Low Dose Naltrexone (LDN) - Mechanism of Action

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2 жыл бұрын

Low Dose Naltrexone (LDN) - Mechanism of Action
LDN is used for chronic diseases, multiple sclerosis, autoimmune thyroid disease, and various cancers. Let's review its mechanism of action.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Wednesday, Feb. 2 2022
Naltrexone | Naltrexone - Bupropion Combination - Mechanism of Action
psychscenehub.com/psychinsigh...
IL-6 in Inflammation, Immunity, and Disease - PMC
www.ncbi.nlm.nih.gov/labs/pmc...
Ventral tegmental area - Wikipedia
en.wikipedia.org/wiki/Ventral...
Mesolimbic pathway - Wikipedia
en.wikipedia.org/wiki/Mesolim...
Striatum - Wikipedia
en.wikipedia.org/wiki/Striatu...
Frontiers | Naltrexone Inhibits IL-6 and TNFα Production in Human Immune Cell Subsets following Stimulation with Ligands for Intracellular Toll-Like Receptors | Immunology
www.frontiersin.org/articles/...

Пікірлер: 531

@stephaniekelly3223 2 жыл бұрын

All of your discussions are great, but I had to comment on this one- outstanding teaching!! The way you presented this makes it so clear and easy to understand. Your visual drawings and verbal analogies such as "... imagine you are in a room half filled with water..." help to clarify concepts which may not be so easy to conceptualize. Not sure if teaching has been something you have worked on or it just came naturally, but either way we are lucky to have access to your wonderful teaching- thank you!!

@kerrymartin7557 2 жыл бұрын

He is a pretty talented guy!

@altheeaself76 2 жыл бұрын

He is awesome 👏

@ernairvine6810 2 жыл бұрын

YES totally in agreeance with that input!!

@Tinky456 3 ай бұрын

I agree. Really great. Who can prescribe me, my GP is ignorant of these things. I can't even get a rheumatology referral!!

@tonyaaberli5145 4 ай бұрын

Thank you for this. I have Gulf War Illness and have inflammation of my joints but all blood tests have been normal. I don’t think I have ever had my IL6 checked. I’m trying LDN now praying it helps.

@Sungodv Жыл бұрын

LDN needs to be more widely prescribed to patients from compounding pharmacies. I have taken LDN for over a decade with no side effects

@samanthatorres9517 5 ай бұрын

Did you take it consistently without stopping? What happens when you stop?

@Sungodv 5 ай бұрын

@@samanthatorres9517 Yes. I did stop here in the last few years, but have gone back to it to help with long Covid (china's SARS CoV2)

@TheGodWalk 2 жыл бұрын

I’m so glad I stumbled on this video. I’ve been using LDN for 4 months now, since I went to see a new functional doctor for mast cell activation dysfunction (MCAS). It was an absolute godsend, especially as I had covid in June and then again in December last year. I’m also epileptic. My histamines were flaring all the time and I couldn’t get a good night’s sleep. From the first night I took LDN, everything calmed down and I sleep like a baby now. I’m also so much more motivated and content in every way. I have a much better tolerance to exercise. It’s an amazing drug for anyone battling with nervous system or autoimmune disease.

@ScottDieken Жыл бұрын

Wow i hope it has the same effect on sleep for me. I can't sleep without xanax, and my doctor won't prescribe it.

@beatricejacobowitz7264 Жыл бұрын

May I ask what dose you started at and what dose you found most helpful?

@TheGodWalk Жыл бұрын

@@beatricejacobowitz7264 I use 1.5mg at 21:00 every night.

@leannshort2211 Жыл бұрын

I think a leaky gut is also a very real issue. I am currently doing the GAPS nutritional protocol. I started it Jan 2022 but was only able to stay on it for a few months before going to a low histamine diet because I just couldn’t incorporate a lot of the homemade probiotic rich foods that the protocol requires. However I wish I had just stuck with it because all the low histamine diet did for me was continue to take out foods until I was down to eating 8 foods! I should’ve pushed through SLOWLY the histamine intolerance issues. I have currently restarted with GAPS and have been on it for a month. So far so good, just going very slowly this time. The GAPS main source of fixing leaky gut is meat stock, (chicken broth) to seal and heal your gut lining, homemade probiotic foods, lots of high quality animal fats, tallow, lard, ghee. Now, I also got Covid in April 2021. I have long Covid and have been suffering since. I had all sorts of weird health issues for years prior to contracting Covid. Severe Congestion, diagnosed chronic, sinusitis and allergic rhinitis. This only got worse and more symptoms appeared after getting Covid. I have been taking Ivermectin for 3 weeks and am adding LDN today. I hope it helps! It’s a long prescription but hoping after I finish it, symptoms don’t return!

@lynnjohnson651 Жыл бұрын

What dose did you take of Naltrexone.

@Total_Body_Fitness_USA 2 жыл бұрын

I used LDN when I contracted COVID in June 2020 and again in January 2022 and my immune system ran like a fine tuned Swiss Watch. I also used Sulforaphane which stops IL-6 as well. Used a couple of other things, but this last go around with COVID my low grade fever only lasted 36 hours or so. Had the sniffles for a few more days but no big deal. I'm 57 and not vaccinated and no underlying medical issues. LDN works and it has countless health benefits! Excellent video explaining the details!

