High LDL on a Keto Diet. Should You Worry? | Nick Norwitz & Dave Feldman

  Рет қаралды 64,255

Plant Chompers

Plant Chompers

Күн бұрын

Your cardiologist just freaked out. Should you?
High LDL Cholesterol Increases on a Low Carb Diet - The Lipid Energy Model
• High LDL Cholesterol I...
Are you a Lean Mass Hyper-responder?
cholesterolcode.com/are-you-a...
Effect of low carbohydrate high fat diet on LDL cholesterol and gene
expression in normal-weight, young adults: A randomized controlled study
drive.google.com/file/d/1udKR...
Elevated LDL Cholesterol with a Carbohydrate-Restricted Diet: Evidence for a "Lean Mass Hyper-Responder" Phenotype
pubmed.ncbi.nlm.nih.gov/35106...
Case Report: Hypercholesterolemia “Lean Mass Hyper-Responder” Phenotype Presents in the Context of a Low Saturated Fat Carbohydrate-Restricted Diet
www.ncbi.nlm.nih.gov/pmc/arti...
Elevated LDL-cholesterol levels among lean mass hyper-responders on low-carbohydrate ketogenic diets deserve urgent clinical attention and further research
www.lipidjournal.com/article/...
Ketone body β-hydroxybutyrate ameliorates colitis by promoting M2 macrophage polarization through the STAT6-dependent signaling pathway
bmcmedicine.biomedcentral.com...
An Ester of β-Hydroxybutyrate Regulates Cholesterol Biosynthesis in Rats and a Cholesterol Biomarker in Humans
pubmed.ncbi.nlm.nih.gov/26498...
Effect of carbohydrate-restricted dietary interventions on LDL particle size and number in adults in the context of weight loss or weight maintenance: a systematic review and meta-analysis
pubmed.ncbi.nlm.nih.gov/34159...
Effect of low carbohydrate high fat diet on LDL cholesterol and gene
expression in normal-weight, young adults: A randomized controlled study
drive.google.com/file/d/1udKR...
Statins decrease leptin expression in human white adipocytes
pubmed.ncbi.nlm.nih.gov/29372...
Dr. John Scharffenberg on statins
drive.google.com/file/d/1xYij...
Role of nonexercise activity thermogenesis in resistance to fat gain in humans
pubmed.ncbi.nlm.nih.gov/9880251/
0:00 Nick Norwitz
2:06 Dave Feldman
4:22 Lean Mass Hyper Responders
16:59 Heart attacks in children
20:01 Studies of plaque buildup
29:19 LDL in older adults
45:10 HDL
49:06 The LMHR model
59:38 How Dave Feldman discovered LMHR
1:09:18 Nick's Oreo cookie experiment
1:21:50 keto diets and the LDL receptor

Пікірлер: 979
@MictheVegan
@MictheVegan 9 ай бұрын
The moment he said his LDL can still be high without saturated fat I thought it must be some liver-related energy metabolism result of ketosis when there isn't fat stores to pull from. Later in the video it turns out that is part of their hypothesis. It's the only thing that makes sense given his information but the potential risk decades out could be massive. Was that Carnivore Kid guy with a six pack and a 95% clogged windowmaker artery a lean mass hyper-responder? I wouldn't be surprised if there isn't a 1:1 risk for LDL for people up around 400 or 500 in this situation but I would be astounded if there isn't a serious elevated risk that warrants trying other options. Additionally, I am concerned that this 1-year study is going to be taken as a golden ticket to not care about LDL despite the warning of being short term. If the subjects are younger when atherosclerosis progresses really minimally, will the age-matching miss detecting what could become rapid artery damage in middle age or as the age-related oxidative stress sets in? Yeah most of these CTA studies might be one year long but most are in middle-aged individuals. People might view it as an LDL pass for keto diets but as the LMHRs or even average high LDL keto dieters hit their 50s and 60s it could be atherosclerosis city. My other concern with this topic is that people (like Jenny Mitich who I just responded to) take cases of people like Nick in their 20s not having plaque on a keto diet as a reason that they will personally be fine with high LDL on a low carb diet. Nick seems to be concerned about LDL in these cases but that warning is not making it to or being taken seriously by keto people on the ground. They simply use his paper to deny any potential negative of high LDL. Total dismissal of LDL's risk is part of the ethos of these weight loss keto dieters and that is dangerous. I also can't help but wonder what particular option Nick has tried for his colitis and if he has looked into his gut biome. How could he eat carbs just fine until senior year? What happened? Maybe some bacterial dysbiosis is to blame? He also says that perhaps exogenous ketones are a therapy for his colon. Why not take the ketones and include enough carbs to lower his LDL for his main diet? That would be lowest LDL risk it seems, assuming the ketones prevent his colitis symptoms. Lastly, I would love to see how fiber would influence LDL levels in these people. Is it just LDL being clearly more slowly or is the reabsorption of biliary cholesterol in the digestive tract playing a role? If you don't have fiber to bind to it and remove it, would that be a missing explanation here for the carnivore dieters, etc.?
@narbs8944
@narbs8944 9 ай бұрын
hugely agree with the 2nd paragraph, these results can't be generalized to the larger group of ketogenic dieters but it is anyway
@defeqel6537
@defeqel6537 9 ай бұрын
On dietary saturated fat: kzfaq.info/get/bejne/gc18orp7u9ushH0.html
@nicknorwitzPhD
@nicknorwitzPhD 9 ай бұрын
"Was that Carnivore Kid guy with a six pack and a 95% clogged windowmaker artery a lean mass hyper-responder?" - No he wasn't. I actually chatted with Michael R. after the event. Sad case. He went 'carnivore' AFTER he found out he had advanced disease. He has a strong family history and actually a mutation in one of the ANGPTL proteins involved in our LEM model to explain LMHR. In my convos with Michael I was clear that, while I couldn't give medical advice, his was a case in which I would have accepted treatment and - thought I didn't tell him this - were I him with his coronary findings I probably would be eating more tempeh and less buttered steak. His story has been distorted for propaganda, which is sad. Sorry not going to get to all your points... time pressed... trying to drive though some replies. Thanks for watching!
@wocket42
@wocket42 9 ай бұрын
Average age of the study subjects is 55.
@cypriano8763
@cypriano8763 Ай бұрын
just seams to me that hes starting with a desperate need to find a result. that if you eat tons of sat fat but exercise and stay lean your not increasing your risk of heart disease. why would you get on a diet like that.
@realDaveFeldman
@realDaveFeldman 10 ай бұрын
Thanks for having us on, Chris - it was a fantastic discussion
@Mimulus2717
@Mimulus2717 10 ай бұрын
thank you for this excellent fair, honest and balanced discussion of LMHR. I was aware of this phenom, but never did a deep dive because the discussion around it seemed so polarized and tribal. this answered all my questions and more. Nick Norwitz and Dave Feldman appear to be gentlemen, scholars, excellent scientists and true mensches! Wonderful video Chris. You are a scholar, gentleman and mensch yourself.
@nicknorwitzPhD
@nicknorwitzPhD 9 ай бұрын
Thanks for this!
@jessrx1
@jessrx1 9 ай бұрын
As a LMHR myself, I am very eagerly awaiting more results from these trials. I was sick as a longtime vegan and have a lot of warm feelings for the passionate and kind vegan community. It's where I found my love of gardening and yoga. However, I healed on keto and as I got very fit, my LDL went up. Gaining weight makes my LDL go down. FIber has no effect on my LDL Carbs make my LDL go down and make me feel lousy. BMI 21, HBA1c 5.1, LDL 220, HDL 89, VLDL 10, TG 50. Can teach 5 yoga classes in a row and feel awesome. Keep an open mind!
@nicknorwitzPhD
@nicknorwitzPhD 8 ай бұрын
Thanks for this reply!!!
@annwilliams6438
@annwilliams6438 8 ай бұрын
I would be very interested to hear whether you ate a lot of oats and various other grains when you were eating vegan? It sounds like you might have cealiac disease.
@nicknorwitzPhD
@nicknorwitzPhD 8 ай бұрын
@@annwilliams6438 I do not. Have been tested
@acke26
@acke26 7 ай бұрын
Interesting numbers. Can anyone answer my question if I'm a LMHR? I've always been very lean and quite muscular. Can eat whatever I want without gaining weight even without exercise. The slightest gain i weight is concentrated around the abdomen. I'm for sure a TOFI (Thin Outside Fat Inside) Normal healthy diet with carbs; Tot.chol 6,5 LDL 4,5 HDL 0,6 Trig 2 In attempts to increase my HDL I've tried a LCHF-diet/ketosis. My HDL-levels is raised but is still too low; Tot.chol 8 LDL 6 HDL 0,8-0,9 Trig 1,5 - 2 My lipids differ from the criteria LMHR with a low HDL. Any thoughts? Am I insulinresistent?
@TheBigEmstos
@TheBigEmstos 5 ай бұрын
What did you eat on keto?
@brucerubenstein7843
@brucerubenstein7843 9 ай бұрын
What a thrill it is for me to see plant chompers speaking to cholesterol coders! I didn’t expect this conversation ever to happen, but it’s a credit to all three of you that it did. The only thing that would make me happier is for Tom Dayspring to join the discussion next time.
@nicknorwitzPhD
@nicknorwitzPhD 9 ай бұрын
Isn't it interesting that Dayspring refuses to acknowledge I exist? In the past year+ on Twitter he's not replied to even one of my questions. I even had a Tweet naming him specifically w/ >200K impressions... and not a single comment
@brucerubenstein7843
@brucerubenstein7843 9 ай бұрын
@@nicknorwitzPhD You’re only 2 degrees of separation away from Tom Dayspring, who I believe now works at Peter Attia’s clinic. Your associate Dave Feldman has been on Peter’s podcast. Perhaps try a more personal approach to contacting him through Dave and Peter?
