The Role of p53 in Cancer

  Рет қаралды 100,413

Maja Divjak

Maja Divjak

4 жыл бұрын

p53 is a sentinel protein recruited rapidly in response to DNA damage. p53 slides along the DNA until it finds a critical site, to which it binds. p53 then sends the message, to halt cell division until DNA is repaired, or If damage is too severe, the cell is destroyed. p53 is therefore known as the ‘guardian of the genome.’ A tiny change in p53 results in a structure that is unable to securely bind to the critical site. This means no decisions can be made about whether to repair DNA or destroy the cell. Without functional p53, cells can accumulate more and more DNA damage, possibly leading to cancer.

Пікірлер: 78
@kanetao
@kanetao 10 ай бұрын
That rattle! I will never imagine DNA without that sound again.
@PatientsPortal
@PatientsPortal 2 ай бұрын
I just visited my friend in hospital day 36 at UCLA, who has the P53 mutation and Diffuse Large B-Cell Lymphoma (DLBCL). Seeing her strength firsthand, despite her white blood cell count being at 0.9, has been incredibly inspiring. It's true what they say: the best teacher is learning from a patient. My friend is the most resilient person I know, and their journey is a powerful reminder of the strength and courage in the face of adversity.
@marlondavid1108
@marlondavid1108 3 жыл бұрын
I’m from Germany and I’m 16 years old and no teacher in my school and no German video could help me more than you! Thank you now i understand :)
@majadivjak4538
@majadivjak4538 3 жыл бұрын
Thank you so much for your kind message. I'm so happy this helped you!
@7urak
@7urak 3 жыл бұрын
ohne witz
@alexwhatever4757
@alexwhatever4757 3 жыл бұрын
pretty much same here, I study in the French educational system, and to be fair I did understand all that before, but it's still oddly satisfying and pleasant to watch that video 😌
@justlol9474
@justlol9474 Жыл бұрын
ich auch! :))
@yunxizha2276
@yunxizha2276 2 жыл бұрын
I have my finals today. I never understood 053 throughout the semister. You helped me so much. THANKYOU!!!
@nightmaregamer3711
@nightmaregamer3711 2 жыл бұрын
Just what I was looking for. Great video; informative narration and superb visuals 🧬
@pierpaolocasamassima8652
@pierpaolocasamassima8652 4 жыл бұрын
Amazing animation and explanation, thanks
@peters972
@peters972 Ай бұрын
What a great video! It’s not that often I find out something new these days there is quite a lot of recycling. But this was new to me! Thank you.
@EzioAuditore
@EzioAuditore 2 жыл бұрын
Wow such an amazingly well done presentation , great work!
@majadivjak4538
@majadivjak4538 2 жыл бұрын
Thank you so much 😀
@josefvymazal7091
@josefvymazal7091 3 жыл бұрын
A very good explanation. Thanks!! Josef
@kamendinand7
@kamendinand7 4 жыл бұрын
This is so well made and easy to understand. Thank you soo much for helping my study 🙏🙏
@majadivjak4538
@majadivjak4538 3 жыл бұрын
Glad it helped!
@randjietsingh
@randjietsingh Жыл бұрын
Extremely well explained. I did my minor on this subject. Also your vid sound like the inside of Starcraft Zerg hive, which makes it extra cool!
@lisa-rouletlawfirm9307
@lisa-rouletlawfirm9307 Жыл бұрын
Excellent explanation, thank you!!!
@hishamaly9090
@hishamaly9090 2 жыл бұрын
Excellent animation
@katerinaslama312
@katerinaslama312 2 жыл бұрын
super video thank you
@farahdeebakhan5322
@farahdeebakhan5322 Жыл бұрын
Wow what an amazing animation
@fijianhustler6879
@fijianhustler6879 2 жыл бұрын
This was helpful. Thanks!!! Bula from Fiji.
@majadivjak4538
@majadivjak4538 2 жыл бұрын
Thank you!
@islemabdelmalek1115
@islemabdelmalek1115 3 жыл бұрын
Very well made
@majadivjak4538
@majadivjak4538 3 жыл бұрын
Thank you!
@piamuller6744
@piamuller6744 3 жыл бұрын
I could only focus on these sounds
@israelfernhill
@israelfernhill Жыл бұрын
Loved the video! Any chance that you guys could add the source of the information?
@mukarambhat
@mukarambhat 4 жыл бұрын
wow amazing
@cosmicsailor7329
@cosmicsailor7329 3 жыл бұрын
amazing
@isapinales-torres5160
@isapinales-torres5160 10 ай бұрын
That was great
@fragrantbloom
@fragrantbloom 2 жыл бұрын
wow thnk u
@oliviapereira364
@oliviapereira364 3 жыл бұрын
Thanl you so much for the video and explanation! I don't get why cells with damaged DNA grow out of control... And if p53 does repairing, why doesn't it prevent mutagenesis instead of growing.. ? thanks!!!
