Epigenetics and Aging: The effects of DNA breakage and repair

Рет қаралды 133,620

Жыл бұрын

A 13-year international study in mice demonstrates that loss of epigenetic information, which influences how DNA is organized and regulated, can drive aging independently of changes to the genetic code itself. It also shows that restoring the integrity of the epigenome reverses age-related symptoms.
Version that includes an audio-description: • Epigenetics and Aging ...
Learn more at hms.harvard.edu/news/loss-epi...

Пікірлер: 331

@militiamc Жыл бұрын

Still lots of work to be done. Epigenetic age reversal in mice was done a couple of weeks ago and the mice lived 9% longer than the control. Rapamycin gets mice to live 30%+ longer. This epigenetic reversal was only done once though. The trick is there are 200 different cell types in the body - some types of cells 'age' faster than the other. The liver for example regenerates quickly so if you give the same factor to a liver cell as a brain cell, the liver cell would be rejuvenated too much and become a cancerous tumor. In addition, just because you're say 50 years old doesn't meet all of your cells are 50. The age of your individual cells follow some distribution such that if you give them all the same factor the old cells get rejuvenated and the young cells get cancerous. So in theory age reversal is possible but I think we're one breakthrough away. How can you identify at what stage of the cell cycle each cell is and only target certain cells at certain stages - that my KZfaq friends will be the end of aging.

@sufficientmagister9061 Жыл бұрын

You raise genuine concerns; I wonder if quantum computers will solve these problems within the next few decades?

@alessandrobruni9746 Жыл бұрын

If we only knew the exosomic code then we could put the substance into a lyposome and be much more specific. Also couldn't we try to add PARP inhibitors to the drug as to minimize the chance of developing a tumor?

@ChrisBear1989 Жыл бұрын

Won't be long now.

@AP-ei4jt Жыл бұрын

If we just ditch industrial seed oil, we could live another 10-20 years longer, plus less DNA damage along the way. There are many ways to skin the cat, some are way cheaper.

@candyazz28 Жыл бұрын

Diet plays a huge factor in this as well. If you eat things that cause genes damage then there's no use on trying. A vegan diet is optimal on genetic repair be it that plants have antioxidants which stops aging on it's own.

@markwalker2986 Жыл бұрын

I'm in my mid 50s and I hope in my lifetime we can reverse ageing.

@aimanhazeem7852 11 ай бұрын

Aminnn

@user-iv7ny9he9d 10 ай бұрын

We will make it I promise you sir

@ten10_ten10 10 ай бұрын

@@user-iv7ny9he9d I hope so. My parents are younger than Dr. Sinclair is so him believing he'll do it in his lifetime makes me hopeful my parents will be around for a lot longer than I initially thought.

@Emiliah1996 9 ай бұрын

@@user-iv7ny9he9dcan I change how I look then? Like my eyes lips face shape butt etc and look younger?

@user-om4bz9cv3n 8 ай бұрын

You should still enjoy every second of your life though sir, realistically it's unlikely to happen (and even unlikelier to be affordable). It might not be a healthy attitude to hope for a prolonged lifespan, as we should all be grateful for what we have

@radwizard Жыл бұрын

Thank you Dr. Sinclair to you and your group for dedicating your life to studying this arduous work.

@2drealms196 Жыл бұрын

Hopefully his company's petitioning the FDA to pull NMN off the US market doesn't get approved. Given NMN has been sold as a supplement for years before Sinclair's studies began, if only his company is allowed to monopolize the sale NMN it will very likely mean a large jump in the costs for the average consumer. Its not good to deify people or put them on pedestals or refuse to see their flaws. Watch as this comment gets deleted or shadow blocked.

@qd___741 Жыл бұрын

@@2drealms196 Yeah this guy went from doing cool things to becoming a money greedy cunt, to say it bluntly.

@slartymcbartfarst7559 Жыл бұрын

Arduous? I would think rather exciting myself.

@alexharvey9721 2 ай бұрын

Many of us might one day owe our lives (or part of them) to this guy. Doesn't sound like it was easy to get where he is now either. Definitely recommend his book "Lifespan".

