I purchased it based on Sarah’s recommendation and have not looked back. It’s a must in my routine and has replaced multiple serums.

Dooood. I started using the DRMTLGY needless serum which is a copper peptide serum along with .25% tret at night and saame. When I wash my face it feels so smooth clear. A lot of the redness I used to get is gone. I use the every sun day sunscreen which is zinc and it makes my skin look perfect. I was skeptical of copper peptides, but it’s definitely doing something that tret was not doing alone.

Im on the same routine and my skin has never looked better!

So you use copper peptide serum together with tret? What goes first? Do you layer something between? Thanks

same I have seen the products in many stores in Spain but never paid attention to the special serums @Sarah thx for showing us this product. I also got their Retinal serums (2 different ones) amazing

I use tret too and am not sure where to incorporate copper peptide serum. I use vitamin C serum in the morning, so ideally, I would use the copper peptide serum at night, but there are some controversy about whether to use it at the same time as Tretinoin. Thanks

@littlesthepitbull The reason they caution against copper peptides with tretinoin is that copper peptides, the regular ones, not the encapsulated ones, can cause a flushing/blushing effect increasing blood flow and increasing the efficacy and side effects of the tretinoin. I've used them together, TO copper peptides and NIOD CAIS, (depending on which one I had) with tretinoin for years with no issue. Of course, I don't think I've blushed in years 😆😂🤣 If you're not having issues with tretinoin side effects, I should think you would be more than fine combining them in the evening routine. Hope this helped 🥰

@@debbie_LJ Thank you so much; that’s so helpful! Are TO & NIOD the encapsulated ones or not? It would be interesting to see how my skin responded as it does well on Tret without issue but the second I add a mineral sunscreen, it completely freaks out. I had terrible allergic reactions to the two mineral sunscreens. I tried and can only imagine that, unless I’m allergic to a specific ingredient (or zinc oxide/titanium dioxide which I understand is super rare), perhaps my skin is more sensitive now that I’m using. Tret? I used to use U.S. chemical sunscreen in a moisturizer (by Dermatology) prior to Tret with no issue. i’m not sure if it was you, but I think it might have been who reached out to me to answer this, on YT on someone else’s video or possible in a Reddit post? (Are you the retired chemist who keeps a low social media profile?) Either way, thank you so much!

I know what you mean, I've found that copper peptides are well worth changing my routine up a bit. Today my skin was super irritated and this serum really helped calm it down.

Oh thank you so much for being the one to tell me about this brand!! I picked up a ton of their other stuff too. Cannot wait to review that too. So jealous that you live in Italy! Wonderful country and such smashing food and wine 🤗

@@NOBSBeauty Wonderful place.I live in Tuscany.Hungarian Italian.Check the Retinylretinoate serum,alsaw 1 month new.For me a dup of Medic8 Intens Retinilretinoate 280€serum.

I'm wondering if the addition of palmitic acid in the NIOD ones could be what caused my breakouts from it? I hadn't thought of that before. I'd love to know where both brands source their raw peptides from and what country they come from, purity, etc.

@@NOBSBeauty AFAIK the lipid form was/is developed by Deciem. Most of the raw copper (possibly all) peptide comes from either China or India, as with many raw cosmetic ingredients these days. Can't really compete otherwise.

Which is best would you say? Overwhelmed by all the peptide info!

@@grzeszczny when searching for raw copper peptides online, the ones I found were also from China.

Did I misunderstand or are you saying the Ordinarys 1% copper peptide serum is stronger than this Theramid 3%? I haven’t tried either, but wasn’t going to try the ordinary one as i’ve heard many complaints about the tackiness leaves on the skin and was leaning towards ordering this. Thanks for clarifying. I hope the irritation dies down for you. I certainly have been there. I tolerate tretinoin really well but ever since I started it, I’ve had major issues with sunscreen. I can’t wear mineral sunscreens, so I just ordered a bunch of chemical ones from overseas and I’m hoping to find one that doesn’t seriously irritate my skin. I never had sensitive skin before tretinoin and haven’t had any reactions to it, but once I put on the sunscreen, even before leaving the house, my skin looks like it has a red chemical burn. Really frustrating.