@Shasha8674 2 жыл бұрын

LDN helps block gluten which you can do yourself, but hidden gluten is harder to avoid which LDN helps being a low dose. People may not realize gluten is hurting them. Those are the ones who infections may hurt more since gluten hurts the gut lining so less nutrients absorb like Zn/Mg. This vax/infection may lower Zn/Mg and many are not taking supplements or are gluten free which helps them absorb more nutrients. LDN helps the gut lining, by blocking gluten from making the immune system go down and do autoimmune attacks.

@jeanniehorneman6965 2 жыл бұрын

How did you get LDN? Where, from who?

@Total_Body_Fitness_USA 2 жыл бұрын

@@auggie1790 I had COVID in June 2020 and low grade fever of 99-100.8 for 12 days along with loss of sense of smell and taste for 4 of those days. Also had back pain that was pretty significant for about a week. I woke up on the 13th day with no fever and no symptoms except for fatigue that lasted another week or so. I am in the health field as well studying functional integrative medicine for the last 8 years and clinical exercise physiology for the last 27 years. I've been studying this virus since the day it hit the USA. There are other supplements I took that prevented replication and decreased viral load so I'm sure that had something to do with it. However, the LDN works very well too.

@Total_Body_Fitness_USA 2 жыл бұрын

@@jeanniehorneman6965 It's prescribed by a physician. Most physicians who practice holistic, integrative, or functional medicine will prescribe it for you. Search online for LDN and you might find one who can prescribe it through telemedicine.

@Shasha8674 2 жыл бұрын

@@jeanniehorneman6965 LDN can be from any doctor who is open to giving it. Alternative doctors or psychiatrists or regular doctors can give it. It is from a compounding pharmacy and sent to the person. It is about $1 a day and is like s miracle to help health if taken before bed. Some take it earlier in the day since at night it may give too much energy. It helps heal the gut lining from gluten and helps the immune system not attack from gluten. It may cause some constipation, but people can drink more water or adjust the dose. There is a group on Facebook about LDN.

@aleenarae89 9 ай бұрын

Im on day 3 praying this makes me feel half normal again after long covid made me feel like a shell of myself. Staying positive and knowing i will be better soon

@thegrymwolf6360 6 ай бұрын

Did you find LDN helpful?

@maxine1019 4 ай бұрын

It stopped my long-COVID and NOH research also confirms efficacy. Works on many other immune and autoimmune diseases. Doesn’t work in all cases. Could be dosing or other issues, but it’s definitely worth a try and the side effect profile is minimal and can usually be handled by cutting the dose and then re-upping as your body gets used to it, I personally experience vivid dreams for a few days, one of the known side effects. No nightmares so I enjoyed myself and got good night sleep

@louisebriere753 2 ай бұрын

It was a miracle drug for my long covid issues since december 2020. I was desperate to find someting other than antidepressant for the pain. Antidepressant were causing me more brain fog and weight gain. LDN took a while to kick in for the pain, but I felt better after a week! I had to lower the starting dose as I wad having headaches. But even at a low dose of .05, it was working. I'm thankful that my doctors are open minded enough to prescribe it even if it needs to be compounded.

@ThisBloke760 27 күн бұрын

Hang in there, some have quick relief others takes longer. I’m starting week 5 and initially I felt better but stupidly did too much too soon so I crashed. I’m expecting it’ll take a few months before I feel real results. Continue resting and pacing, don’t push yourself

@sami-pe1no 15 күн бұрын

@@ThisBloke760 IAM 2 months on currently at 4.5 mg for the last 10 Days.. Can't say that I feel any benefits.... Wondering if I need to increase or do 4 days on and then 3 days off.

@bettyjeanpetrinovich7373 2 жыл бұрын

Thank you for your thorough, complex, yet accessible explanation. When I started LDN for ME/CFS, it was like a low ceiling that was making me crouch all the time had been lifted. All the normal things I had been doing to optimize good health suddenly became effective, too. (No sugar, milk, wheat, industrial store-bought eggs, etc., good supplements, outdoor sunshine and fresh air, very gentle, limited exercise/ movement, etc.)

@retke922 2 жыл бұрын

Thanks for sharing! What dose do you take and for how long time?? Do you have any side effects? I do have ME/Cfs and fibromyalgia! And some kind of infection with flu symptoms.

@taradrolma2774 2 жыл бұрын

@@retke922 I have ME/CFS. I take an ultra low dose of LDN. There is a Facebook group LDN for people with ME/CFS and fibromyalgia and one for people with chronic disease and inflammation. Both are helpful. Dosing is extremely individual.

@danielvarela5519 2 жыл бұрын

@@retke922 I’ve been taking LDN for almost 2 months and I went from feeling like I’m gonna die, to I’m pretty much back to normal! 1mg a night for like a month and 2mg a night the second. I went off it and had only a few relapses and the strangest acne? Pimples. I’m just still having to deal with the high cholesterol situation? Covid does weird things to your body.. I’m 34 and have no underlying issues. I just wish I could have my children 6yrs old and 10 years old be on this, or something!? They have symptoms like me every day and doctors tell us we’re healthy??

@virajdeshmukh9175 2 жыл бұрын

@daniel valera you had long covid?

@lauracowan100 Жыл бұрын

I feel that low ceiling! I'm about to get hold of LDN for my cfs/long covid

@battfamily435 Жыл бұрын

Been taking this 4.5 mg for the big C 5 years now and all is good. Thriving.

