*ONE AMENDMENT (READ BELOW)* Videos on Studies: GlyNAC (Full Analysis): kzfaq.info/get/bejne/bLKdlpCe0tfcqYU.html Collagen (Full Analysis): kzfaq.info/get/bejne/prNlf8d70NDdaYU.html OMAD (Full Analysis): kzfaq.info/get/bejne/gLGndpukraupmo0.html Reversing Aging/TRIIM Study: kzfaq.info/get/bejne/qLyfq8lyp9WsmGg.html Obese & Autophagy: kzfaq.info/get/bejne/fJ6RpcmhsNjNYIE.html Insulin vs Calories: kzfaq.info/get/bejne/rbCYbJuks9imqoE.html LDL on Heart Disease (Full Analysis): kzfaq.info/get/bejne/Z9popdSXrJenfXU.html Urolithin A: kzfaq.info/get/bejne/mbCUdM-hl9TJp2g.html Omega-3 on Cognition (Full Analysis): kzfaq.info/get/bejne/a5ejh8ylxrveemw.html Reversing Heart Disease (Full Analysis): kzfaq.info/get/bejne/pch0ZKpzup7LmZ8.html AMENDMENT: At 19:19, I say that there are a vocal minority of people who argue LDL is a cause of heart disease risk - that is reversed, it should be "a vocal minority of people who argue LDL is NOT a cause of heart disease risk" - thanks to @mkvalor for pointing it out.
@brianwnc81686 ай бұрын
I love your channel but I'm disappointed that you did not include research on nattokinase around its ability to remove arterial plaque. Also, berberine has been shown to remove arterial plaque. These are very important supplements to help people who can't exercise due to physical limitations or simply to help people who really struggle to get in shape. Many supplements can help people have an advantage until they can reshape all the other lifestyle factors needed for optimal health. They just give you an advantage even if you are healthy but you're older.
@trentriver6 ай бұрын
@@brianwnc8168 The evidence that berberine removes plaque is very early and needs more research - double blinded, case controlled study with enough participants. I do take it for that reason and it also does seems to lower blood sugar, BUT the only reason I take it without more evidence is that it does not seem to do any harm. So, I am hoping we eventually do get more robust/solid data. Nattokinase - not sure the evidence is there ... can you point me to some high quality studies? I AM SURPRISED HE LEFT OUT CREATINE MONOHYDRATE.
@user-bn6yb6de7q6 ай бұрын
New subscriber. Just found your channel. Love it!🙂
@markaldridge50896 ай бұрын
This is great analysis - independent, evidence-based and with context and nuance that is absent from the influencers and supplement sellers who are everywhere on KZfaq. Much appreciated.
@Physionic6 ай бұрын
Thanks, Mark
@m4inline6 ай бұрын
I second this.
@ericsonhazeltine50646 ай бұрын
I third this.
@cattleprods9116 ай бұрын
He’s buying the lipid hypothesis, but hiding behind “one of the contributors…”, otherwise excellent summary.
@whendarknessfalls69696 ай бұрын
A minority also thinks that males can be females, and females can be males. So take that with a grain of soy😂
@chrissparrowhawk6 ай бұрын
An abundance of information using minimal words. No flashy intro, no yo yo music, just the facts and nothing but the facts. Information at it's best.
@g33k376 ай бұрын
Glynac has definitely been my Grandmother is 88. She was starting to show signs of cognitive decline and becoming increasingly frail. Started her on glynac 2.5g and 1.5g taurine twice daily, and the results have been astonishing. Moves faster gets up better, and her cognitive capacity and memory have come back to baseline.
@pavman426 ай бұрын
I've been taking glynac since last summer and taurine since the fall and I must say it has vastly improved my energy levels and I think it's actually improving the speed of my thinking, no small feat, despite being under 50. I also think NAC generally acts as a detoxifier which is beneficial.
@SkyRiver16 ай бұрын
I have a 95 year old aunt who I am going to try this on.
