Good Day I'm currently in a critical state and have been following research programs from the hospital. I was born with a genetic condition called Neurofibromatosis, which Ideally causes lumps of tumours to grow in areas with nerves I also present with brownish spots called coffee au lait spots Anyway, this is just a background. So late last year and this year, I presented a few symptoms on my right hand, pins and needle , numbness across my ulnar nerves ( pinky and ring finger). So Dr thought, ohh Cubital tunnel syndrome So they gave me meds Symptoms got worse and paralyzed my right hand, I couldn't sleep I was in pain. So they request for an MRI, chest and they found the lump in the Right axilla/armpit. I had surgery and the lump wasn't completely removed. The lab results came back positive for a malignant peripheral nerve sheath tumour (MPNST) with rhabdomyoblastic differentiation (Triton tumour), aris. The worst part is I'm still in pain and the lump is growing back. I don't know what to do anymore. I need medical assistance in understanding why the pain is quite persistent. There's a lot more, I just need help because I'm drowning and I'm not getting straight answers. Any response will highly be appreciated.
@slmerts9955Ай бұрын
thank u
@PathologyCentral8 күн бұрын
You're welcome!
@user-ev6zu7yq6cАй бұрын
Thank you Dr. ❤
@PathologyCentral8 күн бұрын
Most welcome!
@dolomuseАй бұрын
What is the implication of IDC without DCIS? Does this imply a lack of local, clonal cellular evolution and suggest breast reseeding from a distant metastatic locus? Thanks so much for this excellent channel!
@mariodelemos45002 ай бұрын
Great presentation, particularly on how the social conditions lead to differences in diseases supposedly based on biological race.
@mariodelemos45002 ай бұрын
Thank you for such great presentation on a very important topic. As an oncology pharmacist, your presentation makes me rethink how useful (or NOT) it is to look at the pharmacokinetics or drug metabolism data that supposedly vary in different races. Medline MeSH still have white people, Asian, etc. as well.
@PathologyCentral8 күн бұрын
Thank you for the feedback! This is so important!
@kamongankanza89022 ай бұрын
Thank you
@PathologyCentral8 күн бұрын
You're welcome
@mariodelemos45002 ай бұрын
Thank you Dr. Deyrup I know that pathologists often describe the gross pathology in food terms, but this description of the histology is so helpful that I will never forget it the difference again. I am an oncology pharmacist and I am systematically going through your videos, including the non-oncology subjects because I found that so educational and engaging.
@PathologyCentral8 күн бұрын
Thank you so much for the feedback!!
@selmgfan2 ай бұрын
thanks this was amazing
@victorialeigh57112 ай бұрын
Thank you for these videos. I was looking for detailed videos to follow along with my Robin's book (I am using the 10th edition of Basis of Disease). I am interested in the Path A direction, and I want to learn as much as I can about pathology before I apply. Your videos have helped a lot.
@PathologyCentral8 күн бұрын
Glad to hear it!
@beatricevaillant51082 ай бұрын
Greetings from Germany! I love your lectures. I am a medical student and I use your lectures to prepare one of my exams. In German medical schools also we are thought only caucasion do get MS for example even though there are so many cases contradicting it. There is even a German study showing that if immigration was before the age of 15 the risk of having MS is similar to the national average. The average time needed to diagnose MS in Germany is over 2 years and when one belongs to the "wrong" community it takes even longer to get a diagnostic.
@PathologyCentral8 күн бұрын
Danke schön!
@obedarmah74022 ай бұрын
You are so good
@PathologyCentral8 күн бұрын
Thank you!
@viswadevr.j22932 ай бұрын
Thank u for this amazing class. Simple and precise ❤
@sannpwintaung12242 ай бұрын
Thank you sir great explanation
@cabsouth2 ай бұрын
Excellent presentation
@dylansolomon34233 ай бұрын
Awesome lecture. To the point, concise, and deeply understandable.
@PathologyCentral8 күн бұрын
Many thanks!
