Live Longer with Fasting? | Educational Video

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Live Longer with Fasting? | Educational Video | Biolayne

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Күн бұрын

A recent video by Ben Azadi has gone viral claiming that eating every 2-3 hours will shorten your lifespan due to raising blood glucose more frequently which is going to lead to greater level of blood glucose long term & thus increase inflammation and shorten lifespan.
Ben makes a common mistake that many scientists make, assuming that short term acute changes are predictive of long term metabolic disruptions, but that is not born out by the data. For example, one study found that feeding obese men a high sugar diet where most of the calories came from sugar, refined white rice, and fruit juice still led to an average of 140 lbs of weight loss due to calories being restricted. Interestingly their blood markers of health, including blood glucose, IMPROVED SIGNIFICANTLY despite significant postprandial elevations in blood glucose and was effective for treating type 2 diabetes:
pubmed.ncbi.nl...
pubmed.ncbi.nl...
For another example, eating a high fat meal actually increases endotoxin more than smoking 3 cigarettes in the short term, but high fat diets do not increase long term inflammation if overall calories are controlled:
pubmed.ncbi.nl...
pubmed.ncbi.nl...
Heck even protein stimulates mTOR which many longevity experts have argued is 'bad' since mTOR is more active in many cancers:
pubmed.ncbi.nl...
According to Ben's own logic, we probably shouldn't eat anything EVER since it's going to elevate 'bad' things in the short term. The reality is that acute changes in blood markers & signaling mean very little for long term outcomes.
Finally, he implies that intermittent fasting improve lifespan, but this is not really supported by the data as an effect that is independent of calories. While intermittent fasting can improve lifespan, it appears to be tied to its effects on reducing caloric consumption. Further, the only studies demonstrating this effect are in rodents, while the most applicable studies have used Rhesus Monkeys. Normal caloric restriction (no intermittent fasting) has been demonstrated to increase their lifespan approximately 10-15%:
journals.sagep...
www.ncbi.nlm.n...
One study claimed to show a unique effect of intermittent fasting that was independent of calories in mice, however in their own data they demonstrate that one of their fasting groups had a LOWER bodyweight than the non-fasting group, indicating that they did indeed consume less calories:
www.ncbi.nlm.n...
Until this limitation is addressed or other studies show similar effects in species that are more applicable to humans, it is irresponsible to claim that meal frequency effects longevity independent of calorie intake
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Пікірлер: 324

@shrimuyopa8117 3 жыл бұрын

So basically if I just stop eating food all together, than I will be immortal! Getting started on this right meow!

@bastipear2864 3 жыл бұрын

You won't grow old, that's for sure

@yoijoe13 3 жыл бұрын

Terns out it works but u just keep getting hungrier

@RRaider 3 жыл бұрын

Haha, look up breatharians.

@valentinrafael9201 3 жыл бұрын

Yeah, I mean, haven’t you heard of breatherians?

@kamo7293 2 жыл бұрын

no. you get to meet god

@para_bellum_1984 3 жыл бұрын

I love these calm, mature, professional, untriggered videos, Layne, keep em coming!

@bengaloux 3 жыл бұрын

Totally agree. HOW-E-VER, do also keep coming videos where you bash and yell and laugh at morons :D

@theotheodorou1374 3 жыл бұрын

what do you mean un triggered , he was ready to explode LOL

@linusjacobsson2419 3 жыл бұрын

Man u gotta keep these videos going. So informative, educational and pedagogical. Great work Layne

@crikeymos22 3 жыл бұрын

Omg Layne, I owe you so much. I can happily keep on track with healthy eating because of you. I would have gone to the dark side so many times with peoples uneducated post. Thank you so much.

@louisdockery6674 3 жыл бұрын

Great explanations, Layne. I love how you not only break down the details and use the technical terms, but also use simple analogies so that none of these details go over our heads.

@titanmaximum239 3 жыл бұрын

Spitting facts my dude. This is one of the best channels out there.

@rcoop2177 3 жыл бұрын

I actually really appreciated the sincerity and focus on the data and education in this one. Sometimes sarcasm is just confusing. This was very helpful.

