DNA Replication: Copying the Molecule of Life
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8 жыл бұрынYour DNA needs to be in every cell in your body, so what happens when cells divide? How does each new cell retain all of the genetic information? The DNA is able to copy itself through a process called replication. Let's go through the finer points, shall we?
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@UnironicWizard 4 жыл бұрын
Gotta love how with quarantined schooling teachers have given up on teaching and recognized that people like you have been the ones actually teaching us.
@Emily-gy8pe 4 жыл бұрын
that why im currently watching this
@danjbro 2 жыл бұрын
@@Emily-gy8pe same!
@danjbro 2 жыл бұрын
🙌🏽
@jenniferstormlambert162 2 жыл бұрын
Professors and teachers are getting lazy and it is so much easier for them to just send us to a website and let someone else explain it! Thank you!
@KB-vd8wq 5 жыл бұрын
You literally just summarized about half of what I learned in an entire semester-long molecular biology class in a 6 minute video. Nice.
@satinderjit4 2 жыл бұрын
Dang what!?!?!?!
@Malik-em6ng 2 жыл бұрын
really this is day one for us..... it is fricking hard XD
@harrietharlow9929 2 жыл бұрын
I love that I can learn by watching videos. I am interested in many subjects and my idea of a good session is learning something new. I will definitely be checking out Professor Dave!
@esahoosa 2 жыл бұрын
Even with a biology degree and in medical school, this is the most straight forward and easy to understand video on DNA replication. You sir are the GOAT.
@nyxieempire8446 2 жыл бұрын
Every time I struggle to understand a course material and find out you have a video for it, I cry tears of joy
@Sara-by7cf 3 жыл бұрын
You single handedly made me not only pass but EXCEL in my biology 101 class. Thank you professor dave
@jakarigainer5165 2 жыл бұрын
I just realized something very important in terms of how to interpret your animation. The directionality of the synthesis of the new strand is correct. However, I initially thought that the numbers you put on the leading strand was identifying the ends of the new strand, not the original strand. In other words, the new strand would read/synthesize as such: 3' under the 5' of the leading strand and 5' under the 3' of the leading strand with the arrow going in the same direction.
@chloeli4405 7 жыл бұрын
5' and 3' DNA template strand should be more specific indicated in the slide. Its a little bit confusing.
@ProfessorDaveExplains 7 жыл бұрын
yeah a lot of people have mentioned this, i wish i had made it a bit more clear. nothing i can do now!
@dawncorbin6140 6 жыл бұрын
Yes, he needs to label the new and old strand as it is very confusing (he's labeling the old strand)......this is where students get mixed up often.
@MuhammadAwais-qc6bh 4 жыл бұрын
@@ProfessorDaveExplains You should make another video... Please sir this is a humble request...
@jamesbort8242 3 жыл бұрын
All the videos I have viewed on DNA replication struggle to explain the 5'-3' process. Unfortunately, this wasn't any better, but the rest of the video was helpful.
@jenm1 3 жыл бұрын
@@ProfessorDaveExplains annotations?
@Akuty1 3 жыл бұрын
Thank you Prof. Dave! I spent like two hours trying to understand my professors lecture, and you helped quite a lot! I am really grateful that I found this video online. Thank you for what you do! :)
@myvideosfortheworld6122 7 жыл бұрын
sir you are a really talented teacher and a speaker ...... a process which would take me hrs to understand was made easy by you and i got it in juat 6 mins ! thanks man
@shanayalnaveed9100 6 жыл бұрын
That Addicted Guy you forgot the 15 seconds
@grantcallen9763 9 ай бұрын
Doesn't polymerase travel 5' to 3' not 3' to 5'?
@HairyGarry 2 ай бұрын
Polymerase starts traveling at the 3’ end of the existing strand(so 3’to5’). The new strand it adds would be in the opposite direction. And that is what is confusing you.
@Bawan2610 7 жыл бұрын
DNA chain can only be synthesized in 5'-to-3' direction, not 3 to 5. As the subunits is being added at the 3' end, that means it runs in 5'-to-3' direction....
@jdmg7284 7 жыл бұрын
Bawan Colnadar I noticed that error in the vid as well
@rototon1992 7 жыл бұрын
He's going to get people confused. Need an upgrade.
@pa800korg92 7 жыл бұрын
Actually he's correct, the DNA polymerase III moves in a direction of 3'- 5' of the preexisting strand. However, the new strand that's being synthesized is 5'-'3. The video is crystal clear .
