pKa - Why most drugs are weak acids or weak bases

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pKa - Why most drugs are weak acids or weak bases

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Pharmapedia

9 жыл бұрын

A description of the pKa and why most drugs are weak acids or weak bases.

Пікірлер: 109

@poojajoshi4013 6 жыл бұрын

My search for understanding pka ph concept ends here...thnks

@NaDa-vv4nu 2 жыл бұрын

+11111

@mattpace433 4 жыл бұрын

Current med school student. That means I have had to learn this concept over 10 different times over the years. AND FINALLY! I found an amazing explanation and i clearly understand it. Thank you so much.

@fishribbon 8 жыл бұрын

I am an old fan of this man (I like his videos on pharmacology) I like his face: He's like - 'Take it easy, man'

@iBuyBitcoin 4 жыл бұрын

This guy is amazing, he genuinely cares about teaching the material

@ahmedassadi9227 3 жыл бұрын

Trueeeee

@ahmedassadi9227 3 жыл бұрын

I really need to hug you man, I can’t believe pka is just so simple, my doctors couldn’t get this straight up my head for weeeeeks

@ludyoviedo4121 5 жыл бұрын

Omg finally I understand this concept. Thank u sooo much

@animeshmisra9467 4 жыл бұрын

Looking beautiful 😍

@yadabk8378 3 жыл бұрын

Wow you must be a genius

@supernovachampions 6 жыл бұрын

thank you so much for posting this. i am in crna school, and they lecturer was explaining pKa with the assumption that we had a strong understanding of chem - for me that was 10 plus years ago. you put things into plain english for me. i also appreciate your practice of equanimity as you teach.

@Pharmapedia 6 жыл бұрын

Thank you! Had to actually google equanimity :) My main youtube page is PHRM203. Pharmapedia is a format experiment.

@yash92951 2 жыл бұрын

This man explained in less than 10 min what my professors couldn't do in 2 hours.

@andijayy9008 2 жыл бұрын

the fact that i now understand this in 10 minutes whilst my prof has been trying to explain it to me multiple times the last 3 weeks… THANK YOU

@danamay9081 4 жыл бұрын

It makes so much sense when you explain it what the hell.. It has taken me months to understand this and I could've just watched this vid to begin with

@myyoutube5157 4 жыл бұрын

I understood this concept after 5 years of my graduation here thanks Dr

@elsalynn9823 8 жыл бұрын

Hallelujah! Thank you so much!

@beaono8997 3 жыл бұрын

loved it. A whole day of class...could have watched this 9min video...

@UtobivbiOghenetega Жыл бұрын

After hours of trying to understand pka, my clarity is actualized.

@yogeshlakshman8488 2 жыл бұрын

I am very grateful to your way of explaining to the basic understanding

@dhandapani9870 Жыл бұрын

Thank you so much. You’re such a blessing

@DavidSmith-dl2yr 6 жыл бұрын

By far the best presentation I have seen on this, thanks!

@harshbirsingh4741 4 жыл бұрын

i am confused about protonated and unprotonated form🤔

@falakjamil3565 6 жыл бұрын

Impressive !!Cleared my confusion :) Thnks a ton and stay blessed :')

@doctort.moahmed645 9 ай бұрын

This is my second time I saw this video and it's excellent ❤❤

@Random24853 2 жыл бұрын

Where’s Woody, Taylor, and Kyle?

@paimanehjoohari7391 4 жыл бұрын

Thanks for these simple definition, I had problems with these elements, but now I understand that, again thanks a lot

@k8reed Жыл бұрын

Thank you so much for sharing your video!

@vibackup 3 жыл бұрын

Very good video, just one error at 1:47: HCl is _not_ a white powder, it's a gas above −85.05 °C (−121.09 °F; 188.10 K).

@hannes_mlbx9599 Жыл бұрын

Classic Taylor

@glaydleicaro256 2 жыл бұрын

Very clear explanation. Thank you Sir!

@DylanHart8 Жыл бұрын

Kyle really thinks he’s some kind of pharmacist now just because he took little acid.

@ASHTUTORIAL 5 жыл бұрын

Best video...thanks sir...great...no words to explain ur teaching clarity

@sabrinadream9178 2 жыл бұрын

Very good explanation sir

@joycebritto8111 3 жыл бұрын

excelente explicação. Aprendi mais por aqui do que assistindo em muitos outros vídeos. Grata!