@Ensource6 ай бұрын
let us know your anecdote @@SkyRiver1
@joejojo59666 ай бұрын
@@SkyRiver1 Please let us know how it goes! Well wishes!
@m4inline6 ай бұрын
MDMA works wonders on pensioners too.
@destmichael6 ай бұрын
I am back in school finishing my Nursing degree at 50 partially because of this man. His videos help me stay fit by running to KZfaq every time he posts. He's had me print out and read studies he's mentioned on here. It's like he's our own personal TLDR superhero. I trust his analysis.
@kwilliams19586 ай бұрын
NIck, your "technical takes" and ability to say "I don't know" are why your audience finds your credibility A+.
@melimoo66566 ай бұрын
Your channel and nutrition made simple are the only 2 I trust. Independent non-biased clinical evaluation of data. and no products or gimmicks being sold to me! ❤
@Physionic6 ай бұрын
Gil is awesome. Humbled to be in his company.
@StanDupp63715 ай бұрын
You should only get diet advice from a real Ph.D in nutritional biochemistry with awards and honors and or a Nobel Prize with a long term track record of being right such as Roger J. Williams, Frederick Gowland Hopkins, Fred Kummerow, George H. Whipple, William Parry Murphy, Edward Adelbert Doisy. All 6 would say the same that Linus Pauling said that meat, poultry, fish and eggs are good for you in moderation and that dairy is ok in small amounts if you like it and are not allergic to it. Gil Carvalho has zero experience in anything.
@ImJarlen6 ай бұрын
What a great video! The fact that people can get acces to this kind of useful knowledge for free and with so little effort is awesome
@RickNuthman6 ай бұрын
I am 48 and have suffered from severe chronic depression and anxiety for years. I have used all of the drugs, psychological treatment modalities and nothing ever gave me much relief until a couple of years ago I hears about glycine and NAC. I had seen a study somewhere that chronically anxious people were often found to be depleted in glutathione. Obviously this can lead to all kinds of problems. At the time, I started taking about 2 grams of NAC along with 2 grams of TMG daily. I started noticing after a few weeks everything was changing. It was like reality was becoming brighter. I could also breathe more deeply and freely (nac also helps the lungs) On top of that, my blood pressure normalized and my energy increased 10x. It was like getting my life back. I just wanted to point this out because I think people who have generalized anxiety even in their 20s and 30s could recover using glycine and nac. I think this needs more attention!
@shahzamanhaque6 ай бұрын
Thank you for this. When you take this ? During or after meal ?
@oolala535 ай бұрын
So you are now less bothered by critical thoughts about yourself and the world, past and future?
@RickNuthman5 ай бұрын
@@shahzamanhaque I try to take it on an empty stomach. I usually take a NOW 1G NAC pill with a glass of water mixed with glycine powder. Lately I have added 3 grams of Taurine to the mix as well as 2.5 grams of creatine.
@RickNuthman5 ай бұрын
@@oolala53 I think what the glycine/nac combination did for me was end the constant exhaustion, depression and edginess I experienced every moment of every day. It has given me space to work on the critical thoughts and destructive thinking patterns. Self enquiry and meditation have been extremely useful. anything that brings circulation to the prefrontal cortex. I really like the meditation devices like the Muse 2 and the Mendi.
@salmanuel40536 ай бұрын
Who wouldn't want to learn the 10 best tips for your health that a Ph.D. student has gleaned from reading 250 research reports? At the least, it can point up vitamins that you should look at more closely. Immense value in this channel!
@grantlikes2sing6 ай бұрын
You are a gifted teacher. Great dissemination of useful information!
@thirdworldperspective24096 ай бұрын
That’s some great stuff Nic, really proud to see how far you’ve come and happy to have been here since the start. Keep up the awesome work…Richard
@Physionic6 ай бұрын
Thanks so much for the kind words, Richard. :)
@wolfrahmphosphoros58086 ай бұрын
thank You. I always look forward to your monday-video but this 1 is another level, it's exceeded my expectations. regards.
@harku1236 ай бұрын
You have so many views nowadays!! Awesome! I've not followed anything nutrition related in a while because I started working in politics lol! But I'm so glad to see your current success!
