Fischer esterification | Carboxylic acids and derivatives | Organic chemistry

No video

Fischer esterification | Carboxylic acids and derivatives | Organic chemistry | Khan Academy

Рет қаралды 251,740

Күн бұрын

Courses on Khan Academy are always 100% free. Start practicing-and saving your progress-now: www.khanacadem...
Fischer esterification of carboxylic acids. Created by Sal Khan.
Watch the next lesson: www.khanacadem...
Missed the previous lesson? www.khanacadem...
Organic Chemistry on Khan Academy: Carbon can form covalent bonds with itself and other elements to create a mind-boggling array of structures. In organic chemistry, we will learn about the reactions chemists use to synthesize crazy carbon based structures, as well as the analytical methods to characterize them. We will also think about how those reactions are occurring on a molecular level with reaction mechanisms. Simply put, organic chemistry is like building with molecular Legos. Let's make some beautiful organic molecules!
About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content.
For free. For everyone. Forever. #YouCanLearnAnything
Subscribe to Khan Academy’s Organic Chemistry channel: / channel
Subscribe to Khan Academy: www.youtube.co...

Пікірлер: 83

@katiestadler2278 3 жыл бұрын

This guy continues to save my life every time I take an organic chemistry related class. Thank you!!

@Ps3COD4Fan 9 жыл бұрын

the easy shortcut that I used without even doing any work is, whenever you have an alcohol and the reactant has an alcohol, the attacking OH steals the H from the molecule, then leaves, leaving O connecting to the remaining chain (CH3CH2).

@norenaventosa3463 6 жыл бұрын

thank you so much for this

@eightarmedshiva 8 ай бұрын

This video is doing all kinds of possibilities and is making it confusing for people that are less advanced. The method you speak of is the most realistic approach for sure

@divinusnobilite 10 жыл бұрын

This video was extremely well done.

@aidanloewen2712 8 жыл бұрын

"Let's think about what might be happen".

@vetetima1 12 жыл бұрын

you are great ! i have an exam on monday, you helped me so much !!! thank you thank you a lot !!

@Hands4Surgery 12 жыл бұрын

I don't see how you could have made a Fisher esterification any more complicated, difficult to understand, and long. I'm goong back to my Organic book

@horbergus 12 жыл бұрын

Incredible, I've learned invaluable things from this, thank you!

@murtyyalamarty4879 6 жыл бұрын

Very well explained than the other videos out on KZfaq. Thanks Sal

@richardcook8490 3 жыл бұрын

A gifted teacher who is not highly conversant in organic chemistry. There are better videos on the web.

@hannahpereira176 9 жыл бұрын

This was such a great help! Thank you!!! I totally understand it now :)

@rongeetbanerjee5205 4 жыл бұрын

Really this was a very realistic and practical explanation.We are being taught very strict mechanisms . Thanks Sal.

@midnightsilverpuppy 7 жыл бұрын

Mmm, I feel like it's more likely that the hydroxyl group on the right will pick up the hydrogen that you say might be picked up from an ethanol molecule. Then, because water is a good leaving group, the lone pairs will come down, reform the carbonyl, and result in the ester

@ArjunSingh-vw4ru 8 жыл бұрын

Pndped, protonated, nucleophillic addition, deprotonate, protonated, eliminate and deprotonate brilliant video really helpful thanks.

@weezilla 13 жыл бұрын

Heard you on NPR a while ago :) I was excited because I had seen your videos before. Congrats :) Keep up the good work.

@TheOneTheyCallTurner 12 жыл бұрын

i have a test tomorrow on Carboxylic acid derivative reactions as well as reactions involving amines and then the Aldol reactions and the Claisen reactions.

@dynamicdimensions 10 жыл бұрын

Yes, VERY USEFUL! Thanks!

@reddustspider5830 Жыл бұрын

Saved my extended essay, saved my day :')

@gokula8508 5 жыл бұрын

Wow Sal, fantastic explanation of Fischer *esturfurcation* !

@montyhorseman4264 5 жыл бұрын

Noone likes you

@MonkeyDLuffy-xr4fl 8 жыл бұрын

Thank you, Sal!

@ji-yongahn6527 8 жыл бұрын

Thanks Khan! your video lecture helps me alot. A Big Thank You!

@iamlea 13 жыл бұрын

Thanks Khan! I finally get it!!

@tizianoalimandi150 3 жыл бұрын

@11:03 "two three four five six seven doubl...oh actully SINGLE BOND HERE!"

@kaiveen09 9 жыл бұрын

YOU ARE AMAZING SIR! THANK YOU!!!!

@helenaellis5927 5 жыл бұрын

THANK YOU SO MUCH SAL!

@rjsd7 7 жыл бұрын

11:14 color change from yellow to purple was a bit distracting

@710418oo 13 жыл бұрын

@salamut2202 they don't really bond. Its just the oxygen who likes to hug more electrons, so it takes the hydrogen ones.

@jennymaldives 11 жыл бұрын

superb video sal. thank you

@andrepulford7236 7 жыл бұрын

Brilliant, thanks!

@mcantele 10 жыл бұрын

11:45-12:00 Why does one of the two hydroxyls have to protonate in step 4? I can't understand why the reaction doesn't stop at the stage of thetraedal (sp3 carbon) intermediate. I mean, of course this has something to do (as always) with overall better molecule stability and lower energy state, but I don't seem to get the point of that H2O elimination.