@adreamanapron2993 ай бұрын
It’s super useful mam ❤ Thanks 🤩
@ozguromak3 ай бұрын
That was so interesting, thank you so much !
@thibo33233 ай бұрын
Was just diagnosed with Clear Renal Cell Carcinoma...thanks for the interesting explanation. I have worked in a hematology lab for 41 years but have always been interested in pathology.
@PathologyCentral8 күн бұрын
You are most welcome. Wishing you the best of luck!
@thibo33238 күн бұрын
@@PathologyCentral Robotic partial nephrectomy was a complete success...cancer free!!
@mariodelemos45003 ай бұрын
I assume most cells in human body are dormant (permanently differentiated, senescent, quiescent) and therefore not taking up labelled glucose in PET scan?
@royaledits_13 ай бұрын
Gate keeping this channel! You r the best!!
@mariodelemos45003 ай бұрын
Thank you Dr. Deyrup for such an engaging and clear presentation, particularly in pointing the relevance of various new information. As an oncology pharmacist, I find it challenging to remember the genes and proteins involved in carcinogenesis, many of which have become targets for drug therapy. Knowing what the do in normal cells give me a better framework to learn about them.
@jugnu3613 ай бұрын
Thanks
@dudethatsbad85413 ай бұрын
I’m being %100 honest, your explanations are just a masterpiece This need more attention fr
@PathologyCentral8 күн бұрын
Please spread the word!
@melon88703 ай бұрын
you are the best thank you doc :)
@melirj3 ай бұрын
Thanks 🤩 It is so understandable 👏🏻
@MariaVargas-uw1kn3 ай бұрын
Fantastic Content !!!!! I've just discovered your channel and I loved it !!!! Thank you for this high standard lesson❤
@PathologyCentral8 күн бұрын
You are welcome! Please spread the word!
@EternianIrish4 ай бұрын
Brilliant, thank you. I've started working in ENT as a Physio and this is a terrific resource
@ruwiem93674 ай бұрын
this really helped me thank you
@mariodelemos45004 ай бұрын
Thank you Dr. Deyrup for the excellent lecture that helps me appreciate the RB more clearly than how I learned it and the two-hit hypothesis through Cancer Biology lecture
@elijahsmith56834 ай бұрын
Nursing student here and I found this helpful. I’m trying to wrap my head around DIC and HELLP syndrome because my instructors are burnt out lol
@mariodelemos45004 ай бұрын
Thank you Dr Deyrup for a great short lecture. I am an oncology pharmacist with some basic general basic pathology and oncology pathology training as part of my postgraduate studies. Your opening slides of why we need to histopathology are similar to what I have been telling my pharmacy colleagues of why oncology pharmacists need to know about pathology. More than other therapeutic areas, pathology report is the central part of oncology, and not knowing it well deprives me from communicating not only with the physicians and other healthcare disciplines, but also with the patients who usually know a lot about their pathology. Over the past decade, more and more drugs are more targeted with specific histology so it's no longer enough to know NSCLC vs. SCLC, I also have to know NSCLC other than squamous cells, etc. Now we have to know about ER-low positive, HER2-low positive, and how that fits into triple negative breast cancer. Having an appreciation of the challenges in differentiating different intensity of ICH staining for ER is so important, when trying to understand the therapeutic decision. I hope you can do more oncology pathology and if possible molecular pathology related to cellular targets due to gene mutations or overexpressions, and PD-1 staining for the checkpoint inhibitor immunotherapy.
@nickname82464 ай бұрын
Can we mention that p53 gene is located at chromosome 17 p arm, so deletion of 17p is associated similar problems as p53 mutations
@mariodelemos45004 ай бұрын
Thank you Dr. Deyrup for the excellent lecture, both in contents and presentation. I feel such a privilege to have discovered to access to your lectures, which further increased my interest in cancer pathology. I am a clinical pharmacist practising in oncology for the past 25 years. I have always been interested in pathology, initially because no retake exam was allowed for the basic medical pathology course during my postgraduate PharmD program, and then because pathology plays such an essential part of cancer care, that cancer pathology was mandatory for my MSc in Oncology program. For the past 15 years I have been trying to understand more in-depth because more and more new oncology drugs are targeting the molecular pathology of the tumours.
