Inositol Triphosphate (IP3) and Calcium Signaling Pathway

Inositol Triphosphate (IP3) and Calcium Signaling Pathway | Second Messenger System

Рет қаралды 166,445

6 жыл бұрын

Lesson on the Inositol Trisphosphate (IP3) and Calcium Signaling Pathway. IP3, calcium and diacylglycerol (DAG) are important second messengers that are unregulated upon activation of a G protein-coupled receptor. Inositol triphosphate and DAG are cleavage products of phosphatidyl inositol 4,5 bisphosphate (PIP2), which is cleaved by phospholipase C. Increasing levels of IP3 lead to augmented cytosolic calcium levels that further lead to activation of downstream cellular targets.
Hey everyone. In this lesson you will be introduced to the IP3 and calcium signaling pathway. We will also discuss the purpose of the pathway, enzymes involved in the pathway, and how the pathway is regulated.
I hope you find this video helpful. If you do, please like and subscribe for more videos like this one. :)
JJ
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I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)
Thanks for watching! If you found this video helpful, please like and subscribe! JJ
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DISCLAIMER: This video is for educational purposes only and information in this lesson SHOULD NOT be used for medical purposes alone. Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.

Пікірлер: 88

@danielareyes9920 5 жыл бұрын

Thanks so much for this!! I sat through a 2 hr lecture and didnt understand but I got it here after less than 6 mins lol. You’re a lifesaver

@nishantsen6820 3 жыл бұрын

Yeah he is

@nishantsen6820 3 жыл бұрын

After 2 years to lol😅

@bhupendraavasthi5742 Жыл бұрын

OSeeez

@josephandhopelopez8492 Ай бұрын

Who created this magnificent, elegant, yet simple mechanism? The way PIP2 is disassembled into two useful parts is genius! Calcium is stored and is only released with the key (IP3), genius! This is a very controlled chemical pathway needing several keys (DAg, IP3, and Calcium. It must be responsible for very intricate balances in the cell. Thank you for making this elegant pathway simple to understand and accessible to marvel at. Thank you!

@user-di6zt6jc3b Ай бұрын

nature did 🏞. Sometimes I wonder how a human could kill another one, if they are both such attuned systems where every molecule or ion counts 😣

@CT--gs1wj 5 жыл бұрын

you should have included the activation of G alpha subunit by GPCR which then activates phospholipase C... regardless, the video is excellent.

@jacksilver2884 2 жыл бұрын

Unbelievably useful explanation, so well laid out. Thanks

@nyawirawaithaka4993 4 жыл бұрын

WoW! Best explanation I have found on this topic. Thank you!

@keurinrin16 2 жыл бұрын

Read my book for a week and I had a hard time understanding this topic. And I just discovered this video and now I understand hahah thankyou very much!Please make more videos like these

@MustafaAhmed-eh1kk 9 ай бұрын

Thank you so much! It's very simple & clear.

@lmelimelo031 4 жыл бұрын

Wow I've just discovered your channel, and it's really good ! Really simple explanation for so big pathway, you save me for an oral I have. Thanks !

@diffimalonekavunga6549 2 жыл бұрын

Thank you for this ! A life saver!

@esraa5179 2 жыл бұрын

simple and clear! thank you so much

@Esraa-mr9ce 3 жыл бұрын

Wow!! It is clear explaination to a complex pathway ...please keep on

@buho3539 6 жыл бұрын

Thank you. You have great videos. Greetings from Colombia

@pureispure3184 5 жыл бұрын

Saved my brain cells, thx

@MaitiaVangLover 5 жыл бұрын

Thank you for this!! I appreciate it!

@peggy1998qiqi 5 жыл бұрын

thank you so much! Easy and simple explanation.

@FatSpanishLaLaLadies 4 жыл бұрын

Great supplement to my notes, thank you!

@Student-jb8pe 5 жыл бұрын

Your channel is so underrated!

@andreasalazar4126 3 жыл бұрын

YOU ARE AMAZING. THIS WAS SO EASY TO UNDERSTAND! ALL CAPS CUZ YOU ROCKED IT

@sihlemnisi1310 5 жыл бұрын

Thank you. This was extremely helpful.

@cardiacmyxoma4073 3 жыл бұрын

This is perfect, thank you!!!

@krokodilledertasche8412 5 жыл бұрын

A wonderful work! Well done and Thank you👍👌

@biancalmg 5 ай бұрын

Great video, thank you!

@rohitrchavan1543 4 жыл бұрын

Saved my day!! Thank you

@sometimes418 2 жыл бұрын

The best video on this topic !

@Veronica-nx3ss 4 жыл бұрын

I think I may have a metabolic disorder, and my doctor keeps telling my symptoms are psychosomatic, I am trying to do some personal research about non epileptic childhood seizures and how that effected my metabolism. I appreciate the video in helping me better understand the concepts in the papers I am reading.

