FX-322 Hearing Loss Treatment: Clinical Trial Data Shows Promise in Hair Cell Regeneration

Рет қаралды 13,002

Күн бұрын

The ability of human cochlear hair cells to regenerate has been nothing more than a pipe dream - until recently. Frequency Therapeutics, a publicly traded (NASDAQ) company based in Lexington, Massachusetts, has published a series of clinical trials showing early promise that a pharmacologic agent, FX-322, regenerates human hair cells in the cochlea.
During this interview Franck and LeBel review biology of progenitor cells, their published clinical trials data and current status of a larger, blinded placebo control trial.
Results of the published trial, discussed in the interview, can be found at this link: journals.lww.com/otology-neur...
Transcript available: hearinghealthmatters.org/this...
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TIMESTAMP
00:00 Introduction
03:40 How does FX-322 work?
07:11 How does FX-322 get into the cochlea?
10:13 Published data on FX-322 effectiveness
14:09 FX-322-208 clinical trial
20:27 FX-322 in future practice

Пікірлер: 127

@_lombk-5149 2 жыл бұрын

Many teenagers lost their lives due to tinnitus please help us and maybe ur kids could have pleasee

@lilyhuerta4532 Жыл бұрын

I first just want to tell the doctors thank you so much for giving us hope. My 19 year old son was born with deteriorating hearing loss meaning bad nerve damage with no hope in a surgical procedure. From what I understood there now is some hope for improvement and hope for a better future for him.

@giblaz 2 жыл бұрын

10:06 those are amazing results!!

@sayem444 2 жыл бұрын

God help the Scientists to make the medicine...

@Wowwwzaaa Жыл бұрын

I agree! Gods made these people for us

@aayazahmed5389 Жыл бұрын

I hope the evil capitalists don't harm them too.

@stephentackett4064 Жыл бұрын

This had so much hope and so many potentials. Why did it fail? It looked like it was working. What went wrong? The lack of progress on the Pure Tone frequencies could be point toward the drug only affecting the inner hair cells which is where speech is centered. I would love to see a follow up video!!

@joeylodes Жыл бұрын

Exactly

@ImranAnsari-qn5ke 11 ай бұрын

@@joeylodesbhai fake hai koi dawa nhi bani hai ki kan ki nas ko thik kiya ja sake

@olitonottero7620 Жыл бұрын

Thank you for sharing this

@allehman8660 2 жыл бұрын

I would really like to be a part of this study, are you still taking candidates?

@yanikemann 2 жыл бұрын

God bless!

@wilfordfootball79 2 жыл бұрын

As for me despite wearing hearing aids since I was 6 year old im still losing more of my hearing got ringing in my left ears past 16 years and im deaf in my left ear but still hear ringing in my left ear now I got ringing in my right ear going deaf in my right ear SMH sad 😥😭😭😭😭😭😭😭😭😭😭

@ShOwStOpp3rr Жыл бұрын

try to get yourself into one of the trials maybe they can help you..see if you can sign up

@zenglider2145 Жыл бұрын

Trials resulted in zero improvement in speech recognition (compared to placebo) and abandonment of further work by the company in developing a cure for sensorineural hearing loss.

@sayem444 2 жыл бұрын

Sir Im 46.Suffering SSHL in my right rar from 2021.passing very taft time.Waiting something which will help to regenarate my inner hearcell....

@RajeshKumar-zw2wp 2 жыл бұрын

Good 👍

@_lombk-5149 2 жыл бұрын

There is something how it regenerate hair cells for people who dont have hair cells

@gtaiv2993 2 жыл бұрын

activates, progenitor cells, to form the hair cells.

@RabinoRodrigoRamirez Жыл бұрын

As Doctor Ben Thompson said, unfortunately the world's governments especially in the U.S where there are over a billion people who suffer from tinnitus but as the doctor and other specialists dedicated to tinnitus said there is no financing, he doesn't even care just because it is not something deadly like cancer in other diseases etc.meanwhile millions of people commit suicide because they cannot lead their normal lives. Because every moment when exposed to the noises of the city and of daily life, he has enough headaches and unbearable acoustic traumas

2 жыл бұрын

Hi, I am a deaf person with senso neuronal loss. I am really interested in the ability to improve speech perception more than audibility because I can get it from hearing devices, but, speech perception is almost impossible to reach. Therefore, if the second trial tests experiments shows consistently the 10% improvement, when will be commercially available the drug? Is there any possibility to be part of that experiment despite my native language is spanish? Thank you very much for your possible answer.

@ThisWeekinHearing Жыл бұрын

Please visit the Frequency page for more details on their trial and candidacy requirements www.frequencytx.com/patients/

@timmiller-basscal Жыл бұрын

When is pediatric testing going to occur?

@wednesdayschild3627 Жыл бұрын

A person I know was born too early. He is losing his hearing gradually and he is old now. I took him to audiologist. There were lots of little children in the office. I pray so hard for all of these people. Could the mrna technology be used to deliver the medication into the area of the hair cells.

@elenatsuchiya9230 Жыл бұрын

When will you be doing pediatric trials ?