@Bloomkorth2 11 ай бұрын

I have been taking LDN for chronic inflammation for about 6 months now and I just wanna give this drug a big hug, too. Wonderful to listen to your explanation of the mechanism of action!! Thank you, Dr. Bean! 🤗

@vickydittfield9822 5 ай бұрын

I loved it also,when you said that a big hug would be in order were LDN a person. It’s a life enhancer for me,in providing a block of energy,less pain and cognitive assistance ❤🎉😊

@lisamarie73100 3 ай бұрын

I'm starting at 4.5 mg tonight for rheumatoid arthritis and horrible inflammation. How long did it take for you to know it was working for you. How long should I give it before trying another drug?

@seanvogel8067 11 күн бұрын

⁠@@lisamarie73100, I can give you one perspective. I've been looking into this for sometime now, and some people say it starts working the first day, but I see people saying try it for up to two months. For a neurological damage but I think it takes longer. Also, if you have unwanted side effects, you can try a lower dose. 4.5 is kind of in the middle of the range 0.5 to about 6 mg. Some people even go lower than 0.5. Please treat this as only one small source of information.

@michellewahl4756 2 жыл бұрын

“Diseases of the soul are more dangerous and more numerous than those of the body. “Cicero

@shubhamdahiya1677 Ай бұрын

I’m worried mine are really of that kind

@rituparnsingh1725 2 жыл бұрын

One of the best lectures ,I have attended. I know about LDN have intermittently used it. Stopped it ,but would now again use it. Basically what I understood is that LDN brings homeostasis to the system m And tries to reset it to factory made settings. That you food doctor. You are a voice of sanity in this cacophony. RESPECTS

@mammajeanine 2 жыл бұрын

Hi Dr. Been, these lectures are such a gift. It's like being back in college without the looming, staggering, debt. I just bought you 3 coffees, wish I could do more. Don't lose faith in the power of honestly and transparently disseminating these studies for us. Keep on keeping on!

@stefrzchicago 2 жыл бұрын

I am on LDN and have been for 3 years. Hasn't helped me throughout this COVID and long COVID journey that I know of.

@christy1052 2 жыл бұрын

Another great lecture! Thanks, Dr. Been. You provide such a wonderful service with your videos!

@michaelblosser5277 2 жыл бұрын

You are great! You are expressive, knowledgeable and use your words wisely. I am happy to subscribe to you channel.

@drblaneyphysics Жыл бұрын

I just learned LDN us used for lupus too. Best talk ever, thank you Dr. Been!!!

@wheelzeightyone 2 жыл бұрын

Thank you Dr Been. I am so glad you have shared this with the Cool Beens. I am immunocompromised and had suffered from Crohn's Disease for 8 years. I started using low dose Naltrexone about 2 years ago. I have had 95% healing including mucosal healing of my entire digestive system!! It has also brought me almost complete healing from Psoriasis. I have experienced no side effects. Compare that with the harsh side effects as the Doctor recommended prescription drugs. I simply dissolve one 50 mg tablet in water and so I can take 4.5mg before bedtime. Simple, effective and inexpensive. As Dr Been says it is a beautiful drug!!

@thedevilsadvocate5210 2 жыл бұрын

Do you have to go to the doctor to get this?

@beatricejacobowitz7264 Жыл бұрын

Can I ask - how much water to dilute the 50mg naltrexone tablet. ?

@AlexSelf-Help Жыл бұрын

thank you! did you have any sexual side effects while on LDN? Like weak orgasms/no joy, and much less sexual interest? Thank you!

@beckyharris347 6 ай бұрын

@@beatricejacobowitz7264I dissolve 50mg tablet in 50ml of distilled water. Then 1ml of solution gives 1mg of medication. 4.5ml of the solution will give 4.5mg of medication. That’s just how I do it.

@georgemoller2206 2 жыл бұрын

What a fantastic discussion with so many implications for many with autoimmune problems etc.

@romygime5822 2 жыл бұрын

Dr Been So clear you explain teaching the students, a Dr with so much knowledge they are not many like Dr Been Thank you and God bless

@angp2027 2 жыл бұрын

So glad I found this video... I have been struggling with new onset autoimmunity and one of my providers will be trying me on this...im very excited to be trying it. I have been trying to do more research on it.

@ME-hv9kx 2 жыл бұрын

Some used Naltrexone for cancers …seems like a good medicine to help people with chronic disease.

@radhagold1371 2 жыл бұрын

Thank you Doctor. I will use this information and approach my medical professionals. what you outlined makes sense.

@lawrenbordelon4012 Жыл бұрын

I just started LDN yesterday for long covid! I’m TWO YEARS OUT, This video made me shed tears of JOY!!!! THANK YOU!!! I do have some questions, I wish I could ask..

@adanguerra6351 Жыл бұрын

How are things coming along?

@marlac.876 9 ай бұрын

I’m finally trying it for long haul - how are you doing in it

@AlpacaRenee 11 ай бұрын

A friend told me about this presentation…amazing, brilliant and easy to understand. THANK YOU SO MUCH! I was just diagnosed with Hashi’s. Learning so much! God bless you!

@PhishedOff 2 жыл бұрын

Wow Dr. Been, I can’t thank you enough for doing this particular teaching because I am not that old and I’ve been suffering with chronic pain for 20 years. At 58 I just got to where I was hurting from head to toe and went to my doctor just crying and all of the blood work was negative, they tried everything, they tested everything, rheumatoid test, all of it and finally the woman who handles my HRT decided to try me on this low-dose naltrexone which no other doctor had ever mentioned to me and I have to tell you it is a miracle. Although it doesn’t help with my tendinitis as much as I wish it did, it tremendously cuts down on the nerve pain from my neuropathy and shooting nerve pain from the facet arthritis in my low back. A wonderful side effect has been that I am much happier and I seem to be more agile. Which is great because I have six grandkids and a husband who needs his wife to be able to do things like cook and run the house as he works two jobs. But I was worried that such a great medication could come with side effects and you are explaining that it’s not really got many and you backed up what my doctor said. I’ve not had a second opinion so I’m very grateful and I now understand why I had the inflammation and the chronic pain in the first place. No one has ever explained all of that to me and maybe most patients don’t wanna know but all of us that follow you crave this information because we want to understand. I’m so grateful.