@Physionic6 ай бұрын
Hope things are going well on your end. :)
@mattshelfreliance6 ай бұрын
Glad to see how much your channel has grown and you are getting better and better each year with the delivery 👊 Brilliant vid bro🤙🔥
@stargazerbird6 ай бұрын
So take glynac and omega 3 if you are over 60 and do the usual (weight,exercise,whole foods) for heart health.
@nvrancher5 ай бұрын
Toss in taurine and creatine monohydrate.
@amrs77625 ай бұрын
Thank you @Physionic for being a voice of reason. I LOVE your videos! I'm so glad I found you and now I can stop wasting hours of my time watching all the others debate. Please never stop what you're doing! We need you!
@EduardQualls6 ай бұрын
RE: Human growth hormone ("Reversing Aging/TRIIM Study) Studies indicate that betaine [anhydrous] (aka, trimethylglycine (TMG)) at c. 3g a day (in split dosages, morning and evening, with meals) increases serum HGH naturally. (Glycine, in its various forms [like glynac], appears to be very actively important to maintaining/optimizing health.)
@pavman426 ай бұрын
By day two of a water fast you will feel HGH in your body. So if you can do a 3 to 5 day water fast you will generate your own HGH. In my opinion the most efficient way to maximize water fasting is 7 days but it's not easy for a lot of people. The key here is that when you come off of the water fast your body will make up for the protein deficit by maximizing efficiency and rebuilding once you start adding protein as it leverages the HGH that was used to preserve muscle mass during the fast to build up even further; it might be 3 days of water fasting @ a minimum to see the HGH effect, I don't usually pay attention until I start feeling it in the morning and that's not until I'm already well into the fast.
@SkyRiver16 ай бұрын
I am going to check you on the TMG, but thanks in advance for the info if it checks out.
@thierryvidal636 ай бұрын
The thing is can you produce any HGH when you're 50+ ? or Testosterone ? No... not really, the charts crash badly. You produce very little, there's not much to stimulate "naturally". You have to supplement.
@mmimoman6 ай бұрын
@@pavman42how does one feel HGH?
@GYMETRIUS6 ай бұрын
I was legitimately expecting you to discuss high dose Vitamin K2 and reversing atherosclerosis at the end.
@w8what5756 ай бұрын
And boron
@larryc16165 ай бұрын
Nattokinase can do that
@KatieMcTalmage5 ай бұрын
Because it's high in k2, right? I've heard it is not tasty 😂
@tracymullane88186 ай бұрын
Thanks for your summary. Terrific content as usual.
@lexvtd6 ай бұрын
i used to eat once a day for years and was 140kgs and miserable when i started eating 3 to 5-6 times a day in an 10h interval since waking up with 14h pause i got down to 100kg and felt amazing, no gym or exercise, just doing basic stuff + work. for reference i am also 1.95m tall
@gur2625 ай бұрын
I think it really depends. I can see the point in not eating for a long time as kind of exercise in restraint. But I lost 20 kg last year with frequent small meals. Often just a protein shake as snack at work. I feel that helped shrink down my stomach making me feel full being less full. Couldn't have happened with Giant 1-2 meals
@_negentropy_6 ай бұрын
Thanks so much for this, Nic! As a student I’m grateful for the lessons in research literacy, and I so appreciate the way you approach analysis with equal parts intelligence, tenacity and humility. From a student’s perspective that is rare in both academia and wellness communication spheres, and highly worthy of emulation. 🙏
@robbroyles25446 ай бұрын
appreciate your insights and opinions. Good to see the science community come out on these hot topic items circulating today.
@billytheweasel6 ай бұрын
Thank you very much for sharing this work!
@ChuckleberrySoup6 ай бұрын
Thanks for the Roundup! .. Maybe when you get time maybe you could analyze the literature on Aspirin/Salicylic Acid's benefit for CVD & Cancer treatment
@midnightodellewest19996 ай бұрын
Wow. I don’t know why the algorithm suggested this video (though I suspect you do), but I am sure glad it did. Thank you for the wealth of trustworthy information.
