PHARMACOKINETICS; Metabolism & Excretion by Professor Fink

Рет қаралды 109,543

11 жыл бұрын

This is Part 2 of Pharmacokinetics by Professor Fink. In this Video Lecture, Professor Fink explains the Metabolism (Biotransformation) and Excretion of Drugs in the Human Body. In the Metabolism discussion, reference is made to the more water-soluble metabolite, Phase 1 Reactions (hydrolysis, oxidation, reduction & deamination), Phase 2 Reactions (conjugation to glucuronic acid), factors that affect the rate of metabolism and the 1/2-life of the active drug in the bloodstream.
Professor Fink also explains Excretion of both the active form of a drug and its metabolite by the Kidneys (including glomerular filtration, tubular reabsorption & tubular secretion). Reference is also made to Biliary Secretion, Exhalation by the Lungs and other routes of Excretion.
Check-out professor fink's web-site or additional resources in Biology, Anatomy, Physiology & Pharmacology: www.professorfink.com
Down-loadable e-Books of the Lecture Outlines by Professor Fink can be purchased at: wlac.redshelf.com/
The “hard copy” of the Pharmacology Lecture Outline CAN BE purchased. Please e-mail Mr. Nilhson Zelaya, in charge of sales at the WLAC Bookstore. His e-mail is: ZelayaN@wlac.edu
He can tell you the cost.

Пікірлер: 105

@NicoleSolomon94 9 жыл бұрын

I get a fright every time you slap your hands together lol. You are a great lecturer, I don't even get tired when watching your videos. Thank you for sharing your gift of teaching and your knowledge of Pharmacology with us. You are phenomenal. God bless you. Love from a Med student in South Africa.

@DeronAdams 8 жыл бұрын

+Nicole Solomon the slapping of the hands.... gets me everytime.

@luzmarieramirez5369 3 жыл бұрын

Same hahaha

@ibrahimjumu4973 4 ай бұрын

Don't be stressed 😂

@ibrahimjumu4973 4 ай бұрын

Don't be stressed 😂

@scaligeri44 Жыл бұрын

I'm a British student to become a nurse prescriber and your lectures are better than my universities. I haven't got a clue what they're going on about but using your videos alongside is helping things fall into place 🙏

@serakwanejunior8315 6 жыл бұрын

You sir must sometimes look in the mirror and be like "wow am i great or what". You are a great lecturer, absolutely the best. From a pharmacy student in South Africa

@tituskibaara2340 6 жыл бұрын

You are gift to medicine!I hope my lecturer sees this and notices the difference between lecturing and teaching

@emmaa8743 3 жыл бұрын

I've never understood Pharama till I watched your videos! I wish I had these lectures when I was at school more than 10 years ago!

@ahilikedinos 11 ай бұрын

I love just having your videos in the back round of me drawing. I still understand everything you are talking about and it’s so fun to learn

@masihmasihmasih 8 жыл бұрын

You are a true legend Sir. I wish all my teachers were like you.

@bonganiadriaan2234 3 жыл бұрын

Felt this

@Chetnikpuri 3 жыл бұрын

Your way of simplifying complex topics is the best . 🔥🔥🔥

@dr.nehagupta4376 2 жыл бұрын

Dear Prof. Fink. Excellent lecture. I really like the way you explain the concept in a deep and simple manner. Thanks for sharing your videos. It is of great benefit to me and students as well.

@violetaturner4998 Жыл бұрын

Thank you so much for teaching Pharmacology so well Dr. Fink. I can understand it better than when I was in nursing school. Now that I’m in NP school your videos are so helpful to help me to understand concepts better than the textbook or on line classes. Thank you again!

@scoovadia9452 Жыл бұрын

Wow!! You’re such an extraordinary lecturer! Others should learn how to teach from you. Most of my lecturers don’t know how to teach. They simply read from their slides.