@lynnjohnson651 Жыл бұрын

What dose did you take?

@Southerngrl Жыл бұрын

He’s such a good Dr and better teacher. ❤

@marciamcmahonmastroddi8304 Жыл бұрын

Thank you so much dr Bean for another great teaching session!

@xander22m11 2 жыл бұрын

Thank you for the great information Dr. I appreciate it so much

@kevinb1574 2 жыл бұрын

Thank you for the video. I had just heard of this while searching for treatments for ME/CFS.

@Stacylatchman 2 жыл бұрын

Thank you so much for all you time and dedication to helping people with long covid and chronic illnesses. I got covid in March 2020 and have long covid symptoms up today. LDN has been on my list of medications to try and your explanation really made me understand how dangerous it is for our immune system to remain being activated for such a along time. It completely explains why my joint are only now starting to hurt so much and fatigue that never ends. I will definitely give LDN a try now. Thank you so much...

@jhonybraavo Жыл бұрын

Did you try ldn?

@carrievieira5894 2 жыл бұрын

Ty so much for this discussion. I’ve been thinking about trying this for chronic sx/AI. I did t understand the exact mechanisms until now. I will talk to a provider. Thanks again.

@okthen9145 2 жыл бұрын

Thank you doctor. The part of this lecture that talked about collagen overproduction really struck me. I ended up with ANA tests showing for Scleroderma (SCL70) as a post covid result. I had everything else as well - sore joints, sore muscles, fatigue, plus more. After going through 10 MD specialists an ND put me on LDN. I dealt with these long haul symptoms for 10 months before LDN was introduced. I am now a full year into my LDN regiment and my symptoms are so well controlled I sometimes think they're gone. Also, after a year and a half of high ANA test results the last test came back negative. Not sure if it's all thanks to LDN or LDN plus the other anti-inflammatories my ND has me on but either way I have improved.

@xtian384 2 жыл бұрын

so you never get off the medication??

@prilby 2 жыл бұрын

I had the EXACT SAME THING! positive ANA SCL-70 pain chronic fatigue. I already suffer with fibromyalgia. They also prescribed me LDN just started it. Hopefully it helps. I also take hydroxycloraquin and steroids for lupus which has helped some. I have been looking for others who got positive SCL-70 from Covid! So happy I found your comment

@prilby 2 жыл бұрын

P.s. my last ana came back negative as well. Ofcourse I had the more effective test done. The first two were done through labcorp but the last one my rheumatologist had done through Elissa which is more effective in testing for scleroderma

@okthen9145 2 жыл бұрын

@@xtian384 As long as you have autoimmune issues present you will need to treat them. Taking LDN is much better than taking chemo.

@okthen9145 2 жыл бұрын

@@prilby There are a few of us in my support groups. It's not unheard of at this point, unfortunately. I also had the ELISA test as well which indicated something outside of SCL. The Lab Corp constantly indicates SCL. In the end - more research will need to be done to determine if we're suffering from genetic triggered autoimmunity (disease) thanks to covid or if covid is somehow replicating an autoimmune response as a syndrome. I am at month 24 at this time of my longhaul hell. I am getting better but I can tell you I didn't bargain for longhaul to be two+ years and going.

@angelasprayberry65 16 күн бұрын

Just prescribed LDN and very excited. My body has been stuck in a constant fight or flight mode due to childhood trauma, chronic inflammation and hopefully LDN will help with my ic pain. Will follow up..

@williamblaney3316 2 жыл бұрын

I suffer from ptsd and fibro, have for over a decade. Nothing else touched the fibro pain. One low dose the first night my pain has been reduced an incredible amount. It is very strange but welcome compared to the other drugs they give

@VeganCheeseburger 2 ай бұрын

I’ve been taking 2 mg of LDN for 1.5 months for long Covid and it seems to help a lot

@dianapaloma3102 Ай бұрын

Dr. Been thank you so much for this detailed information. My doctor recommended low-dose naltrexone to me today for fibromyalgia and depression. I had remembered you had done this talk so I went back and found it. it’s extremely helpful. Bless you for the work you do. Bless you and your beautiful family. Thank you for everything. 🙏❤️

@rachelrodgers9171 2 жыл бұрын

I love your drawings and diagrams, they tickle my funny bone. I really enjoy these informative videos.

@877swissmiss 2 жыл бұрын

So well explained, once again! 🙏🏻

@carlaveliz8475 2 жыл бұрын

Excellent presentation and explanation . Thank you so much

@barbarawarren9443 2 жыл бұрын

This is a great, innovative video.

@evanwilliamson3602 2 жыл бұрын

I’m 28 years of age (male), I have ASD, ME/CFS, chronic pain and just been diagnosed with Rheumatoid Arthritis. LDN and high dose CBD is my first go-to.

@nikhilreddy6476 2 жыл бұрын

How much cbd

@alexisflowers4440 2 жыл бұрын

I’m 23 and just started taking it for RA. Do you take anything else for RA?