@alfabsc Жыл бұрын

Thank you for explaining this complicated topic in a way that people with only basic biology education can understand.

@cameddy4081 Жыл бұрын

Thanks for sharing this info so freely Harvard - optimism through science!! Disregard at your own folly PLEASE keep posting and keep the love of learning alive 🙏

@ranjitpelia3267 Жыл бұрын

wow, amazing work. Asides from aging, just in terms of chromatin remodeling and PIC-recycling, paradigm shifting.

@MarcelaBellyDance Жыл бұрын

Wonderful news! Thank you so much for your amazing work 👏🏼👏🏼👏🏼

@flareonspotify Жыл бұрын

That video was surprisingly well made

@SpringChickensOnlyMan Жыл бұрын

It’s coming. I can’t wait for us to finally stay looking good our whole lives. I hate how old age disfigures your body and makes it impossible to date when you’re older

@LukeRosee Жыл бұрын

lmao dating is ur worry ??

@SpringChickensOnlyMan Жыл бұрын

@@gurugamer8632 great for you

@LukeRosee Жыл бұрын

@@gurugamer8632 yeah no 74 year old is using that ID and commenting here

@SpringChickensOnlyMan Жыл бұрын

@@LukeRosee he didn’t show ID he just commented

@LukeRosee Жыл бұрын

@@SpringChickensOnlyMan userid ? its not that deep

@jbond5834 Жыл бұрын

thanks for the amazing work and groundbreaking study about the meaning of life.

@larsnystrom6698 Жыл бұрын

@J Bond The meaning of life is living it.

@aishoolas Жыл бұрын

Thank you for explaining such a difficult research in an accessible language. Love you, HMS 🤍

@vonwolly2 Жыл бұрын

David Sinclair looks good for his age.

@dellaatkins8336 21 күн бұрын

This is amazing!!! Thank you!!

@soundsofcodes Жыл бұрын

You've found immortality and only a few million people know about it. This discovery is beyond incredible. I'm proud to live in the same era as you. I kiss your hands. I'm in tears. Thanks a million❤

@AndrewShevchuk Жыл бұрын

I wish you good luck and success in your future research.

@lyrooo326 Жыл бұрын

I would never be able to learn all the things I want to within the normal life span of the average person and as we get older the harder it for us to learn, hopefully this can help us all.

@stultuses Жыл бұрын

I don't find it gets that much harder I find it harder to invest the time in specific areas because there is just so much to learn I don't have enough time to investigate fully a topic of interest

@ars571 Жыл бұрын

There’s a video from wired here on KZfaq that debunks that idea that it’s harder to learn as we age, in certain areas it’s exact opposite.

@Kaizen747 Жыл бұрын

@@ars571 sounds like BS

@jostsomuan8012 Жыл бұрын

I know right. There are times that I feel so sad I won’t be able to devote more time in the topics that interest mes So, if we were to ever get to live to a thousand or so, i’m going to have plenty of time to do what I want.

@markyay Жыл бұрын

@@stultuses no it definitely gets harder as neuroplasticity declines

@SilverFan21k Жыл бұрын

Deserves more views…

@pumamanta1771 Жыл бұрын

The sound effect of DNA “loosing” was VERY disturbing

@mouazalem2807 Жыл бұрын

Love it.

@canalsentir 4 ай бұрын

Good stuff David! Keep going with it all, hopefully you can put things like PKD (kidney diaease) , and othera into the hiatory books.

@nakkurenlinux9765 5 ай бұрын

omg this is amazing AMAZIIIIIIIING

@canalsentir 4 ай бұрын

Good stuff David! Keep going with it all, hopefully you can put things like PKD (kidney diaease) , and others, into the history books.

@vulcan4d Жыл бұрын

Very nice, perhaps my kids will love longer and healthier lives.

@LainSerrato1 Жыл бұрын

I love how everyone in the comments is an expert on this stuff. Thanks for all the hard work doc now hurry up and keep me young forever so I can create my familial army

@thelatentsexualfreak 11 ай бұрын

Both mice are adorable

@dcjohnson2208 9 ай бұрын

They were both sacrificed in the advancing March to make humans live longer.