@nicknorwitzPhD
@nicknorwitzPhD 9 ай бұрын
@@brucerubenstein7843 I've tried several ways: direct question, intermediary messaging, etc. He's aware I exist. When he's prepared to chat he knows how to find me.
@gavtex1065
@gavtex1065 9 ай бұрын
@@nicknorwitzPhDIn my mind this is clear evidence of 2 things, being 1. An inability to come up with a satisfactory answer and knowing it, and 2. An irrational and / or emotional attachment to the status quo.
@williamdixon4936
@williamdixon4936 10 ай бұрын
I've been on a wfpb, sos-free diet since your video on hyper-palatability. I was an obese vegetarian 275 lbs, 6'2" at the start. But I've seen remarkable weight loss in the last 4 months, just recently hitting 233 lbs and falling, exiting my bmi range for obesity. My diet is loaded with starches, oats, whole grain pasta, beans, lentils, etc. as well as all the fruits, potato, corn. I eat as much as I'm hungry for, and whatever my body craves as long as it follows wfpb sos free. So you could say I'm on a high-carb diet and so far thriving! Although I understand 4 months is early days when talking about the rest of my life (in my early 30s). I tried a ketogenic diet in my early 20s with good early weight loss results, but I didn't have the meal planning skill at the time to stick to it, and I crashed hard into the SAD. I've since become convinced by your channel and Gil Carvalho that the preponderance of evidence shows that a wfpd diet is the most healthful diet. However I appreciate your inquires into other level-headed scientists who are looking in different directions, to make sure we're making the best possible decisions for our food-based health.
@janco333
@janco333 10 ай бұрын
Try popping all the food you eat on cronometer to see if you have any micro nutrient deficiencies of your diet.
@eugenetswong
@eugenetswong 10 ай бұрын
Congratulations on the progress!
@williamdixon4936
@williamdixon4936 10 ай бұрын
@@janco333 Thanks for the idea, I'm also planning on getting blood work done at the 6 and 12 month markers.
@williamdixon4936
@williamdixon4936 10 ай бұрын
@@eugenetswong Thank you!
@eugenetswong
@eugenetswong 10 ай бұрын
You're welcome. 😄@@williamdixon4936
@NF-bt6rw
@NF-bt6rw 9 ай бұрын
Thanks Chris for your episodes. I am a practicing physician in Canada who has tried to promote healthy lifestyle including nutrition for 20+ years . Your episodes are much appreciated.
@JWB671
@JWB671 9 ай бұрын
I was on low carb for a few years. I developed a Xanthelasma under my eyelid. Blood tests showed I had an LDL of 238. They also showed I had high lp(a) and very small LDL particle size and low HDL. In other words, I have a lipid disorder that leads to heart disease without question. I drastically reduced my red meat consumption, added in sweet potatoes, steel cut oats and fruit whilst keeping vegetables high. I also structured my meals in a way I have never seen anyone else do before. It is what I call dose response eating. My LDL went from 238 to 77 in 3 months without any drugs.
@robertbrown6531
@robertbrown6531 9 ай бұрын
Can you explain a bit more what you mean by "dose response eating"? Sounds interesting, thanks.
@janco333
@janco333 8 ай бұрын
Two weeks ago my total cholesterol was 274, I went full plant based, just had cholesterol tested again today, came back 185. It is incredible how bad meat and dairy is.
@stargazerbird
@stargazerbird 10 ай бұрын
I got a blood test for health insurance in the middle of going keto and losing a lot of weight fast and upping my cardio. Felt fantastic. My lipids were horrific. The doctor was stunned. I went off the diet. Four years later I was still needing to lose a bit of stubborn weight. IBS that was getting more frequent. Went back on keto, weight flew off, stomach issues disappeared. I am confused. Seems for me doing keto improves everything and makes me lean and happy. It’s a cruel twist if the very thing that improves everything else will kill me. I have decided to stick to the diet that makes my life better and not stress over something that is invisible to me.
@sandywendelfred8260
@sandywendelfred8260 10 ай бұрын
sounds like it could be that your keto diet as accidentally an elimination diet for foods that you were sensitive to. Have you tried doing a proper elimination diet and slowly reintroducing foods, tracking them as you do to try and determine what specifically is causing GI issues?
@defeqel6537
@defeqel6537 10 ай бұрын
@@MB10097 it could also save them from other diseases: on average, all-cause mortality seems lowest with an LDL level of about 150mg/dl, or 4 mmol/l, and HDL of about 75 mg/dl, or 1.9 mmol/l, and the risks go up faster the lower the numbers. LDL seems to vary quite a lot between individuals though, and is likely more of a marker than a cause of disease (which explains why all-cause mortality does not improve with statins). Plant sterols can also be used to lower LDL, but it is unknown to me whether that is actually beneficial, at least I haven't seen any long term data, unlike with statins.
@salparadiso
@salparadiso 10 ай бұрын
@@sandywendelfred8260 It's no accident that removing factory food and going whole food, low carb, make you healthy. Health has only gone down as factorys making food increased
@salparadiso
@salparadiso 10 ай бұрын
smart choice! It works because it's natural.
@marynoonan6111
@marynoonan6111 9 ай бұрын
Stick to you diet. Use olive oil instead of saturated fats, and there are always cholesterol tablets to take if all else fails.
@RalfWiggam
@RalfWiggam 9 ай бұрын
Thank you for taking so much time and care to put this data out to the public. over the years I been eating like a jerk, knowing I could be doing better but giving into convenience and indulgence. Your videos have helped tilt the balance on my dinner plate.
@sabby123456789
@sabby123456789 4 ай бұрын
Many years ago, an overweight relative of mine saw how I ate a lot of vegetables and told me that eating too many vegetables are bad for you. A few years later, she started having chest pain and her cholesterol was 400 mg/dL!
@fossilvivo
@fossilvivo 9 ай бұрын
The feeling I have after watching this and other videos plus some books is that scientists are victims of personal preferences of diets that worked for them personally or foods they have a taste for: Prof Tim Spector with his defence of red wine ,for example, or his special focus on sugar picks after he was diagnosed pre diabetic, Dr Mario Kratz also focus on diabetes and diets to control insulin resistance, Dr Gil Carvalho has a special focus on cholesterol, and diets that control it and some people with IBS orbit towards low carb diets. After that some followers of a specific diet become like religious converts searching for the ultimate "redemption" through food. And like religious groups they break up into more fanatical "pure" sub groups; Vegans-> raw vegan->fruitarians or Low carbs-> carnivore diet-> lion diet. It's interesting to step outside and look at the Human Play... hope it has a happy ending.
@timh-c7186
@timh-c7186 9 ай бұрын
Great logic. It's called "confirmation bias". Dietary extremes (vegan and carnivore) are very vulnerable to it...both appear to have mental blocks to alternative info and research. Sick people seem to have success with "elimination diets" of which vegan and carnivore are both examples
@jgreen9361
@jgreen9361 9 ай бұрын
6 years ago, stress induced IBS was diagnosed, cut things out added stuff back. Stable, for 4 years on pescatarian diet, with much reduced refined carbs. Then, one bad flare up and a diagnosis if inflammatory bowel disease. I am now on a mainly vegetarian diet, carbs pretty much inline with traditional food pyramid. All bread is now high quality grains and home baked. All symptoms gone. It seems to me the modern highly processed diet is not good for longevity and not good for coping with personal stress or emotional trauma. Our gut becomes sensitised by the toxic crap in modern food and we get to a point where even foods that are good for us cause inflammation.
@SpookyScarecrow
@SpookyScarecrow 4 ай бұрын
Regarding Gil, I really like his open-minded approach. It’s pretty clear after you watch him for a while that he is vegan or nearly vegan, but I see him talk all the time about doing what works for oneself and how plenty of different foods can be part of a healthy dietary pattern.
@Joy80JJ
@Joy80JJ 10 ай бұрын
Very interesting interview & info. Enjoyed this. Thank you.
@younutre
@younutre 9 ай бұрын
I think it's important to point out that this possibly non-problematic increase in LDL occurs specifically on ketogenic diets where muscle glycogen is depleted (in addition to other adaptations). That is, if this theory is proven, it does not mean that LDL does not matter, it still matters a lot, if you do not eat well and your LDL is high, be concerned. The video refers to a very specific situation.
@shellderp
@shellderp 8 ай бұрын
I mean if you're eating keto and your LDL is low, great, if it's high, great
@catchristo9406
@catchristo9406 4 ай бұрын
Yeah, I no longer worry about lipids. I am more concerned with insulin resistance and blood sugar levels. As long as we don't eat sugar or processed foods, most of us should do fine.
@uowebfoot
@uowebfoot 4 ай бұрын
You're making an assumption that LDL still matters. I would argue it may not matter. The medical community may be wrong about it. It wouldn't be the first time.
@juanpablosanchezaveleyra6454
@juanpablosanchezaveleyra6454 2 ай бұрын
But it also kind of supports the idea that LDL is not causal, but triglycerides, right? Not a confirmation, but definitely a smoking gun.
@betzib8021
@betzib8021 5 ай бұрын
This is absolutely fascinating! I'm so glad this research is happening.
@vanpotts2410
@vanpotts2410 10 ай бұрын
Great discussion! Thank you. Enjoyed it so much.
@angelakesecker6291
@angelakesecker6291 9 ай бұрын
Thank you so much for what you do. I love watching you on Plant Based News, but only just found out that you have your own channel after seeing you on Switch 4 Good. Thank you for sharing your story with us there. I had a rough start too, but nothing like what you went through. I'm so grateful that you were able to get through it to the other side, and that those experiences informed who you are today. Because really, who you are is a gift to us. I think from some of your wanderings that we're practically neighbors, so hello from Sonoma County!
@whoisdkm
@whoisdkm 9 ай бұрын
Thank you for bringing every direction of this field together, have your I love you for this video.
@nicknorwitzPhD
@nicknorwitzPhD 9 ай бұрын
Thank you!
@chip877
@chip877 10 ай бұрын
Much Respect !!! we need more of this !!!!!
