Elizabeth Blackburn (UCSF) Part 1: The Roles of Telomeres and Telomerase

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Күн бұрын

www.ibiology.org/genetics-and...
Lecture Overview
Telomerase, a specialized ribonucleprotein reverse transcriptase, is important for long-term eukaryotic cell proliferation and genomic stability, because it replenishes the DNA at telomeres. Thus depending on cell type telomerase partially or completely (depending on cell type) counteracts the progressive shortening of telomeres that otherwise occurs.
Telomerase is highly active in many human malignancies, and a potential target for anti-cancer approaches. Furthermore, recent collaborative studies have shown the relationship between accelerated telomere shortening and life stress and that low telomerase levels are associated with six prominent risk factors for cardiovascular disease.

Пікірлер: 92

@Gamer_Pro571 4 жыл бұрын

Elizabeth blackburn one of the great scientist and also nobel prize winner your work is amazing i am in class 11th i got much information from your lecture thank you mam

@ani5cal 3 жыл бұрын

Dear Professor Blackburn, many thanks for the talk.I feel deeply honoured to have your lecture as part of your audience at the Academia Sinica auditorium in Taiwan several years ago. Best regards, Anindita Banerjee, India

@rasumidurais4145 4 жыл бұрын

Excellent presentation Elizabeth! Congratulations with your partnership win to the Nobel 🏆 prize!

@web3developers 8 жыл бұрын

hey congrats on the Nobel prize Elizabeth! Well deserved!

@scicommlab 11 жыл бұрын

Hi Henike! If you click on the "CC" button below the video, you will see an option to turn on English subtitles that we created for the video. We hope this is helpful! Best, iBiology team

@micahpardee1467 8 жыл бұрын

Out of all of the subjects I have studied and learned about in various biology classes, this is by far my favorite. There is just something so captivating about the whole concept.

@lassusprophetam8209 6 жыл бұрын

Lady Elizabeth of telomeres this is so fascinating and the way she explains it so wonderful you can truly see how she loves her work and she's helping us to understand it.

@StephenGillie 4 жыл бұрын

For DNA-as-data, telomeres are like brackets. For DNA-as-objects, telomeres act like a panhandle or lathe that can be clamped and hold the DNA.

@eddieleong6490 5 ай бұрын

Excellent; With patience and some foundation knowledge, even a non-biologist can understand. She speaks slowly and the transcription helps a lot.

@jackdevonarason 13 жыл бұрын

Great Job! If people only knew just how important this research is they would not bring a strange word against you. Thank you for all your world in this area thank you for this video very informative. Congratulations on that little prize you were given, you are the one person I thing that really deserves it.

@usmanasghar1127 4 жыл бұрын

Very very good lecture. She is so clear and so central in her explanation

@jonassalk1387 5 жыл бұрын

You are A Good teacher. I hope you keep making such good videos. I hope to be able to keep up grading my limited understanding of genetics. It is a magical subject. Thank you.

@dinulsromans 12 жыл бұрын

These are so far most usefully spent 48 minutes 27 seconds of my life. Thought I have 62 minutes 13 seconds ahead.

@maddenfootballtalk6544 5 жыл бұрын

Ok how do we uncap this ?? How can we stop the need do telomeres or stop the shortening of them completely? Let's discuss how our lives can surpass that 120 year cap that's been spliced into our DNA. This is all great info but let's look at remedies

@thanosspeedy2321 2 жыл бұрын

I HAVE THE NATURAL SOLUTION TO ACTIVATE TELOMERASE IF you still need it send me your e mail

@eddieleong6490 5 ай бұрын

I am grateful to Dr. William Li. In his book...Eat to Beat Diseases, he mentioned Nobel Prize Winner Elizabeth Blackburn. Her team discovered the enzyme Telomerase. This is the most exciting topic for me... Longevity, old age, diseases, etc. seem to relate to the health of the telomere. I am learning deeply from her videos.

@rgcamsf 10 жыл бұрын

Amazing discovery! Lot's of great implications being researched!

@tonyrabone4668 3 жыл бұрын

Thank you for a great presentation.

@seanmastro6782 4 жыл бұрын

It will take energy to repair telomere, so clearly an outside source to repair telomere is needed.

@Rosana007 12 жыл бұрын

Well finally I understood! Thank you.

@nonglucknarkchamnarn1548 9 жыл бұрын

Thank you everything idea..regulation about concentration. I'm maintain one's health.

@zephaniahmarion8578 6 жыл бұрын

Thank You.

@sayoksarkar1106 6 жыл бұрын

There is a part in the video where we see that telomerase sequencing reverse transcriptase the Adenine and Guanine are pairing which is unlike the complementary base pairing. Is it a mistake or it happens?

@seans4893 10 жыл бұрын

Fantastic!!! She is Awesome

@muricamarine9473 4 жыл бұрын

No she is extra freaking fucking awesome bro

@erwinrogers9470 Жыл бұрын

Great information 🔥

@quantumbiofeedback1781 3 жыл бұрын

Thank you

@Barbarossar 10 жыл бұрын

There is one thing, I don't understand. At 27.38, a picture is shown. And is seems like telomerase is adding 3 G's. But the telomere-end already has 2 G's..? And does telomerase Always 'binds' to the last three nucleotides or does it 'read' where it has to bind in order to complete the sequence? Might be a silly question, but is there anyone who can explain? (Sorry for my english)...

