I just want you to know that your videos are literally the only things that have helped me get through organic chemistry. So thank you!
@PunmasterSTP2 жыл бұрын
How did the rest of your ochem classes go?
@ClicClikBang6 жыл бұрын
I'm pissed. My professor didn't say anything about making the carbon groups nucleophilic. Suddenly this makes so much more sense.
@shanemichael94045 жыл бұрын
They often don't. They know chemistry like the back of their hand and they sometimes teach as if you should already know this stuff. I hate it !
@akhilgajjala49223 жыл бұрын
@@shanemichael9404 Ikr
@PunmasterSTP2 жыл бұрын
I know it's been awhile, but I was just curious; how did the rest of your class go?
@ClicClikBang2 жыл бұрын
@@PunmasterSTP awful but I passed with a B, and I’m in medical school now. I never have to look at another dumb ochem reaction again. All’s well that ends well.
@PunmasterSTP2 жыл бұрын
@@ClicClikBang I'm glad you passed, and I wish you the best with medical school! Also, yeah, I don't think ochem is going to come up in there...
@ARRRRRRRRFUL8 жыл бұрын
The handsomeness makes it difficult to focus sir
@lavishagera13028 жыл бұрын
If i had a professor this hot i'd never be missing classes. NEVER.
@subikksha49414 жыл бұрын
Guys! He's our teacher! It's not fine to speak like this!
@duleetharajapaksha64934 жыл бұрын
dafaqs wrong with you
@besimeaslan95893 жыл бұрын
😂😂
@soniafragoso53763 жыл бұрын
but for real tho!
@zinebmakesvideos3 жыл бұрын
1.5 minutes in i had my first "OHHH" moment. bless u kind sir
@abirdas39552 жыл бұрын
Best video on grignard regent I have ever seen. Thank you professor ❤
@hamedhosseini49387 жыл бұрын
Hi Professor I just want to say thank you very very much for your videos, I finally finished my organic chem with acing my final exam because of your awesome videos. I owe you a lot and I wish you the best again, thank you very much. Sincerely, Hamed.
@ProfessorDaveExplains7 жыл бұрын
congrats! thanks for watching!
@soziljain53658 жыл бұрын
thnk's sir a lot teachers like u make student confident that we can solve problems and are not stupids
@darraghh63847 жыл бұрын
the opening jingle is stuck in my head forever.
@deen60338 жыл бұрын
Sweet, everything I needed in 8 minutes!
@rizzarizzo8 жыл бұрын
True
@SelenaSanchezGiancola4 жыл бұрын
this was so helpful. thank you for actually explaining what it is. I was trying to watch the o chem tutor and he was just doin problems like I already had all of this background knowledge about what happens and why. thank you!
@CCC93772 Жыл бұрын
This is the best video that I have watched so far about this topic. THANK YOU SOOOO MUUUUCHHH!!!!!!!
@Karimdaniel8 жыл бұрын
simple, easy and concrete. Thanks man =)
@sehmio8 жыл бұрын
Thank you so much for this video Professor Dave! This is by far the most engaging video on youtube about Grignard reactions and it is always helpful to see the person teaching being interactive in the video! Have subscribed and will recommend to friends!
@murv.31828 ай бұрын
Studying for the MCAT this January, absolutely amazing I stumbled across this video. Thank you for the blessing
@alexpapad44382 жыл бұрын
the fact that in Greece we're learning these in high-school is something out of your minds. I'm going to cry alone😭
@NEETAspirant-li3tu2 жыл бұрын
Lol In india we have to learn 100x more than this, in high school lmao
@@andy0695 yup, pretty much XD what a pain in the ass
@psychedelicpain4205 жыл бұрын
I like it. The videos are short and straight to the point.
@JMSouchak8 жыл бұрын
Thank you for your help, you have no idea how much this this video taught me.
@danieleby7995 жыл бұрын
Thank you professor grohl
@wtbgothgf8 жыл бұрын
Your videos are easy to digest and very helpful. My exam is tomorrow and you've helped so much! Thanks for all the hard work!
