2-Minute Neuroscience: CBD

Рет қаралды 96,823

4 жыл бұрын

CBD is one of a class of compounds known as cannabinoids, which are found in the cannabis plant. Unlike THC (the main psychoactive component of cannabis), CBD is not thought to have intoxicating effects. It is, however, believed to interact with the nervous system. In this video, I discuss what we know about CBD’s mechanism of action and its potential in treating various conditions like epilepsy and anxiety.
TRANSCRIPT:
CBD is one of a class of compounds known as cannabinoids, which are found in the cannabis plant. Unlike THC (the main psychoactive component of cannabis) CBD is not thought to have intoxicating effects. It is, however, believed to interact with the nervous system, which may enable it to modulate the effects of thc as well as have actions of its own.
CBD is chemically similar to THC, but it does not have the same mechanism of action, and some evidence suggests it may even interfere with some of the actions of THC. One way it may do this is by binding to receptors that THC binds to known as CB1 receptors, but instead of activating them, causing a change in the receptor that reduces THC’s ability to interact with it. This type of effect is known as negative allosteric modulation, and it may enable CBD to mitigate some of the adverse effects of THC, like anxiety. Other research, however, suggests CBD can enhance certain effects of THC, and CBD is also thought to act at a number of other targets besides the CB1 receptor. For example, CBD is believed to activate serotonin receptors and may increase levels of a natural cannabinoid called anandamide by blocking anandamide reuptake and inhibiting the enzymatic breakdown of anandamide. Overall, although a number of targets for CBD have been identified, its mechanism of action is still poorly understood.
CBD is generally well-tolerated, but some have raised concerns about the need for more research before we can be confident about its safety in all populations. CBD, however, is not thought to have potential for abuse, and some believe it does have potential for treating a number of conditions, like anxiety, insomnia, and pain. But most of these claims don’t yet have strong evidence to support them, and more research is needed, although CBD has been found to be a viable treatment for at least some types of epilepsy.
REFERENCES:
Laprairie RB, Bagher AM, Kelly ME, Denovan-Wright EM. Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor. Br J Pharmacol. 2015;172(20):4790-4805. doi:10.1111/bph.13250
McPartland JM, Duncan M, Di Marzo V, Pertwee RG. Are cannabidiol and Δ(9) -tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review. Br J Pharmacol. 2015;172(3):737-753. doi:10.1111/bph.12944
Pisanti S, Malfitano AM, Ciaglia E, et al. Cannabidiol: State of the art and new challenges for therapeutic applications. Pharmacol Ther. 2017;175:133-150. doi:10.1016/j.pharmthera.2017.02.041
World Health Organization (WHO). Cannabidiol (CBD): Pre-Review Report. November 2017. Accessed June 28, 2020. www.who.int/medicines/access/...
Special thanks to Srikar Gade for help with fact-checking this video.

Пікірлер: 95

@Chris-pt6hh 4 жыл бұрын

2 second neuroscience: CBD may do things but it may not

@Nuka0915 2 жыл бұрын

Lol

@devitus781 2 жыл бұрын

lmao

@frailvoid5844 Жыл бұрын

Better that they're open about the ambiguity of it's various mechanisms of action than to paint a false narrative by oversimplifying things.

@dreamerstripsitting6786 10 ай бұрын

I dose pretty high 250mg dosage about 1.5g a day and it sure does something.....

@deezalmonds7680 3 ай бұрын

@@dreamerstripsitting6786 When you say does something, what do you mean? Is it worth taking for anxiety?

@jmhemtp 2 жыл бұрын

I am not a psychiatrist, nor should the following comment be taken as medical advice. I am a former paramedic and quit the field due to diagnoses: Bipolar, Autism and PTSD. I have been given many types of psych meds, psychotherapy and shock therapy. In an attempt cigarettes, I bought a vape pen for nicotine. I was asked by the stores employee if I wanted cbd oil. I have only had it a week, bit nothing has ever been better.

@Daddyvader7 Жыл бұрын

So do you feel the CBD has helped with your bipolar or PTSD?

@inspiradorupees3029 7 ай бұрын

Was it placebo or did it actually help??

@jmhemtp 7 ай бұрын

Sorry I just saw these, I ended up stopping, I felt like I needed more and more over time.

@lionelgrisbane-ud87 4 ай бұрын

You’re a psychiatrist but don’t understand placebo effect LMFAO

@deezalmonds7680 3 ай бұрын

@lionelgrisbane-ud87 Clealry writes, "I'M NOT A PSYCHIATRIST, I WAS A PARAMEDIC."

@jeffreyfernandez3540 7 ай бұрын

I had a panic attack a few years back on THC, took a break from it but missed weed. I switched over to CBD dominant strains and have been able to enjoy the calming effects even when Introducing low THC to the mix.

@brandonyafanaro9710 6 ай бұрын

Love that for you. I’ve been smoking strict CBD in flower form, best decision ever

@GodbreadGilfredBiago 5 ай бұрын

CBD doesn't do shit. You were more calm because THC is biphasic, meaning that at lower doses, it relieves anxiety and induces calm, it is anxiolytic. At higher doses, it can cause anxiety due to activating the amygdala. You consumed lower doses of THC and the CBD did fuck all like always.

