Howard Sachs, MD is developer of the 12DaysinMarch lecture series. He is proud to offer this lecture written and prepared by David Toomey, Class of 2018, UMass Medical School. David is section editor for the Biochemistry series.
Пікірлер: 36
@jorge.limafilho5 жыл бұрын
Best video about Lysosomal Storage Diseases in KZfaq! Congrats!
@sosololo47712 ай бұрын
Best video ever thank you so much for this masterpiece 🥰
@stellate25 жыл бұрын
Perfect explanation.
@ЭндокринологЭлбекМаматкулов3 жыл бұрын
Great job. We are waiting your videos. Especially about inborn errors of metabolism. Thanks.
@drswetaruparel4 жыл бұрын
Thank you so much for making such difficult topic so easy!!! 👍🙏
@kianatehrani5 жыл бұрын
This is one of the best explanations I've ever seen for these disorders! Thank you so much! I just had a question about Tay-Sachs. The "onion skinning" is of the lysosomes, not of the affected cells themselves, so shouldn't we technically not be able to see that on histology? Shouldn't we only be able to see it on EM and not on H&E microscopy? Thanks again for making these difficult-to-remember disorders memorable!
@HowardSachs12DaysinMarch5 жыл бұрын
You are VERY observant! Well done. The H&E would should cytoplasmic 'ballooning' (vacuolation) with accumulation of glycolipids. The onion-skinning is found on EM and does represent lysosomal accumulation of glycolipids. The text and narration appropriately refer to onion-skinning within the lysosome and seen on EM BUT the image is an H&E preparation demonstrating an onion-skin appearance unrelated to Tay-Sachs. It's tough to call but that is probably a renal arteriole (malignant HTN?) demonstrating an onion-skin appearance? Although not neuronal tissue, it does offer a graphic display of the onion-skin appearance. This video has >1000 views and you are the first to pick up on the discrepancy. Really outstanding.
@kianatehrani5 жыл бұрын
Howard Sachs Thank you so much! I'd attribute it to the fact that I was a histology TA for my first two years! I very much appreciate your kind words! And I agree - the onion-skinning image used in the video is similar to what you'd see on EM anyway, so, if an exam question's stem was clearly pointing to one of these lysosomal storage disorders and used an EM pic, the student would still get the question right remembering the hints given in this brilliant video! Thanks so much again! I look forward to going through all your videos very soon! :D
@tarekrahman41014 жыл бұрын
Best explanation in KZfaq about the lysosomal storage diseases
@HowardSachs12DaysinMarch4 жыл бұрын
Thank you. I will pass your comments along to the good Dr Toomey. He'll be pleased. Best of luck with your studies. HS
@didarmirzamidinov12843 жыл бұрын
This was the most amazing way to learn this hard subject, bravoooi
@rehamsobeih48632 ай бұрын
This is Great!
@MBBSZaraHutKay2 жыл бұрын
Thank You.. finally I got this topic
@rajmehta64023 жыл бұрын
Thank you so much!!!! I love this video. Will definitely check out more and already subscribed. Please keep making videos like this.
@HowardSachs12DaysinMarch3 жыл бұрын
Thank you! I am about to teach my course at the med school (for the next 12 days in March! Hopefully, I will be able to generate more material from those lectures. I appreciate your input. HS
@theodule013 жыл бұрын
Unbelievably great! Thank you!
@restlessram5 жыл бұрын
Wow, really amazing. This also helps in improving question taking 🙂 many thanks
@AnthonyThorburn5 жыл бұрын
This was so high yield with regards to this topic. Thanks so much
@sajadkhoja925 жыл бұрын
Very productive. ❤️❤️❤️❤️❤️❤️
@dr.omkarpawar34784 жыл бұрын
Really helpful
@syphoresdrow50774 жыл бұрын
Bruh u saved my life :) great explanation
@Queenofnidra5 жыл бұрын
Amazing explanation! Very well thought :D sure won't be getting these wrong on the step.
@robb33422 жыл бұрын
Beautifully done
@hindabdalaziz82932 ай бұрын
Perfect
@makeitaleapyear60626 жыл бұрын
Fabulous stuff!please do videos on hardy wein . Eq. N genetic
@douglas80512 жыл бұрын
Great videos, helps a lot.
@thepacemaker81654 жыл бұрын
Youre amazing! More power!
@mohammadkhayait4740 Жыл бұрын
Best video , very recommended Is there such one about glycogen storage diseases😊
@HowardSachs12DaysinMarch Жыл бұрын
I agree but Dr Toomey has moved on to other endeavors. I will certainly share your comments and concerns.
@mariamaboutouk8849 Жыл бұрын
Great🎉thank you for sharing
@archangel803033 жыл бұрын
Great video.Can you make a video on glycogen storage diseases.?