@ProfessorDaveExplains8 жыл бұрын
+Hunter Goodreau my great pleasure! tell your classmates!
@PunmasterSTP2 жыл бұрын
I know it's been awhile, but how did your exam go?
@bikramsardar70103 жыл бұрын
Sir I am from India and Iwant to tell you that your teaching style is so beautiful!!!!!!
@swaroopdiddi35504 жыл бұрын
This video was uploaded in 2015, Just saw a comment given 2 days back and he had replied to it!!! Awesome
@monicholopainen4 жыл бұрын
Thank you, professor Dave, for this videos, specially during the corona virus, I'm going to take an exam of Organic chemistry II, you helped a lot !
@PunmasterSTP2 жыл бұрын
How did your exam go?
@OmniversalInsect6 ай бұрын
When you think about it it's pretty remarkable how as a species we have been able to develop such chemical reactions.
@LucasCastro-je7zp7 жыл бұрын
Wow, man! Your lessons are really amazing. I love that there's always subtitles. Congrats! ;)
@xxikxx1016 жыл бұрын
I cannot thank you enough for these videos! Not only did you get me through Gen Chem 2 but now you make Orgo 2 simple.
@PunmasterSTP2 жыл бұрын
How'd the rest of Orgo 2 go?
@soco20202 жыл бұрын
Dave, your youtube channel has been incredibly helpful for me in understanding organic chemistry. Thanks for all of the great and informative content!
@PunmasterSTP2 жыл бұрын
Are you still taking ochem or did you finish that up? And if so, how did the rest of it go?
@dzsisters88833 жыл бұрын
I love your explanations. straightforward. thanks!!!
@mhonnie6 жыл бұрын
I was looking for a video like this 😌 In Spanish I couldn't find it, but KZfaq recommended me this video 🤣❤
@justg0tow3d24 жыл бұрын
Amazing video... thank you for your time
@digthegrig Жыл бұрын
Haha, love how the chemists decided to use my nickname to name this reaction😂
@Physics-j6c8 күн бұрын
Grignard is a very famous reagent, & It just simply used in most of reaction to proceed and formation of different compounds ... Btw you have a good name ! 😅😊
@dayuuum017 жыл бұрын
Thank you.
@namenlos35746 жыл бұрын
Just found this and I'm a biology student from Germany and I just have so much problems with OC and I think you just saved my life.
@Gunner772695 жыл бұрын
Thank you Professor. Idk how in eight minutes you can do what in 50 my professor cannot
@PunmasterSTP2 жыл бұрын
How'd the rest of ochem go?
@msoliman42563 жыл бұрын
This is the best explanation ever. I finally understand Grignard reactions. Thank you so much professor!!!!
@bleuemoone87104 жыл бұрын
Thanks for not having a 2hr long video
@vanessaharo85626 жыл бұрын
!!! Thank you so much! Your video was extremely helpful for my organic chemistry final!!
@PunmasterSTP2 жыл бұрын
I know it's been awhile, but how did your final go?
@tonka34393 жыл бұрын
You are really helping people learn, thank you so much for this free and wonderful content! I wish you were my professor
@The0687221078 жыл бұрын
I love it! Well explained and easy to take in. Thanks
@ChoocoCaramell6 жыл бұрын
Thank you so much! you answered one question that I had of one retrosynthesis, now I know why we used grignard reaction, c:
@susisorglos89867 жыл бұрын
thank you for this video! im from germany so its sometimes a little bit hard for me understand the... chemical term but your videos are much better than the german ones! thanks a lot!
@irinakovach96244 жыл бұрын
Now it makes sense! Thank you, just reading it is so confusing. I really appreciate!!
@bernadetteg.tharngan40413 жыл бұрын
Thank you so much. I was really struggling with understanding this.
@patrycjapajdak2491 Жыл бұрын
a very clear and helpful video. thank you very much!