@fancywaifu9821 Жыл бұрын

I used to do Hemp CBD edibles. So the edibles had less then 0.3% THC. Compared to like a 1:1 ratio. I can definitely feel a noticeable difference. Like I felt more of it in my body rather then in my head. Never felt any anxiety and if I did, it would immediately go away. I would highly recommend Hemp CBD edibles to anymore who doesn’t want to feel super stoned but still want the THC effects

@michaelarturo6864 2 жыл бұрын

It's too bad that the "Righteous" people from the 70's and 80's never bothered to study these effects, while destroying so many lives with criminal records?

@jmhemtp 2 жыл бұрын

I saw a quote by the Cia that they criminalized weed and heroin to disrupt the Hispanic and black communities.

@lorrainepascua9707 5 ай бұрын

Exciting times for the CBD industry! MidnightCBD's commitment to quality and compliance gives me peace of mind as a consumer.

@willbrown1220 4 жыл бұрын

Great content as always

@nazeeraharmanza 4 жыл бұрын

this is a good video! hi from neuroscience enthusiast here!

@Sage-hl5ir 4 жыл бұрын

Nice video, keep it coming!

@manehellalerotholi3312 Жыл бұрын

Treats my Insomnia and anxiety like👌

@AlbertaTrainignAcademy Жыл бұрын

please do one on the others, CBG and CBN, THT, difference of THC^8/9/10 and THC-P & THCO!

@connoregan5784 2 жыл бұрын

Great video

@farhanbaig678 Жыл бұрын

Ive found that blending intermittent fasting and 100mg cbd oil before sleep help me drift off naturally to sleep and waking up more giggle than usual

@Nards_1997 2 жыл бұрын

I am using it to help with my anxiety and substance use

@deezalmonds7680 3 ай бұрын

Any joy?

@Ronithimself 4 жыл бұрын

Thanks

@Mellow_Flow 2 ай бұрын

People talk about weed having a side effect of anxiety, but I personally just think weed gets you sucked into what you’re immersed in, which means when an anxious thought comes along you latch onto it hardcore. I treat weed like a psychedelic. Set and setting are crucial, don’t just go get stoned at the funeral you’re attending

@Lovelife21i2 5 күн бұрын

I use to think this too and I was in pretty good place mentally and I decided to roll up. Then all the anxiety came back and the next few days were rough but honestly it’s probably just not for me 😭

@manehellalerotholi3312 3 ай бұрын

It has helped me a lot with my cognitive functioning..

@patratcan 2 жыл бұрын

Are you aware of there has been more scientific consensus or broadly accepted clinical trials on CBD since you made this video?

@BrokeMyCrayon Жыл бұрын

Care to give some examples

@louise3953 Жыл бұрын

@@BrokeMyCrayonI’d like to know as well

@Max-cz8mf Ай бұрын

I’ve tried quitting weed a few times but always relapsed. Whenever I try and quit, I have the shortest temper in the world. I am currently on my 5th day of quitting weed again but have been taking CBD oil and I have a calmness and not snapped once.

@official_albertson 5 ай бұрын

Could you pretty please post a quick visualization on the theory of how CBD blocks the uptake? Sounds super interesting.

@vaehinarahiri9815 4 жыл бұрын

Cbd always put me to sleep no matter what time I take it. Very strange.

@jarryd8167 4 жыл бұрын

I use a CBD roll on - by applying it to my legs, it eases my Restless Leg Syndrome.

@dawnlauren7377 2 жыл бұрын

Take magnesium citrate at bedtime.itstops it

@shantelleadeline6053 3 жыл бұрын

Hi guys. I think you need to take your time and take a quick trip around the Weedborn side.

@janeromnicki6598 5 ай бұрын

Trusted quality, unparalleled relief ! THX

@klokateer4372 10 ай бұрын

THCA exposure on my brain has effected my conitive ability to function stoned, with my increasing nerve pain(backs going out maybe)/ a single seizure rewired my brain. Trauma is definitely something that should be experienced through trial and error. Thank you for that lesson Valve. Who'd a thunk it 😂 😏. Just like Wheatley my flaw is procrastination because of Pain.... But Wait Theres More!......

@danielt6856 4 жыл бұрын

Doesn't CBD also have protective effects against strokes? I remember seeing far less damage from induced strokes in rats administered CBD compared to controls.

@neurochallenged 4 жыл бұрын

There is some evidence from animal experiments, but I don't believe there's any good evidence from human studies so I would say we don't know until some good human studies are done. There are a lot of positive findings in animals that don't end up being able to be replicated in humans.

@ChaoticOrder73 2 жыл бұрын

My friend has a rare genetic condition (some variant of vasculitis) and she has experienced many strokes as a teenager/young adult. 3 major strokes and many asymptomatic strokes that were found retroactively thru CT/MRI examination. She told me at a party that she hasn't had a stroke since smoking weed, and it's been almost a decade. CBD seems to have anti-inflammatory effects and are seeming to help her stabilize her quality of life.

