Alpha-1 Antitrypsin Deficiency - causes, symptoms, diagnosis, treatment, pathology

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Күн бұрын

What is alpha-1 antitrypsin deficiency (A1AT)? A1AT deficiency is a genetic disorder where somebody has low circulating A1AT, resulting in both lung and liver problems. Find our full video library only on Osmosis: osms.it/more.
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Пікірлер: 149

@Snowchris1 2 жыл бұрын

Healthy my entire life. In 2018 I was at work and suddenly felt like I was shot in my stomach. Dr said, I had deep vein thrombosis, further test showed I had cirrhosis and A1AT. My heath diminished rapidly, it was horrible. I received a Liver Transplant, woke up and instantly felt better!!! I now feel great again

@frisky6727 3 ай бұрын

god bless you

@sameerapinky2995 5 жыл бұрын

Every video made by u is extraodinary i note each and every word spoken in ur video its really helpful to grab entire concept on a specific topic....

@alexjames1284 4 жыл бұрын

I was born with this and i’m 15 now. I have been completely healthy my entire life tho and this hasn’t affected my life at all. I don’t even notice that I have it so i’m lucky.

@ChilupaKing 3 жыл бұрын

Thank you for explaining. I'm about to be discharged from the military and just NOW got diagnosed with this. They just kept telling me I was being lazy, the same with some of my other airmen who had ACTUAL issues.

@toddkeeton7450 3 жыл бұрын

Hey there. Was this something that was an auto MEB and auto med discharge? I’ve been in 15 years and am being tested for this soon and am nervous.

@1houndgal 2 жыл бұрын

Thank you for your for service.

@StephyGrowsWeed Жыл бұрын

what’s been ur symptoms? I only got here because my sons a1-globulin came back decreased. 2,4 instead of 2,9 and read it’s mainly caused by this? 🤷🏻‍♀️

@diegovarela2441 10 ай бұрын

I was just diagnosed with this and am separated from the Air Force as well. How much VA did you get from this?

@victoriawarren9526 4 жыл бұрын

Thanks for this. I needed to clear this up in my head. Also, how about some NP merch! 🥰

@oreskoul 3 жыл бұрын

simply explained . great work . once again ! Thank you osmosis !

@cassieleedarlin 5 жыл бұрын

Omg thank you for existing! I've been trying to understand this for days reading in text book and I have been so confused! You clarified EVERYTHING in 8 minutes! Wow! Thank you!!!

@speachless5576 4 жыл бұрын

hello

@abdoufekroun4195 Жыл бұрын

Yes

@MedCalUniverse 5 жыл бұрын

hola saludos desde argerntina!!! impecable como siempre!! you inspired me to start my own channel on youtube!! thannks !!

@ganchimeganjik9692 5 жыл бұрын

thank youuuuuuuuuu love OSMOSIS. GOOD LUCK GUYS

@shirlvin777 5 жыл бұрын

Your videos are so so helpful. Thank you so much.

@dalamorshed5435 2 жыл бұрын

this channel is the best thing that ever happened to me

@osmosis 2 жыл бұрын

Thanks for your comment, Dala! Glad to be of help! 😊

@krutidesai18 4 жыл бұрын

You have great videos!! Great work. Kudos

@JustWanaComment 5 жыл бұрын

Love the channel. Life saver. PS. You sound like Morty

@utkarshdubeyingoogleplus 3 жыл бұрын

Keep up the great work Osmosis ❤️

@joseph6948 2 жыл бұрын

My Mom was diagnosed with Alpha-1 Antitrypsin Deficiency! At 47 years old she was on full-time oxygen and died at 52. I was tested for this deficiency and Thank God, I wasn't missing the Gene, I'm okay ( I do have mild COPD however, because of the environment)...It was hard to watch her suffer, not really being able to help. It was like she was drowning, no air over and over for years! Her lungs just didn't have the elasticity to function! R.I.P. Mom

@osmosis 2 жыл бұрын

Sorry for your loss, Joseph. 🙏🏼

@anmoldhawan2671 2 жыл бұрын

Neet aspirant here after biotech chapter to understand how alpha1 anti trypsinogen deficiency causes emphysema, got it , thx sir 👍

@MariaReyes-jp4lb 9 ай бұрын

My father died of emphysema and blamed it on smoking. He also died at the age of 52 😢. Marine and stationed at call L in N Carolina. Mother also passed away young at age 62, sister conceived and died at 3 months there. Brother conceived there and passed at age 48. I wonder if they all had this deficiency?

