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This video for medical students focuses on the pathophysiology of the two pathways to fatty liver disease: 1) excess alcohol (alcohol-related fatty liver disease) and 2) insulin resistance/metabolic syndrome (nonalcoholic fatty liver disease, NAFLD). Morphologic findings (steatosis, steatohepatitis & steatofibrosis/cirrhosis) and clinical features are also discussed. Material is based on Robbins & Kumar Basic Pathology, 11th edition.