@evanwilliamson3602 2 жыл бұрын

@@nikhilreddy6476 - 500mg CBD ISOLATE (250mg x2 daily). I’d recommend the isolate as it’s cheaper and pure CBD. Remember it’s fat soluble, so mix in some oil like hempseed oil or olive oil.

@evanwilliamson3602 2 жыл бұрын

@@alexisflowers4440 - Hope it helps. No I don’t take anything else apart from “weed” and CBD of course.

@alexisflowers4440 2 жыл бұрын

@@evanwilliamson3602 same. also curcumin and boswellia. look into those and good luck. does your onset of ra have anyhting to do with you getting covid?

@miaisheree Жыл бұрын

LDN saved my life!!!

@livia1256 2 жыл бұрын

Have used this for my Hashimotos and it has worked tremendously for reducing my tpo antibodies

@annakasprzak8371 4 ай бұрын

What is ur dosage and how did it takes for TPO to go down? Thanks!

@erinhession Жыл бұрын

This was very helpful info, thanks so much!

@deborahmoshiek6943 2 жыл бұрын

I love your teaching method dr.been!

@AnneGoggansQHHT 2 жыл бұрын

I’ve been using LDN post Lyme and mold

@michelleg6 Жыл бұрын

My ldn is on the way & I’m so excited. I keep checking the mail. I have Fibromyalgia & Hashimotos among other things! Hoping for some relief 🥲

@michaelhopkins5088 Жыл бұрын

Brilliant presentation!

@georgiamackinlay5706 2 жыл бұрын

Fascinating! I actually use LDN to treat CRPS and its the only thing that helps. Drs very reluctant to orescribe it, thankfully my GP is amazing and looked at the studies I had and let me try it

@nathanhyde2079 2 жыл бұрын

All you had to do was tell them you wanted to cut down on drinking alcohol.

@HeirloomReviews 2 жыл бұрын

Yes that was what i am looking for! 😁👋 Thanks for sharing 🤟👌S👀 you on the next one ~!~ 🙏👉👍👍💯Much love💝west

@NaveDelAmor 2 жыл бұрын

Best advice is at the end -- how does it interact with other meds already being taken? Vit D also modulates immune system.

@Shasha8674 2 жыл бұрын

LDN is awesome help to help the immune system work right. LDN helps the gut lining by blocking gluten's harm, but is a low dose so trying to eat gluten free may help the immune system etc..

@pointshealthcoaching8474 2 жыл бұрын

You are a treasure Dr B... thank you

@DrZ-notthatone 2 жыл бұрын

Yes the pain gate theory - the brain is amazing!

@RealMattCook 10 ай бұрын

Absolutely fantastic explanation. LDN is indeed a miracle drug, and it’s super cheap. I have found that dosages that work vary a lot. Less than 1mg to 8 or 10mg even.

@luluadapa5222 2 жыл бұрын

As a fibro/cfs/cluster headache sufferer, this information is very informatve. Thank you Dr Been, you are a scholar and a gentleman 🙏

@elainerobertson1988 9 ай бұрын

After 44 years with ME/CFS/Fibro I found out about LDN a few months ago. My GP wouldn’t prescribe it so I got it privately. I’m 6 days in and hopeful. I will go back and direct my GP to this video and others.

@illement7 8 ай бұрын

How are you doing so far? Most likely it's going to take more time for LDN to work, I hope it does help you. Wow 44 years.. that's tough.

@elainerobertson1988 16 күн бұрын

@@illement7Thanks never got your comment until today. I didn’t like it in liquid form so I stopped for a while - I’ve now been diagnosed with FND so am started again on LDN in capsule form - hopeful again. 😊

@CMoore8539 2 жыл бұрын

As an ex-opiate addict and a sober alcoholic, maybe I should get on this medication.

@ScottDieken Жыл бұрын

yeah get a script for addiction and then compound it into smaller dosages. from what I have seen the larger doses won't work, why its called LDN. not HDN

@nikkypezza Жыл бұрын

Absolutely love this presentation! Wondering if this is good for EBV as well?

@lynnewilley9464 2 жыл бұрын

Wow great job ! Thanks!

@lucyswannsunsafespace7313 2 жыл бұрын

So glad to see this video! I was taking LDN back in 2010/11 for MS lesions. I had to stop taking it because doc wouldn’t prescribe any more. Mainly because I wouldn’t take the injections, I’m thinking. All those kick backs lol

@danielvarela5519 2 жыл бұрын

@@melodymelomaniac yes, it’s disgusting what the world has become or still is.. this is what it’s all about. Just people helping people. And spreading the truth. Love conquers all ❤️‍🩹

@lucyswannsunsafespace7313 2 жыл бұрын

Still taking no traditional MS treatments (injections, immunomodulators), yet MRI 2 weeks ago show no new lesions! In the 14 years since diagnosis, 24 since first almost certain MS symptom, NO progression! I’m convinced it was my diet that was making it worse, and I radically changed that since diagnosis. I only eat meals once a day, and a protein bar for brunch. I’m thinking eating whatever is fine, but very little of it. I basically “fast” most of the day every day. Wish I could say I’m feeling GREAT, but the damage has been done from lesions/scaring, so not likely to get rid of fatigue/temperature sensitivity/random muscle weakness, but I’ve learned how to manage and it’s not getting worse. LDN could potentially heal lesions, but not if I can’t get it. I’m at risk at the moment of losing the one thing that overcomes fatigue which is vyvanse, because my insurance doesn’t cover the one doc willing to prescribe and I’m racking up $150 bills every time I see her, every 3 months. That clinic has already sued me for past bill owed and I have to pay them. That’s been my life for many years now. It is what it is I guess.

