The field of biological drug discovery and diagnostics development is exciting and dynamic, yet highly complex and often challenging. Already a game-changer in the world of binding kinetics analysis, Malvern Panalytical’s Creoptix® WAVEsystem, with the underlying Grating-Coupled Interferometry (GCI) technology combines high sensitivity and signal stability with crude compatibility and rapid throughput.
Now, we are also providing a label-free concentration analysis thanks to our new software wizard: CFCA! CFCA is a label-free approach using the relationship between the diffusion properties of the analyte and the absolute analyte concentration.
The WAVEsystem allows you to measure the binding of an injected protein (analyte) to a binding partner immobilized on the surface (ligand) under diffusion-limiting conditions. The transport of the analyte to the sensor surface determines the observed binding rate. The system is said to be under mass transport limitation (MTL) and dose-response curves are independent of the binding affinity; instead, they are determined by the protein diffusion properties.
Benefits of the CFCA software wizard for biologics:
► No need to set calibration curve and suitable standard
► Active protein fraction quantification
► Streamlined workflow as antibodies are quantified directly from serum or cell lysate
------------------------------------------------------
► Read more about biologics: www.malvernpanalytical.com/en...
► About Creoptix: www.malvernpanalytical.com/en...
► Get in touch with us: www.malvernpanalytical.com/en...
► Follow us on LinkedIn: / creoptix
► Follow us on Twitter: / creoptix​
-------------------------------------------------------
Creoptix AG
Zugerstrasse 76
8820 Waedenswil
Switzerland