NEOPLASIA 4: p53 gene: The Guardian of the genome. functions, regulation and inactivation

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7 жыл бұрын

This Short tutorial explains p53 Gene.
click • NEOPLASIA 3: TUMOR SUP... for understanding the Retinoblastoma Gene
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p53 GENE
This is a tumor suppressor gene ( its activity stops the formation of tumors)
Located on 17p13, first discovered in 1979
The p53 protein is the product of p53 gene
P-protein
53- weight of the protein, 53 kDa
Located in almost all normal tissues
Unstable and degrades very quickly
Is one of the most commonly mutated gene in cancer
Function
Regulation of Cell cycle
DNA repair
Apoptosis
Prevents neoplastic transformation either by cell cycle arrest or by triggering apoptosis.
In cases of DNA damage, there is triggering of expression of p53 gene whcich increases the production of p53 proteins. These preoteins Prevent Cell from entering S phase of cell cycle
and Allows time for the DNA repair to take place. also p53 induces DNA repair genes. If the DNA is repaired,the p53 degrades and the cell cycle continues. if the DNA is not repaired, the p53 induces permanent arrest in the cell or activates pro apoptotic proteins bax and bad thereby promoting apoptosis. By these mechanisms, it is understood that the p53 conserves the stability of the cell and thus aptly called as ' THE GAURDIAN OF THE GENOME"
How p53 causes cell cycl arrest?
P53 is the transcriptional regulator of one of the genes named WAF 1
Resulting in increased WAF proteins named as p 21
P21 blocks CDK4/CyclinD complex ….. Cell cycle is halted in G1 stage resulting in cell cycle arrest.
Regulation of p53 protein: by formation of p53 and mdme protein complex which is degraded by ubiquitin mediated pathway.
What happens when p53 is inactivated?
There will be no cell cycle arrest in cases of damaged DNA and the cell cycle progresses with damaged DNa which results in genomic instability and the neoplastic transformation.
How p53 is inactivated??
Mutations
Heterozygous and homozygous loss of alleles
What are the cancers associated with p53 mutations??
Most human cancers!
MC breast, colorectal, liver, lung, and ovarian cancers.
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Please watch: "WARBURG EFFECT: Hallmark of CANCER. What, Why & How?"
• NEOPLASIA 6: WARBURG E...
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Пікірлер: 225

@naomiirhontumhan1544 2 ай бұрын

And 7 year later your videos are still saving lives👏 Thank you 🙏

@ilovepathologyVijayPatho 2 ай бұрын

Thank you😊 glad it still helps😊

@haripriyar8291 6 жыл бұрын

You're the reason I'm passing exams with a clear concept instead of just writing what's in the book. Thankyou so much :)

@nathaamruth9751 5 жыл бұрын

😂🙌me too

@dariofilipovic893 4 жыл бұрын

Harsh truth

@tharunkumar5587 2 жыл бұрын

so cutee haripriya

@Arcanescrunchies99 Жыл бұрын

me too

@janefrancesayogu2806 Жыл бұрын

5 years ago and still very helpful. I can now go into the exam hall in a few hours with more confidence. Thank you.

@ilovepathologyVijayPatho Жыл бұрын

Thank you 😊 best wishes 😊

@janefrancesayogu2806 Жыл бұрын

@@ilovepathologyVijayPatho Thank you

@ilovepathologyVijayPatho 2 ай бұрын

Thank you 😊 am glad it helps😊

@umairhabib4618 Жыл бұрын

Just 10 minutes lecture give alot of information is a miracle Thanks sir Our prayer always with your dedication and hardwork.

@ilovepathologyVijayPatho Жыл бұрын

Thank you 😊

@MDISLAM-qw7ic 3 жыл бұрын

P53 is guardian of the genome / old man of the genome/ police man of the genome / care taker / gate keeper of the genome . The information which did not get from dr.sparsh gupta & dr.najeeb but i have found amazing & very effective information from your channel. It is why i have subscribed and followed your you tube channel. Thank you sir and i really love " i love pathology " channel..😊

@zcameron_ 3 ай бұрын

I’m a week out from a huge pathology exam and I really wish I’d just studied from your videos from the beginning. I read all this info in a textbook and never retained it, and now it makes so much more sense to me. You break concepts up really well and you also keep it focused on the important stuff. Thank you!

@pinrani98794 7 жыл бұрын

i already have subscribed to this channel and gave thumbs up to this channel/video. He will be fool who will not do this ... great work and proper guidance provided .... bravo....

@marioaraprotopapa1503 4 жыл бұрын

You are a really good teacher , thank you for all the time and energy put in to make these videos extremely clear and concise ♡♡ .

@ilovepathologyVijayPatho 4 жыл бұрын

Marioara Protopapa thanks so much 😊

@andreapella4234 6 жыл бұрын

I love you. This is so well explained i'm in tears.

@asmitajain7201 Жыл бұрын

U are a really wonderful teacher, making the basics so understandable in a simple way, thanks for taking all the efforts in making such wonderful presentations

@ilovepathologyVijayPatho Жыл бұрын

Thank you very much 😊.glad the video was of help 😊 Best wishes.

