Overall good video, except: LPS is located in gram-negative bacterias and not in gram-positive. LTA is located in gram-positive bacterias and not in gram-negative.

LPS is in Gram (-ve) not Gram (+ve), and LTA is in Gram (+ve) not Gram (-ve). This should be fixed by now, this could affect someone's grade. I don't mean this in a rude way by the way, I just mean PLEASE fix this so that it doesn't confuse anyone and result in them getting a lower mark.

This guy deserves all the recognition he has received, these videos are amazing, I wish I could make something half as good as this guys stuff.

I cannot thank you enough for this video. I have been struggling to understand TLRs. My textbook did not go into depth about them and my instructor just confused me when it came to them. Thank you thank you thank you!!!!!

In case any one trying to remember thier individual function , TLR 2 gram +ve bacteria LTA(two lines in plus sign) TLR 4 opposite =gram negative bacteria LPS remember TLR 3 and 7 together: 3 for double stranded viral RNA, 7 single stranded viral RNA TLR5 - Five for Flagellin TLR 9-nine for nucleic acid =DNA

Thanks so much for doing these videos! you don't know how much they have helped me! thanks a ton~

Loving your videos! They are getting me through med school!

Thank you so much and it is very useful for me. May I suggest to talk more about NF-kB and pro-inflammatory cytokines?

Great! Thank you. very clear and concise.

Thank you a lot for a bright and legible overview.

hi ! amazing video as usual,please add it to the immunology video series ,you're awesome ! thanks !

Great page! Extremely helpful

Great job, Armando!

Awesome animated lesson. I like it very much.

You are just amazing,I love you Armando ❤️

Armando, Karin Kolbe is right, peptidoglycan cell wall is huge for Gram positive bacteria and is the outermost "layer" of said bacteria. LPS is only on gram negative bacteria as far as I understand it. So you are right as far as what the TLR recognizes, but I think you got the "+" and "-" signs mixed up. Thanks for all the videos!

Fantastic video of TLRs, Armando.

Great explanation, thank you very much.

Pretty good your video, I've undesrtood very well about this topic, thank`s you

this is really helpful thank you

Loved it. Thanks so much.

Armando you are the best! Thank you!

I really did enjoy the vidéo Thank you ❤

amazing work

great presentation. I like it.

Good description, thanks

Thank you very much. It was very useful.

In single word you are GREAT

You have severely reduced the 'Toll' this topic was having on me. Great diagrams btw.

such a nice video. thank you

I really wish to buy the pdf image of this but I cant find it on your website, please advise. Thanks!

Your drawings are amazing!! I searched through your Facebook to find this specific lesson and no luck :( Can you please post it if you still have it? Thanks again for your superb lectures!

So nice to find u : )

Perfect video! Help me very much!

Ty so much

Thank you so. Much

U are brilliant 💖

Thank you

God bless your soul.

Thank you so much for the amazing explanation! Any chance to get this drawing? Couldn't find it on fb..

There is one mistake. TLR4 is for gram (-) negative bacteria.

Very nice explation ,new subscriber

Your Präsentations are very helpful but there is sometimes minor error. Example you exchanged the peptidoglaycan of gram +ve and gram -ve bacteria's. Lipopolysaccharide (LPS), which also called endotoxin, is found exclusively in Gram-negative bacteria, while lipoteichoic acid (LTA) is specific to Gram-positive bacteria.

Gram positive's do not have LPL's(it is in gram -) they have teichoic and lipoteichoic acids

Good video

I love all this and it is truly interesting to me but, I just dont know how it is possible to remember every name for every protein that does this and that etc. HOW??????

Nucleus has a double membrane, not a simple one as we can find in the plasmatic membrane

what's the difference between TCR or BCR and Toll Like Receptor?

What about the transcription of genes that make co-stimulating molecules such as CD80 and CD86??