@user-cd4bx6uq1y
@user-cd4bx6uq1y 3 жыл бұрын
The better the video, the faster I eat the fruit, I ate very fast for this video.
@DrHimanshiTheUnicorn
@DrHimanshiTheUnicorn Жыл бұрын
Amazing amazing
@JBulsa
@JBulsa 11 ай бұрын
Inject photolayse into the bone and cleave the TT uvc bond with different wavelength of light?
@katzinator5141
@katzinator5141 9 ай бұрын
Is it possible to construct P53 proteins with some sort of protection from getting controlled by the cancer cell, if yes they need to be created in a way that the immune system doesn't recognize them as an virus or bacterium
@larrybethune3909
@larrybethune3909 10 ай бұрын
Quick two part question. How does the introduction of the spike protein impact the ability of p53 to bind to and repair or destroy damaged DNA strands? And does this have an impact on pathosis' like breast cancer?
@Jo.King_
@Jo.King_ 8 ай бұрын
mRNA spike protein binds p53 and other cancer suppressor genes. It is very clear and very frightening that these vaccines have several elements to cause a perfect storm in cancer development in those patients lucky enough to have avoided heart attacks, clots, strokes, autoimmune diseases and other common adverse reactions to the Covid vaccines. To advise booster vaccines, as is the current case, is no more and no less than medical incompetence; to continue to do so with the above information is medical negligence which can carry a custodial sentence. No ifs or buts any longer. All mRNA vaccines must be halted and banned now." Angus Dalgleish
@bio366geethasankar7
@bio366geethasankar7 4 ай бұрын
🙏🏻
@joshuabowman7210
@joshuabowman7210 Жыл бұрын
How can P53 in us be tested to see if they are functioning properly ? I try to study Cancer be nice to chat with you like Bp3
@JBulsa
@JBulsa 3 жыл бұрын
how does uv light cause the p53 to misshape to not bind? The uv light is absorbed? and locks the genes together same as preventing a virus from replicating. Can't unstick a fused bond p53 with a counter UV light wave because it's absorbed but, sound frequency wave could jolt fused area apart.
@rodschmidt8952
@rodschmidt8952 Жыл бұрын
In my ignorance, I would suggest that the uv light contorts the p53 into a shape which has lower energy than its correct shape, so it sticks and stays that way. So it overcomes a potential barrier, as in many chemical reactions, leading to a lower energy (and dysfunctional) shape. If this is the case, then it is unlikely that any form of energy, having "jolted" it apart, would end up with it in the correct shape, since (having enough energy to do so) it would oscillate between the correct and incorrect shapes until that energy was dissipated, and when the available energy dropped below the potential barrier, the p53 would more likely end up in the lower-energy (incorrect) shape. Sorry. Good thinking tho. I expect that once it's in the wrong shape, it's ruined and can only be replaced and discarded.
@themadcunt6948
@themadcunt6948 Жыл бұрын
@@rodschmidt8952 Actually, to my knowledge; UV radiation induces mutations and DNA damages or breaks which result in the activation of DNA repair/ cell cycle arrest pathways. If one of these mutations happened to occur on the gene coding for p53, whether its heriditary or enviromental, this may result in an unfunctional protein if the mutation causes loss of function to the DNA binding domain. Thus, the p53 tetramer would be renedered unfunctional. Additionally, DNA comes in pairs, so if one p53 allele is damaged and the other the is normal this still results in dramatically reduced p53 function. Why? this is because p53 in its active form is a complex of 4 monomers to form a tetramer. So it only takes one mutated monomer to cause the complex to be unfuntional, this means that there is a 1 in 16 change of a functional p53 tetramer forming which translate to ther being only aprroximately only 6% functional p53 and 94% nonfunctional p53. In summary if DNA mutations by chance happens to occur in p53 gene the gene that repairs from DNA damage and controls programmed cell death then that cell no longer respond against DNA damage, which allows for more mutations to the genome to occur and proliferation. eventually one of these mutations may happen in other proto-oncogenes (cancer genes) this leads to cancer.