@ryanrockers Жыл бұрын

I, for one, am glad they animated the tldr for me

@brightbright6768 Жыл бұрын

Pls do it quickly before I turned 40. Life is good here.

@Ianschweitzky 4 ай бұрын

😂

@richardbalboa7161 Жыл бұрын

How a privilege to live in the 21st century !

@keynadaby Жыл бұрын

But now with this video I'm waiting for the privilege to live in the 22nd tho 😅👀

@Saoocey Жыл бұрын

@@keynadabyand from there on lol

@basedmathh Жыл бұрын

This only works so long as the infrastructure remains in place, many factors put perpetual anti aging at risk. Regulatory, civilizational collapse, ect... I could see the government forcing people to die to keep population numbers under control: a less invasion strategy would be removing social security for those who choose to live forever; idiots who are really bad at math will protest this, but people who think and understand compounded interest would take the deal. They also could limit everyone to one child households, assuming every mom has one child this would invert our population to roughly double its current, assuming zero deaths of accident which would also still occur.

@maidung1825 Жыл бұрын

More privilege to live in 22st century.

@capitalisa 3 ай бұрын

Not really, as humans are still so primitive and barbaric. But they sure do love to congratulate themselves on being so brilliant. Ugh.

@mariapilarme Жыл бұрын

Wow Amazing.!

@scrane5500 Жыл бұрын

Please also see the Flaws and Human Harms of Animal Experimentation

@HominidPetro Жыл бұрын

Interesting how anti-aging is essentially negative entropy, and nucleic acids being informational units of the cell, you need to maintain high informational capacity.

@dr.diegomaier 9 ай бұрын

Eu realmente curti seu canal. Obrigado pelo trabalho que você dedica em seu canal!! Eu também tenho temas relacionados à saúde. Efetivamente, eu sou especialista em telemedicina, prestando assistência em todas as regiões do Brasil. Continue postando!

@HD-no4dz Жыл бұрын

If this has been so successful on animal testing as I have been reading, why aren't we offering such treatments to our pets now whilst we work on making it work on humans?

@malindrome9055 Жыл бұрын

right now they are in clinical trials, but I'm sure you'll get it soon!

@waits4noone23 Жыл бұрын

Look up Christ within, if you want a doctor's opinion, cerebrospinal fluid and the fluid nature of consciousness video on yt

@dherman0001 Жыл бұрын

They've been able to speed up aging. The older looking mouse had aging sped up. They have not yet slowed aging. Heck, at the rate of discovery, maybe they have and we just don't know yet.

@itatae10 Жыл бұрын

Rat model are not 1:1 on human models. So oftenly we need a middle stage that prevent detrimental effects to humans. Like cellular tissue. The problem with this is that funding is being pushed back.

@Lyle-xc9pg Жыл бұрын

@@dherman0001 they have slowed aging, you dont know anything. Theyve made live mice live twice as long with one genetic treatment recently

@ChazSmithProductions Жыл бұрын

Give it to us NOW... We had no problem taking part in the mRNA Experiment.

@mariost-onge2395 Жыл бұрын

Morrrrron

@dragonfly4441 Жыл бұрын

What's that part about reversing BLINDNESS??

@123100ozzy Жыл бұрын

This is a new divide to the science of anti aging

@Eyembooks 25 күн бұрын

this is a year old and I am just hearing about it now :(

@baigandinel7956 Жыл бұрын

Good science does not only come from accredited "schools." It can come from any individual practicing the scientific method.

@Yo_uj Жыл бұрын

Let's live better lives

@yinnetteolivo Жыл бұрын

Can stem cells assist in the de-aging process somehow? Im assuming if these proteins/cells are "Getting Tired", can we recruit new stem cells, program them to the specific organ we want to target and send them in to produce "New Born" proteins/cells that will continue producing DNA accurate cells? I know that there are amazing studies and discoveries involving stemcells... is there anything we can do to reverse aging using a combination of epigenetic reprogramming and stem cell therapy?

