there were times when I did not have access to them and had to find a different way to fall asleep. It turned out that a small dose of 25mg - 50mg of Quetiapine was able to make me fall asleep within less than 2 hours. Of course, there'll be a desire for Benzodiazepines upon waking up the following day, but it's no longer coupled with the desperate desire to sleep and only based on the natural anxiety that a Benzodiazepin-addiction goes along with - but to treat this anxiety the amount of Benzos you need is far lower than the one you need to induce sleep. After many years of treating patients with Benzodiazepine addictions and insomnia, I can confirm that the effectiveness of this method wasn't exclusive to me, but works very well in 9/10 cases. I have gone over the filings of MJ's case multiple times and I could not find ANY mention of antipsychotics/neuroleptics/antihistamines throughout ANY of the thousands of pages. This is INSANE. To go from Benzodiazepine-resistant insomnia to freaking PROPOFOL indicates that Dr. Murray is the kind of doctor who's gotten his degree and license through the use of manipulative behavior, forced binge learning, and a dose of dumb luck. He clearly lacks a deeper understanding of medicine and (at the very least) the function and biology of the human brain, neurological functions, and human behavior. But it seems like Mr. Murray didn't exactly take medicine seriously anyway. As a current lead-Psych. with EU directorial licensing and NATO-med.-authorization I have access to view prescriptions per auth. practitioner. And while I'm obviously not allowed to disclose any numbers or give individual substance-related information; I am allowed to give an overall assessment. To make it quick: Dr. Murray has been prescribing roughly 30 times as many sedatives as the average medical practitioner. Also noteworthy is that these prescriptions were almost entirely given to patients between 20- and 30 years. An age-group that's usually associated with the lowest consumption of sedatives. I'm not allowed to make allegations against other MDs, but considering that Murray is no longer licensed, I feel free to confidentially claim that Mr. Murray has been prescribing sedatives in return for monetary compensation for at least 3 years and 8 months. Sorry for the long text, but it's a topic that I'm deeply invested- and interested in. Also, I apologize for any spelling errors; English isn't my first language. Have a great day!
@greg90696 ай бұрын
Yea, if you start taking them throughout the day, instead of only at night, it becomes a detriment to sleep; because it stops sedating you, and simply keeps you out of a seizure/ Akathisia.. you have to take a lottt all the time to get to that point tho.