@aalasad1 3 жыл бұрын

Layne keeps saying "Guess what," "Guess what"... Another great educational video. Thanx Layne always delivers.😎

@simonlamey164 Жыл бұрын

Keep doing these vids Layne - epic analysis and interrogation of the actual data

@TeamYouphoric 3 жыл бұрын

If you want to age faster than anyone you know, become a heavy smoker and drinker.

@yoijoe13 3 жыл бұрын

U forgot no sleeper

@instantsiv 3 жыл бұрын

Or be president. Their before and after photos show some pretty amazing results.

@johnsmiff8328 3 жыл бұрын

@@yoijoe13 Is there any research that proves you have to sleep? 4 days after I quit sleeping I felt my spiritual presence grow closer to God and every day since then he tells me more Wonders of his beautiful Creation.

@simstar6557 3 жыл бұрын

@@johnsmiff8328 those are called sleep deprivation hallucinations.

@johnsmiff8328 3 жыл бұрын

@@simstar6557 It's _healthy_ and it's how God is so close to me. God speaks only to the Strong who swear off their vile addiction to sleep.

@wolfenhauz 3 жыл бұрын

The point about working out raising all those blood markers in the short term was so well made. Great content. Thanks for this!

@krzysztofgorczynski6721 3 жыл бұрын

Dr Peter Attia and dr Ronda Patrick agree that you should alternate eating and fasting periods, e. g. Dr Attia fasts for 7 days every 3 months. I thought this is pretty much a consensus in the scientific longevity community- the fasting periods are to probably activate autophagy (it's not sure what period activates it in humans, but that's what they predict based on the data). Would it not be beneficial to do what data may indicate, even if it's not 100% sure? Because it may not be sure in our lifetime. Is it not optimal to alternate eating and fasting periods to potentially achieve the autophagy-depletion and then regenaration-growth effect? I'd be very interested in Your thoughts.

@biolayne1 3 жыл бұрын

I don’t care. Their opinion is not data

@dannywitt5160 3 жыл бұрын

Layne, longevity scientist do NOT believe mTOR is bad (thats not true), they believe we (humans today) have mTOR turned on to long and need a balance between mTOR and AMPK signaling pathways.

@Sisyphusmyth1993 3 жыл бұрын

I find that sometimes Layne is overexaggerating someones words, just to make a point himself. And I agree with you.

@dannywitt5160 3 жыл бұрын

@@Sisyphusmyth1993 He is bad to devalue a lot of potenially good interventions.

@miharijavec4605 3 жыл бұрын

@@Sisyphusmyth1993 yes... but he is easting every 2 hours... so he cant do that "knowing" and telling about AMPK ;)..

@daniel-zu4kp 2 жыл бұрын

I think he’s saying that if you add up the time mTOR is on is the same, i.e three short periods throughout the day or one long period with something like omad, it’s more of how much than when.

@knockingseeker 2 жыл бұрын

@@daniel-zu4kp he also tries to say a higher protein diet doesnt effect longevity ehre the studies show that its not only caloric defecit that increase longevity its dierectly related to anamal protein. He cherry picks data

@jamesluscombe1234 3 жыл бұрын

Be good to hear you and Peter Attia chat about fasting

@Cymricus 3 жыл бұрын

was thinking the same.

@Multifidi20 3 жыл бұрын

He was on Peter's podcast not too long ago. They plan on doing another one I think.

@blainebowling3303 3 жыл бұрын

That podcast is where I first heard of Layne. Peter said his priority this coming year was to add some muscle mass so he was going to cut back on fasting. I don’t believe they disagree on most points nutritionally. They both understand time restricted eating is a tool in the box that can control calories… The thing they didn’t discuss was autophagy. The future podcast is going to be on leucine, which is Layne’s area of expertise

@justinhurren6818 3 жыл бұрын

The visual quality of your content has definitely improved. Nice job, Layne! Thanks for the info!

@AislingDonohoe 3 жыл бұрын

You deserve way more views and subscribers on this channel.

@qT_p13 3 жыл бұрын

i like the way you explained the short term effect vs long term effect subject. your vids not only educate us as viewers, but also helps us relate the information to others.

@swiper1131 3 жыл бұрын

I love that Layne has such good control of himself that during these educational videos he never drops a single curse word (or maybe he does and they reshoot and edit it 😂)

@ilmostro16 3 жыл бұрын

I just find IF a much easier way to control total calories. Eating many tiny meals is not only inconvenient but I’m hungry all day long rather than just pushing through the morning until lunch time.