@daniahalkhatib8058 2 жыл бұрын

Thankk youuu♥️ god bless you 🙏🏽

@sanalsimon7657 5 жыл бұрын

Thanks a lot!! it helped so much.

@chidalumichelle3009 5 ай бұрын

Thank you so much for this

@QuacK_001 4 жыл бұрын

Very good video, thank you so much.

@akshayapanneer1746 3 жыл бұрын

Amazing xplaination.....i loved it so much 💖

@user-oq8oq3pf3e 4 ай бұрын

Thank you so much, I watched like 5 different videos on this topic but still didn't get it but I do now

@lionsinescanor373 Жыл бұрын

great simplification!

@emran9699 Жыл бұрын

OMG this was so a smooth explanation Thanks alot

@Ivy-nw7ny Ай бұрын

Thank u, it's really helpful❤️

@ayezageza563 5 жыл бұрын

legend ...thank you so much

@haojianli9626 2 жыл бұрын

Very helpful!

@Fienaz1010 3 жыл бұрын

THANK YOU SO MUCH!

@Kats.Aquatics 7 ай бұрын

Amazing thank you

@NourBrahimi-fv8ek 7 ай бұрын

Thank you so much ❤

@Lovefornature555 3 жыл бұрын

Beautiful

@arif-tx1hm 2 жыл бұрын

understood, thankyou🙂

@Ash-bl9ye 3 ай бұрын

Great video

@Rico7817 5 жыл бұрын

ty!! great video!

@misstulip1164 3 жыл бұрын

I fall in love with this video. 😂😂😂.No I am kidding but it’s really helpful thank u so much 💜💜💜💜💜

@ivypellerin1000 3 жыл бұрын

thank you thank you

@welkingunther4298 5 жыл бұрын

Beautiful.

@mwenimumba7227 2 жыл бұрын

Awesome!!!

@user-jh3jy7mo6m 3 ай бұрын

Very informative

@kawther6351 4 жыл бұрын

It is amazing thanks

@salamabbb 7 ай бұрын

Perfect

@songohan393 5 ай бұрын

Thank you

@anaskrazem444 5 жыл бұрын

Thank you ☺

@shiptersclumb 4 жыл бұрын

Thank you!

@qaws1103 5 жыл бұрын

Thanks a lot man

@chroniclesofmydiary 5 жыл бұрын

Great job

@Luffy-wv1kh 4 ай бұрын

excellent

@loubnadr7407 Жыл бұрын

thank you

@user-vq2oe9cs7z 4 жыл бұрын

Thank you so much that was really helpful 😻

@jjmedicine 4 жыл бұрын

You're so welcome! Glad you liked it :)

@user-vz6jp4xh2r 3 жыл бұрын

Thanks

@marishenmarindi6046 8 ай бұрын

2023 this was really helpful

@premalmartin3246 2 ай бұрын

Thank you, my physiology book did a terrible explanation along with a figure that didn't seem to go along with the explanation.

@kashifalikhan5124 6 жыл бұрын

nice video

@mahdiomidvar564 3 жыл бұрын

exactly .... you are a lifesaver

@user-ci8ho8ef4r 3 жыл бұрын

💖💖💖💖

@hybridhelix88 5 жыл бұрын

Sinply the best !

@nurfatihahmohdshariff6136 5 жыл бұрын

👍🏻👍🏻👍🏻

@setsunee 3 жыл бұрын

Hello I have a question, what would cause this pathway to be terminated or stopped? Thank you.

@tiptrick7762 3 жыл бұрын

Tro cool z'espere zaurait 20 sur 20 grasse à toi

@hklena6274 5 жыл бұрын

Great video, just a quick question. Is it not the sarcoplasmic reticulum (rather than endoplasmic) that calcium is released from into the cytosol?

@exiar359 5 жыл бұрын

The sacroplasmic reticulum exists only in muscle cells but I believe the video is talking about a typical body cell.

@sandradee9511 4 жыл бұрын

thank youuuuuuu

@sobialaghari225 4 жыл бұрын

But why is PIP2 no second messenger? It does it work too right?

@giomaraustria2371 5 жыл бұрын

What is the specific ligand

@nesmajawahar7926 Жыл бұрын

Can u tell hw its getting degraded ?

@blackpearl3349 4 жыл бұрын

You have to rename this video how to save your life in less than 6 min ❤️thx ❤️❤️

@jjmedicine 4 жыл бұрын

Haha - glad it helped :)

@sarasims2207 4 жыл бұрын

include the calmodulin and myosin light chain kinase

@esthersim1974 4 жыл бұрын

U da bomb

@jjmedicine 4 жыл бұрын

Thanks :)

@alima9353 4 жыл бұрын

i think i love u

@daedra40 4 жыл бұрын

DAG MAG TAG

@brigienmartin1485 4 жыл бұрын

Hey whatz up

@ghassanauf8103 4 жыл бұрын

DDDDaag