@srushtychafekar3218 7 жыл бұрын

You are an inspiration, Sir. I am an Indian student in final semester of Masters in life science. You have contributed so much to feed my curiosity about human body and its functioning. Its because of your lectures I have not just aced physiology tests but has also had the most conceptual and unequivocal understanding of the subject. Keep doing more of these! Much respect, Sir :) PS: Would be great to have some lectures on some detection techniques like PET, MRI, ECGetc

@reemaalapputhara9698 4 жыл бұрын

I am a Pharm D Student from Mumbai, India. Loved your way of teaching!! You are truly a great lecturer!!! Looking forward for more videos

@kaydengalarneau9504 10 ай бұрын

How’s the Pharm D going?

@anamfirdous510 2 жыл бұрын

Thank you so much Sir! I am from Pakistan, when I prepared for FPGEE and watched your videos and I passed, now I am preparing for NAPLEX, again I am watching your videos and I know I am gonna pass this too. Every time I need to review or refresh my concepts and I watched your video. You are the best teacher and you explain it so well that I become interested in learning more 🤩

@faanross 8 жыл бұрын

Thanks Prof. Fink - you are a master of your trade.

@marisolnavarro5893 Жыл бұрын

Your videos helped me with anatomy and physiology. I am now in nursing school and watching your videos for pharmacology. You are an amazing teacher. You really help me learn! Thank you ❤️

@miriamgarcia72 4 жыл бұрын

2019 first semester nursing program thankfull for your lectures

@nathanchan6409 7 жыл бұрын

Thank you so much Professor Fink! I really enjoy these video lectures.

@mariahnakanyala8862 8 жыл бұрын

you are a very good professor and your videos are very helpful for us in medical university.. thank you so much, we solute you all the way from Namibia. blessings!!

@mariamadiop6650 5 жыл бұрын

This is one of the best videos I've watched so far that has been really helpful you truly are a great teacher 🙌

@abbuambalantota 8 жыл бұрын

What a brilliant lecture! Thank You a Lot. It can easily understood

@maybellinemcleod2868 4 жыл бұрын

I am a nursing student, just wanted to thank you for all your videos. They really help

@kennishareynolds1825 7 жыл бұрын

Dr. Fink you are awesome! I love your videos.

@LS-gh8sz 9 жыл бұрын

This is a really GREAT video- you have explained these concepts reallly well, even dummies can understand this stuff! Hhahah every lecturer should be like you-keeeeep it uppp! THANK U

@estelamino6356 3 жыл бұрын

THANKS for u lectures step by step..an instructors like u i needed at Cuny./NYC

@jenniferaikins2746 8 жыл бұрын

wow, you really made it so easier to understand. God bless you.

@leeanderson2446 2 жыл бұрын

What an incredible teacher - thank you!

@Hendrix710 7 жыл бұрын

Thank you so much for sharing your tremendous knowledge with us!! Your explanation of pharmacology has helped me understand this daunting material!! I truly appreciate it!! And I got a great mark on my quiz!!

@nerdlibrary6044 3 жыл бұрын

I love professor Fink videos. He is so articulate and detailed. I use his channel for research purposes.

@nerdlibrary6044 3 жыл бұрын

How do I get in touch with you?

@fokwadesmond6875 8 жыл бұрын

may God continue to inspire you for this mission here on earth, i am writing from cameroon a clinical psychologist and a consultant. my name FOKWA DESMOND

@professorfink 8 жыл бұрын

Thank you for your kind words. I wish you Much Success!

@anoshaangel 9 жыл бұрын

You are great and I never fully understand these concepts now I easily understood all those thanks for uploading on you tube and God bless you keep postings the vds its very informative

@A_Fallen_Apple 8 жыл бұрын

Thank you Prof Fink! Greetings from Singapore :)

@asadullah459 5 жыл бұрын

V wonderfull teacher !! Keep it up . God bless you Sir !

@BernadethRN 9 жыл бұрын

Tausend Dank, Herr Fink!

@ashleerenae9788 3 жыл бұрын

you used "dank" as an adjective, i prescribe you 5 episodes of loveline with doctor drew circa 2003.