@jasonthomas4928 3 жыл бұрын

Layne hittin us with hard facts 🔥

@petersmith8871 3 жыл бұрын

Great video Layne! I wonder what you'd say in the regards to biologist and geneticist David Sinclair who is a big proponent of infrequent meals for increasing lifespan. It seems he has recently switched from two meals per day to one in the evening. I believe he says that eating infrequently strengthens the body through hormesis, autophagy, and activating genes that are associated with longevity. Another argument for this pattern of eating is that that this eating pattern likely more closely mimics early humans dietary pattern and therefore it makes sense that it can work for us, too.

@stevenbauer5727 3 жыл бұрын

D. Sinclair to came to my mind too, a reaction would be nice

@biolayne1 3 жыл бұрын

Based on research in fucking yeast 😑

@PinataOblongata 3 жыл бұрын

Yes, it's because metabolic "modes" take time to switch into. You can't be in ketosis within 3 hours of not eating or the fast you undertake whilst asleep. You see different pathways activating all the way along from a few hours to a few days to a week of not eating. Even fasting for a whole day is likely not going to cause autophagy in the average person (can take up to 4 days), but obvs if you are already on a sub-maintenance diet, that will happen sooner. Would be great if Layne could let us know if this was something he wasn't considering, or if he thinks autophagy is just not a big deal to longevity or not well evidenced enough, or something.

@G_Doggy_Jr 3 жыл бұрын

@@biolayne1 I've nothing against intermittent fasting or whatever. However, a lot of the fervent enthusiasm towards those diets often seems inspired not by data from human trials, but rather, by some charismatic figure who endorses it, or by some catchy analogy about how our body works, or some story about how how our ancient ancestors must have lived. These aren't terrible reasons to adopt a diet, but they are trumped by good old data from scientific experiments which show how the human body *actually* responds to certain diets.

@petersmith8871 3 жыл бұрын

@@biolayne1 Really appreciated, thank you Layne for clearing that up. That is one key piece he doesn't seem to mention during his interviews. ....In light of this, and since calories don't matter as many would like us to believe, I will ramp up my bread and beer intake to reap some benefits from the hungry yeast hehe

@kieranwhittemore1010 3 жыл бұрын

"you HAVE to eat at SOME point" LMAOOO

@josephr.9360 3 жыл бұрын

Layne’s videos and info are always 🔥!

@justwatchingyoutube3285 3 жыл бұрын

I have really enjoyed your videos.. I just found them a few weeks ago and absolutely enjoy the research you back up with these talking points.. keep it up brother.

@MarcRitzMD 3 жыл бұрын

l believe you are being reductionist by summarizing the negative effects of inflammation by equating outcomes of similiar areas under the curve. One could speculate that long fasting cycles with correspondingly short feeding and inflamed states would optimize healing. That is what working out is after all. You train for two hours, rest for 22h. Heartrate and blood pressure spike. We know however that this is beneficial to cardiovascular health. What about 40 min of training, 3x a day? Same area under the curve but I'd expect different outcomes. What is healthier? A short spike in blood pressure or a prolonged elevation to a proportionally smaller degree? I'd expect different health outcomes despite same area under the curve. Overall, it comes down to whether you'd want inflammation to spike or be chronically elevated. The mechanisms by which the body tries to mitigate them are uncountable but many of them will work better in one scenario over the other.

@biolayne1 3 жыл бұрын

It’s not reductionist. It’s data

@MarcRitzMD 3 жыл бұрын

@@biolayne1 that is such a lazy response

@limoric1 2 жыл бұрын

I totally agree. Layne is clearly very smart and educated, but he’s reducing himself in the same way as the IF evangelists. Longevity scientists have never suggested mTOR reduces lifespan, it’s the over expression of mTOR, just like the over expression of insulin “can” lead to metabolic disease. Humans naturally fasted longer before modern times. Yes obesity is the leading cause of diabetes, however there is also a significant increase of diabetes in normal weight people. I’ve discovered this can be due to stress and cortisol. I started 16/8 IF 8 years ago before a single fitness influencer discovered the marketing potential. I tried it because of the research on life extension and growth hormone increase. A few months in, I discovered I wasn’t experiencing hypoglycaemic events anymore. Something that would happen if I ate in the morning and didn’t have time to eat until mid afternoon. This was generally coupled with high cortisol levels due to stress. I’m normal weight and had dealt with this for 20 plus years. Doctors tested me twice for diabetes. Sure I could have managed the hypoglycaemia without fasting, but busy life and obligations made it really difficult. For 20 years I followed the diabetic diet (bodybuilding diet) of 6 meals per day. It got progressively worse. IF has been a game changer, hypoglycaemia is not fun.