@PathologyCentral8 күн бұрын
Great to meet you! Thank you for all your comments!
@OluRow5 ай бұрын
Thank you for being a proper scientist.
@gurushree20155 ай бұрын
Thank u madam very clear information
@user-nh4xs2wz5c5 ай бұрын
Thank you so much for this very important discussion. I have two reasons, one professional and one personal, that makes this information incredibly relevant to me. Professionally, I work in the biotech industry and am trying to help our company prepare to comply with the draft guidance from the FDA regarding diversity action planning for all of our pivotal and phase 3 trials. It has been a very interesting process to listen to people's responses when I talk about the need to have more solid, scientific data regarding efficacy and safety in under-represented populations and people struggle to understand the why. This is an example of why, it is so important. We need to be sure that people preparing to become medical providers have science and fact-based information about any condition that is accurate and peer reviewed. The personal reason this is compelling to me is that I am a female with severe hemophilia A due to extreme x-inactivation of my mother's non-mutated X chromosome leaving me with the activated X of my father who also had hemophilia. I clearly have 0-1% clotting factor VIII in circulation, yet doctors keep telling me that I don't have classical hemophilia because women don't get hemophilia. They have said this while looking at a lifetime of factor VIII assays. I am always shocked and angry that these physicians anchor so strongly to what they have been "taught" in medical school they cannot set that aside and actually look at data and listen to me describe my medical history and clinical manifestation of the condition. Luckily, one cannot keep arguing with a person with 0-1% factor viii levels and i do get treatment. It is the huge group of women who have a partial x-inactivation who suffer. These women have factor levels, that in men would be classified as mild or moderate hemophilia yet, because they are women, they will not be prescribed treatment for potential internal bleeding. It is 2024 and the story has not changed much from when I was told as a little girl that my mother was wrong, that I did not have hemophilia and that I should only listen to him. Ugh! Thank you so much for your excellent work and making it available on you-tube.
@cheriseobino5 ай бұрын
Appreciate🙏
@jeelo565 ай бұрын
Dear Dr. Deyrup, I thoroughly enjoy your lectures. Just wanted to point out at 13.00 minutes - there is a minor error - the slide says immune complex mediated vasculitis (Goodpastures), I note that Goodpastures is a type 2 antibody mediated hypersensitivity. Keep up the great work! Jay
@ameeshaehelamalpe59045 ай бұрын
Thank you for this informative video. 4th year med student here and this gave me a concise and well round idea of the concept. Grateful ❤
@rakanalyami53396 ай бұрын
With the polyol pathway, I think glucose to sorbitol is the NADPH consumption step. Sorbitol to fructose would be an oxidation reaction by polyol dehydrogenase coupled to a reduction of NAD to NADH. Great content, thank you,
@salomonscheepers63316 ай бұрын
Thanks, great presentation!
@prasanthchakrapani81056 ай бұрын
Very useful information on Myeloid neoplasm
@ahmedsiro16566 ай бұрын
Thank you so much for uploading these video's. Its really helpful to use as a supplemental notes for pathology
@abbyhose73116 ай бұрын
If fasL is expressed on self reactive T cells is it part of autoimmunity?
@LEARNING-MEDICAL-EDUCATION7 ай бұрын
does MS involve cranial nerve nuclei and cranial nerves. i think they are part of PNS, so, MS wont involve cranial nerve nuclei and cranial nerves
@CarlosGomz707 ай бұрын
Thanks for this. Very explicit and didactic 😊
@muksinhamza97827 ай бұрын
🔥🔥
@PathologyCentral7 ай бұрын
Thank you!
@MaybelAninonBalansag8 ай бұрын
Hello doc I always watch your videos, your videos are very helpful aside from reading the Robin patho. Thank you so much
@PathologyCentral7 ай бұрын
Thank you for the feedback!! It means a lot to me!