@kritikasubbiah6412 7 жыл бұрын

Great video. Keep up the good work. God bless you😊

@shahbaz9231 6 жыл бұрын

Thank you Professor !!!

@andreasmith3217 7 жыл бұрын

thank you sir. love from south America

@rxtina1238 10 жыл бұрын

You are an amazing professor. Will definitely go through all your other videos and pass on the knowledge. Thank you, thank you and thank you for your passion and for all the pharmacology (FUN!) videos. Looking forward to more...subscribed*

@murkrohira610 6 жыл бұрын

ِطگگگ

@worldyworld3060 6 жыл бұрын

the best teaching effort contributed by u

@mohamedo.hussein8373 4 жыл бұрын

Thank you professor Fink

@hajarrajayi3925 6 жыл бұрын

woooooowwwwwwww. How can I say the extent I got shocked by your teaching. Fantasticcccc. wooow

@jeffda9201 10 жыл бұрын

Thank you!

@besmayaseen 4 жыл бұрын

Thanku so much professor...I'm a b pharm student ( 2nd year) ....n ur lectures r very much helpful..n I also do enjoy watching these lectures..... .....love from Kashmir...

@azum3185 5 жыл бұрын

Thank you💕

@NamGiaoSanJosebyQ 10 жыл бұрын

thanks for the video

@chikouchehaminanourelhouda2129 7 жыл бұрын

thank you sir 😃 all my respect

@mohammad.salehi19853 Жыл бұрын

your are amazing teacher

@harmeetsingh3684 7 жыл бұрын

you are above the stars sir ji...😄

@Poopyduckling9999 5 жыл бұрын

Thanks a bunch doc

@grantbolton6346 7 жыл бұрын

nice class!

@AHAASSIRI 4 жыл бұрын

Thanks Fink for such a brilliant lecture. I'm not sure that APAP is eliminate through the biliary route! That is a bit of old info though. I reckon APAP is primarily secreted through the renal route 90%.

@sandeepshankwar8204 8 жыл бұрын

thank you sir

@pratipprateek. 7 жыл бұрын

thanks sir.

@SuperLika17 2 жыл бұрын

brilliant

@shivnarayanrai1936 7 жыл бұрын

love u sir.....

@kailashsingh9737 9 ай бұрын

very nice sir

@AbhilashNairSpartnax Жыл бұрын

You are awesome

@xDomglmao 7 жыл бұрын

Wonder if it's possible to join one of your lectures as an exchange student

@TheForeverFalcon 4 жыл бұрын

Another thing that will effect the rate of metabolism is drug-drug interactions, e.g. Phenytoin will induce more CYP450 enzymes; this must be considered when administering another drug as it will be metabolised at a higher rate so a higher dose may be required to compensate for this.

@Suesaysboo 8 жыл бұрын

YOU ARE AMAZING.

@ashleerenae9788 3 жыл бұрын

Is this UCLA? Do you ever cover Lactulose??? That would be a great med in this context.

@suomynonaanonymous 8 жыл бұрын

Love the *claps* haha

@hiskhois Жыл бұрын

Professor, could you please explain why do we have to take prednisolone during the morning?

@professorfink Жыл бұрын

Prednisolone & other (gluco-) corticosteroids are taken in the morning to mimic the natural release of cortisol from the Adrenal Gland upon waking in the morning.

@SyedAhmed-ll2jg 7 жыл бұрын

Dear sir, I got confused when you said Digitoxin slows heart rate..Doesn't it increases cardiac contractility (increase/positive ionotropy) and hence increase heart rate?

@professorfink 7 жыл бұрын

Digitoxin slows down the Heart Rate ("negative chronotropic effect"), but increases Stroke Volume ("positive ionotropic effect". In contrast, epinephrine has BOTH a positive chronotropic and positive ionotropic effect.

@SyedAhmed-ll2jg 7 жыл бұрын

Thanks so much for your prompt clarification.