@Supernaturalman92 2 жыл бұрын

@@limoric1 humans fasted because they had no access to food. Keep in mind our ancestors who would fast from days to weeks also did not have a life expectancy the exceeded 30 years

@limoric1 2 жыл бұрын

@@Supernaturalman92 life expectancy is a misleading statistic. In 1800, the child mortality rate in the US was 46.3%. Life expectancy was about 35 years. Using today’s child mortality, life expectancy would be around 68 in 1800. That still accounts for disease, war, etc. A Roman who survived birth, did not fight in war and avoided disease, could expect to live into their 70’s.

@MarcRitzMD 3 жыл бұрын

I'm not sure I'm comfortable with "short-term does not predict long-term". Eventually, it comes down to short-term mechanisms being representative to those that happen long-term. If we don't expect short-term to be predictive of longterm, then all initial testing needs to be done long-term to begin with. That isn't the case tho. You start with short-term studies with the assumption that they might also hold up long-term

@NJN23 3 жыл бұрын

didn't you hear his example about short term vs ling term when it comes to exercise? Short term and long term are two different things

@MarcRitzMD 3 жыл бұрын

@@NJN23 it isn't relevant to my objection

@biolayne1 3 жыл бұрын

It’s like you can’t read…

@kristerpresty8033 3 жыл бұрын

This is needed in todays longevity discussions

@BearFackerr 2 жыл бұрын

After a long and painfull IG discussion this is just what I needed, and I like it. Well done!

@lucabalestra1638 3 жыл бұрын

Thanks Layne, great video.

@justinjaya9268 2 жыл бұрын

@biolayne can you please make a video regarding longevity and eating protein from animal/plant sources and also whether fasting like a couple days improve lifespan as Leo and Longevity claims?

@anastasiam1797 3 жыл бұрын

Thank you for the video. I'm really new to nutrition and training and have been learning a lot from you

@r.guerreiro140 2 жыл бұрын

What about authophagy, delaying telomeric erosion and hormesis?

@buddymonkeys 2 жыл бұрын

I agree 100% that short term affects do not mean that that will continue on to the long term. However In the clip you showed the person said eat every 2-3 hours. Even if the short term is only say 1.5 hours, your negative short term affects become half your day, and if you continue to eat every 2-3 hours every single day, Your short term becomes so regular that it becomes a long term affect.

@gustavocubac 3 жыл бұрын

As usual Dr. Layne cleaning the air !

@Solidfreeman01 3 жыл бұрын

Very much precious information in detail. Great vid!

@MarkyMark11J 3 жыл бұрын

I was hoping you would make a video on this topic. I literally just watched a video from a general but popular science channel on "how to slow aging" ; and some of this fasting talk was mentioned at the end of the video that suggested longevity benefits in doing so. But being that this issue is better suited to your wheelhouse; I'm glad to see you've sliced the "fasting = longevity" belief down to what's really going on.

@KineticKitten 3 жыл бұрын

Great video, thank you! I was hoping you would cover some of the diet/lifestyle and longevity claims out there as it's such a hot topic. Could you please also talk about at which point caloric restriction goes from being good to someone to being bad for longevity/health, and why? There's a point where leaner/more CR is detrimental, but where? Is there reliable data on this (the monkey/mice studies are debatable)? Where does that lower BMI limit of 18.5 come from?

@mcfarvo 3 жыл бұрын

Keep debunking these charlatans, Layne. God bless you

@brianbland4837 2 жыл бұрын

Can we evaluate the caloric intake/needs of large mammals that have different meal timing such as a gorilla and a lion? I’m not a zoologist but it seems like the gorilla is not a fan of fasting whereas the lion seems to have extended periods of fasting.