@kartikgaur2 жыл бұрын
Professor Dave you are amazingly amazing, thank you so much ✨🌈
@roshanperera402 Жыл бұрын
Your explainations are super.thank u professor
@yourfuturedocburenbeiya3 жыл бұрын
Thank you for the excellent explanations as always, Professor Dave!!
@josemanuelhernandezcanchol25476 ай бұрын
Should we technically be drawing arrows originating from a carbon atom? Which electrons are specifically forming the new bonds here?
@simmymatharu57218 жыл бұрын
easy to follow i came here after i saw ur comments on khan academy video
@ProfessorDaveExplains8 жыл бұрын
+Simmy Matharu good to know! i should litter some more comments over there then!
@declanbowler73797 жыл бұрын
A subtle form of product placement? ;)
@jhadebredenkamp976 жыл бұрын
shook by how easy you made something that seemed impossible to conquer! infinite thank-yous!!!!
@ellesrevisionsession8 жыл бұрын
Excellent! Wish you had been making videos during my degree!!
@PunmasterSTP2 жыл бұрын
I know it's been awhile but I was just curious; what did you get your degree in?
@bluebabeey93435 жыл бұрын
I would not be a junior without this guy
@likeabanner8 жыл бұрын
THANK YOU so much for this video! Our labs do not mesh with our lecture material. We are chapters behind, and the explanation to the background of the reaction was non-existent. Thank you so much so I can write a more precise lab report!
@ProfessorDaveExplains8 жыл бұрын
+Kelly Burns my pleasure! spread the good word!
@PiyushKumar-cf1iy8 жыл бұрын
thanks sir.....your videos make a difference indeed......:))) helped a lot....thanks
@rem5203 жыл бұрын
You're a life saver
@sadiegiddings16745 ай бұрын
These videos are a godsend, theres a special place in heaven for you!!
@spencerpootis33193 жыл бұрын
Actually, why wouldn't the Grignard reagents react with carboxylic acid? Why isn't that going to work (6:23)?
@lukepereira58803 жыл бұрын
You never knew you had it so good until you go from the audio in 5:40 to the audio in 5:45
@Benjamin-jl2ei2 жыл бұрын
man I love your channel
@rahelsilaen8996 Жыл бұрын
I don't understand why carbocilyt acid. But that compund has carbonyl in it/.
@truealchemy23 жыл бұрын
watch your "absolutes" :) And, to add a practical perspective, a grignard prep will blow up in your face a few times til you get the hang of it. Then it won't blow up in your face as much.
@PunmasterSTP2 жыл бұрын
Grignard reaction? More like "Gee, this video gives me knowledge satisfaction!" Thanks again so much for making so many educational and entertaining videos.
@bu66les218 жыл бұрын
THAAANK you, now I can pass tomorrow's paper!!! yaaaaay
@danielohearn54086 жыл бұрын
H+ doesn't seem like something you could just add. Is it not true that you would have to add a strong acid to water, to even get H+? Then there would be a sodium ion in your products.
@ProfessorDaveExplains6 жыл бұрын
it's a workup step, after the reaction is complete a little ammonium chloride or something similar will just protonate all the oxyanions. but yes you're correct we can't literally add protons, H+ is short hand for acid, something that is a source of protons. even a weak acid will protonate oxyanions to get the alcohol product as they are so basic.
@Mathophile124 Жыл бұрын
This well explained, clearly understood 🎉🎉
@amygarcia22026 жыл бұрын
I always recomend you to my friends 💓
@eyeswithhope136 жыл бұрын
Thank you so much
@baharul35144 жыл бұрын
Thanks Professor Dave.
@killiankane62572 жыл бұрын
This has been really helpful thank you
@desperatewanker7 жыл бұрын
thx alot for your video profefesor dave!