@@ScoobyDoosMom the ordinary's is stronger than peach and Lily's version. I found my skin to prefer the lighter percentage! It worked a lot better with my lifestyle (lots of chlorine exposure) and tretinoin (.05%) on other days. If you don't have sensitive skin or sensitizing lifestyle or strong retinols, it's probably worth going for one of the other brands that have a higher %, and I think they're both cheaper than peach and Lily's

@@gwendolinehall1386 thanks so much for the info and for writing. I’m on Tretinoin for almost 6 mos and about to increase to .05 from .025. I was avoiding Peach & Lily simply because of their built in fragrance & having being warned that this can be irritating to skin using Tret. I never considered myself to have sensitive skin (but I’m now in my young 50s so maybe my skin changed?). I’ve done really well on Tret but when I tried adding mineral sunscreen after going on Tret, my skin had allergic reactions to every one: it was BAD! I had to discontinue all my skin care because I had what felt like a chemical burn. (I had been on Tret for months and reaction happened very shortly after applying the mineral sunscreen and I use no other skin care so I have no doubt it was that . I also only wore it in the house, so it wasn’t from a reaction to the sun; it was a reaction to something in the sunscreen. I don’t know if I was allergic to a specific ingredient or to mineral sunscreens all together. I am waiting for some J&K beauty chemical sunscreens to arrive and hopefully my skin can tolerate those because I obviously need to be wearing SPF. I am homebound at the moment and try to stay away from windows until I can find a sunscreen my face can tolerate. From what I understand, the encapsulated copper peptides are safer/less risky to not work together, but I’m not sure how I know which are encapsulated unless I can find that out from the ingredient list. I’m guessing you haven’t tried the Theramid 3%? Copper Peptide (navy blue bottle). That was the one I was going to order. I’m not sure if the cops are encapsulated. Trying to find ones that are, as well as one with snap 8, is becoming a real pain,

So happy to hear you're enjoying it, always nice to hear what works for everyone whether it's good or bad so thank you for letting me know. 😉

We most have the same skin type. I never been let down by any of your recommendations. Thank you Sarah!

Maybe new years / Christmas sale ??? I’m hoping I missed it too got confused with the web sites for USA 🇺🇸

Oh thank you so much- you are too kind! I appreciate it 😊🤗

Are you sure you’re not allergic to any ingredients in the treatment?

@@tiahnarodriguez3809 All ingredients: Rosa Damascena Flower Water, Butylene Glycol, Panthenol, Glycerin, Niacinamide, 1,2-Hexanediol, Allantoin, Sodium Hyaluronate, sh-Oligopeptide-1, Carbomer, Arginine, Ethylhexylglycerin… I don’t think so??? 🤔

@@TaylorOwenPossibly Rosa damascena. More likely, you returned to using actives too soon. It’s best to wait 48 hours before re-introducing any retinoids or acids such as vitamin c.

@@vetsai8199 I think that’s it. I did it Saturday afternoon and eliminated actives through Sunday but wore makeup Monday - I could have used an active sooner than that… of course, once my skin cleared, I tried the Alpha-H midnight reboot serum I bought before starting Tret and my face blew up again… perhaps the highest strength glycolic acid was a very wrong idea.

If you have dry skin this is great but if you are oily the Niod cais 3. Sometimes cais makes my skin very flaky, it does speed your skin renewal very quickly

@@sunshine9993 thanks!

Omg this is SO smart!!! Thank you for commenting

There is a group of people that don't believe in peptides- I am in the opposite camp on this topic. I also think tools like microneedling help peptides penetrate better if that is their opposition to peptides. The results from peptides are undeniable to me. The research on pubmed is also hard to refute. There's always going to be non-believers in everything, but to me what I've personally experienced using peptides is amazing.

@@NOBSBeautyThank you for your answer. 😊

@@NOBSBeautyIf you do micro needling, do you stop Tretinoin a certain # of days before? are you still using Tret? Id love to know if you prefer the Theramid serums over the Reviv ones you recently reviewed. Thanks, Sarah!

​@@ScoobyDoosMom Great question

I have used both and like both. If I had to choose it would be Theramid. It just has more beneficial ingredients. the ordinary is a great serum if you are on a tight budget and it is easier to find.

I recently got the Natasha Denona Retro Glam Palette on sale and I've been loving it!

@@NOBSBeauty it suits you very much!

Idk if you ever figured it out but I use a hydrating facial mist right before applying! I notice it does way better on slightly damp skin. It’s perfect now!

Interesting question- the Sub Q was holy grail for so many people. I liked it but could only use it occasionally without my skin starting to get irritated. I think that might have been from the salicylic acid in the SubQ. The subq is definitely much thinner in texture. I think a major difference is the inclusion of copper peptides in the Theramid. Here's an ingredient breakdown between the two products you will find interesting: incidecoder.com/compare-products/niche-beauty-lab-theramid-copper-peptide-4/hylamide-subq-anti-age-advanced-serum

@@NOBSBeauty thanks! I still have some bottles left but im trying to prepare.. it really works well for me. I like the texture a lot too. I wonder if the Niod serum with the initials in the title is close.

Very good point, you're right, the US limits it to 10%. I've had good luck with anywhere from 10 up to 20. I think the higher percentage seems to help a bit more with my redness.

You are so welcome!