@Kilo_of_Milk 3 жыл бұрын

One word...autophagy, you don't get that from regular diets

@MusiFitNomad 2 жыл бұрын

You need to use an audio compressor for when you raise your talk, so you don't hurt our ears if we use headphones

@jack-0134 3 жыл бұрын

OMAD is best choice I’ve ever done about diet !

@lombardo141 2 жыл бұрын

OMAD fan here also got me to my weight goals. Am still doing it because it works for me.

@justanotherytaccount1968 2 жыл бұрын

What about 3-7 day fasts (Peter Attia style) with the intent of increasing autophagy, etc.?

@rahulprashar168 3 жыл бұрын

Calories equated, macros equated, does shorter eating window improve insulin sensitivity (area under curve of insulin)? If yes, does that promote longevity because glucose disposal mechanism improves? If yes, does the positive effect of more efficient glucose disposal negated by a possible poorer body composition (loss in lean tissue percentage) due to time restricted eating? What is better for longevity, better body composition (more lean tissue) or more efficient glucose disposal mechanism (better insulin sensitivity)?

@joesimon8479 3 жыл бұрын

I like to fast because it is simply easier than counting calories, also I am Catholic and there is a religious element for fasting. ,

@Trainfeastfast 2 жыл бұрын

👏🏽👏🏽👏🏽👏🏽👏🏽

@rk28984 3 жыл бұрын

Good video! I do IF but it's because I found out that I feel better not eating for the majority of the day. It's also better for my line of work as I work in an ER and sometimes I don't have the time to stop and take a break.

@jameswoodall9261 3 жыл бұрын

I agree! I IF just cause it makes me feel good. And I work out very hard in the gym. Not trying to lose weight buts excess fat is gradually going away. DI like that "hollow" feeling. My posture is better. Not because of IF but I just feel better.

@rk28984 3 жыл бұрын

@@jameswoodall9261 That's great! I lost around 40-50 pounds since I started IF, but I think it's because I can't eat as much as before. I only eat in a 2-3h window now because I don't have more time in the day.

@jameswoodall9261 3 жыл бұрын

@@rk28984 Good for you. I know IF has really been blown up but even if all the claims arn't true, if it works for the person, that's sgood enough. But it's not a magic pill. You're doings your part also. If you can find any time to exercise it will make a difference. Doesn't have to be the gonzo stuff I get into either. Small amounts will make a difference. And yes, walking will do just fine.

@OffTheGrid1982 3 жыл бұрын

We would only know that if everyone in their late 80s 90s and 100s told us by the way I have been fasting for decades etc. Its nice to think we have the power to potentially add years

@phoenixgirl11 3 жыл бұрын

So it comes down to calories consume,not intermittent fasting?

@AdventFate 3 жыл бұрын

Yeah. For example, you can fast for 23 hours a day, if that one hour you eat Little Caesars and a pint of ice cream every day, that's 4000 calories, so you would still get fat.

@bac0129 2 жыл бұрын

@@AdventFate What if I ate all of that once daily but at 0600 breakfast?

@amygreen9662 3 жыл бұрын

It seems they really want the best way to be to just not eat. SMH. How about eat a balanced diet. Eat when hungry. And exercise?

@yoijoe13 3 жыл бұрын

That's to ez and logical for them

@Magic_beans_ 3 жыл бұрын

That’s what happens when people attach their identity to their beliefs. It’s not enough for their chosen diet (or parenting style or investment strategy) to be just as good as other options, it has to be better.

@nikolaibocherov8107 3 жыл бұрын

Great content as always

@DDSmohannad Жыл бұрын

Big fan of your videos. But i have to say, intermittent fasting made it possible to control my hunger and cravings and get into calories deficit without feeling hungry all the time. It’s a great tool.

@MXDRE907 2 жыл бұрын

I’m not a fasting die hard or anything but didn’t someone win a Nobel prize on autophagy? I thought he discovered all kinds of benefits on the cellular level from a 36-72hr fast? Not saying doing that every 3 days is good either but, would doing something like that once every 1-3 months be beneficial? Obviously for those who are eating at a surplus but, are you saying there’s no additional benefits for those who eat in an overall deficit or those who are in a healthy weight and lean/muscular and eat at maintenance either?

