Phenomenal

Good Day I'm currently in a critical state and have been following research programs from the hospital. I was born with a genetic condition called Neurofibromatosis, which Ideally causes lumps of tumours to grow in areas with nerves I also present with brownish spots called coffee au lait spots Anyway, this is just a background. So late last year and this year, I presented a few symptoms on my right hand, pins and needle , numbness across my ulnar nerves ( pinky and ring finger). So Dr thought, ohh Cubital tunnel syndrome So they gave me meds Symptoms got worse and paralyzed my right hand, I couldn't sleep I was in pain. So they request for an MRI, chest and they found the lump in the Right axilla/armpit. I had surgery and the lump wasn't completely removed. The lab results came back positive for a malignant peripheral nerve sheath tumour (MPNST) with rhabdomyoblastic differentiation (Triton tumour), aris. The worst part is I'm still in pain and the lump is growing back. I don't know what to do anymore. I need medical assistance in understanding why the pain is quite persistent. There's a lot more, I just need help because I'm drowning and I'm not getting straight answers. Any response will highly be appreciated.

thank u

Thank you Dr. ❤

What is the implication of IDC without DCIS? Does this imply a lack of local, clonal cellular evolution and suggest breast reseeding from a distant metastatic locus? Thanks so much for this excellent channel!

Great presentation, particularly on how the social conditions lead to differences in diseases supposedly based on biological race.

Thank you for such great presentation on a very important topic. As an oncology pharmacist, your presentation makes me rethink how useful (or NOT) it is to look at the pharmacokinetics or drug metabolism data that supposedly vary in different races. Medline MeSH still have white people, Asian, etc. as well.

Thank you

Thank you Dr. Deyrup I know that pathologists often describe the gross pathology in food terms, but this description of the histology is so helpful that I will never forget it the difference again. I am an oncology pharmacist and I am systematically going through your videos, including the non-oncology subjects because I found that so educational and engaging.

thanks this was amazing

Thank you for these videos. I was looking for detailed videos to follow along with my Robin's book (I am using the 10th edition of Basis of Disease). I am interested in the Path A direction, and I want to learn as much as I can about pathology before I apply. Your videos have helped a lot.

Greetings from Germany! I love your lectures. I am a medical student and I use your lectures to prepare one of my exams. In German medical schools also we are thought only caucasion do get MS for example even though there are so many cases contradicting it. There is even a German study showing that if immigration was before the age of 15 the risk of having MS is similar to the national average. The average time needed to diagnose MS in Germany is over 2 years and when one belongs to the "wrong" community it takes even longer to get a diagnostic.

You are so good

Thank u for this amazing class. Simple and precise ❤

Thank you sir great explanation

Excellent presentation

Awesome lecture. To the point, concise, and deeply understandable.

It’s super useful mam ❤ Thanks 🤩

That was so interesting, thank you so much !

Was just diagnosed with Clear Renal Cell Carcinoma...thanks for the interesting explanation. I have worked in a hematology lab for 41 years but have always been interested in pathology.

I assume most cells in human body are dormant (permanently differentiated, senescent, quiescent) and therefore not taking up labelled glucose in PET scan?

Gate keeping this channel! You r the best!!

Thank you Dr. Deyrup for such an engaging and clear presentation, particularly in pointing the relevance of various new information. As an oncology pharmacist, I find it challenging to remember the genes and proteins involved in carcinogenesis, many of which have become targets for drug therapy. Knowing what the do in normal cells give me a better framework to learn about them.

Thanks

I’m being %100 honest, your explanations are just a masterpiece This need more attention fr

you are the best thank you doc :)

Thanks 🤩 It is so understandable 👏🏻

Fantastic Content !!!!! I've just discovered your channel and I loved it !!!! Thank you for this high standard lesson❤

Brilliant, thank you. I've started working in ENT as a Physio and this is a terrific resource

this really helped me thank you

Thank you Dr. Deyrup for the excellent lecture that helps me appreciate the RB more clearly than how I learned it and the two-hit hypothesis through Cancer Biology lecture

Nursing student here and I found this helpful. I’m trying to wrap my head around DIC and HELLP syndrome because my instructors are burnt out lol