@hanch96 3 жыл бұрын

much appreciated, very clear and helpful

@haseebakram2967 Күн бұрын

The best channel I've seen after a long time ❤

@antonellalucero4919 5 жыл бұрын

Thank you!!! Great video!

@alevelsdemystified3410 5 жыл бұрын

This was really helpful!

@selvalakshmianand6800 5 жыл бұрын

Your videos are the best..Thank you so much😁

@cloudqbaby-yx9eh 4 жыл бұрын

Awesome! Thank you thank you thank you- I'm a nurse and I like to have a better understanding of the IV therapy I will be giving my patients. :0 :)

@bilelhamza114 5 жыл бұрын

A great work , bravo

@akhilka3582 2 жыл бұрын

Amazing video. Helped alot in understanding AATD. Could you please provide the references you used in the video. Thank you

@osmosis 2 жыл бұрын

Hi! You may get in touch with our team at support@osmosis.org and they will be glad to assist you on this. 😊

@wardaarooj3928 4 жыл бұрын

Great work... Keep it up 👍

@m.ichannel3248 5 жыл бұрын

more gain in little time superb... no words thank you.

@skuaogaming2680 4 жыл бұрын

Hay thanks i never really looked into it that much but im 15 and diagnosed. I was diagnosed 4 days after being born

@skuaogaming2680 3 жыл бұрын

@Internet Gangster add me on Instagram g id love to talk

@skuaogaming2680 3 жыл бұрын

@Internet Gangster hello_ im_here_too

@amartyapaul8280 3 жыл бұрын

Well explained 🔥

@judahokonkwo3866 3 жыл бұрын

Thanks a lot for this Video Osmosis

@abmsafiullah4014 4 жыл бұрын

Fine,learn many thing from this youtube

@SanguinaryStrife 4 жыл бұрын

I. LOVE! Yes! Thank you!!

@luisoctavio597 5 жыл бұрын

love your videos :) thanks

@vardaansinghmann3708 5 жыл бұрын

Thank you doc

@StephyGrowsWeed Жыл бұрын

Genetic (imo) testing (mouth swap) is best. Grifols offers it for free in germany. AAT levels in blood can be elevated because of acute infection, therefore CRP should be tested at the same time.

@millylovesyou7703 2 жыл бұрын

great job!!

@tallinhamda4741 5 жыл бұрын

THANK YOU!!!!!!!!!!!!!!!!!!!!

@khdr4165 3 жыл бұрын

I don't know why the shit written in books can't be explained like you do in this video. Veeery clear explanation thanks alot 🔥❤

@michellegeist5421 11 ай бұрын

Thank you I am going to have my lung doctor check on this because I was just diagnosed with copd and asthma and I have been smoke free for 23 years. I understand the environment can cause copd

@osmosis 11 ай бұрын

We hope this helped! 🙏🏼

@abealpha4022 3 жыл бұрын

Thank you.

@elizabethh560 4 жыл бұрын

I'm asymptomatic so far, but I do have it. Whenever I get the flu it will almost always result in me getting bronchitis or pneumonia. I'm 22. My grandmother had it (and died of it), my aunt has it, and so does one of my cousins. My cousin and I also have IBS thanks to A1AT. None of us have liver problems thanks to us not having A1, but we are all monitored just in case.

@nenadsima7105 2 жыл бұрын

Ibs, depression, knuckles inflamation, foot in bruises. With years, weaker and weaker, lost 10kg of muscle

@Alpha1Warrior83 Жыл бұрын

@@nenadsima7105 does the hands hurt and don’t draw up but hurts very bad when I write! I have A1AT and just found out last year , exactly 1 year and I’m on oxygen 24/7 and my genotype is ZZ

@Alpha1Warrior83 Жыл бұрын

I understand I put my number out there. I’m desperate to learn more! Since they’re not really wanting to do anything here!!

@alsson3137 Жыл бұрын

@@Alpha1Warrior83 I'm just now learning about this disease and am also ZZ , tomorrow I begin my infusions . Fingers crossed for you .

@Alpha1Warrior83 Жыл бұрын

@@alsson3137 if you don’t mind me asking how old are you? I haven’t had my infusions yet. I can’t wait until I do but I talk to someone I met on TikTok she’s in Florida. She does her infusions at home

@sarahfernandeswawginiaks5738 5 жыл бұрын

Please, make a video about 17 Hidroxiprogesteron!! Love this channel!!