@nicknorwitzPhD
@nicknorwitzPhD 10 ай бұрын
Hope you enjoy it
@jasonghobbs
@jasonghobbs 6 ай бұрын
What a great and professionally conducted discussion. I have become very passionate about diet and health over the last couple years. My journey has led me to a very low carb, meat centric diet. I try very hard to stay open minded and watch videos from as many credible sources as I can find. I think it's so easy to become tribal and forget that we usually have much more in common than we don't. This video really helped me restore my faith in humanity. Keep up the great work!
@JJMLJ
@JJMLJ 9 ай бұрын
Thanks for the video. I enjoyed and benefited from it, even though I'm not smart enough to fully comprehend it. Thanks for introducing me to these two talented people. I'm thankful there's people like this doing this important work.
@PlantChompers
@PlantChompers 9 ай бұрын
Thanks! I wasn't smart enough either and had to do a lot of work to understand their model and study.
@nicknorwitzPhD
@nicknorwitzPhD 9 ай бұрын
@@PlantChompers you definitely put the work in and it didn't go unrecognized!
@Mr-hq6ox
@Mr-hq6ox 9 ай бұрын
@@nicknorwitzPhD Why don't you talk to Dr. Avi?
@aquamarine99911
@aquamarine99911 9 ай бұрын
I've long respected Dave, and was on a strict keto diet for a while. I was never LMHR per se, but my trigs were in the 20s and my HDL around 60 or so. My cholesterol numbers were so bad (ApoB of 186), that my physicians all begged me to stop the keto diet. I've got two teenage kids, and I can't be experimenting with my health. So I switched to a more Mediterranean diet, mainly by adding two cans of legumes and a serving of steel cut oats per day - and my Apo B dropped to the 80s. Combined with good BP and being physically fit in my 60s, that's good enough for me.
@martinpaddle
@martinpaddle 5 ай бұрын
If you don't have any specific issues that deserve some tuning or experimentation, a standard mediterranean-style diet is the safest bet. It contains all you need and leaves room for variation.
@joesylvia607
@joesylvia607 5 ай бұрын
but how is your blood sugar??? you add these carbs you are susceptible to getting diabetes, i would stay keto, mediterranean is to much carbs
@martinpaddle
@martinpaddle 5 ай бұрын
@@joesylvia607 it seems like everyone in the US is obsessed with diabetes, everything is about extremes there. If you eat sensibly you don't need to worry about that, nothing wrong with carbs for most people
@uowebfoot
@uowebfoot 4 ай бұрын
DYOR. I have and discovered a lot of people have been carno/keto for years with no problems. Cholesterol was high. I think the medical community needs a reset on cholesterol. More and more evidence coming out is challenging the current establishment beliefs.
@twist3d537
@twist3d537 3 ай бұрын
that's an eating disorder@@joesylvia607
@koyuki6113
@koyuki6113 9 ай бұрын
This was incredibly interesting, thanks for inviting these gentle man!
@nicknorwitzPhD
@nicknorwitzPhD 9 ай бұрын
Appreciate it :)
@michaelj2276
@michaelj2276 10 ай бұрын
*Fantastic* conversation, gentlemen. 👏
@Jack_Schularick
@Jack_Schularick 10 ай бұрын
I would love to see this level of ecumenical civility and dialogue in the realm of politics, not least in the US (it's a little better in Denmark but not much). That said, I am looking forward to a good explanation of how the high apo-B or LDL-c causes plaques, if not by the sheer concentration in the blood. Because, no matter what the reason of the high water level in the river is: a dam or a huge flow, the level IS still high.
@GregariousAntithesis
@GregariousAntithesis 10 ай бұрын
Because its not Cholesterol that causes the damage. The Cholestetol is part of the repair mechanism so it shows up like a scab shows up from a cut on your arm. Lions and other obligate carnivores blood is loaded with lipids and cholesterol and yet they dont have plugged up damaged arteries.
@CashMoneyMoore
@CashMoneyMoore 10 ай бұрын
This study is determining if this type of cohort has more plaque and baseline than controls, and if after a year there is more or less plaque progression than normal or in other cohorts. If it turns out to be much less plaque than expected, then it would suggest that the ldl is only damaging in a non LMHR context
@Jack_Schularick
@Jack_Schularick 9 ай бұрын
@@CashMoneyMoore Rather that "... the high LDL-c is not damaging to arteries in LMHRs". There can be, and are, other scenarios where LDL-c is harmless as well, which the study does not address. I have been hyped for the study since well before it started. This question of the formation of plaques and other lipid deposits is very confusing. For example: do LMHRs get xanthomas or xanthelasma? What is really going on at the molecular level at the border between blood and arterial wall?
@Eve1912
@Eve1912 10 ай бұрын
That was a fascinating conversation.
@CPHLiving21
@CPHLiving21 7 күн бұрын
What a Great conversation- thank you all for that.
@robbarnett5501
@robbarnett5501 9 ай бұрын
I love the follow up content added after the interview. Very complete.
@RobertWinter2
@RobertWinter2 10 ай бұрын
Best episode ever. Best KZfaq I've watched in a very long time.
@plants_and_wellness1574
@plants_and_wellness1574 10 ай бұрын
So pumped for this long episode 🎉 I’m gonna listen while I clean 😊
@kevanriley2998
@kevanriley2998 10 ай бұрын
lol, me too! :)
@RXP91
@RXP91 10 ай бұрын
I had no idea about this hypothesis. Very interesting. Thanks Mr Chomper
@larrydykes7643
@larrydykes7643 6 ай бұрын
really enjoyed this discussion. very thorough, very reasoned.
@aaronbr2001
@aaronbr2001 10 ай бұрын
People die from heart disease with a coronary artery calcium score of zero because soft plaque doesn’t show on the test but causes the same blockages
@Greekmuslimah
@Greekmuslimah 9 ай бұрын
He said the study day will measure both soft and hard plaque
@GGeloRob
@GGeloRob 10 ай бұрын
Plant chompers, hell yeah, an hour and a half episode, ohhhh yeahhhh
@poppyseed6487
@poppyseed6487 9 ай бұрын
Fantastic interview! Thank you!
@nicknorwitzPhD
@nicknorwitzPhD 9 ай бұрын
Appreciate it
@carolginsberg662
@carolginsberg662 9 ай бұрын
Thank you for this great discussion.
@nicknorwitzPhD
@nicknorwitzPhD 9 ай бұрын
Thank you!
@aprilek6003
@aprilek6003 10 ай бұрын
Appreciated this interview - as a LMHR I am very interested for my own health
@pixievincent2478
@pixievincent2478 9 ай бұрын
This was fascinating even for a mostly non-medical person. I hope you will alert us and discuss the study results when they come out! I have all kinds of questions about people NOT in that specific group discussed and how the results will apply toward others. It makes me wonder if the low-fat craze has caused changes in our bodies causing health issues, including excess weight, and if a balancing of fats in any kind of a healthy diet, such as we see in a Med. diet, would be beneficial.
@YourLifeRedefined
@YourLifeRedefined 8 ай бұрын
We’ll go to great lengths to convince ourselves based on false beliefs and/or addictions.
@el-bov8034
@el-bov8034 10 ай бұрын
Maybe I missed it, but why would someone use OREOS by way of carb introduction? Why not steamed potatoes? or rice?
@DM-ql6ps
@DM-ql6ps 10 ай бұрын
This confused me too. Oreos are highly processed and high in saturated fat. Would make more sense to use a low-fat whole food carb sources.
@DM-ql6ps
@DM-ql6ps 10 ай бұрын
​@MB-yu6ir possibly. Definitely seems like he is setting it up to fail. No one in the plant based community thinks things like oreos are healthy.
@williamdixon4936
@williamdixon4936 10 ай бұрын
1:14:50 He explains why he chose Oreos. It draws more attention to his experiment and (hopefully) makes it more clear that the experiment isn't a health intervention, its more in the realm of a diagnostic for his LMHR phenotype.
@el-bov8034
@el-bov8034 10 ай бұрын
@@williamdixon4936 Thanks! Perhaps I should’ve watched the entire video before commenting. Perhaps it'll all make sense once I have.
@williamdixon4936
@williamdixon4936 10 ай бұрын
@@el-bov8034 absolutely, its a reasonable concern! Hope you enjoy the rest of the interview, I sure did :)
@JakeRichardsong
@JakeRichardsong 9 ай бұрын
If the target population is less than 1 percent of the general population and a tiny percentage of the keto practitioners, is the point of the research that the 'odd' situation involving the tiny population perhaps is indicative of some larger implications that apply beyond the tiny group?
@11235Aodh
@11235Aodh 9 ай бұрын
I wonder how the speaker would do at True North with Alan Goldhammer, would he still react this same way to carbs after a full reset? Or has he tried living only off sweet potatoes for a while for instance (what drs. John mcDougall and Peter Rogers would recommend)?
@chewiewins
@chewiewins 10 ай бұрын
I could be a LMHR at BMI under 20, body fat ratio 11% with high LDL-C 165 with low TG 47, good HDL 67. Alas, going give up Keto as whilst I hope these guys right that it is safe, not worth me taking risks till proven. So switching to Mediterranean with Portfolio diet for better control
@mathlind
@mathlind 9 ай бұрын
Fantastically nuanced interview.
@nicknorwitzPhD
@nicknorwitzPhD 9 ай бұрын
Thanks!
@docl123
@docl123 10 ай бұрын
Absolutely wonderful education for me!
@cincin4515
@cincin4515 9 ай бұрын
In my country and my mind a hyper responder is a very fast ambulance. 😅
@hiker-uy1bi
@hiker-uy1bi 10 ай бұрын
Nick came across much more reasonably here than the preexisting image I had of him in my mind.
@saintwithatie
@saintwithatie 10 ай бұрын
What image did you have of him and why?
@hiker-uy1bi
@hiker-uy1bi 10 ай бұрын
@@saintwithatie Unscientific “low carb hack”. I think we need to get out of tribal echo chambers and have open dialogue.