@arturlyaptyap4926
@arturlyaptyap4926 Жыл бұрын
The 21st century and scientists cannot figure out how to fix this gene so that the body can kill cancer cells itself. I have this gene and I have cancer and I want to be healthy
@HL-qv3yd
@HL-qv3yd Жыл бұрын
I agree with you, so many good souls suffer from this disease, yet all over the world governments pouring money on war and going Mars instead put the money cure this bloody disease, I'm upset for that reason.
@daltonfreire6328
@daltonfreire6328 Жыл бұрын
Fasting is the solution to the body promote self healing. Even at DNA level. It promotes autofagy, and can reverse any chronic disease, includind cancer. Unfortunately, the medications industry don't invest in researches about fasting, for financial reasons.
@SJ-wu9gx
@SJ-wu9gx 10 ай бұрын
Exactly my thoughts ..
@sagarikapati9612
@sagarikapati9612 3 ай бұрын
My mom has this
@Nikthehermit
@Nikthehermit 3 ай бұрын
Everyone has the p53. It is a gene that regulates cell proliferation. This means when a cell decides what to do with its energy potential, divide or die are the options. P53 regulates this, it is a gene which is part of your DNA. It’s how your DNA knows how to function, gene is like “key” or tool for your DNA. Deregulation of this cell can change the rate at which cells are created. When functioning properly in (remember when all this gene, put some have mutations) a human body it fights cancer, and viruses. It regulated any biological process related to the cell’s ability to reproduce. As cell may choose “Apotosis” and die, because it is corrupted. A cell would understand that it’s necessary to program its own death, due to it becoming a corrupted “file” in the body. Modulating this gene is difficult because it’s not so much amount turning it “up” or “down” it’s about getting it to regulate itself consistently where cell regulation is concerned. Hope this helps, best of luck.
@pjaworek6793
@pjaworek6793 Жыл бұрын
wow!
@leahmerlijn5473
@leahmerlijn5473 2 жыл бұрын
So this is the sound our DNA makes!??!?
@johnwaas7958
@johnwaas7958 2 жыл бұрын
It must be so noisy deep down.
@shengsheng3029
@shengsheng3029 3 жыл бұрын
Mmmmm.... Interesting
@ritadecassia9616
@ritadecassia9616 5 ай бұрын
Sou brasileira e tô aqui😅😢
@L.O.O
@L.O.O Жыл бұрын
🧬
@highapproximate3358
@highapproximate3358 Жыл бұрын
Hi can u give me the most simple information between the differences of gene and dna 😥😥 my teacher don't give me these information
@PatientsPortal
@PatientsPortal 2 ай бұрын
The best teacher is the patient.
@lucyvonella5617
@lucyvonella5617 Жыл бұрын
Wow
@TheSintha13
@TheSintha13 3 жыл бұрын
This made me sick to my stomach... 😕
@JBulsa
@JBulsa 11 ай бұрын
Instruct the cell that a new P53 is needed
@ZuzannaSmolarek
@ZuzannaSmolarek Жыл бұрын
I would just like to mention that DNA code will not change (1:09). Amino acid which is encoded by a codon may, althoguh DNA code will remain the same.
@tdu188
@tdu188 Жыл бұрын
DNA code will change in situations depending on how harsh the mutagenic agents are that are causing the DNA damage.
@shannoncho5578
@shannoncho5578 Жыл бұрын
Zuzanna Smolarek, you're incorrect. Mutations are, by definition, changes to the DNA code. They happen all the time, and we have repair mechanisms to try and mitigate that.
@Bambotb
@Bambotb 3 жыл бұрын
This is an amazing channel...isn't this proof of God an intelligent being who designed everything? For people to deny it is pure arrogance and evil
@nikotakai8796
@nikotakai8796 3 жыл бұрын
Calling people arrogant and evil just because of their belief. How ironic.
@Bambotb
@Bambotb 3 жыл бұрын
@@nikotakai8796 because of their denial and irrational arrogant beliefs not their innocent beliefs...it's not like they said strawberry is better than banana
@nikotakai8796
@nikotakai8796 3 жыл бұрын
@@Bambotb you mean people who believe in some mystic thing with absolutely no evidence?
@Bambotb
@Bambotb 3 жыл бұрын
@@nikotakai8796 how is this in front lf you not evidence lol see you prove my point...you have no problem Hating on God yet...
@nikotakai8796
@nikotakai8796 3 жыл бұрын
@@Bambotb are you high?
@mightiestmouse8833
@mightiestmouse8833 3 жыл бұрын
Wonderful explanation! Thank you
@majadivjak4538
@majadivjak4538 3 жыл бұрын
Thank you, glad you found it helpful.
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