@damo7776 Жыл бұрын

Love the content 👌Always

@ExdruidGaming 2 жыл бұрын

Since this is a relatively recent video I'm hoping to get some sort of response here. While I understand that the gist of lifespan improvements is simply due to calorie restriction, what does the data say about other lifestyle/lifespan diseases and regular bouts of long term fasts, like 24-48 hours? My main thought here is the effect of the autophagy response in longer fasting periods (Which I know can also be induced by hard exercise.)?

@Fighter58773 2 жыл бұрын

So important video thank you!

@Asphesteros 7 ай бұрын

I wish he talked a bit about personal glucose tolerance (and personal fat threshold) he talked around it, but it’s actually pretty unsurprising- glucose only matters if it’s above your ability to tolerate it, which, like everything else in the world, isn’t so delicate as anything fractionally above some baseline. Humans have wiggle room. And also like everything else, which his does point out, humans can even exceed their limits occasionally and recover from it. You don’t lose a year of your life with every single hangover, better believe a doughnut isn’t going to be worse. But live above your limits, yea, of course you wreck yourself

@przemysawj6499 3 жыл бұрын

BEST. CHANNEL. EVER.

@hyperretroactivehyperretro5992 Жыл бұрын

Eating constantly over a lifetime increases the need for more insulin. This leads to higher blood pressure and arterial damage.

@Lesminster 3 жыл бұрын

I think it is about autophagy with fasting, but that requires pretty drastic fasting that would be very destructive if applied too often. This is that part of fasting that may actually make a difference in longevity.

@mcfarvo 3 жыл бұрын

That still may be making the mistake of conflating acute spikes in autophagy versus chronic levels or basal levels in the long term

@BMGipe45 3 жыл бұрын

I think the effects of autophagy have been grossly exaggerated to seem like this miracle drug type effect, just like most aspects of these fad diets tend to sell so you join their cult instead of the next.

@Magic_beans_ 3 жыл бұрын

Layne’s talked about autophagy before, for example here: kzfaq.info/get/bejne/hLKcY6eLp7aWh6M.html Long story short, it’s not something that IF unlocks, it’s something that already happens. Many actions and conditions can increase autophagy, including exercise and caloric restriction of any sort.

@loganwolv3393 2 жыл бұрын

What about autophagy then? Like if you compare 2 approaches where 1 is just plain old calorie restriction and one OMAD but control have both of them in an identical calorie deficit. I'd be intrested to look into that.

@laurent.2350 10 ай бұрын

Thanks! I found fasting stressful. I am at moderate to high activity. I initially lost weight because of calorie deficit but then calories ended up too low. I could tell that my metabolism slowed because I plateaued. When I had to add calories back, it was hard and actually uncomfortable when I only had 8 hours to eat. Protein is very satiating and I just wasn’t hungry enough to eat 100 g of protein in 8 hours! Now that I’m eating smaller amounts throughout my waking hours, I feel better and my clothes fit even better. I lost an additional two pounds since I stopped fasting and increased calories by 300.

@sarabennett6295 8 ай бұрын

I lost more weight when I'm not starving myself. My body stopped holding onto every single calorie and worked better when it knows I'm eating regularly

@davidwelburn 2 жыл бұрын

I understood there were health/longevity benefits from early time-restricted feeding (eating morning/afternoon, but not evening). Is this not correct? Also, we need data on longer fasts, and whether that improves longevity.

@Dustin_Amberg 3 жыл бұрын

So very helpful! Thank you for doing these videos! It has helped my wife and I so much to stay focused on what matters when eating and dieting and allowing us to enjoy life. Also thank you for your amazing products we use carbon diet and the workout builder. Awesome stuff!

@marcdaniels9079 3 жыл бұрын

Another brilliant science based video. We need more. Please👍

@bethadams2752 3 жыл бұрын

Another fantastic video! Thank you! I'd love to see you do one on the belief that "too much" protein "makes you fat." Oddly, I've had several female clients come to me lately with this concern. They're convinced that if they eat more than ~40g/day, they'll suddenly tip the scales.

@mr_wright_official_ 3 жыл бұрын

What is your opinion on Leo and longevity's channel? In general. Also, don't take this the wrong way, but your Mike audio is terrible in this video, very muffled.

