The searches for solving the greatest mysteries of our Universe require ultra-sensitive detectors and an extreme control of the environment and the background in order to detect a rare signal. Over the last decades, technologies have reached such unprecedented sensitivity levels that never-before-seen background signals must be considered. In this talk I will give an overview of the requirements for low background detection and what are the current R&D effortsfor developing new cutting-edge technologies in order to address the common challenges of experiments and for pushing the limits of detector performance.