@RashidMalik-LabVIEW6 ай бұрын
Love your humor (and you too), my good young man! Stay well, stay healthy, stay wise, and keep sharing the goodness of your heart! May the universe bless your good life!
@dmenace92886 ай бұрын
NAC definitely has a difference for people above 60, based on my own experience. My joints are less achy, my slight pre diabetic signs disappeared, I’ve noticed more strength as well. I’ve also got Covid recently, and unlike all my previous flu and lung infections, I had the least symptoms, and lasted only 5 days, which is phenomenal based on how I suffered every time I get some kind of lung infection. Still working and learning as I go. My eyesight seems a bit better, although my optician said it’s no change from my last eye examination.
@littlevoice_116 ай бұрын
How many grams per day do you use?
@dmenace92886 ай бұрын
@@littlevoice_11 Initially I bought 600mg capsules and I had 1 in the morning and 1 in the evening. Now I have them as 400mg, and still trying 1 morning and 1 evening. I'm usually giving it a little break every 2 week cycle. 2 days off it every 2 weeks for now. I'm thinking of 3 times a day at the moment.
@juliedevine46952 ай бұрын
Thank you Nic, I really appreciate your sharing all this info to me as an aging young person, keep them coming. Its definately helping to educate me making my decisions.
@spockboy6 ай бұрын
Love your channel. Keep up the good work!
@jeffkilgore63202 ай бұрын
Thanks for your work.
@timpitts92566 ай бұрын
Thank you! I appreciate your hard work and no BS approach.
@shastsanieh6 ай бұрын
That was a quick review of past videos. It was beneficial for me.
@kygo6 ай бұрын
I really like these recap videos you do, please keep doing them!
@littlevoice_116 ай бұрын
Saw the title... clicked immediately! This is THE Physionics video I've been hoping for. Thank you
@rosaflorpuig39716 ай бұрын
This is great! Thank you so much Nicholas! QUESTION: can you do (or, did you do) a video on CA-AKG?
@jeffreydeuitch21466 ай бұрын
Regarding the insulin versus total calorie argument, I would really like to see an explanation of the differences of efficiency of conversion of molecule type into body fat disposition. Meaning, for a given calorie content of carbs versus same calorie content of fats, which results in the greater amount of resultant body fat. Is there some % metric of conversion to body fat? There is an argument amongst keto participants that dietary fat is less efficient at creating body fat then the same calories ingested as carbs. Can of worms here perhaps? Invigorating to hear discussions about cell/molecular biology. Studied this way back in the day but never went into the field. You never lose the passion for the science. Great work.
@garjog16 ай бұрын
Nic is the best! LOVE this channel.
@kennethyuman19406 ай бұрын
This is an awesome analysis. I wish you could update this once a year and make it an event we look forward to. Then the title needs a bit adjustment: It needs an edition marker, such as "2024 Edition".
@treesoul006 ай бұрын
I do glycine and nac separately. You know the only supplements that have helped at a level that I can notice are b vitamins, d vitamins, c, creatine and NAD+
@ilevitatecs26 ай бұрын
Well, if you’re subjectively feeling a difference it’s likely you were previously deficient…specifically with vitamin supplementation. Creatine is a totally different animal and can likely end up pushing the upper-bound ceilings of both skeletal muscle and cognition through tissue perfusion above supraphysiological states. NAD+ can be lower post infection, from chronic inflammation or stress, etc, so rebalancing that with supplementation may help with energy levels there.
@djurius6 ай бұрын
@@ilevitatecs2are you a doctor?
@ilevitatecs26 ай бұрын
@@djurius I work in the research field but I do not have a postdoc
@filippo85betti6 ай бұрын
great analysis, mate! 🙌 thank you so much 🤩🤗
@saskhiker39356 ай бұрын
I love how this man embraces his nerd, and I am here for it!
@Joy80JJ6 ай бұрын
LMAO on your charming sense of humor. Yes Nick your charming. Thanks for sharing your research with us & most important explaining it for the non nerdy tribe.