@UHFStation1 Жыл бұрын

I hope gene therapy can allow scar tissue removal so healthy tissue can replace it retina, heart, brain, liver, etc.

@juliusmillermusic Жыл бұрын

I hope so, that way you could also get a step closer to lab build transplantable organs.

@winstonmarlowe5254 Ай бұрын

look up verteporfin

@EveryTimeV2 25 күн бұрын

I read something about ERK pathway related to scar tissue. Scarless healing does exist in early human stages but we lose that ability later in life, it can apparently be reactivated.

@richardnunziata3221 Жыл бұрын

Has anyone tried this on normal aged mice and was the imbalance from transcriptional stress from DNA lesions favoring short proteins present.

@over2seeyer Жыл бұрын

Ding ding ding! They didn't because it probably wouldn't work, progeria is a well known disease that only look like aging but isn't, the dna is still normal age its just filled with crap that interfere with its normal work. If you remove the crap the cell will work normally for its age. its not reversing agin, just curing progeria

@woloabel Жыл бұрын

(On Monday of January 30, 2023). On the Matter of PhD David Sinclair's Ideation of Epigenetic Ageometry (Epigenetic Dysregulation, or, My Personal Touch, Entropy at both the Genetic and Epigenetic Levels). A Phenotype of Frailty Syndrome (FS) is hardly disintergratable form the Genetic and Epigenetic Mechanisms as much as Function is a Direct Correlation to Structure. Malnutrition seems to be herein Common to all Phenotypes in the Matter of Geriatrics, for which I indicate naturally an Increase in Protein(s), Amino Acids, along with Standard Vitamination And Minerals (Essential Nutrients if not Biological Molecules of Trace Proportions); and only indicate Caloric Restriction (Anorexia is a common Cause of Malnutrition along with other Factors) when Diet is Questionable (As in Pesticide ridden foodstuff). And, this genuinely seems to be the parameters influencing the Mice Studies also; The Aged Homologue (altered mouse) might have been Epigenetically Altered but notwithstanding the Diet Cofactor is a Plausible source of more rapid Aging while the non-Aged one is rather less phenotypically manifested. However, determining length of Lifespan on wholly on Epigenetic Chronometry and Aetiologic Agent of Ageing is an Overstretching of Molecular Mechanism(s) therein. I have delved in the Matter of Epigenetics slightly but could not negate the Genetic Disarray (Both Genomic and Gene Expression [Transcription/Translation Axis]) in a Homeostatic Dysregulated and Sarcopenic Subject as much as I would attribute Healthy attributes to mice on the same terms as to Man (even if such an Experimental Human Could Exist). While Genomic And Genetics are a Thriving and Flourishing Enterprise (Certainly More than as A Science), the Standard of Care (SOC) should still include Basic and Fundamental Essentials (Geriatric Comorbidities of Dehydration and Malnourishment should not be Relevant in a "Well-Developed, Industrial Society") and Therapeutics therein should still be under such traditional Methods because the best part of our Failures as a society are in Common Sense--Preventable--Factors based (Cardiovascular Disease, Metabolic Syndrome(s), Stroke etcetera) and less having to do with inherited Disease of a Genetic Basis (Even though such are not yet proven but associated with Genetic Regions only). Perhaps, one day there will be such Sophistication of Technology and Understanding; but, to forsake the Standard of Care (Conventional Science Basis) for a Speculative (Most theoretical) therapeutics, is sheer Malpractice. Heil!

@user-bd1ge2fd4f 11 ай бұрын

Dr Pius Ozigbe is Always on time. compassionate. Empathetic. easy to take to and relates exceptionally well. Hands down the most effective and efficient doctor I recommend him. thank you doctor!!!!!

@ET-oq9mg Жыл бұрын

Nice video and content

@LayneRoxxx Жыл бұрын

So they aged the mouse that is grey, they didn't reverse age of the other mouse. What this did tell me is that they are able to make it so you could be born with the ability to age you, or reverse age you.....I wonder what they could do with that? What would you do in order to be reverse aged?....or keep them from aging you?