@danielvarela5519 2 жыл бұрын

@@lucyswannsunsafespace7313 I heard that some people are getting LDN for as little as $15 a month!? Don’t give up! I know LDN helped me get back to feeling great again! I used it for 2 months.

@karilockremwellness8123 2 жыл бұрын

This was amazing! Thank you!

@langesanti-agingwellnessp.350 2 ай бұрын

Great lecture, thank you!

@gordongroves8519 2 жыл бұрын

great lectures

@joestratton5803 10 ай бұрын

I’ve been taking ldn for fibromyalgia for 3 years and had was unaffected by Covid and didn’t understand why. Great explanation here

@pollycook7692 Ай бұрын

Thank you.. a real doctor!

@muinbear4702 2 жыл бұрын

Thank you so much Dr been. Am going to approach doctors (again) armed with this information and see if I can finally get started on something to help break the cycle, having had LC since March 20 with many obvious symptoms pertaining to this pathway but no pro-active help. Just told nothing can be done & ivm not available yet nothing else suggested. I suggested it was mcas a year ago but wasn't heard. Just gave up. Meanwhile a year more of potential damage has been done. Bless you for all you do and have done, and I'm so pleased you and your family have recovered 🙏❤️ Well I didn't get any where! Told naltrexone only available in 50 mg. Now have the new omicron on top of LC. Struggling. On day 12. Left to suffer again. Don't know who to buy ivm or ldn from online. GP prescribed codeine for head pain which my body reacted badly to so am stuck taking paracetamol. Trying homeopathic remedies. Take high dose vit d and zinc. Complete lack of motivation to be pro active to treat covid in the uk. Left to your own devices unless unlucky enough to end up in hospital. They're not even debating ivm or other treatments. They're just apathetically waiting for the powers that be to tell them to do something. How can they let people suffer unnecessarily?? Without even trying to help?

@ascendingwithrachellovell3239 2 жыл бұрын

It only comes in a nasal spray in 4mg but not in a pill. I’m not sure if he covered that but that’s what we have in Canada so not sure if that helps you.

@bigbugz2056 2 жыл бұрын

You have to have a compounding pharmacy make the LDN for you. Make sure the pharmacy does not use the slow release form of naltrexone because you will not get the therapeutic benefits in the SR form.

@muinbear4702 2 жыл бұрын

@@bigbugz2056 thank you. I guess I will have to have a prescription from the doc for the pharmacy to make up and not sure they'll give me one. Will try. And also try to source a compounding pharmacy online.

@akikodiana 2 жыл бұрын

Thank you for your medical lecture. I’ve always wanted to know how LDN reduces LC symptoms.

@gordongroves8519 2 жыл бұрын

interviews with researchers are great too, only way I found Dr. Patterson and his team who could help me. My pulmonologist kept telling me I had asthma, for ten months until I had to search for myself and found these great lectures and interviews with brilliant researchers who are really helping long covid sufferers and vaccine-injured. First dose of Miraviroc and suddenly I could breathe after ten months of using atomic inhalers to little effect.

@BrandonGreenShow Жыл бұрын

Who gave you that drug? HIV drug

@samanthajoslyn7251 2 жыл бұрын

Amazing. Now someone show this to my Dr and vet so me and my cat can fix our autoimmune conditions. This is so underground doctors keep lecturing me like I’m crazy for asking for it. So frustrating to not have access to it.

@battfamily435 Жыл бұрын

Find a doctor who call CareFirst compound pharmacy and ask if they can refer you to a doctor who will write an RX. Keep trying. I was getting it from Singapore for $80 a month without RX, my amazing RN wrote me a prescription. It's amazing.

@xenosaiyan-8106 6 күн бұрын

I've been convinced to start taking this stuff

@evaschmidt2436 2 жыл бұрын

awesome! Thank you so much

@tinathenurse9073 Жыл бұрын

Outstanding presentation! I’m three weeks on LDN for full body CRPS. Fingers crossed.

@NurseMidwifeBAE 5 ай бұрын

Any update?

@tinathenurse9073 5 ай бұрын

Not good. I lasted 2 weeks, titrating up. The first week, especially the first 48 hours, I had hope; the fire was definitely less. But as the week went on, and with the increase, I actually had MORE pain. I was so sad! So… this didn’t work for me. I am jealous of those that get relief from this med; it makes sense, just not with my body chemistry. Thanks for asking!

@NurseMidwifeBAE 5 ай бұрын

Oh no! I’m sorry to hear that. Can I ask what dose you started at?

@tinathenurse9073 5 ай бұрын

.5mg then up to 1

@MariaKGrace 2 жыл бұрын

Outstanding! This nurse has a medical crush on you :)

@susantisdell1725 2 жыл бұрын

Inflammation of body from pancreatitis, MS, ME, and Fibromyalgia which is neurological disorders that isn't fully understood by many Doctors. How does methadone or Naltrexone affect inflammation. I take Suldinac twice a day. Amyloid come from where? Liver disease? NFLD? I take vitamin D3 and zinc supplements calcium,magnesium, b complex.