@easyacademy81106 ай бұрын
Thank you so much for your great content!!
@gregoryhatt64756 ай бұрын
Thx yet again, you are doing your fellow man a great service! Cheers, to our health, and to science!
@trentriver6 ай бұрын
Top Drawer commentary - thanks!
@oleinkar39333 ай бұрын
Thank you for your hard work. I really enjoy your videos!
@proudtobeweird6 ай бұрын
So clear and well explained…thank you 😊
@jimmychan91386 ай бұрын
This is so informative. Thank you very much. This is one of the best and most comprehensive videos out there.
@elchappo13205 ай бұрын
Best health channel by far!
@petermoliner72505 ай бұрын
You might do a segment on the following relationship: Hruby A, O'Donnell CJ, Jacques PF, Meigs JB, Hoffmann U, McKeown NM. Magnesium intake is inversely associated with coronary artery calcification: the Framingham Heart Study. JACC Cardiovasc Imaging. 2014 Jan;7(1):59-69. doi: 10.1016/j.jcmg.2013.10.006. Epub 2013 Nov 27. PMID: 24290571; PMCID: PMC3957229.
@lumskeja32786 ай бұрын
Love all the content you put up, been following for a while and the sheer amount of work you put into your videos is astounding. Keep it up, we really appreciate you! Lum S.
@atanasivanov8816 ай бұрын
Thank for putting in the hard work to make this easy to understand.
@silviahayakawa66556 ай бұрын
It’s be super helpful to place your videos linked in a playlist so it just plays one after another. Thanks!!
@gad3iii5326 ай бұрын
That was awesome info! Thank you!
@mikeroll98686 ай бұрын
Thanks I really appreciated all of your analysis . Looking forward to the one on CVD.
@mrdev52816 ай бұрын
Exactly what ive been waiting for. A Perfect video.
@looking4leasuretime6 ай бұрын
Awesome. Thankyou for making me double check my routine.
@asdf8asdf8asdf8asdf6 ай бұрын
Humor with mild snark works great Nic. Never change.
@fishnski92116 ай бұрын
Thx for all your hard work...very much appreciated!
@machine694206 ай бұрын
@physionic FYI there's a high-pitched buzz above 10kHz throughout the entire video. It was more prominent in this video than your others. Otherwise, the content was informative as usual. EqualizerAPO, Krisp, RTX Voice are among several solutions that could help. They can filter out noise during recording, so you wouldn't have to edit it in post-production. Keep up the good work!
@SkyRiver16 ай бұрын
No buzz on my system.
@Derpcat6 ай бұрын
Soothe2 / Supertone / Adobe Podcast / DXrevivePro 2 could work too in post production / while recording :)
@pavman426 ай бұрын
That's for the physionic Insiders... to decode the secret message.
@jjktng5 ай бұрын
You deserve way more subscribers ! !
@janiceg76615 ай бұрын
Great video! New sub here! I’ve been feeling defeated by post menopausal hashi hypo 25 lbs. Im not sure where I go next as I feel I’ve tried sooo many diets, coaches, purchased food, FMD, omad, keto, vegan, it’s been exhausting! I think I could seriously become a nutritionist which it shouldn’t be that hard. I’m going to give low carb, adding macadamia nuts for good fat, sardines and see how that works. Thank you ❤
@pierrebaril36 ай бұрын
Merci beaucoup pour cette synthèse.
@Physionic6 ай бұрын
De rien, Pierre.
