0:00 - Glycolysis 0:29 - Pyruvate to Acetyl-CoA by PDC (pyruvate dehydrogenase complex) 0:43 - Krebs Cycle, Citric Acid Cycle 1:11 - Central Metabolism 1:29 - Why go through central metabolism? ATP!! 1:53 - Reduced cofactors (more ATP through ETC) → ATPs for cells to survive 2:19 - Other monosaccharides can enter central metabolism 2:57 - What about Proteins (amino acids)? Glucogenic & Ketogenic AAs 4:23 - Excess nitrogens → Urea Cycle (in Liver) 5:58 - What about Fatty Acids? Beta-Oxidation (reduced cofactors & acetyl-CoA produced) 7:13 - Reversible Glycolysis → Gluconeogenesis 7:35 - Irreversible Reaction: Pyruvate to Acetyl-CoA 7:52 - Gluconeogenesis (genesis of new glucose molecules) 8:15 - Sources of carbons for glucose (for gluconeogenesis): lactate, glycerol 9:00 - Alpha-keto acids as a source of carbons for glucose? NOPE (Acetyl-CoA enters TCA cycle) 9:31 - Can we take proteins/amino acids to form glucose? Depends (Glucogenic vs. Ketogenic AAs) 12:05 - Using fatty acids to form glucose? Acetyl-CoA? No, BUT last 3-carbon molecules can be converted to glucose 12:40 - Importance of Acetyl-CoA (for fatty acid synthesis, phospholipids, triacylglycerides) 13:37 - Fed State (excess carbs & proteins stored as triacylglycerides) 15:04 - Serine + Palmitic Acid → sphingosine backbone → cerimide → sphingomyelin/cerebroside/ganglioside) 16:05 - Fasted State (breakdown of triacylglycerides) 16:54 - Fasted State (ketogenesis in liver): 3 Acetyl Co-A molecules converted to HMG-CoA 17:33 - Why forming ketoacids? (ketolysis: ketoacids to acetyl-CoA to enter TCA Cycle) 18:15 - HMG-CoA can be converted to Isoprene → build larger molecules (Fed State) 19:07 - Biosynthesis of Cholesterol 19:26 - Cholesterol used to create hormones 20:16 - Biosynthesis of amino acids 22:09 - Importance of Serine (Folate cycle, Methionine cycle; SAM - universal methyl donor) 23:20 - PAPS (universal sulfur donor) 23:55 - Glycosylation (monosaccharides from intermediates of glycolysis) 25:32 - Pentose Phosphate Pathway (PPP) 25:50 - NADPH cofactors - electron donor to build bond during anabolism 26:14 - Reduced glutathione (endogenous anti-oxidant) 27:21 - Free radicals produced from ETC 28:46 - Biosynthesis of nucleic acids 30:02 - Degradation of nucleic acids 30:47 - Biosynthesis of nuerotransmitters 32:05 - Biosynthesis of porphyrin ring (used for hemoglobin, myoglobin, cytochrome, ETC) 32:44 - Big picture - see the forest! (links in the description box for each pathway in detail) 33:22 - Limitations to central metabolism: Essential Vitamins (must be obtained from diet) 34:04 - Essential Minerals (must be obtained from diet) 34:42 - Our limitations to central metabolism - final note El fin! Now go get that 528 you guys 🏃‍♀️🏃‍♂️

I've taken biochem, sat in on biochem classes, and have been in an MCAT prep course and this was the BEST EXPLANATION I have ever had on these processes. I knew bits and pieces but this guy explained them in a way that had everything just click. I feel so empowered now! Biochem is amazing!

I can't believe you don't have more followers. This was better than Khan academy.

currently on the MCAT grind and praying for everyone here AAAAAA

“So that’s pretty Cool!” Never change brother, you’re saving everyone in bio chem!

Amazing summary, this approach should be the first class of every biochemistry class, unfortunately they dive into details and never give us the big picture. Essential video for first learners!

I watch this once a week as part of my MCAT studying. Thank you for this gem

This might be the best explanation I have ever seen. Someone hire this guy. I mean seriously. Not only does he explain everything like a tenured professor at Harvard, but relates everything to the holistic vision of biochemical processes in our bodies. Unreal. Thank you!

Not ONE college-level textbook ever explained the relationship between cellular metabolism all in one scoop. sure they gave you ONE diagram with vague descriptions, but they never connected it as a whole mechanism like you. It's really easier to understand the role of cellular respiration taking into consideration proteins/fatty acids/and sugars. THANK YOU SO MUCH for the time and dedication to this video, you explained all these really way and simplified (w/o dumbing it down) :)

The best overview I've ever come across! THANK YOU!

This was so helpful to just tie in all the concepts together! Thank you so much

each minute of this video feels so heavy and packed w amazing and concise info. THANK YOU

This 30m video has tied together everything I've learned in all my years of schooling and a TON of my things that I never even thought of. This is gold bra!!

absolute must watch video. everything is so clearly explained and logically put together, thank you!

This is hands down the best biochem video I've ever seen

You made extremely complex topic to extremely simplified. Thanks man! ❤️

I love how you just sound so stinkin excited over how cool all this chemistry is - really sets a positive atmosphere for me as a learner.

Thank you so much for this video! I've been trying to figure out the details of metabolism for the last 2 weeks and you summarized it all so well in just 34 minutes. You are the best!

I love this guys enthusiasm. Makes it easy to listen to.

This is a video with a very well explained biochemistry in 30 mins. Thank you!

Thank you so much, you should have more views. i'm definitely sharing this.