@ericcaclark6760 7 жыл бұрын

Question- if codeine is excreted through the hepatic process, how dose it show up on a urinalysis?

@jenniferstewart5429 3 жыл бұрын

Its excreted through the urine

@jenniferstewart5429 3 жыл бұрын

www.medicines.org.uk/emc/product/11268/smpc

@jeffda9201 10 жыл бұрын

Is the half time of your example 2 hours. Or 4 hours.

@abukhattabfarrah4132 9 жыл бұрын

2 hours

@zuhairsniper8041 9 жыл бұрын

You are a greatest professor in the world I had some question you said the the metabolism is changing the drug to water soluble that it will be difficult to enter the cell membrane but their is some drugs hepatic excreted and reabsorbed by gut and carry to the kidney how it's across the intestine membrane while it's water soluble

@shahbaz9231 6 жыл бұрын

they are most likely lipid soluble than water soluble....

@AbhilashNairSpartnax Жыл бұрын

Wait why did it end

@aminaashrafi8803 8 жыл бұрын

it was awesome sir. but I have a question. u said all inactive drugs or metabolites and 1/2 of active, lipid soluble drugs remain in the kidney tubule. other 1/2 of active, lipid soluble drugs are re-absorbed from the tubule. my question is why only half of active drugs are re-absorbed? why not all of them are re-absorbed? as they are active and lipid soluble that can easily cross cell membrane. thank u sir...

@professorfink 8 жыл бұрын

Diffusion is when a chemical flows from an area of higher to lower concentration, and will tend to distribute evenly. The lipid-soluble form of the drug simply follows this diffusion pattern, distributing roughly evenly between the renal tubule and the bloodstream.

@aminaashrafi8803 7 жыл бұрын

Thank you sir.... :-)

@karadhitulasiram9211 7 жыл бұрын

Sir I have doubts if drug is taken firstly it will goes to liver and where it metabolites and excreted through urin , how the drugs goes to active site sir plz give reply sir

@professorfink 7 жыл бұрын

As a drug is absorbed from the digestive tract into the bloodstream , it is carried to the Liver. There in the Liver, some of the drug will be metabolized (altered) -- let's say 25%. So, what leaves the Liver and then flows into the Inferior Vena Cava are the Active form of the Drug (75%) and the Metabolized form of the Drug (25%). The Active form of the Drug can still act on the active (Receptor) Sites. See: www.ncbi.nlm.nih.gov/pubmed/6362950

@josephabotsi5570 3 жыл бұрын

I like the man like something.. wow

@msasyhero7559 2 жыл бұрын

I want these lectures professor , is there a book or pdf ?

@professorfink 2 жыл бұрын

You can purchase the Pharmacology Lecture Outline for $20 at: wlac.redshelf.com/ This is a 100% downloadable PDF that is 100% printable.

@msasyhero7559 2 жыл бұрын

@@professorfink thank you professor, i will do soon💜 , it’s for pharmacy student isn’t it?

@professorfink 2 жыл бұрын

@@msasyhero7559 The lectures were given to Allied Health students (Nursing, Dental Hygiene, Physical Therapy, etc.)

@msasyhero7559 2 жыл бұрын

@@professorfink thank you professor 🌼

@farahali5754 Жыл бұрын

I am at elementary level

@leemcdonald7830 9 жыл бұрын

please stop slapping I was already paying attention now my ears are just bleeding

@zeusdavidtesorobspharmacy5314 2 жыл бұрын

Excretion 24:30

@professorfink 6 жыл бұрын

Down-loadable e-Books of the Lecture Outlines by Professor Fink can be purchased at: wlac.redshelf.com/ The “hard copy” of the Pharmacology Lecture Outline CAN BE purchased. Please e-mail Mr. Nilhson Zelaya, in charge of sales at the WLAC Bookstore. His e-mail is: ZelayaN@wlac.edu He can tell you the cost.

@suomynonaanonymous 8 жыл бұрын

You are awesome