@georgelewis57406 ай бұрын
I recently came across something saying basically that if you are overweight and insulin resistant you have a hell of a time switching to fat burning(meaning that when you try to exercise to burn fat you end up out of energy because you cant make the switch and you feel like crap)...I experienced this when I started getting back in shape 3 years ago. I couldnt lose weight my old school way of training hard first then having my body ask for a better diet...Instead I had to eat once per day and go walking for my exercise. Once I dropped about 8 kilos in two months I was able to exercise normally and off I went. I can now eat reasonably and train hard....like a psycho. To me eating once a day is a good way to get the weight lose going but once you are in decent shape you can expand the window..and have to in order to build some muscle and train properly. Just my experience and thoughts
@krazyk5005 ай бұрын
Been watching your vids this one earned a sub. Great work 👏
@WholeCosmos6 ай бұрын
Wow I just saw a video you did 3 years ago on that old anecdote of a carnivore guy in GB a hundred years ago. You appear much heathier now in weight and confidence. However now you appear pasty white and puffy under the eyes. maybe dial back the sodium and creatine intake and ingest more potassium for less water retention and get more sleep. It could be the lights/lighting but I do recommend getting more sun, sleep and a little less sodium/creatine. Also eating more carotenoids will give your skin more pigmentation and UV protection. Great info BTW and thanks for the synopsis of your due diligence. I commend your efforts. We need more people like you as influencers.
@smudge786 ай бұрын
Do you have any idea what a suitable dose would be for GlyNAC? Thanks for your great videos!
@ash9x96 ай бұрын
3 gm/day(min)
@jp73576 ай бұрын
Excellent summary .. thank you
@Star-Bright6 ай бұрын
Can you share your workout & nutrition routine?
@michaelblacktree6 ай бұрын
This is good stuff! Thanks for sharing. 👍
@bryanspicer906 ай бұрын
Great video. Thanks for sharing.
@edwardnino98966 ай бұрын
You remind me of a proto Huberman, keep up the good work!!
@jpintero63306 ай бұрын
You should do a video on ellagic acid and osteoclast differentiation. If pomegranates can build bone, everyone needs to know about it!
@mariannetm6 ай бұрын
I am 70 yrs of age and boy would I like to try some of these supplements !
@ericwarmath10916 ай бұрын
But what about the Rotterdam data that shows that people with higher cholesterol live 2 years longer? Is it just that older people need more cholesterol?
@markaldridge50896 ай бұрын
Found this: LDL cholesterol still a problem in old age? A Mendelian randomization study. Iris Postmus, Joris Deelen, Sanaz Sedaghat, Stella Trompet, Anton J M de Craen, Bastiaan T Heijmans, Oscar H Franco, Albert Hofman, Abbas Dehghan, P Eline Slagboom, Rudi G J Westendorp, J Wouter Jukema Author Information PMID: 25855712 DOI: 10.1093/ije/dyv031 BACKGROUND: Observational studies in older subjects have shown no or inverse associations between cholesterol levels and mortality. However, in old age plasma low-density lipoprotein cholesterol (LDL-C) may not reflect the lifetime level due to reverse causality, and hence the risk may be underestimated. In the current study, we used an LDL genetic risk score (GRS) to overcome this problem. METHODS: A weighted GRS was created using 51 single nucleotide polymorphisms associated with LDL-C levels. The LDL GRS was calculated in three Dutch cohorts: the Leiden Longevity Study (LLS) (n = 3270), the Leiden 85-plus study (n = 316) and the Rotterdam Study (n = 4035). We assessed the association between the LDL GRS and LDL-C levels, chronological age, familial longevity and mortality. RESULTS: Up to 90 years of age, in each age stratum individuals with high LDL GRS had higher LDL-C levels (P = 0.010 to P = 1.1 x 10(-16)). The frequency of LDL-increasing alleles decreased with increasing age [β = -0.021 (SE = 0.01) per year, P = 0.018]. Moreover, individuals with a genetic predisposition for longevity had significantly lower LDL GRS compared with age-matched individuals of the general population [LLS nonagenarians vs > 90 years: β = 0.73 (SE = 0.33), P = 0.029, LLS offspring vs partners: β = 0.66 (SE = 0.23), P = 0.005]. In longitudinal analysis, high GRS was associated with increased all-cause mortality in individuals > 90 years, with a 13% increased risk in individuals with the highest LDL GRS (P-trend = 0.043). CONCLUSION: Results of the current study indicate that a genetic predisposition to high LDL-C levels contributes to mortality throughout life, including in the oldest old, and a beneficial LDL genetic risk profile is associated with familial longevity.
