Metabolism | Pentose Phosphate Pathway

Рет қаралды 993,305

7 жыл бұрын

Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
In this lecture Professor Zach Murphy will present on the pentose phosphate pathway. We discuss how glucose can use an alternative pathway to make NADPH's, which are essential in antioxidant reactions, cholesterol synthesis, and fatty acid synthesis. It's also important in the synthesis of nucleotides. We hope you enjoy this lecture and be sure to support us below!
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#ninjanerd #PentosePhosphatePathway #Metabolism

Пікірлер: 750

@vjbele 5 жыл бұрын

I got a 98 on my biochem exam because of this vid; keep doing what you're doing bro!

@serva8334 3 жыл бұрын

Tomorrow I will have mine

@vjbele 3 жыл бұрын

@@serva8334 good luck!

@fejiroedeki9014 3 жыл бұрын

I concur

@nhattranminh2970 2 жыл бұрын

congrats! I hope I can do it.

@mudassarbutt7728 2 жыл бұрын

@@biasedjedi4353 l

@jonathanissa3123 3 жыл бұрын

It is sad that I got more out of this video than in 3 lectures from my university professor. Some people really should not teach, thank you for being someone who is reliably good at teaching.

@someguyontheinternet4277 9 ай бұрын

your med school split the pentose phosphate pathway into 3 lectures my med school put it in as a single slide in a different lecture

@A-K.14 7 ай бұрын

same here

@estherkhondowe62 7 ай бұрын

@Nejiglenna 6 ай бұрын

It was barely mentioned at our medschool university (just randomly inbetween something else) and then it popped up multiple times on the exam where we were just supposed to memorize a random enzyme at a certain step etc. It is fair to say that the majority is up for credit test as the first midterm was just as bad. I wish they tested us in understanding rather than pointless memorization.

@maheethpattem5262 4 жыл бұрын

im sure after few years ninja nerd science is going to be one of the most effective medical videos on KZfaq, the way you explain things we cant forget.

@ogunyemisherif1638 2 жыл бұрын

I am a Biochemistry student from Nigeria and I have benefitted stupendously from your videos. I can't for the life of me fathom how you developed these teaching skills. Thanks so much. Please do more.

@bensmainebensmaine7635 6 ай бұрын

who would choose biochem as a major :"))))))

@obafemiomobosola190 4 ай бұрын

@@bensmainebensmaine7635Mind yo business.

@REDI____ Ай бұрын

people who have mental issues like us@@bensmainebensmaine7635

@parvinswift9301 5 жыл бұрын

May god bless you.. Never stop making videos.. Really love ur channel.. U saved my life 😭😭

@lesterclerigo5134 3 жыл бұрын

Don’t skip ads, or don’t skip the commercials, it’s they way also of earning money. At least we help them earn by not skipping the commercials, so they can make more videos in the future😍

@emmamorgan6690 3 жыл бұрын

I never comment on videos on KZfaq but I have to just to say this guy is amazing. I was ready to quit my course after my metabolism lecture as it made me want to cry. I left my lecture halfway through and then the following day I found these videos, and not only did I understand it all, I actually really enjoyed it. Thank you so much!!!!

@saroosh4193 2 жыл бұрын

the same thing 💕

@learnenglishwithridwan 2 жыл бұрын

A little note to take at 17:17 very important correction... it's unfortunate we can not draw diagrams in the comment section but I hope this piece helps out .. 😆😂😂 Ribulose 5-phosphate is first epimerized to xylulose 5-phosphate. Transketolase catalyzes the transfer of a two-carbon fragment from a ketose donor to an aldose acceptor .In its first appearance in the pentose phosphate pathway, transketolase transfers C-1 and C-2 of xylulose 5-phosphate to ribose 5-phosphate, forming the seven-carbon product sedoheptulose 7-phosphate . The remaining three-carbon fragment from xylulose is glyceraldehyde 3-phosphate.