@jamesm.9285 2 жыл бұрын

I would love to hear your thoughts about mitochondrial uncoupling in response to TRF and dietary polyphenols & MCT's and the potential impacts in humans. Your content is a true gift Doc. 🙂

@Deciden0w. 3 жыл бұрын

So explain to me why Layne still doesn't have over a million subscribers?

@outerspacing9207 3 жыл бұрын

Hard to get to a million subs man. Especially Layne is very educational. Most channels that have that many subs are more entertainment based. Now to me Layne is entertaining as well. But to answer your question, yea I answered it.

@Deciden0w. 3 жыл бұрын

@@outerspacing9207 Well I like that Layne has kept it real all this time and didn't dilute his content. Hope he gets more subscribers soon though

@artemike Жыл бұрын

No wonder he doesn't

@Macgee826 5 ай бұрын

Because he has a personality disorder and lots of people can't stand him including me!

@robertnaus88 3 жыл бұрын

from my experience this is highly individual, some people just feel better eating often, others less often and more. you do you.

@auseryt 2 жыл бұрын

Very interesting and clarifying. But a question: i read a study that fasting increases stem cells production especially on older people. What's your position on this?

@Seanonyoutube 2 жыл бұрын

I find the term “caloric restriction” so confusing. It sounds like eating at a caloric deficit for life will make you live longer. Does caloric restriction just mean eating at maintenance?

@bills6583 3 жыл бұрын

love the editing!

@zwanzikahatzel9296 2 жыл бұрын

For those who remember the BBC documentary with Mosley, which started the fasting craze, it was clear from the doctors in the doc that CR is the driver of longevity, fasting and intermittent fasting were just presented as tools for making CR achievable in the general population. CR is notoriously miserable. Doctor Valter Longo had an interview where he belaboured this point at length, there are studies with monkeys where they lead incredibly miserable lives under constant CR and deprivation, while the bulk of the same longevity effects could be achieved with small bursts of fasting (5 days a few times a year). In the doc they showed that 5 days fasting can halve igf1 and keep it relatively low for a couple of months. Mosley did the less extreme 5:2 version and showed nice effects, which he considered easier than the 5 days prolonged fast approach. fasting originally was presented as just a hack around CR to make it doable for most people, then came the gurus along and magical thinking ensued

@claudiucosar 2 жыл бұрын

very well said. it s a tool for ending result of caloric restriction however true being all my life in a caloric restriction can make maybe lifespan increase however health span would go down.

@coletcyre 3 жыл бұрын

I used to utilize IF when I had a busy school schedule, it made sticking to the restriction window extremely easy. Once I got out of school and had a more free schedule, I swapped to caloric restriction by increasing fibre. Applicability, adherence and circumstance will be the deciding factor in what 'diet' protocol works for someone. I never bought into the blood sugar spike nonsense cause it all sounded like marketing tactics to me. Having said that I do enjoy practicing an extended fast once a year, simply cause it helps me psychologically retrain my hunger cues.

@laurentweisgerber3846 3 жыл бұрын

So is there actually a Study or Data which shows if Autophagy has any real life benefits apart from all the theoretical ones?

@chewher4171 2 жыл бұрын

Students always ask why I hardly lose my temper at their antics, in a way I know they will be better in the long term. How they choose to act in class doesn't really define them. I know my time is coming to an end eventually and that they are the next generation.

@ghostman824 3 жыл бұрын

Hey layne, I was taught that it's thought that eating excess and trying to grow shortens life expectancy due to mitosis. Seeing cells only have a limited number of times they can divide before telomeres shorten and chromosomes get affected and cell cycle turn to apoptosis as checkpoints find errors. Obviously environment and diet plus lifestyle habits can keeps telomeres there at different lengths but yeah, that's where I think the fasting myth came from?

@ryanz2919 3 жыл бұрын

Great video!

@joaomanaia 2 жыл бұрын

Love your videos! 👏

@Luke-tm6oo 3 жыл бұрын

Dude have you reviewed the vertical diet?? If not we need that one peer reviewed.

@ashurany 2 жыл бұрын

Correction Layne. In the context of eating healthy and exercising, the scientific evidence shows that acute responses such as mTOR, cortisol, insulin increases ARE predictive of long term outcomes, just that they are not predictive of *negative* long term outcomes. Of course you're not wrong, it just amuses me how you have to clear this up for some people who should understand this somewhat of a paradoxical idea implicitly.

