How to interpret AlphaFold structures

Рет қаралды 52,166

European Bioinformatics Institute - EMBL-EBI

2 жыл бұрын

This webinar will introduce AlphaFold system for prediction and interpretation of protein structures. This webinar is designed for experimental biologists who wish to understand the strengths and limitations of AlphaFold and use the models to guide their experimental studies.
In this webinar we will provide an overview for the AlphaFold method and statistics that can be used to understand the reliability of the models. We will also introduce the AlphaFold Database, which provides hundreds of thousands of ready-made models across the tree of life, as well as highlight the AlphaFold Open Source and Colab notebooks that can be used to generate structures of sequences not yet available within the AlphaFold Database.
We will conclude by demonstrating a range of use cases followed by a question and answer session with all the presenters.
Who is this course for?
This webinar is suitable for lab-based and computational researchers with an interest in structural biology.
This webinar was recorded on 08 September 2021. The slides can be viewed on the EMBL-EBI Training site www.ebi.ac.uk/training/events...
Future webinars are listed here www.ebi.ac.uk/training/live-e...

Пікірлер: 33

@practicalmicrofabrication1858 2 жыл бұрын

Amazing work! Thanks for sharing

@xinformatics 2 жыл бұрын

Thanks for uploading

@HelysonLucas 2 жыл бұрын

fantastic video lesson!!

@orafurman-schueler1839 2 жыл бұрын

Thanks for this very useful webinar! Is it possible to use this material for teaching? Specifically, the description of the different parts of AF are excellent, but the slides say "private and confidential". Thanks!

@5602KK 2 жыл бұрын

So helpful

@TALKyLIKEENGLISH 2 жыл бұрын

Do u have a course for Alphafold2&Ebi coding?, or bioinformatics in general?

@5602KK 2 жыл бұрын

At 5:21, you mention that a large MSA provides sufficient information to do accurate structure prediction (doesn't need template data). What information is supplements template data when an MSA is large?

@lolerie 2 жыл бұрын

Nice, complexes hack is beautiful indeed. I hope you will do > 2700 human proteins in Molstar viewer, after all Molstar can do even insane Viruses, no problem.

@joonyoon7900 2 жыл бұрын

Hey folks, beautiful session! I have a question where I ran a local version of the alphafold and want to get the 3D structure, but cannot produce anything. Is there a certain program I should be using to render the images?

@christophohlknecht5905 2 жыл бұрын

use pymol

@ranam Жыл бұрын

I prefer to sphere pack all those with a spherical formula by implicit equation I know it's not practical to morph the manifolds analytical but it's a piece of cake and a beauty of mathematics can be applied at micro level but applying some 3d morphing computational algorithms which have minimal computational time but a symbolic one would be a work of beauty to unfold these protein cells

@itsagooday 11 ай бұрын

720p please. sorry but i'm old...my vision's blurry...

@mattarnold8139 2 жыл бұрын

Does anyone know how to access PAE metrics when running inferences on a local install of AlphaFold?

@SeriousBartYT Жыл бұрын

Check the FAQ section of the AlphaFold database.

@RavindraThakkar369 2 жыл бұрын

I have two peptides with 17 residues each, one is head to tail cyclic peptide and the other is stapled peptide. Does alphafold2 work with chemically modified peptides?

@SeriousBartYT Жыл бұрын

No.

@RavindraThakkar369 Жыл бұрын

@@SeriousBartYT Thanks