@ScottDieken Жыл бұрын

methadone relives pain also but causes liver issues. u must be of methadone for a long time before using ldn ask doctor

@gordongroves8519 2 жыл бұрын

Let us bow down and beg the FDA and CDC for our lives and our children's' lives

@sherrieh2062 2 жыл бұрын

Thank you Dr Been for this discussion. I’ve been on LDN for over 3 1/2 years, as prescribed by my alternative doctor, for fibromyalgia. It has to be made by a compounding pharmacy because LDN used for fibro is really used as an off-label drug, since it’s not actually FDA approved for autoimmune diseases and fibromyalgia. I have to pay a LOT for a 1-month supply x’s 12 (p/year). Maybe that has changed in the last few years…I will have to check with my doctor to see if I am able to get it through a regular pharmacy now. 🥰

@gilbertosilva3869 2 жыл бұрын

Research Co Q10 (ubiquinol) for fibromyalgia.

@elizabethguenther7319 2 жыл бұрын

My internist listened to me when I tried to be in a clinical trial for LDN and couldn't get in. He taught me to grind up one 50 mg. pill, then add 30 ml of water. So I am now tiered up to 5ml per night. I use an oral plastic syringe marked with lines to draw out the mixture I keep in fridge, using a brown tint cough syrup bottle. One pill of Naltrexone 50mg= 6 doses for the LDN. Less than 10 bucks/month.

@monicaweaver4522 2 жыл бұрын

Maizie - Yes, check on the price again, perhaps with a different compounding pharmacy. I use Belmar Pharmacy in CO and mail order three months at a time and in the past 5 years have never paid more than approx $15/ mo. First couple of nights had very vivid dreams, not bad just bright, bizarre dreams then great results for fibromyalgia.

@adyarym 2 жыл бұрын

@@elizabethguenther7319 - Hi! And how about tolerance? Is it well tolerated?

@geauxp 2 жыл бұрын

@@elizabethguenther7319 Hey Elizabeth!! This is close to what I do.

@jillbetts1241 2 жыл бұрын

Yes outstanding

@CreativeEat Жыл бұрын

Thank you for sharing your knowlege. I have taken ldn years ago and it has changed my life extremely positive. I also noticed an effect within a few hours with the first capsule of 1 mg. That's why I took it sometime in the morning because under all the enegy I couldn't sleep. Now and then I had auxh side effects like accelerated pulse / as if I had drunk too much coffee. In itself, as I said, it gave me new life. With currently, however, the effect disappeared. I have then first higher tosidrt on up to 3 mg. This brought no effect. On the contrary I had aif once more pain. Auh. at 1mg . Since I was aware of the effect mechanism, I had the idea to take less, so 0.5 mg. And lo and behold it worked again for a few weeks. At some point, however, more pain than before. Now I ask myself do you or someone else know something like that? And should I have dosed higher and or held out longer? That would really help me if someone could tell me something about it and I would be incredibly grateful :) Ps." I suffer from "Me/ Cfs" after an epstein barr infection 2008

@kathb1683 2 жыл бұрын

I’d be interested in hearing more about NLN and cancer, particularly kidney and skin cancer.

@akadee2986 Жыл бұрын

Thanks!

@jaktag 2 жыл бұрын

i love this as i have Multiple Sclerosis and had it for 30 years and theres a lot of people i know take low dose naltraxone for there MS with very good results,i keep thinking of trying it but i am a bit scared to take drugs.Its a case of it works very well for some and not at all for others.There is one lady i know of that was very ill and very disabled with her MS and when she started taking it she could live a normal life and her MS symptoms went away.

@TheJoan48 2 жыл бұрын

Since you know so many people who have had good results, why are you so afraid? It's not like you're inexperienced on this subject. The doctor said to start out with a tiny dose and not go up, or be in no hurry to go up because that could cause side effects and to increase the dose slowly if side effects develop, back off. It's not like a doctor wouldn't be watching you.. Seems like getting control of MS symptoms would be worth a shot. You'll never know if it works for you without trying.

@jaktag 2 жыл бұрын

@@TheJoan48 very true i think i am scared of taking it and it not working if you know what i mean.

@BrandonGreenShow Жыл бұрын

@@jaktag did you try it?

@leannshort2211 Жыл бұрын

Great discussion and explanation Dr! I have a question. My Ivermectin comes in red capsules and my LDN is in orange capsules. Now, I don’t know what they’re dyed with but can I just pour the contents of the capsules in a glass of water and take it that way? I’m already dealing with a leaky gut so I really don’t want to take anything artificial or dyed that may make my leaky gut worse, or hinder my hard work through the GAPS nutritional protocol which I am on right now. Thank you! ❤️

@nitisapru8510 Жыл бұрын

Excellent Dr. So, in chronic autoimmune siseases one should take LDN for how l9ng, say Lupus, MS ,Psoriasis arthritis etc? You said if no effects noticed in a week's time - what should on look out for? How many days b4 surgery shd LDN be stopped? Since it's immediate release and low dose for how long does it circulate in the body? Thank you

@charlesdavis7461 2 жыл бұрын

When I used to jog, the endorphins would make even this depressed person feel great.

@jac1161 2 жыл бұрын

Yes, exercise doesn't do what it used to when you have long covid. Yyyyup. Was an active nurse, zumba instructor, hiker, skier, etc. Feel it....23 months.

@charlesdavis7461 2 жыл бұрын

@@jac1161 sorry, didn't mean to slight anyone with long covid just heard it spoke about for helping with depression I believe.

@LisaRichards_123 2 жыл бұрын

On this for systemic lupus, but I have other autoimmune diseases also.

@Saybooboy Жыл бұрын

Dr Bean, did you ever do a follow up to this? Would love to see it if you did. Thanks.