@coocat2318 жыл бұрын
Very helpful, better than the kahn academy video which showed 5 bonds on carbon
@ProfessorDaveExplains8 жыл бұрын
haha i know! i commented on that video to tell them that pentavalent carbon is the biggest cardinal sin in organic chemistry.
@declanbowler73797 жыл бұрын
Maybe they'd had a bit of the alcohol they'd been talking about, eh? ;P
@declanbowler73797 жыл бұрын
Diethyl ether? That stuff that catches fire easily, has a low flash point and a poor heat capacity? Seems ideal for a highly exothermic reaction :P and my uni lecturer just won't let me use it. What a spoil sport eh?
@ProfessorDaveExplains7 жыл бұрын
a spoil sport indeed! it's a very common solvent.
@declanbowler73797 жыл бұрын
Edit: We did use it :) Nothing caught fire. Also thanks for the video, came back to it trying to understand the mechanism. Think I have it now, formed triphenylmethanol from bromobenzene and bromophenone (I think).
@JP-wx6uh6 жыл бұрын
Smart professor. Ether is just nasty stuff and for people who aren't disciplined with safety or well-organized and attentive to the dates of their chemicals, ether just isn't a good choice. Need to also think about how the chemicals are disposed afterwards. Real headaches.
@karimak46338 жыл бұрын
Thank you :)
@mena_fire6 жыл бұрын
I saw your comment on the Khan Academy’s video explaining how the bond between R-Mg-X forms and you said that it was incorrect because the C cannot have more than 4 electrons so it can’t take one more electron from Mg. So why don’t you explain it? I’d rather understand how things happen rather then memorise it
@ProfessorDaveExplains6 жыл бұрын
Oh I remember that, yeah they showed a pentavalent carbon intermediate, definitely not accurate. The precise way it happens is not fully understood, but it's gotta be some kind of oxidative addition, very common in inorganic chemistry.
@nikki5948 жыл бұрын
Great explanations. Well done. Better than the professor at our college.
@vibez3667 жыл бұрын
Jesus teaching me chemistry? Thats the dream!
@fukpoeslaw36133 жыл бұрын
legend says he's able to turn H2O into wine!
@jaykemm3472 Жыл бұрын
I got into a fist fight with my wife about this the other day. She won, but I was right.
@georgeclooney91647 жыл бұрын
wow, "destroy" your grignard reagent? Man, i'd feel bad if i was that hydrated magnesium bromide byproduct Like, I never meant to destroy anything man, jesus, can't i be valuable too?
@venkateshbennur36403 жыл бұрын
Your videos are quite impressive and very helpful sir. My exams are day after tomorrow..............and special thanks for clearing this concept sir🙏.........
@PunmasterSTP2 жыл бұрын
How did your exams go?
@midzy_panda04198 жыл бұрын
Thx very much professor Dave!!!! u clear all my doubt about grignard reagent since i was on secondary school..XD
@songohan3934 жыл бұрын
thank you sir
@foxsotired30383 жыл бұрын
These videos are really nice.
@guddubhakta22285 жыл бұрын
This is so easy example for grignard reaction.
@24shagufakhan46 жыл бұрын
Thankyou sir
@sinamt29824 жыл бұрын
very helpful, thx so much
@Amy-se5ld7 жыл бұрын
I think I love you so much
@ProfessorDaveExplains7 жыл бұрын
and i love you!
@dejanasimic5176 жыл бұрын
You say that it a Grignard connection shall not interact with a water molecule, but before getting the 5-Carbon alcohol, there is water...?
@ProfessorDaveExplains6 жыл бұрын
that's aqueous workup! the oxyanion has formed so the grignard reaction is complete, then you just toss in some aqueous ammonium chloride or some other weak acid to protonate and get the alcohol product.
@jasminferreira35449 жыл бұрын
Metal-halogen exchange is awesome. Great video! :)
@011073457 жыл бұрын
The first reaction is not a Grignard reaction, but provides a Grignard reagent. Is that correct?
@ProfessorDaveExplains7 жыл бұрын
correct! preparation of grignard reagent, which will then do grignard reactions.