@biolayne1 2 жыл бұрын

What science is this? Please feel free to make a citation

@ashurany 2 жыл бұрын

@@biolayne1 My comment was rather clunkily stated. I was merely attempting to support your central point (w/tongue in cheek) about the confusion between short-term acute effects and chronic effects. Take resistance training e.g., would not the rise in cortisol or the microtearing of muscles from weightlifting--i.e. ostensibly short term *negative* effects be predictive of or associated with long term positive effects?

@Macgee826 5 ай бұрын

@@ashuranyyou're wasting your time and energy mate he ain't interested in anything you've got to say.

@4uto_4ddict 2 жыл бұрын

Yep, long overdue…I’m subscribing.

@LaSource911 2 жыл бұрын

It makes sense that eating equated calories over many meals or during a time restricted window should have similar outcomes. However for foodophiles like me, I am much more likely to overeat if grabbing food regularly during the day than when intermittent fasting. So for me it is not the fasting itself that gives the benefit, but fasting enables me to just eat less and not go off piste! :)

@AngelTyraelGM 2 жыл бұрын

same goes for weight loss, i had trouble or at the very least felt really hard loseing weight with calorie restriction, yet i can do water fasting 1-4 days quite easy, and not overeat when done, or maybe a bit just first day after, still overall big caloric restriction, + i get a massive mental boost seeing weight drop by the day and not just the water weight, altho that honestly still gives a nice mental boost as well xD

@-tendinitis 2 жыл бұрын

Sounds like the gym guy that says when he lifts he gains muscle easily last time he worked out for a 2 months he gained 10lbs of muscle and believes what he says.. so he doesn’t work out that often otherwise he will get so big! Some girls say the same thing, they get too muscular so they don’t like lifting weights often 🙄

@gstlynx 2 жыл бұрын

Thank you, thank you. I really need to hear the common sense breakdown sometimes because I am susceptible to the simplicity of extremes.

@musikinspace 2 жыл бұрын

I think you are wrong. All of that is David Sinclair's wheelhouse. He is much more familiar than you with the literature as a whole, and he says the longevity effect of fasting is universal as far as he can tell from the research, and that fasting works better than just caloric restriction, according to the research.

@lukaspasak7339 Жыл бұрын

What do you think about the longevity diet by Valter Longo?

@zachuttke 3 жыл бұрын

I work at the NIA :)

@theoneandonly668 3 жыл бұрын

Fasting is a great tool.. but if it’s all you do it sucks, your whole day revolves around waiting to eat and you end up just killing time to get to your eating window.

@RO-LDSLNGR 3 жыл бұрын

Great stuff you my dude. What happened to kiefer?

@balazshajdu3018 2 жыл бұрын

I love these videos.

@lombardo141 2 жыл бұрын

I don’t care what you say or what any doctors say. Over 50% of Americans are overweight or obese. High carb, low carb, vegans, vegetarian it don’t matter. Calories in, calories out and move more. 🤦‍♂️. Stop making it so complicated!!!!

@paul11ful 3 жыл бұрын

I am doing fasting not for the weight but for the autofagi. Please do a video on this subject.

@G_Doggy_Jr 3 жыл бұрын

kzfaq.info/get/bejne/hLKcY6eLp7aWh6M.html&ab_channel=biolayne

@apothe6 3 жыл бұрын

Good video Layne

@choboruin 2 жыл бұрын

Super educational stuff what I've taken away from this is intermittent fasting has 0 health benefits? Outside of being a tool to restrict ur calories / possible eating window? Wow... That's depressing lol

@ogonwaneri5553 Жыл бұрын

What about skinny diabetics? What's making them insulin resistant?

@contentlemur5311 3 жыл бұрын

Damn finally o voice of hope on YT

@Persto1208 2 жыл бұрын

God I’m so happy I found this channel

@joerockhead7246 3 жыл бұрын

Party on, Layne!

@user-cf4jj8gb8p 2 жыл бұрын

tell that to my Italian aunts who all lived past 100 lmao waking up with coffee and pastries every morning and throughout the day never mind all the pasta, bread and butter!