@margaretsmyth1564 2 жыл бұрын

Would like to take part of trials and could find a doctor that specializes in this anyone in New Hampshire I have pulseitile tinnitus

@Andreas01 2 жыл бұрын

Maybe they can deliver the drug with the implementation from Otomagnetics?

@sterlingferguson1704 2 жыл бұрын

How can I become part of this study?

@johnmcdonald6452 Ай бұрын

I lort my hearing due to an ear infection not being treated properly had a scan inner ear hairs damaged that tells brain what your doing tells me I now walk off balance . Any hope if hair regeneration.

@humanexpert2088 Жыл бұрын

FX322 and FX-345 Trials have been Discontinued according to FREQ. Is there a way to still get the treatment Post clinical Trial?

@ThisWeekinHearing Жыл бұрын

We are still awaiting updates, but we would encourage anyone with questions to reach out to the company directly www.frequencytx.com/contact/

@zenglider2145 Жыл бұрын

Why? Trials resulted in zero improvement in speech recognition (compared to placebo) and abandonment of further work by the company in developing a cure for sensorineural hearing loss. Did you know this? Am I missing something?

@samuelgulizia7711 3 ай бұрын

Lost my hearing due to labyrinthitis, the ringing and the sensory overload can be crippling sometimes…. Hopefully they can get something going on here.

@rickjordan8470 Жыл бұрын

Could you give a review of the AirPods Pro 2nd generation as hearing aids?

@poojaverma4311 Жыл бұрын

hello sir this treatment also do on 18 months baby for hearing loss

@EMIPictures Жыл бұрын

Hello Sir/Madam My name is Himanshu Kamdar and My son is having waardenburg syndrome and he is having seviar to profound hearing loss and doctors suggest cochler implants if there any other options Please help 🙏

@ShOwStOpp3rr Жыл бұрын

there working hard on this drug unfortunately in America the trials take a long time,,maybe in the next 2 years this drug might be an option for him at least your son is young and will have more chances of getting a new drug as science advances

@KrishnaPrasad-hg2ip Жыл бұрын

On both ears??

@EMIPictures Жыл бұрын

@@KrishnaPrasad-hg2ip Yes 😭😭😭

@KrishnaPrasad-hg2ip Жыл бұрын

@@EMIPictures so sad ... hope this upcoming drug come as soon as possible to cure your son

@MrAceman77 Жыл бұрын

How can I become a part of the clinic

@nababrampur7781 2 жыл бұрын

Sir aap kaha se ho ?

@Condor1970 2 жыл бұрын

If you already have cochlear implants, could therapy like this ever be helpful?

@alexandremendesdonasciment6435 2 жыл бұрын

I should also like to know

@Wowwwzaaa Жыл бұрын

I have been asking every video this question, nobody answers me.,

@EMIPictures Жыл бұрын

kzfaq.info/get/bejne/l5N-a9qltJbeomQ.html

@cruzelenasanchez6654 Жыл бұрын

I would like that

@michaelconway4316 Жыл бұрын

I'm currently in the clinical trial. Hoping for good results. I've had my first test about a month after the injection, not noticing any improvement yet.

@lektor8987 Жыл бұрын

Hi Michael! I hope you see improvment soon. Any sideffects you notice ?

@michaelconway4316 Жыл бұрын

@@lektor8987 I haven't noticed any side effects, but I will say the injection wasn't very pleasant. The initial injection wasn't too bad but the pressure put on my inner ear from the medicine being pushed in was pretty uncomfortable. It's basically like having the worst ear ach you've ever had for a few minutes as the medicine flowed to where it needed to go.

@lektor8987 Жыл бұрын

Thanks for replay Michael. Do you feel any improvment ?

@michaelconway4316 Жыл бұрын

@@lektor8987 no not yet. I'm beginning to think I was one of the placebos.

@lektor8987 Жыл бұрын

Lets hope you are and I really hope this drug works. I heard that it is suppose to work on the high frequence.

@billyshears921 Жыл бұрын

God, give the scientists a clue, please?

@farhat-nazlakhkarkhan2971 2 жыл бұрын

When it will be established in Middle East Bahrain

@Wowwwzaaa Жыл бұрын

My parents used to me too Bahrain to me. They were from Barsa Koura

@worstplayer4521 Жыл бұрын

@@Wowwwzaaa do you know when this drug is gonna be available to the public?

@KrishnaPrasad-hg2ip Жыл бұрын

@@worstplayer4521 probably 2028

@karwanduski8307 Жыл бұрын

Doctor There is a rumor that the fx345 failed, how true is that?😢

@Art-hl9mv 2 жыл бұрын

Can this work for pain Hyperacusis ?

@naelbeno6249 2 жыл бұрын

I think so…. Hyperacusis comes due damage From the haircells

@Wowwwzaaa Жыл бұрын

Why upload a video and not reply to us? That’s why I won’t subscribe to your channel…answer us! Can we get the drug if have the CI already

@ThisWeekinHearing Жыл бұрын

Hi, Frequency Therapeutics has a patient resource section where you can learn more about candidacy and to see if you qualify for a trial www.frequencytx.com/patients/

@chad5617 Жыл бұрын

It seems unlikely FX-322 would work if you already have a cochlear implant.