@elletronmatic7 жыл бұрын
Hi! Thanks so much for these tutorials :) Just a quick question though. I see that you're using H2O as a step to protonate the oxygen. But we need to avoid water in a Grignard reeaction (to avoid forming R-H). Does H2O just represent an easy proton source for the purpose of this video?
@ProfessorDaveExplains7 жыл бұрын
so that's just the aqueous workup step, in the lab you would do the grignard in anhydrous conditions and you get oxyanions in solution, then work up with aqueous ammonium chloride or something when you're done which will go and protonate everything to give the alcohol product.
@elletronmatic7 жыл бұрын
oh, I see now! Thanks for the prompt reply :) have a good evening!
@68xnico68 Жыл бұрын
Very nice Video! Easy to understand! thank you : )
@annesam83679 жыл бұрын
thanks!
@dougrutana57607 жыл бұрын
Would a second product of the last reaction with the ester be CH3OH? Since the OCH3 breaks off and could pick up an H from the H+, H20?
@ProfessorDaveExplains7 жыл бұрын
yes indeed!
@catyy2236 жыл бұрын
Thank you so much! you saved my day
@parthaupadhyay47676 жыл бұрын
Thank You Sir
@kamarunizamuhammmed59564 жыл бұрын
Thank uuuuu soooooooo muchhhh God bless you😍😍
@buzoo23464 жыл бұрын
thanks sir
@locatedsomewhere Жыл бұрын
the only thing that I do not understand is if a grignard reagent must not come into contact with a water molecule because it will be destroyed how is it okay to protonate! there are water molecule won't they destroy the grignard reagent??
@ProfessorDaveExplains Жыл бұрын
Yes water will destroy a Grignard reagent so the reaction must be carried out in strictly anhydrous conditions.
@agent4758168 жыл бұрын
The bond between the carbon and MgBr is actually ionic. The R-group has a full negative charge and the MgBr has a positive charge.
@ProfessorDaveExplains8 жыл бұрын
+agent475816 i would beg to differ! lots of evidence to the contrary. like the proposed six membered ring transition state involving two grignard reagents. also, it seems like if it had a formal charge, there'd be too much opportunity for intramolecular reactions, skeletal rearrangements, etc. i can find nothing online supporting the idea of a formally charged grignard reagent, do you have a source?
@ProfessorDaveExplains8 жыл бұрын
+agent475816 i've never seen anything like that mechanism for grignard reagent formation in the kahn video, and i'm extremely dubious. carbon is strictly tetravalent, so picking up an additional electron goes against everything i've ever seen in organic chemistry. textbooks may say the reagent reacts "like a carbanion", but the key word is like, the bond is polar covalent, to our best knowledge.
@agent4758168 жыл бұрын
Professor Dave Explains There are carbanions formed in lots of reactions. The Birch reduction is a good example. Another is the acidity of terminal alkynes. React a terminal alkyne with NaNH2, and you will get a terminal sp hybridized carbanion with Na+ on it. You may be right, I'm just going off what I learned in my class and that Khan Academy videos and your videos.
@ProfessorDaveExplains8 жыл бұрын
carbanions yes, but always with three bonds and a lone pair, never four bonds plus a radical, that i've ever seen anyway. carbon can't accommodate five coordination sites.
@agent4758168 жыл бұрын
Professor Dave Explains But that is what it is in the grignard reagent. It is very unstable, that is why the halogen is kicked off, and the magnesium donates it's second electron to form the carbanion with 3 bonds like in the video. You are saying that that is not correct?
@kanzasoomro13174 жыл бұрын
ty omg savior we love u man
@shotdoctor58696 жыл бұрын
I didn't think methoxy was a good leaving group unless it was protnated first, but you can't use a gringnard reagent in acidic conditions. Am I mistaken by this?
@ProfessorDaveExplains6 жыл бұрын
in this situation it's no problem! but yes, no acidic conditions for grignards.