@mmv84166 ай бұрын
Excellent video. Thank you!
@rdo12316 ай бұрын
excellent work!
@TheReminderChannnel6 ай бұрын
Amazing! Thank you for this! Still unsure about Urolithin A - think I’ll wait for further studies as it’s quite an expensive supplement.
@kenpumford7546 ай бұрын
I am a lean mass hyper responder whose LDL cholesterol went through the roof when I stopped eating crap processed food and started eating natural food. I lost 10% body mass, almost all of it visceral fat that was hiding out behind my abdominal muscles. I am very much looking forward to release of data from ongoing studies on LMHRs. I have a hard time believing that the increase in LDL that accompanies all the beneficial changes from eating a diet much closer to what humans evolved eating is anything but a natural normal phenomenon.
@Physionic6 ай бұрын
Could be, Ken. I'm not convinced, yet, but I'm open to the idea.
@thiagodumont7196 ай бұрын
Excellent work, brother. 👏🏻👏🏻👏🏻👏🏻👏🏻🫶🏻
@NewDarkKnight6 ай бұрын
Really important video. Nic deserves Huberman level of audience.
@rhondaurb5 ай бұрын
Thank you for this great video
@perdex6 ай бұрын
Awesome work. Thank you so much!
@gherty2126 ай бұрын
the dose and form of zinc in this study was "50mg of elemental zinc" and I am wondering about safety and feasibility of getting this dose IRL- from what I am reading, over the counter zinc contains only a fraction of elemental zinc- eg 50 mg of zinc gluconate contains 7.14 mg of elemental zinc, and 50mg of zinc picolinate contains 10mg of elemental zinc. how should we think about this?
@paulhindle39616 ай бұрын
It's hard to imagine that CVD would be as significant a disease as it currently is if people all had a healthy endothelium. Lowering LDL seems to be a strategy that is effectively masking the most significant risk factor for atherosclerosis. If someone can't or won't implement lifestyle changes to improve their metabolic health then sure, give them statins. But statins only marginally reduce risk, for this to be a first line defense promoted by doctors seems to be unethical.
@jeffkilgore63202 ай бұрын
The side effects of each cocktail supplement seems worth discussing in more depth.
@contagiousintelligence50073 ай бұрын
- glyNAC (above 60) - collagen - OMAD (for weight loss it may be beneficial, but it caused high blood sugar in one study)
@postnubilaphoebus965 ай бұрын
Hello, thanks for the in-depth video. Can you do a supplement special on autoimmune diseases? I have Long Covid and am trying to figure out how to recover. Studies are few and far between, so it's tough to get your hands on useful information. Maybe some general strategies that work for autoimmune could work with LC? Who knows. I'm gonna try Glynac in any case, as LC is supposed to at least partly be due to oxidative stress
@gaston.6 ай бұрын
Agree.. hitting my 60s, I am more aware of my lack of energy and what affects it. Taking note of anything that might increase it. TMG, Glycine NAC.. not consistently but do seem to give a power boost taken intermittently. As well as some other sups.. Amla with Cordyceps, Creatine.
@LLS7105 ай бұрын
I took Omega 3 for the advertised reasons for years (and still do). What kept me taking it was how much it calmed my psoriasis. I had no idea that it could do that. I suppose it calms the inflammation down? It's the only reason I keep taking it.
@stefanklaeser37116 ай бұрын
Hi Nicholas, I really enjoy your videos and learned a lot. One question: I’ve heard many times the most important information in a study is, who provided the funding. 😉 What’s your take on that? Thx from Germany 👍
@Physionic6 ай бұрын
I cover funding in my analyses. I agree that funding is important, but it's often overblown in importance as if it is *the* deciding factor to believe or not believe a study, and I disagree with that notion.
@joebartles39866 ай бұрын
Fantastic video. Bravo.
@stevemc26266 ай бұрын
Another great video. Could you please do one on Lp(a). For those of us that suffer very high numbers, we really need your take on the subject. Worry/don’t worry? Niacin/no niacin? Carbs/no carbs? Thanks.