@terkos3734 5 жыл бұрын

Good idea 👍👍

@speachless5576 4 жыл бұрын

hiii

@user-tw5gf4uo9i 5 жыл бұрын

Thank you

@selvalakshmianand6800 5 жыл бұрын

Can u make a video on Grave's disease?

@amyboyd3535 3 ай бұрын

There is also a mutant S allele which is not as severe as Z but still problematic.

@matchmedicines8209 3 жыл бұрын

it was so useful, thanks a lot

@thingsthatgobumpinthenight6967 4 жыл бұрын

Had a abnormallaity in a blood test a month ago, got a second blood test for this couple weeks ago. Dr called an I'm going in on Friday, I'm concerned there is a history of lung disease in my family. I dont know what this means long term. I dont expect any replys, just felt like a good place to vent.

@brandongillette35 2 жыл бұрын

Yo you dead yet

@joycethorne3100 2 жыл бұрын

I live in England I was diagnosed with alpha anitripsine deficiency and am waiting to hear back. Hope you are coping OK

@xDougg 2 жыл бұрын

@@joycethorne3100 I also was just diagnosed, I know it’s been 2 years since you posted this, any advice? Or updates jsut got diagnosed w this

@firdausfarrah3223 Жыл бұрын

Any updates?

@StephyGrowsWeed Жыл бұрын

any updates on anyone? Appreciated. My son (17) just had his bloodwork done… mainly because of hairloss…. bloodwork turned back normal except decreased DHT and decreased a1-globulin (which can be caused by AA? )

@vuanhtuyen781 2 жыл бұрын

Some segments in the video are stamped not adjacent to each other

@castawayswearecastaways3670 3 жыл бұрын

People in the comment section is studying this for school while I'm studying this for my book

@tomato_6681 2 жыл бұрын

Lmao me too. I started to be interested in diseases when I was writing the ‘sick kids’ story on Wattpad 5 years ago and now I incorporate diseases in every story I write

@melaniefordham9142 Ай бұрын

Some of us are here because we have A1AD. This is a difficult disease to understand, when you are just getting diagnosed, or were diagnosed before google/KZfaq. I’m 47 and was born with A1AD but was adopted and it wasn’t explained well to my parents. I saw a dr 25 years ago who basically just told me not to smoke or drink and that I should be okay until I was into my 40s or 50s. 🥴 I’m the past 10 years, I’ve had additional medical problems arise and it all goes back to A1AD and fibromyalgia.

@melaniefordham9142 Ай бұрын

I have A1AD and my genotype is SZ 75. In 2022 my FEV1 was 87%, so normal. This past July my liver enzymes were concerning and my Rheumatologist is having me do bloodwork every 6 months now.

@mujeebjaffal433 2 жыл бұрын

What is normal level of antirypsin Alfa-1 test????

@sarahgh4069 5 жыл бұрын

Thank you thank you thank you

@antonellalucero4919 5 жыл бұрын

Please make one of hashimotos and hypothyroidism / herperthyroidism

@osmosis 5 жыл бұрын

Hi Antonella, we have those! www.osmosis.org/learn/Hashimoto's_thyroiditis www.osmosis.org/learn/Hypothyroidism www.osmosis.org/learn/Hyperthyroidism

@kavitakumari7180 3 жыл бұрын

You are democratising education

@nishaniusmle4248 3 жыл бұрын

Thank you so muchhhhhh

@markster8456 5 жыл бұрын

Please make a video about Fetal Lung Maturity and Sperm Analysis. :)

@067girishramanan8 3 жыл бұрын

Awesome👏

@mickeysingh7443 5 жыл бұрын

Can a prior liver disease cause at deficiency

@kadethayer3708 7 ай бұрын

Since less oxygen ia supplied due to the effects on the avioli, does the heart become more stressed as it attempts to move the lungs more? Can it cause side effects in the heart?

@tinusftbl 5 жыл бұрын

I have this

@capedcod19 4 жыл бұрын

why isn't a liver transplant in the treatment section?

@colleenmeyers3257 Жыл бұрын

What happens if you’re results are too high?

@tristanblack1920 5 ай бұрын

I have a 99 level but also have a vitamin d deficiency. Could that be the reason my level is slightly lower?

@lekimngan609 2 жыл бұрын

the video image is too poor, you need to fix it more

@osmosis 2 жыл бұрын

Hi! Thanks for your feedback, if you have time, we'd love to hear more from you. Please reach out to our team at support@osmosis.org 😊

@_yeojo 2 жыл бұрын

my family have history of lung, liver, and skin health problem.. should i be concerned about this disorder?