@nicknorwitzPhD
@nicknorwitzPhD 9 ай бұрын
Well... thanks for admitting you were swayed by a false narrative. I'm not so bothered by the rumors and lies with concern to my ego... but I think it undermines good discussion. If someone wants to raise an accusation, I feel that's fair but it needs to be concrete, direct, and supported by evidence, e.g. 1:21:52.
@marilynbeth5993
@marilynbeth5993 10 ай бұрын
I was a lean mass hyper-responser when I was eating lower carbohydrate. I ate nowhere near a keto diet. I since have moved to a high carbohydrate diet since my body seems to response better. However, it was also due to high cost of meat since the start of the pandemic. Anyway, I went from eating three large servings of meat a day to two or three smaller ones a week. I eat most of my carbohydrates as fruits and vegetables. It took me three years to go from an ldl of over two hundred to one of around a hundred even with this change in diet.
@anawilliams7342
@anawilliams7342 9 ай бұрын
that's brilliant! I went WFPB but with a little bit of oil and salt 4 years ago. I didn't have too much weight to lose, but I lost a couple of kilos. The more I think about the more sense it makes: for health, for the animals, for the planet.
@marilynbeth5993
@marilynbeth5993 9 ай бұрын
My BMI runs between 18 and 19 so definitely lean.
@JakeRichardsong
@JakeRichardsong 9 ай бұрын
Why not eliminate all meat?
@toni4729
@toni4729 9 ай бұрын
@@JakeRichardsong Why?
@jobrown8146
@jobrown8146 9 ай бұрын
How did it affect your trigs and HDL? I'm asking because my LDL went up a lot when I changed to low carb but my trigs decreased and my HDL increased. I am still a little bit overweight. All my other blood results are within the "normal" ranges, I'm now insulin sensitive and my liver tests are good. Thank you.
@mattzilla331
@mattzilla331 9 ай бұрын
Hi Plant Chomper. Do you believe your marathon or triathlon training could have anything to do with your high LDL? I watched a lecture from a cardiologist named O'Keeffe talk about how extreme endurance athletes tend to have significantly worse heart health and more plaque. He wasn't sure if it was because of all the calories they ate to fuel their performance or was the training actually harmful to the arteries themselves and causing inflammation. I know you said you eat a vegan plant based diet. How "clean" would you say it is? Is it per what Dr. Esselstyn recommends no oil no nuts? I'm very curious about this topic because my family history is terrible when it comes to heart disease diabetes cancer. But most of my family also smoked drinks doesn't exercise and eats processed food. My mom was told by her dr she has "genetically high" cholesterol. I don't remember the numbers but i think she was high 300s or even 400s and medication only brought it down a little. One statin did bring it down a lot but that one has sense been discontinued. I bring up Dr esselstyn because I got her his book and while she wasn't 100% compliant with his diet she saw a huge drop in cholesterol. It was still high but significant enough where the dr asked her what she was doing. Unfortunately i haven't been able to get her to commit 100%. I even told her she should do it 100% for a month and i would pay for the blood test to see what the result would be. Oh well. My cholesterol was never as high as my moms but it was going up with every physical. Doctor was starting to get concerned. When i went on esselstyn total dropped to 120. My LDL was like 65 or something. I also noticed how much better doing cardio felt. I did cardio pretty consistently for years but always hated it. About 2 weeks on the diet it suddenly felt much easier.
@silence1869
@silence1869 10 ай бұрын
As someone who reads drug trials and reads nutrition research articles as a hobby, there are many examples where dietary changes results in greater metabolic marker and outcome shifts greater than what is seem in clinical trials.
@DM-ql6ps
@DM-ql6ps 10 ай бұрын
This is because clinical trials look at averages over many people and only look at one change in isolation. When you look at trials where results for each participant is shown, you can see this more clearly. On any given dietary change (keto, vegan, low fat, fasting, etc) you will have some people improve (usually most people - if the dietary change results in less processed food and fewer calories) and others get worse.
@uowebfoot
@uowebfoot 3 ай бұрын
Most clinical trials are not scientific. In fact if you research it most of them are wrong or very flawed.
@TangoMasterclassCom
@TangoMasterclassCom 10 ай бұрын
Thanks for another great video!!!
@robertbrown6531
@robertbrown6531 9 ай бұрын
Hi Chris, just posting a question for you here though probably small chance you might see it. I just watched your interview with Simon Hill which was amazing, your stories and anecdotes made for riveting viewing. In particular the insight you gave into Steve Jobs, a much analysed and discussed person, was the most enlightening I've ever seen on this contradictory man. You touched on his cancer and I've always wondered about this. There are lots of theories on why he developed this so young, from fad diet choices, exposure to chemical, or just unlucky. Do you have any more info on what his diet was really like over the long term? Also you made an intriguing comment about Dean Ornish perhaps being able to cure him. What did you mean by that? Thanks and keep up the good work, a voice of reason in a mad world. Ps I always think a good starting point for getting nutritional advice on you tube is if the person is fully clothed, if they need to show you a six pack, forget it!
@xanxus8272
@xanxus8272 9 ай бұрын
Great interview Chris! Have you noticed that you lower your voice slightly, when you interview people?
@miagraff2726
@miagraff2726 9 ай бұрын
I appreciate that you are open minded in your search for the best foods for health. What I think I heard is that lean healthy people eating a keto diet are healthy on the keto diet. I would like to learn about benefits v risks for long term ketosis. I would like to see if it truly does what whole food plant based can: reversing type 2 diabetes, reducing inflammation. It is also interesting that keto helped his IBD, because I have had the same result with WFPB. Chris, thank you for your always enlightening channel!
@joezeigler1064
@joezeigler1064 4 ай бұрын
It’s been a trip Great interviews Keep up this fantastic work
@boydmccollum692
@boydmccollum692 10 ай бұрын
The one thing we should keep in mind. LDL as the only measurement of an issue is most likely wrong. It's a very mechanistic view of human health, but humans are not machines. We're biological organisms. A marker can show that there's an underlying issue, but it's the height of hubris to think an effect is the sole cause of something. We may bring a specific number down, but that doesn't mean the root cause is being addressed. It's also harder when hundreds of billions of dollars are being made on just that one metric. In the description of this video you asked "Your cardiologist just freaked out. Should you?" My cardiologist wanted to put me on statins when my LDL was 73. I was 58 and just had a cardio sonogram that showed I had little plague build up, consistent with a person my age. It's this shotgun approach to prescribing statins that is really disturbing, as the centenarian guy says. 7 out of 100 will benefit from a statin. But medicine can't narrow that down. Maybe to 7 out of 50 or 7 out of 10? I like the theory of take a statin to lower risk of heart disease, become diabetic as a side effect, which increases your risk of heart disease. Hmmm. Arnold might be, but we are not machines.
@AdAm-cw3gi
@AdAm-cw3gi 9 ай бұрын
Dude you don’t know what you are talking about 😂
@boydmccollum692
@boydmccollum692 9 ай бұрын
@@AdAm-cw3gi actually I do. Tell me why folks with lower LDLs still get heart attacks - from a 2009 UCLA study: Specifically, these patients had low-density lipoprotein (LDL) cholesterol levels that met current guidelines, and close to half had LDL levels classified in guidelines as optimal (less than 100 mg/dL). "Almost 75 percent of heart attack patients fell within recommended targets for LDL cholesterol, demonstrating that the current guidelines may not be low enough to cut heart attack risk in most who could benefit," said Dr. Gregg C. Fonarow, Eliot Corday Professor of Cardiovascular Medicine and Science at the David Geffen School of Medicine at UCLA and the study's principal investigator." ... Researchers also found that more than half of patients hospitalized for a heart attack had high-density lipoprotein (HDL) cholesterol levels characterized as poor by the national guidelines. ________________________ This is in line with current research. So what's your LDL level? How about in relation to your HDL level? Low HDL is also a risk for disease. Your triglycerides are important too, as well your level of insulin resistance. That same study stated "the risk of cardiovascular events increases substantially with LDL levels above 40-60 mg/dL". If you LDLs are higher than that, are you going to go on a statin? The American Diabetes Association in 2023 is currently recommending LDLs below 70, and what to see it down around 50. So when I had my stroke I was pre-diabetic (insulin resistant) and had hypertension. My LDLs were great, though my HDL was lower than the minimum recommendation. My triglycerides were high. I wonder why I had an issue with such great LDL numbers though... So please tell me exactly where I'm wrong. Easy to say that from your keyboard. Making an argument is a little tougher.
@DouglasAbramskiOfficial
@DouglasAbramskiOfficial 10 ай бұрын
What do you think about Dr. Zach Bush's research suggesting that antibiotics/pesticides are a huge factor in metabolic health due to their disruptive nature to carriers in the metabolic systems?
@nicolabenson1155
@nicolabenson1155 10 ай бұрын
As a fellow science nerd this is a fascinating look at the early steps of the scientific method. Observations have led to a question, further background research have led to a hypothesis, and they are now just setting out to test the hypothesis. This could be paradigm shifting, or could shed light on and support current consensus, or simply lead to further questions. Thankyou for a really interesting interview.
@darkfieldcarnivore3928
@darkfieldcarnivore3928 9 ай бұрын
No, this can never be tested experimentally as not all variables can be controlled.
@oldmango8606
@oldmango8606 10 ай бұрын
your best podcast. thanks
@jenniferlavoie2548
@jenniferlavoie2548 10 ай бұрын
I find this study very interesting. I'm vegan, very active triathlete. I have what is considered good lipid numbers and fasting glucose. Never really had interest in a keto diet. I am not considered lean. However, I do believe that this study will give us some good insight. I am interested in the result even though I'd never choose this diet for myself. For the record, I'm the only vegan in a household of 4. I cook all sorts of non-vegan dishes for my family. This could really be a game changer especially for those with epilepsy or other health issues.
@CassandraCassandra.