@hasnainabdurrehman2426 7 жыл бұрын
The video is correct, but NOT clear. This "Dave" person knows the stuff but doesn't know how to explain it to a naive mind. Someone listening to this for the first time can get confused for all his life ! REPLICATION HAPPENS FROM 5 to 3 END !
@pa800korg92 7 жыл бұрын
Sounds like you're not interested in using your logic only in memorizing facts.
@adamgurman8756 7 жыл бұрын
A great, fast, easy and organized video! Thanks!
@harrietharlow9929 2 жыл бұрын
I enjoy that I can learn the basics from your mini-lectures. Great job, Professor Dave. You put me in mind of my late father, a physician, teaching me about reproduction, mitosis, meiosis, etc. He started with onions and went on from there, ending with human reproduction when he felt it was age-appropriate (about 13-14 in my case). This puts me in mind of his teaching methods. I just subscribed a couple of hours ago and will be adding your videos to my Geology/Volcanology and Evolution and Extinctions playlists. So glad I found your channel!
@ians4987 11 ай бұрын
hi professor. i thought polymerase creates the leading strand in a 5'-3' direction towards the fork?
@aleynacabuk7352 2 жыл бұрын
Spending hours in boring college lectures with professors that lack the ability to teach and not learning ANYTHİNG vs watching a 6 minute video from a great teacher and understanding everything. I think I have spoken enough
@frapechinokelsey6451 3 жыл бұрын
I'm in 12 standard from INDIA 🇮🇳 & I found this video which really boosted my knowledge ☺
@lisamathews7971 Жыл бұрын
You remind me of an off-brand Dave Grohl and it makes studying way easier, thank you
@intellect_junction69 5 ай бұрын
Bro, why does the microscopic world low key feels like a mini-society
@zaraanwari126 5 жыл бұрын
Video was crystal clear . I understood the whole topic In ONLY 6 minutes where I didn’t get one thing through my head in a 80 minute class . Thank you so much Professor Dave !!
@sarameame7864 4 жыл бұрын
Its perfect!!!!😍 Each time i want to search for something scientific i find a video for you, your explanation is perfecttttt, keep on Dr.♥️
@kellyedsall9715 6 жыл бұрын
This helped me so so much! Your video really cleared this up! Thank you!
@sarajakobsen1070 3 жыл бұрын
Its so frustrating, I understand the protein syntecis, the DNAs structure, mitoses and meiose, transcription, translation etc. when I get it explained to me, but there is no way I can repeat it😂😭
@anonymousplayer6378 Жыл бұрын
Sir, can you state the difference between DNA polymerase alpha beta, gamma, delta,epsilon and DNA polymerase 1,2,3??
@Carter-wj9wn 7 жыл бұрын
Your videos are so helpful!
@spiritwing9391 4 жыл бұрын
Whenever I am in need of help in biology, I go to this dude! Nice job! 👍🏻
@spiritwing9391 4 жыл бұрын
Thanks for hearting!
@deepseacocoon 8 ай бұрын
This man has Taught me for 3 separate courses, its amazing
@Arvatly 3 жыл бұрын
Dave, polymerase III reads from 3' to 5' but polymerases new strand from 5' to 3'? But you said polymerase copies 3' to 5'. Did you mean polymerase reads 3' to 5'?
@ProfessorDaveExplains 3 жыл бұрын
I said moves along the template strand, so yes "reads" would be a good way to interpret that.
@mayamade9047 7 жыл бұрын
This is one of the best videos I have seen on DNA Replication!! thanks a whole whole lot!!
@arhamcollectionofficial 2 жыл бұрын
Thank you sir I spend 2 days on this topic but this 6 minutes video clear my concepts too much
@oct_rz4736 6 жыл бұрын
You are awesome.. I was jumping from video to another and I can’t understand that. But with you just in 6 min I take it very well !!
@moffeevalverde1403 3 жыл бұрын
I love the way you explain each step of DNA replication and other biological processes in your videos, I'm just glad to find your channel :')
@shaistanazir8752 7 жыл бұрын
it was beautiful sir. it helped me memorize it smoothly.
@italianfire110 5 жыл бұрын
This is the only video I've seen that accurately explains the difference in role of Topoisomerase and Helicase...Thank you
@MyDerpDerpDerp 7 жыл бұрын
As was stated previously, the direction is NOT 3' -5'. According to Mc Graw-Hill 11th ed. Biology, "As with all known DNA polymerases, all three of these enzymes synthesize polynucleotide strands only in the 5'-3' direction and require a primer"
@ProfessorDaveExplains 7 жыл бұрын
i meant that it moves along the template strand 3'-5', though you are correct the new strand is synthesized 5'-3', perhaps i should have been clearer in the animation.