@ridwansalifu6987 2 жыл бұрын

Ninger Ned, you got to pin this comment. 📍📍📍

@aakasha2816 Жыл бұрын

I had the same doubt

@omarghoonem6173 Жыл бұрын

أنا كنت لسي هكتب دا برضو ميرسي لكومنت حضرتك

@lariss640 5 ай бұрын

Thankkk uuuuuu

@abhijitsrichandan 3 ай бұрын

Can you explain same for trans aldolase

@GodfreyMann 3 жыл бұрын

24:52 is where he explains the point of this pathway. Basically, there are two phases: (a) Oxidative Phase that can generate NADPH and Ribose-5-P. (b) Non-Oxidative Phase that makes Ribose-5-P without NADPH using glycolytic intermediates, and in reverse it can make glycolytic intermediates from Ribose-5-P. Note: Glyceraldehyde-3-P (GA3) in steps (5) & (7) can be funnelled into glycolysis or gluconeogenesis.

@jessicagrover1359 4 жыл бұрын

I missed 2 weeks of lecture due to illness and this video cleared everything up!! So wonderfully organized!! Thanks to everyone in the comments making the small corrections too. You are all saving my grade

@sheilamakena6253 6 жыл бұрын

Love your videos, very informative! Theres a slight error i feel you made though; its the xylulose -5-phosphate that donates the two carbons NOT the ribose-5-phosphate. The xylulose-5-phosphate is the donor ketose and the ribose-5-phosphate is the acceptor aldose which becomes glyceraldehyde-3-phosphate.

@NinjaNerdOfficial 6 жыл бұрын

+Shiru Nugi yes you are correct sorry for that mistake!

@emmaaynajar6023 5 жыл бұрын

i have also confusion plzz..correct it ...show me some diagramtic view of this

@ysmusujit 4 жыл бұрын

Also product formed is sedoheptulose, not seduloheptose

@wisdomappiah7409 4 жыл бұрын

That's true Thanks for accepting your mistake💙💙💙💙

@muscledeep 4 жыл бұрын

@@ysmusujit 7Psedoheptulose to be precise

@meme07770 8 ай бұрын

There’s no words can describe how much I’m grateful for you and your team ❤

@tazbibi6876 5 жыл бұрын

I wanted to say thank you for the amazing video and teaching skills which you posses. I simply could NOT pass my biochemistry exam today. I had the shortest time ever to cover the topics and your videos helped me achieve the understanding in the best condensed and effect manner possible. Thank you to the Ninja Nerd Science/medicine. And to Zack Murphy. Thank you so much. You were a God send! God bless!

@rjenchan 4 жыл бұрын

I remember my book in Medicine called "HARPER'S BIOCHEMISTRY". LOVE YOUR SHIRT!

@LaChilena09 6 жыл бұрын

love the way you teach it. makes SO much more sense and you're very clear and very calm when speaking and makes it so much easier to understand this. THANK YOU!

@vladghies3002 5 жыл бұрын

I am studying in first year in a medica school in Romania and these videos are really helping me to understand biochemistry:)) I am very grateful to the author of the videos

@thebeets6055 3 жыл бұрын

It's impossible to teach such concepts via 1 lecture. Your videos are incredible. Thank you

@alchemist585a 5 жыл бұрын

Great stuff! I am going thru ur biochem videos just for fun. I remember, as a student long ago, loving the maze of the various metabolic pathways. For each pathway, there three points that must be made and emphasized. 1. The key, rate-limiting enzymes/reactions. 2. The main purpose or role of the pathway. What primary purpose does it serve? 3. The net energy balance (yield or cost) You described the pathway and what it is good for beautifully.

@sandraschmelzer9961 Жыл бұрын

All your videos are so relevant as I study for my RDN exam. Thank you so much for putting all these together and explaining the details as well as the big picture.

@amirhosseinzarei2597 Жыл бұрын

your videos are exactly a masterpiece!!! the intonation is perfect and it's your art that you make the audience to company you through the lesson keep going please!

@akankshaatulkar7349 6 жыл бұрын

Thank you.. god bless you for adding this series on KZfaq.

@stefanieneufeld3017 3 жыл бұрын

Love your videos! Just a tiny correction: Xylulose-5-Phosphate becomes GA3P and Ribose-5-Phosphate becomes Seduheptulose-7-Phosphate in the reaction catalysed by Transketolase.

@jiro5523 3 жыл бұрын

Finally..i was looking if anyone wrote this comment😄

@Rubara3034 2 жыл бұрын

Exactly thanks for noting this

@benediktatu4573 5 жыл бұрын

You deserve to have millions of views! YOU ARE THE BEST! KEEP UP THE GOOD WORK! Thank you very much. I wish my professors were like you...