@CassandraCassandra. 10 ай бұрын
That’s excellent re: being vegan in a non-vegan household. I’ve been trying to transition to WFPB but slip here and there because of all the non plant-based dishes I prepare - and all those non PB ingredients at home. And as someone who has epilepsy in their family I agree that this is a fascinating study. Revolutionary even.
@nicknorwitzPhD
@nicknorwitzPhD 10 ай бұрын
What a lovely human response. Thank you
@LoveanimalsGovegan-lb4gz
@LoveanimalsGovegan-lb4gz 9 ай бұрын
​​@@rambunctiousvegetableyeah...that's what i think when I see flesh... no longer appetizing... Diary doesn't make me as guilty as it should...but I'm still vegan ...for animals
@supercal333
@supercal333 9 ай бұрын
​​@@rambunctiousvegetableHumans were hunter gatherers for hundreds of thousands of years. It's our evolutionary heritage and it's not wrong or evil. Stop denying our nature. The fact is most people find meat very delicious and nourishing and there's a good reason for that. It's an increadibly nutrient dense food. You won't change hundreds of thousands of years evolution in one generation. As for your care for animals, do you have any carnivorous pets? Do you feed them dead animals?
@mitesh8utube
@mitesh8utube 10 ай бұрын
3 years back for about a year I started serious endurance cycling (at least 200KM a week) and for a blood test done just out of curiosity got my lipid panel done. I'd lost a considerable weight (from 76 KG to 62) and my diet was almost high carb vegan but somewhat calorie restricted, so I was puzzled to see my LDL 132, HDL 39, triglycerides 150. Although I was feeling quite healthy overall, I couldn't make any sense of data. I brought down LDL and Triglycerides below 100 with regular intake of soluble fibres (psyllium, chia, flax seeds, basil seeds) soaked in a glass of water with every meal, though I think it's just cosmetic. I guess lipid profile numbers don't mean what we think they mean.
@KrazyKrzysztof
@KrazyKrzysztof 10 ай бұрын
My ldl was pretty high like 112 and I ate a ton of fiber but I was getting fat like 180 lbs like 26 BMI. I am cycling 6 days a week now and no more junk fats(I am assuming they are the culprit) from stuff like sweets, pizzas, and oils. My tris were also high as yours. I also added healthy fats like you flax seeds and walnuts. Will see how it affects me in 5 months.
@mitesh8utube
@mitesh8utube 10 ай бұрын
@@KrazyKrzysztof Exercise will definitely improve your health but won't impact much on weight. It takes insane amount of exercise to burn miniscule ammount of fat. Also exercise will make you hungrier, so calorie control is a must. When I was doing mild calorie restriction what worked for me was Salads and soluble fibre drink, which filled my stomach mostly and reduced my cooked food intake. I don't even grind my chia seeds, basil seeds, so they don't provide me much healthy fats. They're just convenient fiber sources.
@KrazyKrzysztof
@KrazyKrzysztof 10 ай бұрын
@mitesh8utube for sure. I am just eating good food while minimizing any junk. I have reduced my servings and I measure my food for things like smoothies because it's easy to overeat on stuff like peanut butter. I am lifting every third day and doing a lot of cardio. It will take time but I'm looking much leaner and less bloated at 175 5 foot 10
@Typhoonbladefist
@Typhoonbladefist 10 ай бұрын
⁠​⁠@@KrazyKrzysztofone great way to help lose weight is have a big salad before every meal. You won’t really have to deal with portion control then because your stomach will tell you that you are full sooner. Check our Dr. Greger’s book “How Not to Diet” it’s packed full of science backed information. A whole food plant based diet without added (or at least limited) salt, oil, and sugar is great. Dump the peanut butter in the trash and eat peanuts IMO. And chew your fruits and vegetables instead of drinking them, like with a salad before meals, it helps your brain get the signal that it had enough to eat unlike with drinking when you can easily chug down too much. This helped me lose the 50lbs I gained during the pandemic and kept it off.
@healthglobalinstitute
@healthglobalinstitute 10 ай бұрын
Yes. You are right. For most people, psyllium husk intake as soluble fibre is good enough. 😊
@jedmaple
@jedmaple 10 ай бұрын
Looks like an interesting rabbit hole for those in the field.
@yangtse55
@yangtse55 10 ай бұрын
My weight is now normal and steadily headed for ideal, and my LDL was 70 even when I was overweight thanks to a moderate detour into "conventional" eating patterns. Thankfully cycling 50 to 100 miles a week was protective. I'm sticking to my vegan whole plant diet I adopted 42 years ago. I must be getting 15 portions of veggies a day and heavy tahini consumption gives my diet a Mediterranean macro balance. At 63 I'm fitter and healthier than anyone I meet.
@anawilliams7342
@anawilliams7342 9 ай бұрын
congratulations. You seem to have a lucky set of genes
@marcdaniels9079
@marcdaniels9079 9 ай бұрын
Happy for you but it’s an extraordinary claim you make at the end of your comment. First it is a rather arrogant, and it is confusing because I have read many other KZfaq commenters making similar claims. In reality there is no objective way you could know that you are either fitter (undefined term), or healthier (also undefined term) than everyone you meet unless you meet only a extreme subset of the population. I guess you never meet very young very fit healthy athletes. And why would you even make this comparison? If you are are fit and healthy that’s the objective irrespective of anyone else’s condition.
@yangtse55
@yangtse55 9 ай бұрын
@@marcdaniels9079 ok it's age related, but my 33 yr old niece is literally killing herself. It is heartbreaking when it's younger siblings. Even with their oldest brother as an example, they are trapped by their eating habits and maybe sign up for Weightwatchers yet again.... People think of vegetables as a garnish. The dietary recommendations are ridiculously conservative. One day I will exercise enough to justify adding bread back into my diet.
@yangtse55
@yangtse55 9 ай бұрын
@@anawilliams7342 my own family are overweight and sick.
@yangtse55
@yangtse55 9 ай бұрын
And veggies are YUMMY
@isabellezablocki7447
@isabellezablocki7447 9 ай бұрын
Oreo cookies study? Carbs? Junk carbs. No wonder he is not feeling well. I admire your openness of mind Chris.
@leenysnell8804
@leenysnell8804 9 ай бұрын
It is to see what happens to his LDL, that is all.
@chuckv8838
@chuckv8838 9 ай бұрын
After watching this, I’m scratching my head a bit. Most - maybe all - of your videos at the end I feel enlightened. Maybe this is over my head…most likely…but it seems like 90 minutes of talking that could be summarized in 10 minutes. There is a group of folks we’ll call LMHR who might tell us something about lipid mechanistic. We’ll study them some and maybe learn something. At this point we have no idea if their high LDL is an issue, we’ll find out. And it appears that the Keto diet helps at least one dude with this digestive issues. So is it worth learning more about…yes. Is it at this point a pointer that the “Keto” diet is healthy…no. Does it disprove any theories at this early stage…wasn’t clear to me it does.
@bonnieo8
@bonnieo8 7 ай бұрын
Looking forward to the study’s results. Love this conversation. Do you think you’re having a harder time understanding, because you’re a bit resistant to the information presented? I agree, though, that this information doesn’t have to negate how and what you want to eat.
@chuckv8838
@chuckv8838 7 ай бұрын
@@bonnieo8 yep you’ve got me pegged…oh wait nope, there is no definitive data yet.
@gregszczygiel814
@gregszczygiel814 2 ай бұрын
I feel the same. No clear on what to take away from this for non-lmhr
@justinhale5693
@justinhale5693 10 ай бұрын
A potential mechanism not covered here is the gut microbiome ecosystem. Perhaps bacterial lipo-polysacharides are carried by some types of fat and cleared by LDL cholesterol. Perhaps fiber can be added to mitigate some side-effects.
@JohnSmith-zs1bf
@JohnSmith-zs1bf 10 ай бұрын
Not sure if they get to it in here, but lots of LMHR have shown that adding 50-100g of carbs (with or without replacing the fat calories) significantly drop those LDLs.
@nicknorwitzPhD
@nicknorwitzPhD 9 ай бұрын
FWIW I've been LMHR on as high at 40g fiber. It does have an impact (on me) but net carbs more so... far more so... hence the Oreos (in part)
@justinhale5693
@justinhale5693 9 ай бұрын
Thank you for sharing. Can you elaborate: which metabolic parameter is impacted by fiber? LDL, glucose, etc? @@nicknorwitzPhD
@nicknorwitzPhD
@nicknorwitzPhD 9 ай бұрын
@@justinhale5693 Sure. LDL tends to drop, although fiber type matters. I did a YT video on this a while back (kzfaq.info/get/bejne/paiDrbKSq9y7d58.html) In the short-term fiber rich foods may have an acute effect on increasing glucose area under the curve, but in a mixed diet condition the chronic effect tends to be lowering.
@lilytea3
@lilytea3 8 ай бұрын
0:00: 😮 The video discusses the rise in LDL cholesterol in some people on ketogenic diets and the lack of understanding about its impact on arteries. 6:40: 📚 There is an inverse association between BMI and LDL cholesterol change on low-carb diets, and being leaner may be associated with LDL bumps in some people. 13:36: 🤔 The speaker discusses the importance of questioning and pushing for answers in scientific research. 20:21: 📚 The video discusses a study on lean mass hyper-responders and the use of coronary CT angiograms to measure plaque progression. 27:40: 📚 The video discusses the question of whether high levels of LDL cholesterol alone can cause plaque progression in heart disease. 34:26: 💊 The speaker's health was deteriorating, but they found a ketogenic diet that helped them regain their life and continue their academic pursuits, although it caused their LDL cholesterol levels to skyrocket. 40:59: 🗣 The speaker agrees with Walter Willett's statement and emphasizes the importance of considering individual cases when determining the benefits and consequences of interventions to lower LDL levels. 47:48: 📚 The speaker discusses their experience collaborating on a cookbook that combines Mediterranean and ketogenic diets. 54:21: ! The video explains the process of how VLDL becomes LDL and the role of triglycerides and cholesterol in this process. 1:01:14: 📚 The speaker discusses the lean mass hyper-responder phenotype and its connection to a low-carb diet. 1:08:25: 🔬 The speaker discusses a study on the relationship between being powered by fat and higher levels of LDL and ApoB. 1:16:01: 😳 The speaker is preparing to come out and has been experiencing emotional ups and downs. 1:22:33: 📚 Verbal precision and clear communication of data and hypotheses are important for experts in the field. Recap by Tammy AI
@peterscott2662
@peterscott2662 10 ай бұрын
If the LMHR study shows negligible plaque progression, then we have everyone with high LDL, thinking they LMHR (or close enough) so LDL doesn't matter. When this is a fairly nuanced, warranting more study.
