My Doctor agreed with me that meds have such dreadful side effects. Affecting appetite sleep and the ability to feel real and not like a zombie. A lot of meds psyche meds can make matters worse. I wonder if they would ever consider controlled trials with keto versus meds. The other issue I have is the classification of the various terms used to describe clusters of symptoms that mostly overlap. It may be a matter of lowering stress and keto and water therapy and talking about how problems may be really a better option. And rather than being genetics or inherited traits could similar people growing up in similar environments have similar symptoms? People with mental health issues are starting to prefer keto and excercise to swallowing pills. Keep up the good work Brett

Interesting! I wonder how important the diagnosis is. I've read online before that schizophrenia, schizoaffective, and bipolar are really on the same spectrum, making me think they're related/very similar but he's wanting medicines/treatment specifically for bipolar. I've had diagnoses of all three conditions I mentioned all on numerous separate occasions by different doctors (one said to not pay attention to the diagnosis) and I take a medication that targets at least two of the conditions and has worked though I'd much rather be off it someday and not need any medicine so just curious about the relations of the conditions. Anyways, I am glad Dr. Frye is so open to nutrition helping his patients and how that system can look for success.

Very interesting how diet can improve mood and mental health. 🤔"'

Great interview! I took the anti seizure medication oxcarbazepine that up-regulates TRPV1 and TRPV4. Glp-1 stimulates TRPV1 as the neurolymphocrine axis and stimulates insulin. Insulin then stimulates more TRPV1 that puts glucose into the cell independent of the insulin receptor. This leads to glucose and lipid oxidation in excess of the cell’s antioxidants. I developed severe osteoporosis within a couple years of being on oxcarbazepine and atherosclerosis, Brugada syndrome, ovarian and other cysts throughout my body. Glp-1 receptor and TRPV1 in the hypothalamus increases gonadotropin releasing hormone that stimulates ovaries. TRPV1 over stimulation in primary cilia on cell membranes leads to out pouching of tissue diverticula and cysts. I switched to the low carbohydrate diet and the diseases began to resolve and resolved significantly with the cessation of oxcarbazepine in addition to the low carbohydrate diet.

Thank you so much for this thoughtful interview. I am coming at this from a couple of different directions. I’ve always had a weight issue (9+lb. baby), food scarcity as a child, food addiction as an adult, nursing as my first career and clinical depression for the past 30 years. This is an exciting time to see real advancement in mental health treatment. I now much better understand the need for research in terms of convincing reluctant clinicians both for efficacy and because it would mean a real shift in approach. At the same time, keto diets can be used now if supervised. I am pleased to report that I will be doing my own “research” this Spring with the support of my VA nurse-practitioner, my VA psychopharmacologist and my VA RN- health coach. They were willing to do ALL of the suggested lab work to establish baseline. And I have support from family and years in various support groups. Never underestimate the determination of a patient who just wants to feel normal! I never take that for granted. “Thanks for letting me share.”

Can reframing expectations be effective in satisfaction. For example if you expect ten dollars and someone gives you twenty dollars you'd be happy. If you frame your mind and reduce expectations you will mostly succeed. On a larger scale of reducing expectations, consider you are an insignificant super micro spec in the vast infinity of time and space. Your personal troubles are insignificant and will be forgotten. Then look at how lucky you are to be at the top of the evolution on this planet with the most sophisticated supercomputer, your brain and an elegant self growing/healing body. Plus you are living in time where any question you have can be found on the internet ofter with Bret Sher!

Thanks for interviewing a variety of professional s with unique perspectives

Metabolic Mind should start a bilibili account, patients in CN need you

Is it possible that keto can diminish gender dysphoria?

Dr. Frye mentions a study relating dietary quality and depressive symptoms. Hoping someone will have a link to that.

I think he's bought a little too much into the promise of atypical antipsychotics, he ought to know about the enrichment and the "Mexico effect". Still good information.