@hamnamalhi4721 5 ай бұрын

I've an exam tomorrow and I dunno how I'm storing all this in my brain 😭

@ARHAYEMXD 5 ай бұрын

U good now bro ?

@halimazamouche2442 4 жыл бұрын

You cannot imagine how much grateful I am for finding your channel! You did a great job here!

@fayyoosh7870 3 жыл бұрын

Me too !

@noursamy7163 3 жыл бұрын

I’m new as a teacher, u make every single topic as so easy I’m really lucky to hear u. Best of luck

@joymumo8173 3 жыл бұрын

Thankyou for taking your time to make these videos,you have no idea how helpful they are.

@amyokazak9114 7 ай бұрын

Kudos to Professor Zach for consistently delivering top-notch educational content! The clear explanations and engaging presentation make learning complex topics a breeze. Keep up the fantastic work!

@maxruphio5515 5 жыл бұрын

Just cant express in words how helpful your vedio are. They have helped me a lot in building concepts and then going into detail of each concept.

@hadas8731 6 жыл бұрын

Just wanted to tell you that the first time I tried to study biochimestrey for my exam I got 56..than I discovered your videos, study with them, took the exam again and got 100!!!!thank you so so much!youre a m a z i n g ! I still hate biochimestrey though lol...😋

@AmanKumar-kh8bc 5 жыл бұрын

😂😂😂

@rickbaruah2216 6 сағат бұрын

I got 96 in biochem special paper only because of you sir. Thank you so much for all the hard work that you do❤

@clover2196 2 жыл бұрын

This is my first ever comment on KZfaq...never felt the need to do it...but sir ! ..i am so thankful to you ...you are a gem of a person ...THANKYOU SO MUCH! ...thank you for making studying easier

@mol_biologist30 2 жыл бұрын

Just a busy day of being a Ninjanerd🌟 Your lectures are truly life-saving !!

@jbswagger9934 5 жыл бұрын

Thank you sooooo much. Mr.Ninja. Im on the first year of medical school. This makes me want to learn more, makes me feel like it good to know, it is super cool to understand. You just light up my world. Promise will be a good doctor.

@koftasam 4 жыл бұрын

Waah ninja beta waah Kamal kr Diya tune .tum jio hazaro saal

@eliasali9383 4 жыл бұрын

You and AK lectures are spectacular! Will do my best to support you bud, keep up the great work.

@myforever13 5 жыл бұрын

Thank you for these videos, I still don't remember everything but, with these vids I start seeing some connections between the pathways that feel like maybe I understand

@wrxefx3931 Жыл бұрын

Having G6PD deficiency I am fascinated by your complete breakdown of what would happen in my body without the deficiency vs what is happening. Awesome video! Also, I get like...shamwow vibes or something from this...."then you get this, what can happen what does this give you!?" (feel like I'm gonna win the prize), but I think that's why you kept my attention so well-played sir!

@christianmendoza3634 4 жыл бұрын

thank you for all your videos you have helped me more then any professor or TA ever will!

@its_Dr.Glass-Man 3 жыл бұрын

There're so many things this sucker is used for. Love it sir❤❤❤

@anabrundic2630 3 жыл бұрын

best videos! u first saved me with your anatomy videos, now with biochemistry videos!!! thank you from the bottom of my heart!

@shibanithyagarajan7308 6 жыл бұрын

this is amazing! This gave me a clear understanding of this pathway. God bless!

@NinjaNerdOfficial 6 жыл бұрын

+Shibani Thyaga rajan So happy the ninja nerd team could help you!

@sergiocarusi1570 4 жыл бұрын

@@NinjaNerdOfficial in italiano

@dr.wafaaeyaid3283 5 жыл бұрын

Thank you I am a Physician who diagnosed couple of patients with trasaldolase deficiency that was named after my name “Eyaid syndrome” . Your great video is the best one to explain the PPP Wish u the best

@tariqjagmag 5 жыл бұрын

Dr. Wafaa Eyaid does giving nac (n acetyl cysteine)help patients with transaldolase def?

@user-js6to2jh6f 9 ай бұрын

Grateful is an understatement! Thank you for making these!!

@matheusmartins9405 3 жыл бұрын

Dude love your videos, i study medicine in argentina but everything is so easy to understand that it doesn't matter being in english, awesome man , saved my year!