@OvErShadOweDaZn 7 жыл бұрын

Keep up the good work! I love this video and it was very helpful in understanding. You are a great instructor.

@mahfuzajebun5968 7 жыл бұрын

Best pathology tutorials site I have ever seen.. Really grateful to u .

@ilovepathologyVijayPatho 7 жыл бұрын

Thank you.

@Josef2820 5 жыл бұрын

Man i really have to thank you so much for your Video. Somehow we dont have anything that easy to understand in germany related to p53 Thanks a lot !!!!!

@irem0090 5 жыл бұрын

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@songbaolin5479 5 жыл бұрын

Thanks to the author，I will finish my paper easily.

@animeloverXinuyasha 6 жыл бұрын

Very good job at outlining this topic - this is a perfect and easy to understand introduction to p53, so now I can go and delve deeper! I do wish you had explained a bit more as to what causes p53 inactivation and how, but all in all great video!

@chinmayeechhotaray7116 4 жыл бұрын

Thanks dude...i was searching for p53 explanation and ended up in your video with perfect explanation.....you helped me a lot.

@kniiknoi6197 3 жыл бұрын

Wow ... Great video. Excellent, detailed yet simplified tuition. Thanks a lot

@vaishnavik7367 6 жыл бұрын

You're a gem sir. Pls upload some more videos. I have my uni exams in 10 days and your videos on neoplasia are a saviour. Keep it up, good luck :)

@shubhamkushwaha8513 3 жыл бұрын

Thank you for the amazing video sir! You explain things so simply!

@zoyawinfield3011 5 жыл бұрын

Thank you so much you made this concept so easy to understand. I was really struggling with this concept. Really helped with studying for my exam!

@cindysababa0204 4 жыл бұрын

I was reading my book, but it makes no sense to me. You made it clearer! thank you so much!

@ayokcomfort729 3 жыл бұрын

I can relate

@84-pavithradevi2 3 жыл бұрын

yass!!!

@drabdul86 2 жыл бұрын

Thank you Sir , I am from Pakistan , u made this tough topic much easy to understand , love you

@dartanveer2046 7 жыл бұрын

really a good art of teaching...Amazing...

@divyamachevar9156 2 жыл бұрын

You are doing a great job. Please continue doing it, your videos are of great help. Thank you ❤️

@lucelence6312 3 жыл бұрын

Thank you so much for making the concept clear and easy to understand

@ChukimeRMarak Жыл бұрын

One of the besttttt explanations I've come across. So systematic and made easy to grasp the concept. So grateful to have found this.

@ilovepathologyVijayPatho Жыл бұрын

Thank you 😊

@alienatedaliens 4 жыл бұрын

This was so helpful and clear, thank you!

@Artsylove4 3 жыл бұрын

I'm super thankful that I found ur channel sir..

@thickassunicorn 5 жыл бұрын

Best video ever...pathology would never been so interesting

@roohullahaminsafi2240 3 жыл бұрын

Thanks sir, really appreciate your hard work and hope to keep loving pathology. Lots of love from Afg🇦🇫

@parthjobanputra3742 6 жыл бұрын

I have my exam tomorrow n this video helped me to drill the concept really quick... ty ... great explanation...😎🤘

@krishnamanikalita1612 6 ай бұрын

You are doing great work sir... thank you so much ❤

@20imke 6 жыл бұрын

Thanks for helping me understand it so easily. Textbooks are just overcomplicating everything.

@shaileshrao8694 3 жыл бұрын

Neoplasia was one of the hardest topics i've ever studied and thanks to your videos my concepts are very clear!! please keep uploading more videos on pathology it is indeed very very helpful!!❤❤❤

@ilovepathologyVijayPatho 3 жыл бұрын

Thanks so much..glad these videos are helping 😊 do share with your friends

@080mirdhulak9 2 жыл бұрын

Just an amazing clear cut concept I have ever seen🤩

@samina9199 2 ай бұрын

Thank you so much sir for making Neoplasia too much easy and understandable😊🎉

@maryamaslam1612 4 жыл бұрын

These are so helpful and easy to understand :) THANK YOU!!!!

@debigdogk9563 6 ай бұрын

Great teaching and illustrations thank you for teaching and sharing ❤❤❤❤❤

@cossav2560 Жыл бұрын

Thank you from London. Great work.

@bayanalkhalifa1853 7 жыл бұрын

the most helpful video! Thank u so much!

@euge6994 5 жыл бұрын

Thank you so much! This was really helpfull and clear.

@kishori4621 4 ай бұрын

You have made us love Pathology ❤️

@pradyumnakumar6988 6 жыл бұрын

Really helpful. I'm impressed sir. Thank you so much🙂

@priyachakraborty2260 6 жыл бұрын

It was great.... 2moro is my exam nd this video worked for me a lot....