@mattbellon828 2 жыл бұрын

I've been a long hauler for 6 months. I did Dr. Patterson's cytokine panel and I have 7 markers high except for IL-6. Would LDN still be beneficial to take since my IL-6 is within normal range? And does it only target IL-6? Also they mentioned my T cells are washed out. Would this help with those as well? Thanks

@Pmjs 2 жыл бұрын

I have Psoriatic Arthritis on Cimzia have read IL 6 has a pathogenic role in PsA. I recently stopped Cimzia due to Dental Surgery next week. My PsA has flared up in 1wk . I inject Cimzia every 2wks.

@simhifree2416 2 жыл бұрын

Dr. I'm one of the users that took the wrong dose of LDN, causing the worst dreams. It was so horrible that I didn't want to go through the process of finding a better doze.

@chrisshepherd828 2 жыл бұрын

Most people that this happens to tend to take the LDN by 5pm eve, some earlier. I’ve been taking now for 5years and just adjusted the time of taking until my body adapted to it.

@danielvarela5519 2 жыл бұрын

I had this too but I thought it was because of the melatonin high dose?

@selenekranz4061 2 жыл бұрын

Would Naltrexone be effective for the blood pressure and heart rate issues that have been seen with Onicron?

@CarolBlaneyPhD 2 жыл бұрын

both CBD and THC shown to have similar beneficial inflammatory-modulating functions, many papers in PubMed

@lawrenbordelon4012 Жыл бұрын

Can you take CBD & THC while taking LDN?

@stevo5000 Жыл бұрын

Great video. thanks. I wouod have loved to hear your opinion on how LDN can start to restore and up regulate dopamine receptors that have been 'damaged' after years of opiod abuse. I presume it can help return the opiod system to some sort of homeostasis whereby someone in long term recovery from opood abuse can start to feel normal happiness again. Qouod have loved your opinion on that. Any way great video....thank you Dr.

@tishie42 8 ай бұрын

I'm very curious too. I have taken suboxone for 4 years now at 8 MG of sub and 2 MG of naltrexone daily. I didn't get covid. I worked all through it and didn't live in a crazy lock down state. I also haven't caught the flu or anything really now that I'm thinking about it.

@tammygravis1462 Жыл бұрын

I wish I knew all you did. If so, I'd been well so much sooner. Took me 1.5 years to figure out the vaccine destroyed my body. Day by day I'm coming back but what a devastation to my body. Thank you.

@cespo77 6 ай бұрын

Are you taking LDN? Has it helped?

@tammygravis1462 6 ай бұрын

Yes been taking it a couple years and it helps with pain a lot.@@cespo77

@adogonmychair 2 жыл бұрын

Would this be something that could help Sarcodiosis? I'd like to talk to my Doctor about it.

@RJ-ry4pu 2 жыл бұрын

“If it was a thing I would hug it” ha ha ha ha. I like this guy.

@randyhalvorson3060 2 жыл бұрын

Dr. I have Lupus and arthritis so I have chronic pain. LDN has been recommended for me but I take morphine ER 15 mg and they say I can’t take it. I’m afraid to go off morphine due to pain. Any recommendations?

@chetabird 2 жыл бұрын

Ive had covid symptoms 2 mos, got pneumonia, and blood clot in my left lung. I Just got LDN 1.5mg. I saw your talk on flccc. I need to know how to take ldn. You said start w/ .5. So Im breaking open the 1.5 capsule to estimate .5, and taking that. You said if improvement in 1 week continue w the same. If no improvement, increase. So I could go to 1mg, up to 1.5? If improvement stay at .5, or should I eventually increase up to 1.5 even when I'm improving? How long should I take it? Should I continue w the blood thinner, been on it 20 days. Thank you!!

@princesssweetpea9205 2 жыл бұрын

WOW... Thank You!!! I have taken LDN for a few years now, when it began to be tried for Fibromyalgia... I also happen to have Hashimotos and other conditions. THIS IS EYE OPENING! Te fact that the benefits can also come from immune system modulation. This is mind blowing. I am wondering if I should try to go up to 3 doses of the low dose per day???? I would be happy to be a scientific trial guina pig on that.

@princesssweetpea9205 2 жыл бұрын

Okay, I am taking 4.5, so three of those would be to much, and could actually diminish the benefit. Thanks!

@AnnieOBrienAnnie 2 жыл бұрын

Please don't do that. When you take the right dose for you (1.5mg-4.5mg range) it blocks the receptors for the shortest most optimal time. Then your body is tricked into tripling your endorphins and increasing OGF/Met enkephalin up to 12-15 fold. If you keep dosing you will block the receptors for an extended period not allowing this rebound effect and the rebound effect to take place so your body won't have time to rebound and increase endorphin and ogf production.

@bra1nsen Жыл бұрын

How long does it take to action after starting LDN? (4,5mg before sleep) Would you recommend to add 5-HTP to LDN?

@beatz3279 Жыл бұрын

For people with underlining candida or mold toxicity this seems to have a spiralling worse effect. Can you explain why as i now have to sew cardiologist as stopped ldn but HR still wont stabilise below 150bpm and also bP will not raise to stabilise. This is so confusing . I thought at first herx reaction flaring up underlining issue as deals with it so thought was a food thing until i started blacking out and now in severe head and chest pain. Can you please explain what we can do or of this would get better if tried to soldier through. Im so lost on what to do as in a world of pain and feeling helpless with it all

@leg3193 Жыл бұрын

If you are saying, to try LDN to break the cycle in time to prevent to become a chronically disease. What is that for a time frame? I suffered with post covid after infection 16 months, And startet LDN. What are your thoughts about, It’s a lot of time and a lot of energy my body used in that cycle.