@marcuspickens25 Жыл бұрын

Dr.Bruce Lipton said this in like the 70s

@victorprokop9343 Жыл бұрын

when you think of the protein machinery as actual machinery, its reasonable to apply the wear and tear principle When you accelerate the anabolism of proteins and the machinery is cranked, you are accelerating aging because the machinery is slowly getting wore down like with high calorie diets and spiking mTOR all the time, or some growth factors

@butterflyy909 Жыл бұрын

I volunteer to be an experiment 🙋🏻‍♀️

@ronmoore6598 4 ай бұрын

So how much longer do I have to live for the anti-aging drug to be approved and will my insurance cover it?

@Razorokc Жыл бұрын

I saw another one with this guy talking about the same mice he said that they reversed the aging in the younger looking 1. But in this when he said they sped up aging in the older 1. So which is it?

@ImKaboose Жыл бұрын

Two different studies

@Razorokc Жыл бұрын

@@ImKaboose it was the same mice

@quorumlab Жыл бұрын

Amazing work but the aging of cellos is always different . Brain cells and liver cells take paths are different , so a 50 year old could have. Very health liver cells. How would that be regulated .

@jakekisiel7399 Жыл бұрын

How can I help my 72 year old father with this technique.

@gabi.a Жыл бұрын

oh my that sound effect gives me agony. other than that, lovely video

@grasonicus Жыл бұрын

OK, you can now accelerate ageing. But how far on going the other way are you? The next step is preventing it, then reversing it. This will most likely be more difficult than accelerating it. For reversing it, the genes that should be turned off should be turned off and those that should be turned on should be turned on. I suspect that's easier said than done. Bummer. And I wonder what the effect on life expectancy will be.

@Synathidy Жыл бұрын

It's not as difficult as one might think. We already have genetic engineering techniques which alter DNA sequences using things like CRISPR-Cas9. Inducing epigenetic change is just as feasible - you just need to target the right region of DNA with enzymes that make epigenetic changes. Histone deacetylases, methyltransferases.... the various chemical modifications to histones are well-documented. Maybe some specific epigenetic analogue of CRISPR could be developed. The larger hurdle than being ABLE to do it is knowing WHICH genes to turn on or off. We don't yet have such a masterful understanding of genetics that we're able to know the "recipe" for altering gene expression that will "rejuvenate" cells. It's complicated since so many genes have so many interrelated effects and functions. But I believe epigenetics will surely prove a promising clinical frontier to explore. Epigenetic changes can be just as impactful to an organism's health as outright mutations, if gene dysregulation is severe enough.

@grasonicus Жыл бұрын

@@Synathidy You're right. I later wondered if ageing is produced by always the same offending genes being on or off. If it is, a generic treatment, turning set A on and set B off, will do the trick. But will this only stop further ageing or reverse it?

@noobiest09 Жыл бұрын

I wonder if this can do anything for cancer.

@Synathidy Жыл бұрын

For some cancers, it certainly can. Epigenetic dysregulation can induce carcinogenesis. This should become another effective tool in the toolbox for cancer treatment eventually.

@sleekblackroadster Жыл бұрын

Where the pills sold

@Rishwanthsevva 9 ай бұрын

Sir may you help me that what should I study to take part in the reverse aging research can I get your contact sir please help me sir I want to research on reverse aging it's my goal sir please guide me to what I should study

@CloneShockTrooper Жыл бұрын

Wow 🤩

@orazor777 Жыл бұрын

So from the System Administrators' perspective, seems aging is a configuration drift issue.

@psy-v Жыл бұрын

I thought the story of the mice had to do with NMN... was that not the claim in earlier iterations of how one mouse was older and one younger? Or am I encountering another Mandela effect?

@ImKaboose Жыл бұрын

Two different studies

@psy-v Жыл бұрын

@@ImKaboose can you give me a hand looking for where the other one is published? 😅

@tinglin6121 4 ай бұрын

Err, so how is the reversal even done? It seems like it's much easier to enhance aging (cutting DNA) than slowing it down.

