Dr. L. Parker Gregg discusses how best to diagnose and treat fatigue in patients with chronic kidney disease.
Dr. Gregg is Nephrologist and Assistant Professor in the Department of Medicine of Baylor College of Medicine in Houston, Texas. Her major fields of clinical and academic interest are depression and fatigue in patients with chronic kidney disease, health outcomes research in kidney disease and non-traditional cardiovascular risk factors in patients with chronic kidney disease.
The interview was recorded on February 27th, 2024.
Moderators: Prof. Dr. Marcus Säemann (Vienna, Austria), Prof. Dr. Andreas Kronbichler (Innsbruck, Austria) and Prof. Dr. Gunnar Heine (Frankfurt, Germany).
Articles discussed:
Effectiveness of Existing Insomnia Therapies for Patients Undergoing Hemodialysis : A Randomized Clinical Trial.
Mehrotra R, Cukor D, McCurry SM, Rue T, Roumelioti ME, Heagerty PJ, Unruh M
Ann Intern Med 2024
doi: 10.7326/M23-1794
Fatigue in Patients Receiving Maintenance Hemodialysis: A Review.
Bossola M, Hedayati SS, Brys ADH, Gregg LP
Am J Kidney Dis 2023
doi: 10.1053/j.ajkd.2023.02.008
VALOR-CKD: A Multicenter, Randomized, Double-Blind Placebo-Controlled Trial Evaluating Veverimer in Slowing Progression of CKD in Patients with Metabolic Acidosis.
Tangri N, Mathur VS, Bushinsky DA, Klaerner G, Li E, Parsell D, Stasiv Y, Walker M, Wesson DE, Wheeler DC, Perkovic V, Inker LA
J Am Soc Nephrol 2024
doi: 10.1681/ASN.0000000000000292
Sodium bicarbonate for kidney transplant recipients with metabolic acidosis in Switzerland: a multicentre, randomised, single-blind, placebo-controlled, phase 3 trial.
Mohebbi N, Ritter A, Wiegand A, Graf N, Dahdal S, Sidler D, Arampatzis S, Hadaya K, Mueller TF, Wagner CA, Wüthrich RP
Lancet 2023
doi: 10.1016/S0140-6736(22)02606-X
Effect of Sertraline on Depressive Symptoms in Patients With Chronic Kidney Disease Without Dialysis Dependence: The CAST Randomized Clinical Trial.
Hedayati SS, Gregg LP, Carmody T, Jain N, Toups M, Rush AJ, Toto RD, Trivedi MH
JAMA 2017
doi: 10.1001/jama.2017.17131
Depression and the Effect of Sertraline on Inflammatory Biomarkers in Patients with Nondialysis CKD.
Gregg LP, Carmody T, Le D, Bharadwaj N, Trivedi MH, Hedayati SS
Kidney360 2020
doi: 10.34067/KID.0000062020
The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin.
Besarab A, Bolton WK, Browne JK, Egrie JC, Nissenson AR, Okamoto DM, Schwab SJ, Goodkin DA
N Engl J Med 1998
doi: 10.1056/NEJM199808273390903
Intravenous Iron in Patients Undergoing Maintenance Hemodialysis.
Macdougall IC, White C, Anker SD, Bhandari S, Farrington K, Kalra PA, McMurray JJV, Murray H, Tomson CRV, Wheeler DC, Winearls CG, Ford I; PIVOTAL Investigators and Committees.
N Engl J Med 2019
doi: 10.1056/NEJMoa1810742
Normalization of hemoglobin level in patients with chronic kidney disease and anemia.
Drüeke TB, Locatelli F, Clyne N, Eckardt KU, Macdougall IC, Tsakiris D, Burger HU, Scherhag A; CREATE Investigators
N Engl J Med 2006
doi: 10.1056/NEJMoa062276
Correction of anemia with epoetin alfa in chronic kidney disease.
Singh AK, Szczech L, Tang KL, Barnhart H, Sapp S, Wolfson M, Reddan D; CHOIR Investigators.
N Engl J Med 2006
doi: 10.1056/NEJMoa065485
A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease.Pfeffer MA, Burdmann EA, Chen CY, Cooper ME, de Zeeuw D, Eckardt KU, Feyzi JM, Ivanovich P, Kewalramani R, Levey AS, Lewis EF, McGill JB, McMurray JJ, Parfrey P, Parving HH, Remuzzi G, Singh AK, Solomon SD, Toto R; TREAT Investigators.
N Engl J Med 2009
doi: 10.1056/NEJMoa0907845