@nicknorwitzPhD
@nicknorwitzPhD 10 ай бұрын
" then we have everyone with high LDL, thinking they LMHR" - not if we communicate clearly. But the responsibility here is on both sides. Those - not to be named - who use the term "LDL denier" do more of the inappropriate clumping than those interested in LMHR
@Jack_Schularick
@Jack_Schularick 10 ай бұрын
Everything gets misunderstood, no matter what.
@peterscott2662
@peterscott2662 10 ай бұрын
@@nicknorwitzPhD I expect it to be widely miss-used. Remember the Time "Butter is Back" cover. I wouldn't be surprised if Time has a "Cholesterol doesn't matter" cover...
@DM-ql6ps
@DM-ql6ps 10 ай бұрын
That's my worry too. The LDL deniers will pick this up and use it in their propaganda.
@Jack_Schularick
@Jack_Schularick 10 ай бұрын
@@MB10097 Can a glance be frightening? There are idiots everywhere, so what?
@evanlouis8853
@evanlouis8853 10 ай бұрын
An important question that I don’t believe was asked,… What was Dr. Horowitz diet before he developed IBS? And was there a family history of IBS? Another amazing video. Thank you.
@nicknorwitzPhD
@nicknorwitzPhD 9 ай бұрын
It's not irritable bowel syndrome, it's inflammatory bowel disease. After diagnosis I tried a least a dozen diets to help manage it, including low FODMAP, SCD, whole food vegetarian and vegan etc. Only a ketogenic diet has helped me. I would not generalize my experience, but since you asked...
@Rose_Ou
@Rose_Ou 9 ай бұрын
Daniel from Lifting Vegan Logic had Crohn's disease and has been vegan for years. He has no symptoms whatsoever at this point and pretty amazing physique, too. Plant based diet is like heaven to me and I did low carb for 6 years which was pure nightmare. There is no one diet fits all.
@nicknorwitzPhD
@nicknorwitzPhD 9 ай бұрын
@@Rose_Ou I am happy for you both! There is not one diet for everyone, I entirely agree! FWIW, I would love to have a platter of sweet potato with figs and goat cheese every now and then, but I'll do what I need to do for now to live life. If that means less sweet potato and more eggs, ago oil mayo, fatty fish (and maybe even some bugs sprinkled in - we didn't talk about entomophagy, but I'm a fan!), so be it! But if someone is thriving on Tempeh, Brussels and avocado, who am I to tell them otherwise.
@paulatowne
@paulatowne 9 ай бұрын
Is his argument that there are a group of healthy young people who eat a keto diet and have a high LDL? I must be missing something. I don't understand why that's a revelation. And why it means that the keto diet should be applied to as high as 50 percent of the population.
@megavegan5791
@megavegan5791 9 ай бұрын
Nick has inflammatory bowel disease, so he switched to a Keto diet after trying everything else and his symptoms significantly improved (I’m truly happy that he’s found a solution that offers him a better quality of life). But, now he’s latched-on to Dave’s LMHR nonsense to help ease his worries about developing cardiovascular disease from eating Keto.
@paulatowne
@paulatowne 9 ай бұрын
Thank you. I'm also glad he found a way to ease his symptoms and agree he turned his anecdotal story into something that can make him stand out.
@leenysnell8804
@leenysnell8804 9 ай бұрын
umm a lot of the lmhr are not young, by the way. You have taken the 50% out of context. Yes, you are missing something as you haven't listened to the video properly. He says he could probably walk into a gym and turn 50% of the people there into lmhr. He did not say anything about 50% of the population should be keto.
@paulatowne
@paulatowne 9 ай бұрын
Point taken. I listened to it at double speed, so probably miss things.
@pepsiblik874
@pepsiblik874 5 күн бұрын
I got the book yesterday! A much more scientific approach to cooking and now finally with an explanation WHY you should eat certain things. Liking it!
@stephenbalser8015
@stephenbalser8015 9 ай бұрын
I have lean mass hyper responder. I'm lean but not on a low carb. My diet consists of 80 percent veggies, 15 protein and 5 percent fat. My LDL is a little high, HDL is very high and my triglycerides is very low. My doctor wants to put me on statins. I don't want to. I'm 66 yo woman. This might help your research.. I started drinking alcohol more in my 50s. That's when my LDL started to go up. I stopped alcohol 5 months ago and my LDL is starting to go down but still a little high.
@defeqel6537
@defeqel6537 9 ай бұрын
LDL of about 150mg/dl, or 4 mmol/l, seems to be optimal, on average. From what I've read and heard of statins, their efficacy in terms of overall mortality, and the side effects, I'd never start them myself.
@catchristo9406
@catchristo9406 4 ай бұрын
If you started eating keto, your lipids would probably go through the roof. Just make sure to avoid sugars and processed foods and get regular exercise to keep as healthy as possible. I refuse to take statins again.
@narbs8944
@narbs8944 9 ай бұрын
While their work is interesting the real question raised is "how do we build ketogenic diets", the result of the LMHR idea is that it reinforces ketogenic dieters not worrying about ldl and building their diets with high saturated fat foods like red meat and dairy. A more evidence based approach would be a lower saturated fat/ higher fiber approach with vegetables, avocados, fish, etc. Dave and Nick while interesting, are pushing keto dieters away from the second method whether they realize it or not. Most keto fans are NOT going to be LMHRs and are likely being hurt by building their diets in a sub-optimal way.
@tamcon72
@tamcon72 9 ай бұрын
They are stating that proper responsible communication of their research should prevent what you are inferring. Bless them, they are wrong, as anyone who has taken even a passing glance at keto chat threads knows. I hope that community's ideas don't end up _corrupting_ their communication about their research.
@Damcarnivore
@Damcarnivore 6 ай бұрын
Nick I suggest you take CAC before and after both parts of your n=1 experiment
@markkilley2683
@markkilley2683 9 ай бұрын
The trouble is most food is hyper processed. Everywhere you look, it said that most food is bad for you. No wonder people are confused about what to eat.
@yangtse55
@yangtse55 9 ай бұрын
It's very simple My Aldi has everything I need right in front of the door. But I make room for canned beans and tomatoes. Walking past the weird pink stuff to get to the hummus is a bit unsettling. I wonder sometimes how I'm viewed as I pay for two huge IKEA totes of veggies.
@joecaner
@joecaner 10 ай бұрын
I can't wait to share this interview with my brother. We've had a long running dialog on the role SFA and high LDL levels on vascular health. He's been following a high SFA Keto diet and I've been on a low SFA plant strong diet. We are both seem to be doing well on our respective modalities.
@CharlieFader
@CharlieFader 9 ай бұрын
When you say you both seem to be doing well, are you referring to health markers like LDL, or generally feeling well?
@joecaner
@joecaner 9 ай бұрын
​@@CharlieFader We are both feeling well, and most of our bio-markers are good, but his LDL-C's are dimed while mine are in the cellar. There are SFA in all whole foods so they can't be avoided, but whereas I do my best to keep my SFA intake low, he embraces them. I'm worried about his SFA and dietary cholesterol intake. I believe that he's consuming considerably more than optimal, but he's believes differently so there you have it. I suppose I subscribe to the Grandmother Diet which is, "Eat you vegetables and lay off the meat!"
@CharlieFader
@CharlieFader 9 ай бұрын
@@joecaner that’s to be expected I guess. And what is his reasoning for choosing a high SFA intake?
@joecaner
@joecaner 9 ай бұрын
@@CharlieFader I’m sure you’re familiar with the justification. He believes that a high meat, low carb is the diet humans evolved eating and the reason that moderns in industrialized nations are getting sicker and fatter is because they’ve strayed from their natural diets. He’s experienced inflammatory pain, and this diet has ameliorated these symptoms and he has been able to obtain and maintain a healthy weight so he received benefits from this dietary pattern. His sources seem questionable and anecdotal, but it’s difficult to argue with success. Mindful of this, I do my best to engage him in conversations about research that recommend the benefit of lower SFA and dietary cholesterol intake, but it’s a nuanced and emotionally charged topic, and I am an engineer while he is an MD so I need to tread carefully when stating my case. I am well read and researching natural ways to avoid and treat health problems is a passion for me, but he is a doctor after all and this is his profession. He is deserving of respect for his training. It’s tricky.
@CharlieFader
@CharlieFader 9 ай бұрын
@@joecaner yes, I expected something like that. Him being an MD and using such a justification is even more bizarre though.
@skippy6462
@skippy6462 10 ай бұрын
Rather than hearts what about erectile disfunction? Isn't that an early warning symptom? Any good studies? Videos?
@PlantChompers
@PlantChompers 10 ай бұрын
My friends over at switch4good did a fascinating episode on the plant-based penis! kzfaq.info/get/bejne/fNigibGhteCql40.html
@skippy6462
@skippy6462 10 ай бұрын
​@@PlantChomperssmashing.
@kevinahern6607
@kevinahern6607 9 ай бұрын
Dr. Greger's video Low Carb Diets and Coronary Blood Flow discussed the research study that showed that a healthy plant based diet for a year showed a 20 percent decrease in plaque, while a low carb diet showed a 40-50% increase in plaque in coronary arteries. Using actual imaging of the arterial blood flow to the heart. (Fleming, Boyd, "The effect of high protein diets on blood flow' Angiology 2000.)That's enough proof for me to recommend wfpb instead of keto to any non-epilectic adult.