@adambruno4312 4 жыл бұрын

can you do one on schizophrenia/bipolar?

@johncompounder4465 3 жыл бұрын

The interraction between cannabinoids and the role of terpens in it is so underexploited... such a shame...

@LunarAerospace 3 күн бұрын

Brother, it does have an affect on THC users. Im out of weed, just took some CBD oil and im high as a kite. No THC in my system for weeks

@andrewacevedough 5 ай бұрын

Light doses of cbd act as a stimulate for me , allowed me to cut back on caffeine from the groggy ness of thc, also helped me w my munchies ha was putting on weight fast

@ProgressiveTruthSeekers 3 жыл бұрын

How well does CBD help with memory loss?

@borp6912 2 жыл бұрын

I forget

@EM2all Жыл бұрын

@@borp6912 😂

@mariissa-zf5ty 2 жыл бұрын

So it does increase serotonin

@PuffingOnClouds 3 жыл бұрын

*The big question is, what does CBD do to the production of the body’s anandamide* can’t find that answer anywhere on KZfaq

@JohnSmith-dy6op 3 жыл бұрын

If I understand this video properly, it prevents reuptake and makes your body not break it down as quick. Thus, it increases the amount of anandamide in the body. So what does cbd do to the production of anandamide? It increases the concentration of it in the brain.

@devitus781 2 жыл бұрын

go on google!?

@Hakusiyah2 2 жыл бұрын

scientists: CBD is not thought to have a potential for abuse me: let me introduce myself

@devitus781 2 жыл бұрын

lol

@Suitswonderland 2 жыл бұрын

I always had more interest in CBG and CBN than CBD, though ideally a combination of a 1:2:2:1 ratio of CBG, CBN, CBD, THC would be ideal as a perhaps replacement hypnotic for insomnia though more research will need to be done and I think the Delta 8 THC would be far more suited for this type of combination, I don't really know if CBC or THC-V would be needed but they certainly could be added, though THC-V I would only want added in small amounts like 0.2-0.5 in ratio.

@zachperry906 2 жыл бұрын

Like it bro, smart. What about THCA, CBDA, CBGV, THC-P, CBD-P, D8-THC, D10-THC, D9-THC, CBN, CBL, CBT, CBC. We love cannabinoids!

@levigivens Жыл бұрын

Sounds like pseudoscience bs. Nobody listen to this rambling. Cbd is all you need

@shaunussy Ай бұрын

As somebody who feels neuropathic pain, and pressure from the neck up, including my eyes, and sinuses, especially when THC has been stopped for 3 weeks or longer, I can attest to CBDs ability to significantly reduce my symptom set. Whether it is due to increasing available anadamide, or through some other mechanism, it is very apparent. To clarify... when I'm taking CBD, whether I'm smoking or vaping hemp, my symptoms of THC withdrawal in relation to the afomentioned issues, are simply not experienced. Cesation of CBD returns those issues inside a day, and only upon readmission of CBD do those symptoms quieten down once again. Thank you for reading this far. For anyone quitting THC, or simply running out, CBD appears to help a fair amount. Note: I am NOT positive on the THC content. I can only go on the labels promise of

@boardingurban Жыл бұрын

I'm using my waxpen rn to get unhigh.

@petejames9366 6 ай бұрын

@boardingurban 6 ай бұрын

cbd@@petejames9366

@steventheyoutuber2130 Жыл бұрын

If you’re quitting thc cannabis, pure cbd flower or products can help you with painful withdrawal

@fxbyte6085 3 жыл бұрын

Could you do MDMA next?

@xBlackShadowsZz 2 жыл бұрын

He did one two months ago :)

@user-gs1ym8cz4d 4 жыл бұрын

i know people that have tried CBD and everyone has had a bad reaction to it (e.g. extreme paranoia) but it’s meant calming?

@willbrown1220 4 жыл бұрын

Francesa, not everyone has had a bad reaction. Extreme paranoia would only come from very high doses of THC. And yes, CBD is meant to have a calming effect.

@neurochallenged 4 жыл бұрын

A lot of people take it for calming effects, and there is some very preliminary evidence that it might be effective as an anti-anxiety agent. But one thing that's important to note is (in the US at least) it is considered a dietary supplement, and because of that status CBD products don't have to meet FDA quality or purity standards. Thus, it's always a bit of an unknown what is actually in a CBD product. Some analyses have even found certain CBD products to contain THC or synthetic cannabinoids. So that is one reason why someone taking CBD could experience anxiety, as other cannabinoids like THC can sometimes cause it.

@jahnarkevic8968 4 жыл бұрын

That's so strange, must have been some bunk stuff. Literally everyone I know has had some improvement with inflammation or anxiety, even if slight. I second the THC comment as that stuff definitely increases anxiety while CBD nullifies or at least eases it..

@user-gs1ym8cz4d 4 жыл бұрын

Will Brown, obviously not everyone has had a bad reaction i said that everyone I KNOW personally who has taken it had a bad experience to CBD not THC.

@user-gs1ym8cz4d 4 жыл бұрын

Jah Narkevic yeah that could be why, also the people ik take it recreationally so it’s riskier