AMAZING WAY OF EXPLAINING, THANK YOU!

never thought I would say this but biochem is so amazing. THANK YOU for your wholesome explanations🔥

Perfect perfect perfect ! This is exactly what we need, a wholistic view on metabolism to get the big picture, thank you so much !

This is honestly the best, most understandable explanation/teaching of these pathways I've come across! Thank you so much!

This is an amazing summary. I know everyone is saying it in the comments, but this video should literally have a million views. I have spent 20-30 minutes on just the first couple minutes to outline the steps of glycolysis for myself and man you are amazing. In the first 6 minutes, I am having total brain explosions just from the connections that you are putting together that I never quite got. Thank you so much. I always skip ads but not here

Without exaggeration, this is the best video on biochem I've ever watched.

Wow... I never comment on KZfaq videos but this is everything and more that I've been looking for in my MCAT studying! I hope both sides of your pillow are cold at night

This was by far the best video summarizing everything I need in biochemistry. Thank you

WOW WOW WOW WOW!!!! This video should have 1MILLION+ likes!!!!!!! This is sooooo gooood, if someone is able to put everything big picture together like this - you’ll master metabolism forever. Thank you!!!!!

THANK YOU, sir!!! Keep making these wonderful videos!!!

I HAVE BEEN STUDYING FOR THE MCAT FOR 4 MONTHS. I HAVE WATCHED MANY YT VIDEOS... ON MANY TOPICS (BELIEVE ME). THIS. THIS HANDS DOWN. THIS IS THE MOST INFORMATIVE, WELL-ORCHESTRATED, THOUGHTFUL, AND INTUITIVE VIDEO I HAVE WATCHED ON THIS TOPIC. AND OF ALL TOPICS, THIS HAPPENS TO BE THE HARDEST. YOUR CHANNEL DEFINITELY LIVES UP TO ITS NAME BRAVO

this is the most informative biochemistry video I have ever watched. thank you for this

You went straight to the point and had me hooked.

this was beautiful!!!! thank you!!

Seriously awesome and invaluable review video. Many thanks!

This is so neat. I wish all my professors can teach like you

Wow! That was a great, amazing summary of biochemistry course.

Great video . Keep up the good work

This is AWESOME. You rock, dude!!!

you're a great guy and I really appreciate this content

Great content to begin biochem 2 with! thank you!!!

I am not skipping ads, this one is by far the best video of metabolic pathways!!!

MAN THIS IS GOLD GOD BLESS YOU THANK YOU SO MUCH!! Prayers to everyone here

This is such a brilliant overview of biochemistry. Wow!

Your voice is very engaging, it helps with concentrating and you explain everything very well :)

I love how you keep it simple cause I need that lol. Thanks so much for this vid

thank you sooo much for this! my life has changed))

This is a biochemistry gem. Thank you for this.

This video is amazing! Thank you

THIS WAS GREAT! Thank youuu!!!

This was super helpful!!! Thank you!

Wow, really hands down. Super awesome

Voice is crazy funny but information is condensed and accurate. Cool beans

thanks, the best explanation i've ever seen!

wow you've done an amazing job here. thanks a ton

man murdered these videos geez

Wow, I finally found someone putting this together. I am preparing for the MCAT and I have not taken biochemistry. I will watch all your videos and study them as my preparation biochem course. Thank you so much. I only wish the pink structures were more visible.

i'm in love with this man he's gonna save my ass on this biochem midterm in two days

YOOO you need 10 million subscribers. I'm not even kidding. But besides that, holy moly, you are incredible at explaining this subject.

Great level of hardwork has gone in here 💪

this video is absolutely amazing oh my god thank you so much

good stuff! kind of a beautiful process actually:)

this video is great, thank you!

It all makes sense now. Thanks 🙏

Wow! I have to agree with the other commenters here and say that this really helped. Thank you!

This is a better explanation than the Princeton review damn I am impressed fr

This is insane. Bravo

Holy **** ! The channel should be named "Godly simplified science" ! Thank you, awesome work !

I've taken biochem in both undergrad and medical school and this is by far the best video I've seen! Keep simplifying the science and make more videos!

I want to hug you. Thank you good sir for everything!

Thank You -- Great Job..!!

Amazing! Such important to have a general vision of this. Very useful!!

Thank you for this amazing class

Holy Jesus Bless this man. Years of biochem agony just came to an abrupt end. Bro you make me wanna call you daddy!

Dude you freaking are awesome.. so so helpful

You are a god. There is no better way to make this kind of video, and I thank you eternally for every bit of energy you put into it. I could go on in detail

best video about mcat on youtube

Much love. Preciate this

I GET IT NOW! THANK YOU SO MUCHHHH

great video. thanks!

this is such a great video

Awesome video!!

God level. Thank you.

brilliant...absolutely brilliant

Great video!

I am not sure why i think this way! I really think if you can just do 3 of this videos on Biochem, you will be my Biochem textbook and reference source. Esp for those prepping for professional school exams. Biochem needs to be taught by people like you who can help students make meaning and relevance out of them. Without this simplification and connection to the cell as a whole, Biochem becomes unnecessarily complex, irrelevant, and difficult. Thank you sir. You are great. Like Khan Academy, you need a place call Biochemistry Academy (taught by you) lol

PURE EXCELLENCE!

Thank you!!!!!!!!

Great vid.

There should really be a "But wait! There's more!" somewhere in this video. ;) Excellent job, thank you for the help!

Just....Wowwwww🔥

Thank you so much. This overview is what I needed

Thank you a ton

This is so good

You are AMAZING

When you learn more in a 30 min video than an entire kaplan book

thank you!!!!

the big picture way of explaining makes this so much easier

Amazing