@erastvandoren
@erastvandoren 9 ай бұрын
👍
@uruson
@uruson 8 ай бұрын
Thanks to you, I just read that study. It doesn't seem to say anything whatsoever about keto? It talks about, as the study title implies, 'high protein diets.' And while the study defines the diet of the 'treatment group,' the 'high protein diet' is left undefined, with no mention of its composition made. It is left undefined because the so-called 'high protein group' went and did whatever they felt like. To cite the study; "At the conclusion of the study, it became apparent that 10 of the 26 individuals, despite receiving dietary instruction as outlined below, had adopted a high-protein diet throughout the study." And they apparently didn't adhere to whatever mystery diet they went with? To cite the study; "Patients who went on high-protein diets reported varying degrees of satisfaction. Family reports typically reflected initial patient satisfaction, the patients getting to eat foods they 'enjoyed' along with initial weight loss, but difficulty sustaining the dietary pattern for the entire year. Instead patients tended to adhere to the diet for several months at a time, return to prior eating habits, and then return again in an effort to lose weight." They also treated each individual with medication based on their blood work; "Medical management was individualized based on the blood work obtained every 6 weeks. Independent adjustment of medications was made as a result of each patient’s blood work and was not based on the patients dietary habits. Table I shows the treatment guidelines employed. For example, a patient with elevated triglycerides and lipoprotein (a) would be treated with fenofibrate while a patient with only elevated lipoprotein (a) would receive Lovastatin." And treated patients with medication for any other issues they might have; "Patients with anginal symptoms were treated with standard drug regimens including the use of long-acting nitroglycerine (Imdur, Ismo), slow calcium channel antagonists (Procardia XL, Diltiazem,), Beta--blocker (Tenormin, Atenolol), L-arginine (endothelial dysfunction), and macrolide antibiotics (Biaxin) for elevated C-RP with acute-phase antibodies to H. pylori, C. pneumoniae, or S. pneumoniae. " This study is useless for drawing any conclusion about keto, if only because it isn't about keto. As an aside; There's a small oddity in the study. Look at the first quote I have from the study. "At the conclusion of the study" they found out that 10 of the 26 were on their own diet throughout the study. But in the third quote from the study it says "Independent adjustment of medications was made as a result of each patient's blood work and was not based on the patients dietary habits." Why would they specify that? If they 'found out at the end' it would be literally impossible to 'treat their blood work based on the patients dietary habits.' Because how could they treat the blood work based on the patients dietary habits, if they didn't know their patients had changed dietary habits 'til the end? Thanks for the clarification, I guess? Now we're safe from the misapprehension that the study authors used their time machine to inform their prior selves about the diet change.
@LeonardoGarciaguitar
@LeonardoGarciaguitar 9 ай бұрын
I wonder if Nick Norwitz would have solved his health problems with a whole food plant based diet.
@what.the.bleep.do.i.eat.
@what.the.bleep.do.i.eat. 9 ай бұрын
According to him, he did try.
@kevinahern6607
@kevinahern6607 9 ай бұрын
he tried vegan, but that's different from a low fat no oil whole food plant based diet. you can be 200 pounds overweight and sick with all kinds of things on a diet that's just vegan. @@what.the.bleep.do.i.eat.
@nicknorwitzPhD
@nicknorwitzPhD 9 ай бұрын
I've tried. Unfortunately, WFPB did not work. When I say I tried... I do mean WFPB 0 UPF >6 weeks. I wish it did work. I honestly would love to chow on sweet potato with figs
@what.the.bleep.do.i.eat.
@what.the.bleep.do.i.eat. 9 ай бұрын
@@nicknorwitzPhD I'm with you Nick. I would prefer a more plant heavy diet too but my IBS makes it essentially impossible. I really appreciate your research and your Mediterranean Keto book. I don't have to be fully Keto, just lower carb but I'm really trying to do it in a healthier way because I'm also not trying to speed run a heart attack. Cheers!
@ultmiddle4991
@ultmiddle4991 8 ай бұрын
@@nicknorwitzPhDI’m with you, I daydream of baked potatoes piled high with beans, corn, fresh peas, bowls of oatmeal, rice and vegetables, and on and on. Those foods gave me over 30 years of painful digestion that put me to bed for days at a time with a heating pad. I wanted so much to be a starchivore or even just wfpb. No medical intervention and even abdominal surgery made a bit of difference. Like you, I cheer people who thrive with eating that way and I will fight for their right to continue without being maligned.
@anabolicamaranth7140
@anabolicamaranth7140 10 ай бұрын
Nick’s LDL is very high but what is his apo B level? What is the apo B level of these lean hyper responders in general?
@realDaveFeldman
@realDaveFeldman 10 ай бұрын
If LDL-C (LDL Cholesterol) levels are high, it's a near certainty that both LDL particle (LDL-P) and ApoB levels are high. This has been the case with the general LMHR population given the bloodwork we've seen to date.
@nicknorwitzPhD
@nicknorwitzPhD 10 ай бұрын
Has been well into 300s. Trends with the LDL-C in general… enough so that it’s very high
@actyrrel
@actyrrel 9 ай бұрын
Dear Mr. Chomper, I'm not a fan, but do follow you and Rich Roll to avoid confirmation bias. I'm usually dizzy a few minutes in because of your video style. Then I listen only, missing data. Then I can't listen. I LOVED THIS EPISODE. Can't wait for your next interview format!
@fawnburgess1441
@fawnburgess1441 8 ай бұрын
I am a 57 year old woman. I am not "fat" but not super athletic. I am low carb. My LDL is 312; my HDL is 89; My triglycerides are 92. I am almost a hyper responder. What about these numbers is quite rare?
@QuothTheRaven123
@QuothTheRaven123 4 ай бұрын
Hi there, you (Nick, Dave) always point out the low BMI. Where does it come into the model? The figure from the LEM paper (shown e.g. at 52:23) does not explain it, or? Lean means little amount of stored fat, so (2) in the figure should be reduced, or not? (I known, even lean people still have lots of stored TGs.) So, the body is 'giving up' like 'if we have only so little TGs left, then lets dump it out all at once'. Or, just looking at the figure: the more yellow cells (2) the more VLDL the liver should produce, but it is the opposite. You (Nick) point it out again and again (lean, lean, lean...), but without explanation... Or is the LDL lifetime longer with low BMI?
@ordohereticus3427
@ordohereticus3427 9 ай бұрын
Interesting concept with certain outliers, but the river overflowing analogy cuts both ways. Regardless of the cause, it is overflowing and that in itself is a problem. Fortunate for the case study of the LMHR who didn’t develop any calcified or non-calcified plaque over two years of having sky high LDL, but it’s a tough bet that this can be banked on for a long life span.
@Amshatelia88
@Amshatelia88 9 ай бұрын
Exactly. Show me the LMHR data after 20 years of 500+ LDL. I'll wait.
@defeqel6537
@defeqel6537 9 ай бұрын
@@Amshatelia88 if they can show no plaque build up after a year or two, and in multiple age groups, there is no reason to assume a significant change in longer term follow-up, though it would be interesting nonetheless
@yogiyoda
@yogiyoda 10 ай бұрын
I've bashed Dave in the past because I thought he was an ideologue trying to justify dangerous blood lipid levels without the science showing his hypothesis was right. Perhaps I was wrong. Will have to look into it more
@leenysnell8804
@leenysnell8804 9 ай бұрын
oh no, he has never pushed this idea as a sure thing - he also emphasises that it is a hypothesis. He also says don't take his word for it, but that he is trying to learn more.
@yogiyoda
@yogiyoda 9 ай бұрын
@@leenysnell8804 - unfortunately many low-carbers have been referencing Dave for a long time to justify their high-choleserol levels. Until the science is done they are risking their health on a hypothesis
@leenysnell8804
@leenysnell8804 9 ай бұрын
@@yogiyoda if that is the case they are going against Dave's advice. In any case if they are whole food based they are still doing much more for their health than if they stayed on a diet full of processed foods.
@yogiyoda
@yogiyoda 9 ай бұрын
@@leenysnell8804 - Maybe, depending on their particular situation, it's possible the low-carb diet drastically raising blood markers might be more dangerous
@AdAm-cw3gi
@AdAm-cw3gi 9 ай бұрын
You are one easily swayed fellow. The study isn’t done yet. Usually several studies has to be done…
@ElizabethMillerTX
@ElizabethMillerTX 6 ай бұрын
I'm LMHR and match the study's cohort averages. My diet is among many things I do to manage an alphabet soup of chronic conditions, including connective tissue, autoimmune and neurological disease. I'm leaner, stronger, healthier (bg, A1C, thyroid, etc all improved). My trigs are lower than my age. I have trouble believing that my heart health has suffered from these functional and biometric improvements. But even if my diet is risking my heart health, it's worth it. Y'all might as well study us, because many of us refuse to give up these gains. Why someone would even recommend statins in someone with a connective tissue disease or metabolic illness without a CT angio showing a need for them baffles me, but they do. I really, truly appreciate this work. Thanks for being open-minded to it and furthering the conversation.
@nickyoung798
@nickyoung798 6 ай бұрын
1:10:05 😂😂😂 Definitely a time investment to watch this one twice and really try to wrap my head around everything discussed but what a great interview. I'll be very curious to see the results of these trials
@sharkair2839
@sharkair2839 10 ай бұрын
the issue i see is some of these number can radically change day to day. i had a hdl of 119 and triglycerides of 63 the next test was 86 hdl and 105 triglycerides.
@janco333
@janco333 10 ай бұрын
Maybe the lab made a mistake? My results are quite stable over time
@CharlieFader
@CharlieFader 10 ай бұрын
and no change of diet and/or weight? My lab results are very stable for the past decade. What about LDL? HDL levels are pretty much meaningless.