@nareemanzangana2816 4 жыл бұрын

I don't know how are you making these videos for free. Thank you sooo much Best video about this subject ever...

@alexessholt8202 4 жыл бұрын

Saved my life and thousands of dollars of my tuition. Thank you prof!!

@gunelaslanova737 6 жыл бұрын

If I get high mark from biochemistry tomorrow, it will be with your help. Thank you for understandable videos!

@rayaneb5186 5 жыл бұрын

did you get that high mark?

@liongirl2578 5 жыл бұрын

Gunel Aslanova did you get

@whatever9506 5 жыл бұрын

@@rayaneb5186 he died

@TheMusicDiary 5 жыл бұрын

Gunel Aslanova Rest In Peace.

@Antoniooo1206 4 жыл бұрын

LOL

@michellehadinec7628 4 жыл бұрын

2 years old video and it’s still saving lives! Thank you, that MUDr. in front of my name is partly gonna be there because of you ❤️❤️

@kanijfatimamemoshi5602 Жыл бұрын

I love this channel for making my MBBS life easy...its my dream to meet you Teacher❤️

@basilekalyounji2359 4 жыл бұрын

This is some serious great job man. Much respect and a big thank you for this help seriously 👍👌

@Resuno198 5 жыл бұрын

Thank you very much!!!! ❤️❤️ this is what I need to for a long time

@iuliavoicu7860 6 жыл бұрын

You are doing a great work! I have my biochemistry exam in 3 hours, your videos are of huge help right now. The way you explain it helps me connect information and remember easily. Thank you

@bh5169 3 жыл бұрын

Watching to gain more understanding and prepare for my exam on Wednesday! Thank you!!

@Rahul-jq3ko 3 жыл бұрын

Now I started to believe why ninjas are helpful to us , you are our ninja Hattori 😍...

@Rohan-0-Patil 3 жыл бұрын

AMAAZING EXPLANATION!! thankyou so much for making biochemistry so interesting!!!

@Theprofessionalsurgeon 3 жыл бұрын

YESSSS IM SO HAPPY I FOUND THE VIDEO EVEN BEFORE I START THE VIDEO!!

@MusicInsteadOfLife 3 жыл бұрын

In my biochemistry book the reactions are kinda different; After ribulose-5-P becomes Xilulose-5-P + Ribose-5-P then i have these reactions: >Xilulose-5-P reacts with the transketolase enzyme and TPP as a kofactor and gives -> glyceraldehyde-3-P + Glycoaldehyde radical. >Then Ribose-5-P reacts with the glyceraldehyde radical and gives-> sedoheptulose-7-P >Sedoheptulose-7-P reacts with the glyceraldehyde-3-P [transaldose enzyme] and gives-> eritroso-4-P + fructose-6-P. I don’t know why though...

@sahilratnakarmokashi6154 3 жыл бұрын

Sir thank you for making it understand so clearly.

@Babozil1829 3 жыл бұрын

You have made learning so easy and fun!!!

@jeelol1355 3 жыл бұрын

Zach, one day we'll meet and I'll tell to all of my Gratefullness.You Rock.

@kaushalyaseuwandi8906 3 жыл бұрын

I really appreciate this video series. I learn a lot through this.

@Girl_from_HillsUk01 Жыл бұрын

You cleared all my doubts. Thanks a lot for making such an informative video (From Uttrakhand, India)

@Batette 7 ай бұрын

This guy is so f*****g awesome. Besides, his accent is really cool..

@tolulopeogunsanwo6610 6 жыл бұрын

U rock nerd scientist, Ur videos are wow, please can u also do a video on uronic acid pathway and alot others.

@maianhnguyen8939 4 жыл бұрын

thank you for making this video ^^ you've just saved me from this crazy pentose 5 phosphate pathway.

@auroraisabelmards1481 4 жыл бұрын

You are really saving my biochemistry grade!!

@netidekel 4 жыл бұрын

thank you so much for your videos!! never stop making them you are amazing!

@fmbahmed5576 Жыл бұрын

well-constructed and simplified hours of lectures!