@gregorysagegreene Жыл бұрын

The Fusion of Longevity.

@catherinebirch2399 Жыл бұрын

If they want human guinea pigs, I'm up for it.

@bringtheseo 6 ай бұрын

I wish we had a solution to the ageing process right now. I've just turned 50 and I'm not liking this at all.

@easterjateru7801 Жыл бұрын

Clue. Aging is in the circulatory system mostly the lymph.

@hansomekim1219 Жыл бұрын

What makes you say that?

@easterjateru7801 Жыл бұрын

@@hansomekim1219 This is preamble. Tip of the iceberg. On cellular level a simple explanation will not do. It needs state of the art labs to probe the circulatory system and the residue that with passage of time overwhelm the 'return' system and thus the aging markers

@hansomekim1219 Жыл бұрын

@easterjateru7801 why cant blood overwhelm the return system just as well as the lymph? Theres more blood than lymph

@kx4532 8 ай бұрын

Are Chromatins addressable?

@user-zn7rl1en7s 10 ай бұрын

DNA gap is the best solution to epigenetic aging.

@WaheedRafiq Жыл бұрын

Can you add me to your list to have the first injection to prolong my life 🧬

@fitnessnature 9 ай бұрын

To me it is unbelievable that whole humanity is not involved in this in some way. This is way to important to do and life would be so much better for all if there is more involvement to gain control over aging. How is it that only small percentage of people are trying to find the solution for worse f thing that can happen to people ? LET'S ALL INVOLVE using internet for connection, AI for help analyze data and cure this shit already !!!!

@user-pb2xx5ir2x 9 ай бұрын

Because you need sufficcient knowledge and "a pure heart" to do research in this area. Lets say 1/3 of the human pouolation is fighting for survival, (they cant even think about old age) 1/3 doesnt give a shit on anything because they lack the intelectual tendency to think about certain things and 1/3 is greedy and has lots of money so they dont care how long their live ist only how good it is right now. There you have your answer :)

@jacquelineknauff4835 Жыл бұрын

ILL PARTICIPATE IN YOUR STUDY LOL

@aminulhoque1721 9 ай бұрын

So what happens when you reverse the aging beyond age 0

@butter5144 3 ай бұрын

Nothingness

@aiza9052 Жыл бұрын

Excellent research, but all I'm thinking about is that poor mouse. :c

@mariost-onge2395 Жыл бұрын

What about the chicken ,beef , lamb ,shrimp , frog (frog legs if that's your thing ) , escargot , eggs from incarcerated hens ? I would crush the legs of hundreds of very cute little puppies and pull them off with a vice before i bite their necks and cut their arteries while still alive and suffering if that could save 1 child from a deadly disease.

@RJArens Жыл бұрын

This is the way I see it, if you're lucky, you have about 75 years to live and a eternity to be dead. What's the friggin rush to shuffle off this mortal plane? If modern medicine can make me live 2-500 years, I'm all in! Over 100 years ago, the average lifespan of a man was 50 if he was lucky. A fair majority of us surpass that every day. Let's go for it. I gotta see this.

@thejellopster Жыл бұрын

My social media credit score is screwed.

@mattalex8701 Жыл бұрын

At least all people who fight aging and death in their way,be it advocating,research,funding etc...we would have gave a fight for this goal even if we fail in our mission. Only by trying we could succeed. We won't go down the cliff like the ones who are in denial or are naive in some fairy tales who for sure can comfort but in no way stop the suffering of old age and the bleeding in seeing our grandparents and our parents die.

@ToneyCrimson Жыл бұрын

So where is the human version? I need it fast for my parents.

@Surajkumar-eo3ub Жыл бұрын

This is an amazing research, Honestly I’m so glad to know someone is working on this, incredible i must say. I am also using curcumin capsules from planet ayurveda for it

@varunrajurkar2579 Жыл бұрын

Is it like nmn?

@zukofire6424 Жыл бұрын

Intersting work. I couldnt help wanting to free the lab mice. Always been my issue with biology. Let them retire and taste freedom at some point.

@kx4532 8 ай бұрын

Got something to help mom?