@sharkair2839
@sharkair2839 10 ай бұрын
@CharlieFader i am at my target weight. i gain 5 lbs, lose 5 lbs gain 5 lose 5. lol LDL was 190 last time. i quit all dairy so curios to see if that has an effect. all other markers are excellent, dropped all meds.
@CharlieFader
@CharlieFader 10 ай бұрын
@@sharkair2839 so when hdl lowered and trigs rose, what happened to ldl levels?
@anastasiailieva7800
@anastasiailieva7800 10 ай бұрын
It's the microbiome? Along with a still strong metabolism? The healthy liver is working like crazy to process high cholesterol, pushing it away and then puling it in -through high HDL and high LDL, naturally. And no plaque formation, for the time being only. But the IBS surely shows dysbiosis, most probably with acetate-producers (Bacteroidetes) more numerous than butyrate-makers (Firmicutes), a ratio which switches sides when a keto-diet is adopted. Sounds typical for high-fiber, low-fat vegans who go keto. You then get a temporary relief with keto at the price of higher cholesterol& triglycerides values.And acetate (the most abundant SCFA) is a strong cholesterol-formation promoter, right? Due to high (lectin-loaded) fiber? A lectin-free WFPB would be a solution to the problem, I believe.
@Damcarnivore
@Damcarnivore 6 ай бұрын
How do you explain LDL as causal but the biggest association of diabetes not being causal. Is it because we know cholesterol is around the blockage?
@user-tq3fh8xe7q
@user-tq3fh8xe7q 7 ай бұрын
Chris, have you read Silent Fire? I’d love to hear your thoughts!
@davidmoser8901
@davidmoser8901 9 ай бұрын
Great episode. I'm thankful to Chris that he is open minded. In sum this episode arose more questions than it answered to me. Since the LMHR are so uncommon one might easily misinterpret this episode. It would have been great to end with a part that puts everything in the bigger picture. Does this have any implication for the moment for people who have high ApoB but are not a LMHR? As far as I understood it doesn’t. @PlantChompers how about you invite @thenutritional_advocate (Alan Flanagan) together with @nicknorwitzPhD for a next episode with the goal to try to get a bigger picture of this with the current evidence we have. Also it would be very interesting to discuss if being on a ketogenic diet over years and years has any evolutionary advantages. For my understanding the body or better the brain just had to have food in absence of carbohydrate, which is why it also functions on ketones, but this is just in case and not meant as a diet for decades. What are the thoughts around this? I hope there is a second episode that goes on with this thought and elaborates in in different directions.
@leenysnell8804
@leenysnell8804 9 ай бұрын
Some very interesting stuff coming out of Harvard with keto diets for serious mental health. Check out Chris Palmer - this is using ketones as food for brain instead of glucose. Fascinating stuff!
@nicknorwitzPhD
@nicknorwitzPhD 9 ай бұрын
@@leenysnell8804 If you have his book look on the first couple pages... you'll see I wrote an endorsement. Chris is a friend.
@thecapitan1981
@thecapitan1981 9 ай бұрын
Prior to the rise of agriculture 10-12 kya the human diet would have necessarily been low carb as not a lot of readily available high carb plants present in the wild. Couple that with food scarcity and it’s my hypothesis that ketosis would have been a state humans would have been in for significant periods of time. Carbs when consumed would have been fruit or maybe honey for a short period of the year when it was in season and ripe. Those living in higher latitudes particularly during ice ages much like the modern inuit would have had little access to plant foods. We can infer a lot from this information
@seandalai3413
@seandalai3413 9 ай бұрын
It seems that therapeutic diets as a subject is relevant to a whole lot of people to address a whole lot of conditions. I don't see anyone arguing about keto and epileptics. What is a little more cogent to the content of this channel is longevity, and the quality of a measurably longer lifespan. Nick made it clear he's chosen to live comfortably. Who wouldn't choose that? What would be interesting (along with this study) is to see how these fat-based diets affect the lifespans of the sick people they are helping. I wish I could live long enough to see if Nick makes it to 90, but .... And if we learn a bit more about ourselves, there's no limit to how many other people will be able to live longer and better lives.
@plurabelle5
@plurabelle5 9 ай бұрын
If I had to consume baby blood to live comfortably, I would choose the alternative.
@notesfromleisa-land7893
@notesfromleisa-land7893 26 күн бұрын
One thing is for sure...whatever the results of the studies, the lipid results are likely to provide unfavorable underwriting for life insurance policies where health exam is required.
@gregszczygiel814
@gregszczygiel814 2 ай бұрын
Did they talk about the significance of LDL for non-lmhr? I wish someone could summarize this video in lay terms.
@Zenjohnny
@Zenjohnny 9 ай бұрын
What about a low carb wfpb + fish for those with epilepsy. No need for high saturated fat for epilepsy.
@nicknorwitzPhD
@nicknorwitzPhD 9 ай бұрын
Not required, but decreasing sat fat doesn't necessarily have a big impact on LDL-C in LMHR, a point we make
@PhysicsLaure
@PhysicsLaure 10 ай бұрын
Unrealistic nutrition arguments always seem to boil down to a few metrics... Conveniently skipping holistic, long-term metrics of health to hide issues.
@CashMoneyMoore
@CashMoneyMoore 10 ай бұрын
Everything on a low carb diet typically improves except LDL. hba1c, blood pressure, weight etc. etc.
@ilonabaier6042
@ilonabaier6042 10 ай бұрын
much of the info is anticipatory. We have to wait 3-5 years after these have been properly studied and analysed objectively, without corporate interference.
@CharlieFader
@CharlieFader 10 ай бұрын
@@CashMoneyMoore but why follow a diet that raises LDL? You can get improvements in all of them following a low saturated fat low carb diet.
@defeqel6537
@defeqel6537 10 ай бұрын
@@CharlieFader saturated fat does not increase LDL
@CharlieFader
@CharlieFader 10 ай бұрын
@@defeqel6537 it certainly does, it’s very clear.
@Sahira-123
@Sahira-123 5 ай бұрын
Hello, there! Love this channel even totally confused about food & diet. But I wonder; one of the youtubecarnivore guys, seem to have really bad yellow skinproblems under his eyes!? I googled it but cannot really say what it is except that certain yellow patches etc indicates high cholesterol!? Love to hear your view on that 😇
@traceysteinbach5407
@traceysteinbach5407 5 ай бұрын
Don’t we already have the answer to this question ? I remember reading some studies that dr Gregers referenced that talked about two things that progress heart disease.. High LDL and high inflammatory markers like c reactive protein.. given c reactive protein levels can be triggered by illness and pro inflammatory diets, from a dietary point of view, reducing our LDL and inflammation markers through wfpb is more protective.
@steve-adams
@steve-adams 9 ай бұрын
It's so refreshing to see curious people ask interesting questions and acknowledge that we really don't know the truth yet. I still lean on the side of caution (correlations aren't causation, but sometimes I'm willing to take some stock on them), but I'm excited to see what we learn from this.
@nicknorwitzPhD
@nicknorwitzPhD 9 ай бұрын
Thanks!
@scamdem1c
@scamdem1c 9 ай бұрын
bart kay has talked numerous times about LDL. i highly recommend checking him out. he does have lots of experience working in the field of nutrition and cardiology. basically.. there is zero evidence that high LDL is causal for any disease. no properly done interventional study exists proving the claims that high LDL is a problem. even in the context of FH, its not actually high LDL that causes disease and mortaIity but rather the inability to properly take up and utilize LDL. LDL is tightly regulated by the body according to what is going with your life. what makes that so are your genes. those genes have survived for hundreds of thousands of years, tightly regulating LDL according to the bodys needs. it would be ridiculous to assume that high LDL is somehow causal for disease when the body deliberately raises it when appropriate. exercise and losing body fat can raise LDL. does that mean exercise and losing body fat is absolutely bad 100% of the time? being sedentary and eating lots of sugar can lower LDL. does that mean we should be sedentary and eat lots of sugar everyday? i am not concerned about LDL. my genes were passed on to me from my ancestors hundreds of thousands of years ago. those genes that regulate LDL according to my needs know very well what theyre doing.
Match Analysis of High LDL on Keto - Matthew Budoff - #CoSci
30:20
Dave Feldman
Рет қаралды 27 М.
Чай будешь? #чайбудешь
00:14
ПАРОДИИ НА ИЗВЕСТНЫЕ ТРЕКИ
Рет қаралды 2,7 МЛН
Backstage 🤫 tutorial #elsarca #tiktok
00:13
Elsa Arca
Рет қаралды 28 МЛН
🍟Best French Fries Homemade #cooking #shorts
00:42
BANKII
Рет қаралды 53 МЛН
100❤️
00:20
Nonomen ノノメン
Рет қаралды 64 МЛН
High LDL-C with No Plaques?  New LMHR Study with Feldman & Norwitz
1:10:21
Oreo Cookies Reduce LDL More Than Statins
44:54
Drbeen Medical Lectures
Рет қаралды 192 М.
How Nutrition Misinformation Spreads 1: Fact Checking Dr David Diamond
39:11
IS YOUR CHOLESTEROL NORMAL ON KETO? - Dr. Westman Reacts
24:34
Dr. Eric Westman - Adapt Your Life
Рет қаралды 51 М.
The LDL Cholesterol Mystery: Why Low Body Fat = Higher LDL Levels
19:30
High Intensity Health
Рет қаралды 50 М.
The Link Between ADHD & Obesity
34:28
HealthyGamerGG
Рет қаралды 227 М.
i love you subscriber ♥️ #iphone #iphonefold #shortvideo
0:14
Si pamerR
Рет қаралды 1,8 МЛН
КОПИМ НА АЙФОН В ТГК АРСЕНИЙ СЭДГАПП🛒
0:59
Выложил СВОЙ АЙФОН НА АВИТО #shorts
0:42
Дмитрий Левандовский
Рет қаралды 2 МЛН