@octaviotorres9895 6 жыл бұрын

wooow. Extraordinary

@maricruz726 3 жыл бұрын

Como lo puedo escuchar en español? Gracias

@magda3177 4 жыл бұрын

Please! Could enable subtitles for Portuguese (Brazil); Thank you very much!😊

@victoralosi1461 3 жыл бұрын

This got me thinking a bout bread yeast and mutated yeast as compadres to wild yeast. Interesting

@kipling1957 4 жыл бұрын

It's not clear why telomerase expression is very low in most normal adult mammalian somatic cells given that it maintains genomic stability.

@rmg12498ruth 10 жыл бұрын

Nature creates miracles infinitely.

@safdarsafdari7289 3 жыл бұрын

telomers prevent joining of ends of chromosomes to each other or one and other that breaked, what prevents joining of 2 dna breaks in middle of dna of two chromosomes?

@Tazbaby2066 8 жыл бұрын

I find this so interesting, you just told me around 11 minutes that the ends can attach to other cells when depleted, then why on the picture at 12 minutes we can not believe that when the ends are finished, they find another cell to attach to?

@saty 5 жыл бұрын

Inspiring lecture @2018

@disciple1010 4 жыл бұрын

Could Shortening of occasion telomeres is individual DNA itself? Which everyone have different DNA

@darelbutler3953 8 жыл бұрын

Congrats, too, on the Nobel from a former student of Prusiner's!Darel Butler

@exedra88 11 жыл бұрын

As I am not English I would like to read it as well because I do not understand everything.Is it possible?:)

@adakteen2 12 жыл бұрын

How can I get more information on the papers she referenced?

@tonyotis1 6 жыл бұрын

In some part of the video, Ms Blackburn, is there a maximum length of the telomeres and that enzyme is produced when maximum length has been achieved, that will regulate the maximum length? Is there a natural way to get the cells to produce telomerase, if we get into physical activity daily, keep the oxytadive stress to minimum, and high nutritional foods with high levels of vitamins and minerals, would to be possible to stop the shortening and maybe start get the telomeres to grow longer.

@thanosspeedy2321 2 жыл бұрын

I HAVE THE NATURAL SOLUTION TO ACTIVATE TELOMERASE IF you still need it send me your e- mail

@EL_RINCON_DE_BENITO_HENRIQUEZ 4 жыл бұрын

Será posible... subtitulado please .....

@lizandrotorres8654 4 жыл бұрын

She Is genial!!

@kamlakarmore9221 2 жыл бұрын

Beautiful lectute

@siriwanlaiaddee3902 9 жыл бұрын

good

@rogerscottcathey 4 жыл бұрын

Genius

@shadowclans8507 9 жыл бұрын

What are your thoughts on Aubrey De Grey?

@web3developers 8 жыл бұрын

hes definitely involved in the advancement of anti aging research heavily but i truly think at this point this is the research direction that has produced most significant results i.e. mice aging reversed at harvard...e.blackburn was one of three who received the nobel for this discovery (telomerase enzyme)

@noway165 2 жыл бұрын

Anyone else linked here for telomere damage from s protein jabs?

@seanmastro6782 4 жыл бұрын

i guess we are forced to photograph the code while the person is young, and reintroduce to the same person later in life.

@amanteamada1 10 жыл бұрын

X favor en CASTELLANO-ESPAÑOL. GRACIAS

@sidmichael1158 3 жыл бұрын

Now the question is how do we lengthen our telomeres?

@robynhope219 Жыл бұрын

Read The Telomere Effect.

@mtbers 13 жыл бұрын

'the cells are growing well, normally." haha lol

@synoptic1505 3 жыл бұрын

So you are implying a dysfunction might produce cells of another species by duplicating, naturally?

@synoptic1505 3 жыл бұрын

A lice mutagen (airborne)?

@synoptic1505 3 жыл бұрын

A DNA encoded other-species mutagen?

@heyblue5001 4 жыл бұрын

Nobel prize winner. applause3

@BigBearHuskyMusher 13 жыл бұрын

Seems all the great scientist get their inspiration from nature.

@1After100 12 жыл бұрын

Yes, yes, c'mon, get on with it!

@gabrieltremblay3918 5 жыл бұрын

hard to follow as a noob but it seem damn interesting

@noobnoob5153 6 жыл бұрын

After 9 year after

@easyrawlins6271 10 жыл бұрын

13:26

@markhajdari8591 7 жыл бұрын

Why is not any body question if she discovered it why as a sciances she has not tried her own invention and look or become young

@frankpeter6851 5 жыл бұрын

You might know her by her other name; katy perry.

@iwanttocrashmybike 13 жыл бұрын

How does this disprove GOD?

@TheYellowSignal Жыл бұрын

I just learned this is why Wolverine will eventually die in X-Men.

@garbagemanify 6 жыл бұрын

I'm listening to god damned "Mrs. Doubtfire"......Robin Williams... " Toooo-Da-Loooo!"

@deniseseabreeze798 5 жыл бұрын

This chick is way more interesting than Robin Williams. Plus she's a super inquisitive girl👍😎 won that Noble prize

@3suze 8 жыл бұрын

In the future , we will be like vampire

@haroldcarter192 4 жыл бұрын

brett weinstein brought me here.

@BestYoutubeChannelInTheWorld 14 жыл бұрын

Respect for Elizabeth, but man she talks so boring..such a nice lecture but..it should be done more with passion.

@GarrettXHolder 7 жыл бұрын

TmX the subject and information is the passion she's a scientist not a street performer

@kingoflove2013 7 жыл бұрын

TmX she is not one of those losers you see in your life, she is a very serious scientist

@robynhope219 Жыл бұрын

She is not a busker...