@sanaakbar3663 Жыл бұрын

Well explained sir. Neoplasia is one chapter that scares me but you have made it more interesting. Your videos have made it more easy for me to go through the text and understand it in a clear way. No amount of paid online classes have made me understand neoplasia as well as these videos . Please keep posting regularly sir!! 🙂

@yashkumarprajapati9648 Жыл бұрын

Beautifully explained!! Thank you sir 😊

@MA-zo5jl Жыл бұрын

Wow so amazing and very clear ty so much ❤

@rusulkeshwan9297 3 жыл бұрын

Many thanks for you, you make it very easy

@shahidulhchowdhury6411 7 жыл бұрын

wonderful illustration of role of p53 gene

@shahmaf1768 3 жыл бұрын

Thank you so much for the video because I was very tired with p53

@clarksims3776 3 жыл бұрын

Thanks for posting this. It was very informative.

@Rotzfresh89 3 жыл бұрын

Thank you so much for your efforts. Much appreciated!

@gargichakraborty1083 2 жыл бұрын

Great explanation !

@Artsylove4 3 жыл бұрын

U make all the concepts really easy to understand ... thank you so much sir!!

@ilovepathologyVijayPatho 3 жыл бұрын

Thanks 😊 Glad you liked them

@mananvaid2304 7 жыл бұрын

Lovely video! Thanks man! Keep uploading more videos. Greetings from Gujarat.

@riyaan1089 3 жыл бұрын

Tqs so much for this very easy explanation

@oviya7715 4 жыл бұрын

The concept is clear and easy to understand thanks to the author

@VijayKumar-ee2si 2 жыл бұрын

Me studying in PG . really u r explained very well and it's very helpfull to understand easily without confusing tq so much sir❤️

@alaaeltayeb9213 4 жыл бұрын

this is a great time saving explanation thanks alot

@farihahamid7580 7 жыл бұрын

amazing video! you kept it simple and not too complicated ! :)

@kadambriyadav7877 3 жыл бұрын

Amazing video thank you so much

@danzlebronr9807 7 жыл бұрын

Very helpful sir! Thank You :)

@drbiologyarun 4 жыл бұрын

Amazing explanation.. Thank you 😊

@tarunarjunbk8247 4 жыл бұрын

Thank u so much sir saw this video before going into exam.. got this question today

@vrog 5 жыл бұрын

Amazingly done.

@ahmedkhan1560 2 жыл бұрын

Excellent presentation. You made this complex topic so simple that I should recommend that it should be used as a template by the Authors of Molecular pathology Books. Thanks a million, Amjad Ali Khan MD USA

@sanmeetkour8777 3 жыл бұрын

Thank you sir ..god bless ..you made it so easy to understand 😊

@tejasgadekar6153 Жыл бұрын

Great video

@disloyaltyovercovid8350 3 жыл бұрын

Thank you! The video is very clear!

@solangecontreras8325 4 жыл бұрын

Thank you!!!! The information helped me a lot with my classes

@ilovepathologyVijayPatho 4 жыл бұрын

I'm so glad that it helped

@CytochromeC 6 жыл бұрын

I m actually dealing a while with p53 but the Video is Great

@fatimarushwan 7 жыл бұрын

Great explanation, thanks

@nandugopan5973 2 жыл бұрын

Thank you so much sir❣️

@haroldkumar4766 6 жыл бұрын

Good stuff and explanation! However I wish p53 videos also mention that it's part of the BAX/BAK pathway and Bcl2 as that can be a point of confusion.

@aqibsyed8198 7 жыл бұрын

thanks for best explanations.

@DrAasthaKalra 6 жыл бұрын

Very nice Crisp and precise

@rohit_roars 4 жыл бұрын

Thank you for your explanation sir...

@rikkigupta9546 4 жыл бұрын

Thank u so much sir 🙏very clear explanation may god bless u 😇

@jordan4441 6 жыл бұрын

Thank you for this info sir!

@intigutierrez5557 3 жыл бұрын

Thanks for ur videos! I loved them, now i can do my essay easily hehe

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Such a great video!

@NoorKhan-pv3ex 2 жыл бұрын

your lecture is just👌

@rakshanas3960 2 жыл бұрын

Pls do more videos ,its very helpful 🥺

@AliKhan-sr1cm 3 жыл бұрын

Great work bro

@sugu239 5 жыл бұрын

Great presentation

@GauravSharma-ok4gz 5 жыл бұрын

Great explaination.

@SHERLOCKED_ARMY 6 жыл бұрын

Very helpful..thank you sir

@saimas_craftastic_world 3 жыл бұрын

Thanku so much sir... Really vey helpful

@yaqeenyousef8094 4 жыл бұрын

thank youu sooo much you arethe best in pathology :)

@ilovepathologyVijayPatho 4 жыл бұрын

Yaqeen Yousef Thank you very much 😊

@karishmadeegan8297 3 жыл бұрын

Thank you so much Sir for such a beautiful explanation. I wish you all the best, may you continue to educate lots of students like me. I study at Imperial College London and will tell my friends about your channel. Thank you!!!

@ilovepathologyVijayPatho 3 жыл бұрын

Thank you 😊