@Wowwwzaaa Жыл бұрын

@@chad5617 I was hoping the hair cells are that tiny the implanted electrodes won’t be in the way. I guess I will ask and see if I can get it removed when Fx345 comes out . F322 is old

@chad5617 Жыл бұрын

@@Wowwwzaaa Yea, talk to an ENT or cochlear implant specialist.

@hamedelsayed2779 Жыл бұрын

@@Wowwwzaaa plz tell me if this helpful to cochlear implant’s people

@dsolo3250 Жыл бұрын

I just checked the stock price for this frequency therapeutics company it went from seven dollars in beginning of 2023 to0.37 cents in summer 2023. Just another pump and dump scam I guess

@nicholasn.2883 2 жыл бұрын

Let's just hope myself ~1 year from now isn't too pissed at current me's decisions. I helped people hear more clearly or helped turn my own account a sobering red.

@brendadrumm9451 2 жыл бұрын

I lost my hearing in left ear sense of smell taste from grief lost my adult daughter son Yr half after nothing can help I'd be interested if it could

@markofx3223 2 жыл бұрын

@@brendadrumm9451 hi there good possible chance you could get your hearing back in your life ear if this treatment drug work in clinical trials fx345 regenerating new hair cells with this drug 💕👍🀄🀄🀄🤞🤞🤞🇱🇷🇬🇧🇩🇰🇫🇷🇳🇿😇

@chad5617 Жыл бұрын

You a stockholder too? lol. I've taken quite a large position on them as I'm quite confident they have cracked the code.

@Spliffurt Жыл бұрын

Ban microsuction pls

@MOHDJAVED-ti1lu 2 жыл бұрын

I am from India my 3 years old baby she is deaf from birth can she hear from FX 322 When it will come in india

@ShoyaIshi 2 жыл бұрын

Honestly I didn't think it will be coming anytime soon it's still in trials but it is still succeeding in regenerating hair cells which is definitely a good thing it shows we can regrow it might not come around now but it may be soon in two or three or four years.

@theinformationbomber7102 2 жыл бұрын

@@ShoyaIshi damn that's a lot of time man I was hoping it could come in around next year or so

@ShoyaIshi 2 жыл бұрын

@@theinformationbomber7102 take care of your hearing meanwhile do everything you can to take care of them get some earplugs and earmuffs man they really help always carry around earplugs or earmuffs or both!! If you need to know what are good ones to try lmk!!

@theinformationbomber7102 2 жыл бұрын

@@ShoyaIshi yeah too much loud noise comes from the horns of vehicles and then there are many unexpected sounds as well

@JASONZONE Жыл бұрын

😂

@bobhope3716 Жыл бұрын

This drug will fail. It's very difficult to regrow stereo cilia in the inner ear.

@ImranAnsari-qn5ke 11 ай бұрын

Where are madicine

@gheorgheonutu8928 7 ай бұрын

Tradusă în romînă

@greg1030 2 жыл бұрын

NOT FAST ENOUGH!!

@arthursimsa9005 2 жыл бұрын

Ok bro. Way to be rude.

@bobhope3716 Жыл бұрын

This video is 11 months old . What has happened in 11 months ? Probably nothing.

@ThisWeekinHearing Жыл бұрын

We did a follow-up interview last month, which you can view here kzfaq.info/get/bejne/aNukfcKAxrCUp58.html

@bobhope3716 Жыл бұрын

@@ThisWeekinHearing Saw it. Just the usual bullshit talk. Also I am mainly interested in whether or not FX 322 will help alleviate Tinnitus.

@razvanbas9789 2 жыл бұрын

We all be dead for long when a miraculos cure will be discovered. I lost any hope and I recommend you do the same. Protect yourself from being dissapointed.

@jessicavillalobos1822 Жыл бұрын

Y0 ya espero solo morir

@robbieatkinson5282 2 жыл бұрын

😠 Promo_SM!!!

@dsolo3250 Жыл бұрын

The cure for hearing loss is louder noises

@westfield90 6 ай бұрын

Sadly another bust in medicine. Too many of them lately

@gtaiv2993 2 жыл бұрын

im getting kind of sick of you guys marketing, instead of actual research and development, its seeming more and more like a scam.

@dexterstewart3349 2 жыл бұрын

Do some research on how FDA approval works

@gtaiv2993 2 жыл бұрын

@@dexterstewart3349 ouuuuf i work for the fda. still sick of them marketing when stock plummets

@markofx3223 2 жыл бұрын

@@gtaiv2993 hi what your thoughts on 0T0 131 drug tinnitus treatment full results August 2022 and fx345 hope thay speed up people hard of hearing and tinnitus live a normal happy life again 🇬🇧🇱🇷💕😇🀄🀄🀄👍👍

@elisagrossi9973 2 жыл бұрын

To me too It seem scam

@markofx3223 2 жыл бұрын

@@elisagrossi9973 don't understand whatdo you mean fx322 there in clinical trials in us you don't know it could work by regenerating new hair fixing hearing loss and tinnitus