Thank you Dr Deyrup for a great short lecture. I am an oncology pharmacist with some basic general basic pathology and oncology pathology training as part of my postgraduate studies. Your opening slides of why we need to histopathology are similar to what I have been telling my pharmacy colleagues of why oncology pharmacists need to know about pathology. More than other therapeutic areas, pathology report is the central part of oncology, and not knowing it well deprives me from communicating not only with the physicians and other healthcare disciplines, but also with the patients who usually know a lot about their pathology. Over the past decade, more and more drugs are more targeted with specific histology so it's no longer enough to know NSCLC vs. SCLC, I also have to know NSCLC other than squamous cells, etc. Now we have to know about ER-low positive, HER2-low positive, and how that fits into triple negative breast cancer. Having an appreciation of the challenges in differentiating different intensity of ICH staining for ER is so important, when trying to understand the therapeutic decision. I hope you can do more oncology pathology and if possible molecular pathology related to cellular targets due to gene mutations or overexpressions, and PD-1 staining for the checkpoint inhibitor immunotherapy.

Can we mention that p53 gene is located at chromosome 17 p arm, so deletion of 17p is associated similar problems as p53 mutations

Thank you Dr. Deyrup for the excellent lecture, both in contents and presentation. I feel such a privilege to have discovered to access to your lectures, which further increased my interest in cancer pathology. I am a clinical pharmacist practising in oncology for the past 25 years. I have always been interested in pathology, initially because no retake exam was allowed for the basic medical pathology course during my postgraduate PharmD program, and then because pathology plays such an essential part of cancer care, that cancer pathology was mandatory for my MSc in Oncology program. For the past 15 years I have been trying to understand more in-depth because more and more new oncology drugs are targeting the molecular pathology of the tumours.

Thank you for being a proper scientist.

Thank u madam very clear information

Thank you so much for this very important discussion. I have two reasons, one professional and one personal, that makes this information incredibly relevant to me. Professionally, I work in the biotech industry and am trying to help our company prepare to comply with the draft guidance from the FDA regarding diversity action planning for all of our pivotal and phase 3 trials. It has been a very interesting process to listen to people's responses when I talk about the need to have more solid, scientific data regarding efficacy and safety in under-represented populations and people struggle to understand the why. This is an example of why, it is so important. We need to be sure that people preparing to become medical providers have science and fact-based information about any condition that is accurate and peer reviewed. The personal reason this is compelling to me is that I am a female with severe hemophilia A due to extreme x-inactivation of my mother's non-mutated X chromosome leaving me with the activated X of my father who also had hemophilia. I clearly have 0-1% clotting factor VIII in circulation, yet doctors keep telling me that I don't have classical hemophilia because women don't get hemophilia. They have said this while looking at a lifetime of factor VIII assays. I am always shocked and angry that these physicians anchor so strongly to what they have been "taught" in medical school they cannot set that aside and actually look at data and listen to me describe my medical history and clinical manifestation of the condition. Luckily, one cannot keep arguing with a person with 0-1% factor viii levels and i do get treatment. It is the huge group of women who have a partial x-inactivation who suffer. These women have factor levels, that in men would be classified as mild or moderate hemophilia yet, because they are women, they will not be prescribed treatment for potential internal bleeding. It is 2024 and the story has not changed much from when I was told as a little girl that my mother was wrong, that I did not have hemophilia and that I should only listen to him. Ugh! Thank you so much for your excellent work and making it available on you-tube.

Appreciate🙏

Dear Dr. Deyrup, I thoroughly enjoy your lectures. Just wanted to point out at 13.00 minutes - there is a minor error - the slide says immune complex mediated vasculitis (Goodpastures), I note that Goodpastures is a type 2 antibody mediated hypersensitivity. Keep up the great work! Jay

Thank you for this informative video. 4th year med student here and this gave me a concise and well round idea of the concept. Grateful ❤

With the polyol pathway, I think glucose to sorbitol is the NADPH consumption step. Sorbitol to fructose would be an oxidation reaction by polyol dehydrogenase coupled to a reduction of NAD to NADH. Great content, thank you,

Thanks, great presentation!

Very useful information on Myeloid neoplasm

Thank you so much for uploading these video's. Its really helpful to use as a supplemental notes for pathology

If fasL is expressed on self reactive T cells is it part of autoimmunity?

does MS involve cranial nerve nuclei and cranial nerves. i think they are part of PNS, so, MS wont involve cranial nerve nuclei and cranial nerves

Thanks for this. Very explicit and didactic 😊

🔥🔥

Hello doc I always watch your videos, your videos are very helpful aside from reading the Robin patho. Thank you so much