TLR 4 Gram neg bacteria since it recognizes Lipopolysaccharide. TLR 2 for Gram pos bacteria since it recognizes peptidoglycans and lipoproteins

such amazing our body

TLR receptors are localized on both Extracellular & Endosomal membranes.

Hello, could I ask what the red strand represents on CpG? Thank you

Lipopolysaccharide (LPS) are on Gram negative Bacteria. This is recognized by the TLR-4 recptor

A small correction. Lipopolysaccharides are found on gram-negative bacteria, while LTA is found on gram-positive bacteria!

Video is tooooooooooooooooooooooooooo nice!!!! :) Psst ! IF I'M NOT WRONG - Lipoteichoic acid (LTA) is a major constituent of the cell wall of Gram-positive bacteria (and not Gram negative as You mentioned it). But to err is Human!! :) Hope You don't mind me pointing the mistake out.

Can anyone please tell me where do the toll like receptors come from in the first place? Like where did they evolve from? How are they synthesized?

I like your style!!! Great info and drawings. Subscribe

Which of these pathways result in fever?

are toll like receptors,TL3 and TL7 present in ALL cells?

good info, needs volume....

3:39, TLR5 doesn't dimerise? it does! correct me if m wrong. please

What is the meaning of toll-like? Why we call these receptors as toll-like? Thank you.

whats the difference between toll like receptors and the PRR ( pattern recognation receptor) ??? plz answer me

How can we get that image?

anyone else notice that Armando was high af in this video listen to how much slower he talks compared to his other videos

Thanks, good description.

TLR4 = gramnegative (LPS) , not grampositive

This tol reseptort Can bé found in all type of celles or juste the immunologique cells

I thought nfkb produces Il1, Il6 ?

Correction: TLRs are not only extracellular/plasma membrane-bound!

Hi dear, LTA is on Gram (+) not Gram (-)

Which molecule(s) is/are NOT normally induced by TLR signaling (TLR=Toll‐Like Receptor)? A. TNF‐alpha B. IL‐1 C. iNOS D. IL‐6 E. IL‐4

good

Good video overall but at about 4:21, you said that you skipped TLR6 among others and that TLR6 is found in the endosome. That's not true - it's found in the cell surface membrane.

LPS : Gram-negative

3:22 Gram negative not positive

Update from 2024 there are 13 TLR now , hope it helps

You say that TLR - 4 recognise the lipopolysacharide LPS in Gram +ve . Wrong because the LPS found in Gram -ve 👍👍👍❤❤❤❤ Your my best teachers 😍

LPS are on the cell wall of gram negative

If you ever think to leave youtube, do not complain if a stranger hits you in the street...that will be me jajajaja! Thanks!!!

I am very confused. Why does TLR 2 and 6 form a dimer to detect the same things as the dimer of 1 and 2?

Love u

LPS is for gram negative Bacteria... Please correct it!

How could the arn bé found out the virus cell !?

Can you quickly explain, in layman's terms, what a TLR-7 agonist is? Thanks.

big liiiiiiike & thaaaaaaaaaaanks

This isn’t right according to my microbiology book. TLR 2 = G+ (PEPTIDOGLYCAN, LIPOTECHOIC ADIC) TLR4 = G- (LIPID A) 3,7,8,9 = NUCLEIC ACIDS

TLR10 stimulation suppresses the TLR2 responce via the production of il-1ra

Are you half indonesian?

You have switched Gram- with Gram+

Toll like receptors recognize gram negative bacteria not positive

it doesnt help when scientists call it il 18 and il 1B esp if you're writing it out lol great vid btw

TLR4 supposed to be gram negative

WOW

it's leviosa no leviosaah: it´s kappa-b no kb

TLR 4 for gram negative Lipopolysaccaride

TLR5 do dimerize, dont they?

TLR 7 & Herpes & SarsCov19 . . . . . . . . . . . . . . . . . . . .. . . . . Help

please subtitles in portuguese-BR PLEASE!!!!!!!!!!!!