Glucose-6-Phosphate Dehydrogenase Deficiency | Symptoms, Pathophysiology, Diagnosis and Treatment

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Күн бұрын

Lesson on Glucose-6-Phosphate Dehydrogenase Deficiency: Introduction, Pathophysiology, Signs and Symptoms, Diagnosis and Treatment. Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency is the most common inherited red blood cell disorder leading to hemolytic anemia. Decreased levels and activity of the Glucose-6-Phosphate Dehydrogenase enzyme leads to impaired functioning of the pentose phosphate pathway, reduced NADPH generation and reduced ability of the red blood cell to handle oxidative stress in the form of reactive oxygen species (ROS).
The majority of individuals with this condition are asymptomatic but have periods of acute hemolysis due to triggering factors. Triggers can include infections, medications like dapsone and primaquine, chemicals like naphthalene and henna, and foods like fava beans.
Hey everyone! This is a lesson on the blood disorder known as G6PD Deficiency. In this lesson, you will learn about the epidemiology of G6PD Deficiency, the role of the pentose phosphate pathway in the disease, signs and symptoms of this disease, tests to help diagnose the disease and treatments.
I hope you all find this video helpful. If you do, please like and subscribe for more videos like this one :)
JJ
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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
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JJ

Пікірлер: 52

@ranjashraf1824 2 жыл бұрын

great video , im a medical student from kurdistan ( northern iraq) and all i know is that g6pdd is very endemic here .

@kadischon 6 жыл бұрын

Perfect timing, was just looking for a video on this.

@Iii_11 6 ай бұрын

ممتاز اخذت المعلومة التي أحتاجها، شكرًا لك✅.

@marcianoaugusto1 5 жыл бұрын

Thank you from Brazil!

@ashkan.eb1 5 жыл бұрын

U rock even more! Double thanks for the video

@samidkhan6963 3 жыл бұрын

Very helpful more power to u

@mukherjee3412 3 жыл бұрын

Thanks for excellence precious social benefit vedio.... well done.....pl. show more than G6pd video.... God bless you..... Joy Hind...

@asiakhatoon1079 11 ай бұрын

Thank you!

@yadagirimbbs1 11 ай бұрын

Nicely explained. Thank you🙏 sir😊

@cy8146 3 жыл бұрын

thank u very much from turkey

@logistaur 2 жыл бұрын

great explanation man. thanks this helped a lot

@bossha8354 2 жыл бұрын

النفس أمارة بالسوء

@richelsantoslojo 3 жыл бұрын

hello. my baby has a g6pd deficiency. the confirmatory result is 15.61 while the normal range for a new born is > 16.22 U/gHb. Where can you consider my baby? Is it in Class IV or in Class V?

@mohammedzahrani4342 2 жыл бұрын

Many thanks! Brilliant explanation 👌🏼

@MedTechTalk 2 жыл бұрын

Thanks a lot

@nouranoura5391 3 жыл бұрын

I have a question , what is the action of folic acid in this situation like does it reduce the hemolysis or act as a reducing agent??

@chamindirathnayake4797 Жыл бұрын

Thank you sir

@Rachidasister Жыл бұрын

I love how people throw the expression "in parts of Africa" while giving a very precise info on other population. Africa is huge and has very diverse ethnic groups with all the world genes existing just in Sub-Saharian Africa alone. So, please next time, tell us where in Africa.

@83dira 10 ай бұрын

Agreed more information would be great

@blackboy124345 20 күн бұрын

Most intelligent request, Africa is huge bidder than the continent of North America, South America and most of Asia…

@vpsjaura 5 жыл бұрын

hi, My brother is having G6PD, can he take Wheat grass as it is VERY high in chlorophyll which increase Red Blood cells and other things like vitamin A, vitamin C, vitamin E (alpha tocopherol), vitamin K, thiamin, riboflavin, niacin, vitamin B6, pantothenic acid, iron, zinc, copper, manganese, and selenium ?

@srirambhardwaj2343 4 жыл бұрын

Excellent.explanation.

@lunamoondrop Жыл бұрын

so helpful 🤍

@mgdmhd8172 5 жыл бұрын

What about glutathione supplementation instead of folic acid. is it useful for this condition?

@TRU_FAMILY 5 жыл бұрын

Should I take iron supplements?

@angeloramos885 3 ай бұрын

Hi! Just wanted to ask if individuals affected with G6PD can safely drink alcohol. Any answers would be great, Thanks! Great video by the way

@prateekbobby6507 7 ай бұрын

my g6pd level is 36. normal range 6 - 20. anything wrong ?

@bossha8354 2 жыл бұрын

What shall I do I like fava beans so much though I do know that I have had G 6 pd deficiency What shall I do O have the syndrome of bulemia nervosa to الفول المدمس والفلافل and once I eat any component of both I feel all my circumstances and ealth r oing down be severely jaundiced even though heaviness of my head stupor and coma I am ill I need exchange blood transfusion قرف عليه وعلى شكلي

@doctorj7112 2 ай бұрын

I had no clue I had this deficiency. I was going to get a high dose vitamin c IV and my doctor ordered the test. The test came back that I had this gene 🧬. I don’t believe I have any symptoms but it’s good to know

@nnnn-wp9hx 2 жыл бұрын

Thank you so much for the video

@johnpaul.hello. 2 жыл бұрын

No recommendation for foods that help? meh

@AdventureAwaits972 2 жыл бұрын

Question: Would supplementation with "N-acetylcysteine (NAC)" or "S-Acetyl L-Glutathione" or "liposomal glutathione" or "reduced glutathione" directly ... increase or counter-balance glutathione levels-shortages in individuals with a G6PD deficiency ??

@kayolastna2215 10 ай бұрын

Can't answer that but I have heard it's better to supplement with NAC instead of glutathione as this allows for better intracellular regulation of glutathione. Too much can be detrimental as with most things.

@otuokwulillian9092 Жыл бұрын

❤❤❤

@nayjunior 10 ай бұрын

References please

@claireboucher9692 2 жыл бұрын

Hello I have a deficiency in Glucose 6 phosphatase

@Swat_Boi 2 жыл бұрын

I have g6pd

@1joannabullen 6 жыл бұрын

Brilliant video but I don't think you need to say glucose 6 phosphate dehydrogenase as many times.... Perhaps just say the letters and it would be much more pleasant to watch/hear. Good work.

@hakshkumar87 2 ай бұрын

It's only because of remember