@graceusa3942 4 жыл бұрын

Great teaching, thank you so much.

@JN-kk4nk Жыл бұрын

this was very clear ! thanks

@priyarajeshanepla9465 4 жыл бұрын

Thank you so much for explaining it in the best way possible!!

@Lostpanda123 7 жыл бұрын

Great explanation and a great tutor!

@elvinahandini645 6 жыл бұрын

omg your videos saved my life many times :') thankyou so much

@jalaluddinnasim8328 6 жыл бұрын

Elvina Handini Can you explain,why most of the drugs are weak acid or weak base? In the video I found that it is because small change is required to shift between ionized or non ionized form But I don't understand how?

@elvinahandini645 6 жыл бұрын

Most drugs are weak electrolytes, may be weak acids or weak bases. In water, this weak electrolyte will be ionized into its ionic form. For weak acids, a high pH (base atmosphere) will increase its ionization and reduce its nonionic form. In contrast to weak bases, a low pH (acidic atmosphere) that will increase its ionization and reduce its nonion. Only nonionic forms have fat solubility, so only the nonionic and ionic forms are in equilibrium, then after the nonion form is absorbed

@jalaluddinnasim8328 6 жыл бұрын

Elvina Handini,so,they are weak acid or bases,but why are they not strong acid or base?what is the benefit of that?

@elvinahandini645 6 жыл бұрын

Drugs that are weak acids will easily penetrate the cell membrane in the acidic atmosphere. Because in an acidic atmosphere, the drug is relatively unionized or the ionic form is small enough to penetrate the cell membrane more easily. strong acids or strong bases will be easily ionized which is cannot be penetrated to the cell membrane.

@user-si7sk4iz2c 3 жыл бұрын

@@elvinahandini645 thank you ❤️

@hajernt7833 Жыл бұрын

Amazing

@harshitagaur6394 6 жыл бұрын

Thank you sir...so easily explained

@jazewang3543 3 жыл бұрын

This guy is the best!

@minabish1783 3 жыл бұрын

Thank you very much

@vibehealth6828 11 ай бұрын

God bless you

@RomajaneAbrenio 5 жыл бұрын

This is a really good video. Thank you, Sir! 💓

@steveharris1740 4 жыл бұрын

Humm, this is "basically " (haha) acid-base equilibrium.

@sainidhi5617 3 жыл бұрын

Finally understood it.... Thanks Alot!

@Simran-jd4wi 2 ай бұрын

Thank you man ❤

@fredred476 4 жыл бұрын

awesome vi. subscribed, thanks!

@trickjacko8482 4 жыл бұрын

Thank you

@johnmiller323 6 жыл бұрын

I understand the concept now... thank you so much

@jalaluddinnasim8328 6 жыл бұрын

William can you explain why so many drugs are weak acid or base,not strong?

@jyothishk7557 4 жыл бұрын

Thanks for the video.❤️❤️

@damemochi3322 6 жыл бұрын

Quick question. In the example with aspirin, when it's either in the acidic (HCl) or basic solution (NaOH), does it COMPLETELY dissociate into its respective lipid/water soluble form since aspirin is a weak acid??...or is it more so that in an acidic environment aspirin is MOSTLY lipid soluble while in a basic environment aspirin is MOSTLY water soluble?

@Pharmapedia 6 жыл бұрын

GREAT QUESTION! I googled it and came across this. www.ausetute.com.au/aspirin.html They show complete dissociation. But your question is not only outside of my clinical knowledge base, it is outside of the point I want to make. Most drugs are weak acids or weak bases because change in pH change their water solubility. This is an essential concept for drugs that cannot be mixed in the IV lines. So running a drug through a piggyback running normal saline as the maintenance solution can cause that drug to come out of solution and form particulates if it is incompatible with the pH of the maintenance solution. Major med error issue in some hospitals. Hope this helps. Thanks for the great question!

@marceloovg1873 5 жыл бұрын

Suppose you have a closed system like the beaker shown in this video, with a finite amount of plain water , you measure ph and it comes at 6.5, and then you add say 1 gram of powdered HCL and it completely dissociates , it gets the pH of the water to an acid 4, then you add 500 mg of Aspirin (pKa is 3.49) what will happen is Aspirin will slowly dissociate (slowly because the pka is very near the current total solution ph which is 4) until the pH reaches more/less 3.49, then at this moment roughly 50% - 50% of the aspirin will be in the uncharged : ionic (charged) form and right here it will stop dissociating. how much of the aspirin will dissociate? 90% ? 10% it depends how much quantity of it you added , if 500mg was enough to donate enough aditional protons to the already acid solution then ir will stop right there, if not, it will keep dissociating until it reaches the thermodynamic equilibrium constant and will stop dissociating and keep at 50% - 50% no matter how much more aspirin you add it will not lower the pH more. thats what pka means.