@tinacdkh Жыл бұрын

You are AMAZING!!! SO grateful for your videos, and I agree with the others - I'm learning more from your videos than from my biochem class. So wrong... Thank you, thank you, THANK YOU!🤗

@tammyreed9735 2 жыл бұрын

You do a great job! Thank you for the clarity. I'm a very visual learner and would appreciate at the end of your videos, if you could step away so the audience can see the entire board. Thank you again!

@NinjaNerdOfficial 2 жыл бұрын

Members of the ninjanerd.org website get full access to pre and post-lecture whiteboard resources, as well as the lecture notes! - TG

@dhartikachhadiya76 5 жыл бұрын

finally i can write about HMP shunt in next coming exam....☺thank u so much sir

@majinbuu6382 6 жыл бұрын

amazing...the teaching methods are so simple and easy to grasp...thank u so much

@santicruz4012 2 жыл бұрын

wow, the skill to memorize and explain the subject in these videos is awesome :O

@user-uo6ye4uj3b 4 ай бұрын

Thank you for making all these very helpful videos. They’ve been life saving for me

@mathewsmwale3837 Жыл бұрын

Your videos sir they educate me more than any lecture 🙏🙏🙏 I really appreciate

@natimintesnot8065 2 жыл бұрын

as usual you really impressed not only us, the subject too!

@sauravdas2525 6 жыл бұрын

Huge fan of nerd ninja❤️❤️

@assejyojtopilam 6 жыл бұрын

your videos make metabolism look less overwhelming and more understandable. youre amazinggggggg thank u!!!!!!!!!!!!

@NinjaNerdOfficial 6 жыл бұрын

+supercalified that's awesome! I'm so happy that we were able to help!

@zeppelinbtd6788 2 жыл бұрын

Great! Wouldnt know what to do without all these videos

@SadhuBiochemist 2 жыл бұрын

Great pathway recitation!

@carolnawanyambe427 5 жыл бұрын

This is so making me pass my biochem exam tomorrow morning... Thanks

@ivanpeteovitch8865 4 жыл бұрын

You are amazing .. thank you so much for all the effort you put in here .. please keep going and have a good day

@nikolaa1625 3 ай бұрын

This took my teacher 3 hours to explain and I still had no clue what he was talking about. Then Ninja Nerd comes and explains everything perfectly in 34 minutes 🥲

@farhanabashir4524 5 жыл бұрын

Thank you so much sir.your vedios are really very helpfull.The way you explain things is simply amazing ....once again thank you.😊

@elahetolideh2284 3 жыл бұрын

it's was sooo perfect and sweet to learn, thank you so much and please keep on posting more 🙏🏻

@FatimaSarayani Ай бұрын

Ninja I owe you all of my education please keep going on

@dianaelena5236 7 ай бұрын

You are blessing us with your videos sir, i literally had no idea to learn biochemistry, thank you lotsssss

@christopherconroy2805 3 жыл бұрын

You are a truly great teacher.

@hiramalik3874 5 жыл бұрын

hey Sir... a lots of love from Pakistan😍😍 you r just doing an amazing work... thanks alot for our help in studies😍😍 stay blessed😇

@maohadad6893 3 жыл бұрын

May god bless you.. Never stop making videos.. Really love ur channel.. U saved my life 😭😭

@kannankamal5446 4 жыл бұрын

Saving my life also,God bless you, Merry Christmas ninja bro

@mariammansoor2279 4 жыл бұрын

Love your channel... When ever i have any queries related biochem i certainly look forward to your videos😃

@onionlayersed 10 ай бұрын

Thank you Ninja nerd for helping us all Med students...

@deegallarupananda6927 Жыл бұрын

Thank you so much for simplifying 🙏🙏🙏

@saadbaig4491 6 жыл бұрын

i love the way you explained

@drunkmaster2488 5 жыл бұрын

you're all that I need..harpers heroes saves the day!!..

@nas_775 3 ай бұрын

thank you so much, Id be lost without your videos!!

@sylviaani7991 Ай бұрын

If biochemistry was a person it would have been you cause you really make biochem look easy😮 thank you so much prof

@theak3991 Жыл бұрын

thank you, I did not understand anything after watching my uni lecture, but now it makes perfect sense!

@prasathsampath2505 2 жыл бұрын

Thank you very much for those amazing & simplified explanations ❤️💐🇱🇰

@sk8tergirl740 3 жыл бұрын

Saved my life. Thank you. Keep up your videos!!! I love your passion! :)