@pamnewton2160 2 ай бұрын

YES

@noorstudent331 5 жыл бұрын

❤️❤️❤️❤️❤️❤️❤️❤️❤️ U people are amazing

@eucalyptus.sniffer 3 жыл бұрын

4:53 for Symptoms. Timestamp for self😌

@mariamemad8235 Жыл бұрын

good job❤

@osmosis Жыл бұрын

Thank you, Mariam! 💖

@samruddhikale6763 3 жыл бұрын

Osmosis is love life smile heart godddddddd i love u osmosis

@hawaii3231 Жыл бұрын

My dna test says I have this…

@__k9 Жыл бұрын

I'm 24yo and a chronic smoker. We (family) just found out my family has AATD running in it I'm really not feeling well guys.

@melaniefordham9142 Ай бұрын

You need to stop smoking immediately. Alcohol is also not suggested, as our liver is also affected.

@rogerscottcathey 3 жыл бұрын

I wouldn't begin with the wrong term. It is a historic footnote. Put it last.

@madmemomemo 4 жыл бұрын

What’s with the dump sound effects.. my ears

@amtalali5529 4 жыл бұрын

thnk u

@rachaelweeks_84 Жыл бұрын

What if your results are 80 PI MM? On the lab report it says low, but the PI MM is normal..... I'm so confused.

@tristanblack1920 5 ай бұрын

Hey did you ever figure it out. Mines at a 99 and the doctor I see acted like that was a big concern?

@Aqua-world 5 ай бұрын

My baby is now one month old and she was born with jaundince her level was 17 by day 2 after that we did phototherpay so the indirect started to reduce but direct started to raise we were in concussion why it was rasing finally the direct was 5 and indirect was 7 doctor told my baby may have some liver disease did scan and took many test virus but everything was normal... We couldn't find why the direct is high last week we took the blood test again now the direct is 4.8 and indirect is 2.0 total 6.8 .. Direct was reducing slow... They they finally did nuclear scan it was also normal then they did ggt test it's normal.. At the end they did A1AD test the normal range was 145 to 270 it's mentioned but my baby is having 111 is it normal or not?? Doctor told it may be a problem of low level the jaundince was there still now.. Is it normal or not will it get cured plz help

@shazzamyers 5 жыл бұрын

I was born with this

@williamcase3994 4 жыл бұрын

New here its obvious y

@stevenstephens8815 5 жыл бұрын

I just want to say there’s 2 ways you can have this “alpha-1” can be a carrier or have it. My aunt died at age 42 bc the alpha one was effecting her after having a Brian angerizium-don’t quote me on how to spell that- and also my baby cousin just died at 3 months old due to fluid build up in her lungs “another act of this rare genetic disease” So my daughter was born today and since I’m a carrier and could easily pass it down to her... I’m making her get tested the doctors thinks it’s best to do a family tree but I don’t think that’s 110% accurate!! And I know the blood test are I just don’t think I need to waste time and see what my family trees gonna turn out to be. I wish everyone here with this rare disease good luck and wish everyone the best..!!!

@melaniefordham9142 Ай бұрын

I have it (SZ) and when my triplets were born, they tested them all in the neonatal unit in the hospital. Only one was a carrier and other two were not. I would HIGHLY suggest having your baby tested

@shahbaz9231 5 жыл бұрын

It's expensive.

@ThePronounI 4 жыл бұрын

Ugh I think I have this bs.

@aeriozz7047 5 жыл бұрын

I was born with this and im scared now

@shazzamyers 5 жыл бұрын

Aeriozz i have this too

@aeriozz7047 5 жыл бұрын

Fudgenaya 13 but its not bad for me now but it can be if i dont treat myself good

@dawntaylor4210 5 жыл бұрын

Me too x

@that2kguy924 5 жыл бұрын

Aeriozz I have it to from birth but my numbers are good

@injest1928 11 ай бұрын

Oof. Just found today that 1. This genetic protein deficiency exists. 2. I have this protein deficiency, and 3. I have liver disease. Now i just have to wait to find out the next step. Probably biopsy. Fun times 😅

@injest1928 11 ай бұрын

At least now I know why I feel like the walking dead 🫠

@melaniefordham9142 Ай бұрын

The liver biopsy for me, was an easy recovery. They do a small probe and it’s a punch biopsy that takes about the size of a pencil section out. A small stitch and steri stips to cover.