@Physionic6 ай бұрын
I’m on it. 3 months of work. I expect the video to release in 2 weeks.
@stevemc26266 ай бұрын
I’ll be counting down the days. Thanks so much. Just for your info, I’ve been taking niacin in large doses (1000mg) and it has dropped my Lp(a) significantly. But of course I can’t be sure that lowering it alone will actually reduce my risk of atherosclerosis.
@littlevoice_116 ай бұрын
I wonder if any of these learnings in terms of supplements can be translated into dietary modifications, e.g., reduce a certain food that prevents absorption or use of xx. And foods high in the beneficial molecule.
@meltedsnowman96373 ай бұрын
Hi. For the Thymus rejuvenation, have you seen Brian Johnson talk about him trying this? He mentioned on Dr Mike’s podcast that it had the most negative health effects of anything he’s done due to the human growth hormone because of increased intracranial pressure and maybe some other negative health effects that I’ve forgot.
@mikesymth72436 ай бұрын
#7 it’s total apo-b not total ldl that is the risk factor
@markaldridge50896 ай бұрын
Agreed with the slight amendment to "ldl -c is not the best predictor of CVD risk, but often correlates pretty well with apo-B". Total Ldl not great but a very high level should be a red flag which merits further investigation - see below. apo-B represents the measured particle concentration of VLDL, IDL, LDL and chylomicrons (unless lipid panel done on a fasted state in which case less of an issue). Whereas LDL-c is an estimated/calculated representation of the amount/volume of LDL-c in the above particles. For most people, apo-B and LDL-C correlate well. But for a significant minority there is discordance - with High apo-B/low LDL-c or low apo-B and high LDL-c. For all these cases, study after study has found that it is the apo-B level which is the greater predictor of heart disease. Does this mean we should ignore LDL-c? No. If high for example, there is an odds on chance that apo-B will also be high. Some individuals will jump on the "low LDL-c and still had heart disease" so called paradox. But two possible explanations: 1) As above, could be discordant and have high apo-B or 2) Reverse causation - where CVD events (including deaths where blood panel measured post-mortem) show low LDL-c. In these cases it is the event/chronic illness itself which lowers LDL-c at the point of measurement. Hence the U shaped curve for risk vs LDL-c. Conclusion - LDL-c is not irrelevant but is a poor man's surrogate for apo-B which is the better predictive risk factor. Interestingly, in the UK, for some years the lipid panel now includes "Non-HDL cholesterol", which is not perfect by any means but correlates more strongly with apo-B than LDL-c alone. Finally, for me it seems that it is the apo-B concentration over a lifetime that counts (the area under the curve). I have seen some great explanations for this by Dr Thomas Dayspring (good interviews with Simon Hill - The Proof), Peter Attia and Dr Gil Carvalho of Nutritionmadesimple. Their mantra for apo-B is lower, earlier, for longer. Disclaimer: while I have some background in Chemistry (not Biochemistry) I don't claim to have any specialist knowledge of lipids, CVD risk etc etc. I'm just trying to read and learn from a very low base - my apologies if I've got some of the above mangled!
@larryc16165 ай бұрын
Nope! Debunked. Total ldl is a great predictor of atherosclerotic heart disease and death
@jrb.m.95436 ай бұрын
Can you share with us the supplements routine and specific brand you use or would be greatly appreciated! Great video!
@zbyszeks36575 ай бұрын
Absolutely brilliant! the only thing I'm not sure about is calorie model vs insulin model as a mean to weight loss. It should be simple to decide, just put two groups on same calorie load and make a difference in insulin level. There shouldn't be any ambiguity cause none - I think - argues against that calorie restriction do not cause weight loss, it does. If the only parameter you change will be less calorie, than you will loose weight. The claim of minority is that eating food causing high insulin causes: 1. More energy from food will be stored as fat or less fat will be used for energy. 2. You will feel more hungry, and than you will eat more, in effect, in normal life, you will gain weigth.