@talokeen259 Жыл бұрын

Tissue regenerative if human succsesfuly made, then how will look like the future people male to female

@ragingbull8024 Жыл бұрын

If this gonna be successful, can they apply this to humans as soon as possible??

@Dvpainter Жыл бұрын

It's like you're bubbling on a tiny tiny scale

@aimanhazeem7852 11 ай бұрын

in sya allah aminnn ya allah

@mikewalker7385 Жыл бұрын

Eventually, they're going to get this figured out, but how will the mind cope with a thousand years of information.

@Mythologos Жыл бұрын

Should we start celebrating Lamarck Day? See ya August 1.

@Pssst.ByTheWay Жыл бұрын

I winder if i will still het to benefit from this and if private for profit inustry will get its dirty pawns on this. 😢

@ConnieWobbles Жыл бұрын

Any work being done on how NMN might rejuvinate female fertility as yet? A lot of women are now taking NMN in the hope that it can impact human ovaries in the same way it helped those elderly mice that had healthy live births. I hope us females don't get forgotten about, as is so often the case with medical studies. Being able to rejuvenate fertility for women who have had fertility struggles will be pretty major worldwide. I just hope NMN doesn't become prescription only as it will mean UK women won't be able to access it so readily, if at all.

@victorcarlostorresdealmeid5535 Жыл бұрын

The problem of menopause is a little different from the question of physiological aging, since the former comes from the exhaustion of oocytes, which are "manufactured" by the oogonia during the embryonic period of the woman, and is finite, not from changes in the genetic and epigenetic machinery and subsequent "inflammaging" of the tissues. We are not mice or rats... We, humans, have a different breeding strategy, and we still don't know how to reverse the production arrest process, although according to some authors there is some histochemical and histological evidence of oocyte production in female adulthood, albeit, I think, in a residual way. But the ingestion of NMN, together with the use of senolytic molecules and antioxidants, if by itself it cannot reverse the process of menopause, it may eventually improve the efficiency of oocyte recruitment during reproductive cycles and, who knows, prolong the period of female fertile life...

@baigandinel7956 Жыл бұрын

This could also cause many women to procrastinate on the issue another 500 years.

@ConnieWobbles Жыл бұрын

@@victorcarlostorresdealmeid5535 thanks for your detailed reply, and I hear what your saying. The concept of running out of eggs isn't news to women. What I'm interested in is that we have many eggs left at the point of menopause, it's just that the remaining eggs aren't healthy enough to conceive. Women the world over have been told by fertility 'specialists' that they've run out of eggs, only to rejuvenate those eggs with supplements and lifestyle factors like fasting etc. That said I get that those protocols will only go so far and that eggs can't be rejuvenated indefinitely. My focus is on those redundant eggs that still have a chance of becoming healthy. But I'm not holding my breath as sadly men tend to centre men first when it comes to science. Even the mouse fertility discovery seems to have been accidental.

@ConnieWobbles Жыл бұрын

@@baigandinel7956 what procrastination are you referring to exactly?

@brianthompson9485 Жыл бұрын

@@ConnieWobbles Fertility is an easy answer for most women. If you want offspring... do it while you're still young and fertile. If you wait...there are consequences for that action.

@squamish4244 Жыл бұрын

A superintelligent computer could figure all this out in a decade. It might sound crazy, but so did ChatGPT six months ago.

@almackinnon8774 Жыл бұрын

Does the covid mRNA vaccines age you too?

@winstonmarlowe5254 Ай бұрын

yeah, plus they make your eyeballs explode like little grenades!

@zach_harrison Жыл бұрын

🙌🙌🙌🙌🙌🙌

@rayrocher6887 5 ай бұрын

Take chances, roll the dice, screw laws, cure aging by any means necessary, act like God, well done work

@sugarkitty2008 Жыл бұрын

I think, once it's ready and made affordable for the public, euthanasia should also be made legal. Even if it's past an age bracket. I like the thought of getting old without the pain, wrinkles and grey hair. But I wouldn't want to live forever. I can also imagine the population issues if everyone started living twice as long at least.