@carlos16alva 10 жыл бұрын

Because when you add a nucleophile to an ester or a carboxylic acid the O cliffs off because the overall compound is highly reactive when it has 3 oxygen atoms attached to the same carbon carbon. if you have a book with you I advice you to look at grignard reactions when they react to esters. Hope this helps.

@Ferrus91 14 жыл бұрын

Question: you pointed to the carbonyl saying it was a good leaving group... how is this so? Isn't it the acid catalysed water molecule that eventually forms a good leavin group?

@benneven9316 5 жыл бұрын

Hello, I had to carry out this reaction in practice, and I had to heat the mixture of propanoic acid, sulfuric acid and ethanol in a water bath. My question is, why did I have to heat it, since according to the enthalpies of formation this reaction should be slightly exothermal ?

@AnveshKumarReddyDasari 10 жыл бұрын

@5.32 Would not the proton from the acid go to the oxygen next to the hydrogen besides attracting towards carbonyl oxygen in the initial carboxylic acid?

@gemyhk4407 6 жыл бұрын

So can we say that in the elimination of water the H comes from ethanol and OH comes from the acid??

@SirGentleManne 10 жыл бұрын

top-tier nitpicking

@mysefl1 11 жыл бұрын

here's a suggestion make the courser more VISIBLE. i mean seriously a black background and a tiny courser its just not visible.

@MrScarykat 11 жыл бұрын

took me almost an hour to understand this.haha

@InceptionSolver1 8 жыл бұрын

I think it's more easily pronounced eh-stair-ification haha

@rongeetbanerjee5205 4 жыл бұрын

I think this is not the Typical Fischer-Speier Esterification because then Dry HCl gas needs to be used instead of H2SO4.

@utkarshverma1 5 жыл бұрын

Won't intramolecular H deprotonation be more probable at 12:07?

@snehhrd2 11 жыл бұрын

very confusing but now its easy........after watching the video second time

@MrGW2fanboy 12 жыл бұрын

loool "Screen real estate" XD

@avtaras 4 жыл бұрын

Ye dw, he says it all the time. You’ll get used to it, then it won’t be as funny

@MrGW2fanboy 4 жыл бұрын

@@avtarasit's always nice to revisit a comment from 7 years ago and have no idea why you wrote it. Thanks for taking me back to 2013, good times

@justindegroat8987 8 жыл бұрын

sulphuric?

@tazyboy28 8 жыл бұрын

+Justin DeGroat lol sulfuric

@wedfrest 8 жыл бұрын

English FTW

@QuinceyFoxx 10 жыл бұрын

Take all the tuition I've ever paid UT.

@pkdababe 13 жыл бұрын

beast...

@wedfrest 8 жыл бұрын

Nice one on the spelling of Sulphur :)

@MonkeyDLuffy-xr4fl 8 жыл бұрын

Actually both spellings are correct. 'Sulfur' is Latin, 'sulphur' has been modified to obey conventions of the English language. Pretty sure he knows more about chemistry than you do :-)

@wedfrest 8 жыл бұрын

Pretty sure you know absolutely nothing about me whatsoever :)

@MonkeyDLuffy-xr4fl 8 жыл бұрын

Chewie Lewie Of course I don't.

@SOG12341 8 жыл бұрын

What was the point of this interaction right here? Lmao

@avtaras 4 жыл бұрын

Sir, can HCl work as a catalyst?

@sarthaktrivedi8180 4 жыл бұрын

Yes it can work but then Cl^- will not be as stable as HSO4^- so the second one is preferred....also proves that sulphuric acid is a better acid.

@salamut2202 13 жыл бұрын

How do hydrogen ions bond to water to create hydronium?

@basilfeitknecht6430 2 жыл бұрын

12:40 repetition legitimizes

@mabusurrahmansheikh6323 5 жыл бұрын

Can anybody help me to let me know that how to avoid reverse formation of ester to acid??any1 plz

@raheebalsaidi 8 жыл бұрын

lit

@honeykim95 12 жыл бұрын

@58203ju Canada and America has different spellings

@Tazy010383 11 жыл бұрын

pretty sure it's Fischer

@nilstiemer7177 7 жыл бұрын

Is there no talking in this video?

@vijayvarghese1652 6 жыл бұрын

sulFuric acid

@58203ju 13 жыл бұрын

*Sulfuric acid *Fischer Esterification

@7KRexCHAT 12 жыл бұрын

have you seen the movie limitless?... My conclusion.

@blondedcocaine9339 6 жыл бұрын

LETS FIND THE PILL

@honeykim95 12 жыл бұрын

@tjoseph230 I've seen people with the last name Fischer and Fisher before -__-

@davidkain2464 6 жыл бұрын

You went really was on the first example 😔

@micahsimmermandotcom3525 7 жыл бұрын

Jezuz, how much time should it really take to explain this reaction?

@Exercic 10 жыл бұрын

Stop changing color please..

@justindegroat8987 8 жыл бұрын

+Exercic There is a point to the color change.

@sumedhbandivdekar8320 8 жыл бұрын

very boring😡😡

@BigBadVVolf22 4 жыл бұрын

Dude you don't have to explain to us how to name an alcohol or why sulfuric acid is an acid.

@Exercic 10 жыл бұрын

Stop changing color please..