@ED-ez8yd Жыл бұрын

So legit. Thanks.

@dane3030 8 жыл бұрын

This helps a ton, thank you.

@drsheikh 6 жыл бұрын

FAN-tastic.. Thankyou so much

@TMTeeandEmm-uc6si 10 ай бұрын

From galala University thank u ❤️❤️

@pain_is_ultimate 3 жыл бұрын

Nice

@arshithgowda8728 2 жыл бұрын

Oh god finally i understand thank u sir 🙏🙏🙏

@naghmeazadi8294 8 жыл бұрын

It really helped.thanks

@thaslima8688 3 жыл бұрын

Thanks a lot completely clear

@dojrajkhanal9417 5 жыл бұрын

Will the same case be applied to phenol?..just like for aspirin?

@syedataliahaider6578 3 жыл бұрын

thanks to u i understood the concept

@JC-xk8vh 3 жыл бұрын

The 33 dislikes are 33 Professors that couldn't explain it any better.

@mithunvb685 4 жыл бұрын

Thank you boss!

@ThePedroCordero 6 жыл бұрын

It helped me a lot...I couldn't understand this shit from books! Thanks a lot!

@MrKrishanpatel 8 жыл бұрын

Amazing video and explains everything very clearly! Thanks

@aizayy3658 2 жыл бұрын

Om gash Thanks Love ❤️ u🤧🤧🤧🤧🤧🤧

@jaskaur7885 8 жыл бұрын

Thank you so much!!!

@olalaolala4400 8 жыл бұрын

thank you so much ❤️

@yoaimou9798 Жыл бұрын

I love u man

@netspirit79 3 жыл бұрын

"Hydrogen chloride is a white powder" - WTF?

@Peace-fo1vx 4 жыл бұрын

thank you

@sameraahmed7156 7 жыл бұрын

amazing

@iqrabuzzamanshoumik3284 5 жыл бұрын

Thanks

@6sixFace 3 жыл бұрын

0:22 That's Based.

@robertamorgado6908 4 жыл бұрын

thank you!!!!

@RenasAb 5 жыл бұрын

Thanks 🙏🏻 ❤️❤️

@lukehe8663 7 жыл бұрын

Thanks!!

@abdallarohi5429 6 жыл бұрын

such an intelligent guy👍

@brittanym1326 4 жыл бұрын

You’re going to get me thru school

@zainjafry2658 4 жыл бұрын

thank you for make so easy

@artherdoland1050 5 жыл бұрын

thanks

@luvurenemies6127 4 жыл бұрын

Well, let's take this assidic solution, similar to the asssid in our stomachs. Let's put an ASSSSspirin in. This proton wants to come off the aspirin. BUT IT CAN'T. WHY? because of proton mass AACCtion! ...watever u r having, i need it XDDD

@jeevidhabalasubramaniam2341 4 жыл бұрын

Sir y does that substance release the proton instead of releasing electron.. since electron in the Valence is easier to remove than the proton in the nucleus...@0.10 min

@RahulSharma-ew5zp 4 жыл бұрын

Jeevidha Balasubramaniam h+ ion is considered as proton

@RahulSharma-ew5zp 4 жыл бұрын

Acid base concepts are based on h+ and oh- and not on electron

@dp-mason 3 жыл бұрын

Woody looks really different

@himanshudutt5162 4 жыл бұрын

HCl is white powder??

@damntravis6056 Жыл бұрын

RSK

@keeskruithof1123 5 жыл бұрын

HCl is at atmospheric conditions a colourless gas. Painfull to eyes.

@pricilladisuang1690 3 жыл бұрын

I completeeeelyyy understand nowww

@collinsulanja3333 4 жыл бұрын

💪👌

@countrysafari230 8 жыл бұрын

#Pharmapedia Thank you for this amaizing explaination. I am confused about quinolones, how do they have good absorption from gastrointestinal tract despite that they have a carboxyl group at position 3 and amine group at position 7 which will make them ionized in acidic as well as basic fluids ?