@MyDerpDerpDerp 7 жыл бұрын
Thank you for your timely reply! Perhaps it could have been clearer, but you are right as well. Thanks for the video, anyhow :D
@jezrhaymagayones8841 Жыл бұрын
I like the fact that what I learned here was better than what I learned in school, more detailed and compact Keep it up 😊
@missjesseduph 3 жыл бұрын
I have a final task in Genetics, thanks for this vid. It means a lot to me!
@Zetsuke4 4 жыл бұрын
I can leisurely watch Professor Dave in my free time and enjoy every second learning as many videos as I can.
@joshuahalsey1020 2 жыл бұрын
Makes so much more sense hearing it from you vs. in class
@MVD_1I1 2 ай бұрын
Thank you couldn’t understand from the biology book with the diagrams you just made me understand in 6 minutes
@yashgokhale1460 7 жыл бұрын
Super helpful! Would have taken hours for me to understand just by reading this. Thank you Sir!
@ewittka100 7 жыл бұрын
Great explanation, thanks!
@sierraschopp4662 6 жыл бұрын
This is such a great video! short and sweet :)
@elliemcanuff8157 6 жыл бұрын
holy shit i've been looking for videos like this all year
@ProfessorDaveExplains 6 жыл бұрын
search no longer!
@ambiavanessaanti4911 2 жыл бұрын
Thank you so much Prof Dave I wish you could explain the rolling cycle mechanism too
@tuzannegoe9647 7 жыл бұрын
You have the replication going from 3' --> 5'. This is incorrect. Replication always goes from 5' -->3'.
@ProfessorDaveExplains 7 жыл бұрын
the daughter strand is 5' to 3'. polymerase moves along the template strand 3' to 5'.
@achyuthankarthikeyan3287 4 жыл бұрын
Actually even I got confused about it at first, but if you look closely it's actually correct.
@vaibhavbaadkar1450 2 жыл бұрын
Explained in very easy and simple manner... Thank u sir
@janepiccirilli4654 6 жыл бұрын
Thank you so much! You helped clarify a lot of areas that my textbook failed to properly explain.
@irinabains4300 3 жыл бұрын
hi prof, had a few doubts: 1. after binding the primer to the DNA strand, the primase leaves the spot, and DNA polymerase iii takes the same spot to start adding the free DNA nucleotides? 2. on which strand do the following take place first or do the following processes take place simultaneously (as there is one molecule of enzyme allocated for each strand?) on both the strands? a) exonuclease removing the RNA nucleotides/primers b) DNA polymerase I adding DNA nucleotides in place of the primers c) Primase adding primers d) polymerase III adding free DNA nucleotides
@vlihumbtov4236 Жыл бұрын
Do you have a video about endogenous retroviruses (ERVs)? Would like to get a better grasp about the subject. Thanks for these videos btw. Really helpful.
@mushfiqurrahmanshishir8055 3 жыл бұрын
Thanks for this explanation. Some things are simplified. But this is a very good overview. It was really helpful.
@jinkedewilde4792 6 жыл бұрын
Thank you for saving my exam! Very clear and well structured explanation.
@poodle395 5 жыл бұрын
I like how you dont use gimics at all, you tell what needs to be told and have easy to understand diagrams
@lukamtc9188 Жыл бұрын
Loving the vids, I'm revising what I learned in the balkan equivalent of advanced biology & chemistry highschool. Just one thing: the audio volume is a bit low everywhere except the intro. These are old af but if you plan to make more videos maybe amplify the volume a bit in post.
@jxyz9154 6 жыл бұрын
thank you so much for your explaining
@atiyadavids4651 3 жыл бұрын
Best explanation I've ever heard and seen my whole life. Ily.
@bobl9555 7 жыл бұрын
Excellent video, Thanks!
@shayekhabedin4462 3 жыл бұрын
If only I had you as my lecturer ! Absolute legend mate!
@josephinekyalo610 Жыл бұрын
Your explanation is very clear and the footnotes are very helpful, i now can understand the replication process thankyou prof
@dhritimadas6357 4 жыл бұрын
Easy & concept clear explanation.... thank you sir.
@Toothfairy1018 7 жыл бұрын
you're the real MVP! and I love your intro lol it's hella catchy and cute
@cristinajones7211 3 жыл бұрын
Thank you for this.. I had no idea what was going on until I saw your videos! Thank you so so much!
@Youknowwho910 Жыл бұрын
Watched so many videos on this and this one finally made sense. Thank you!
@thumiwemvula3951 3 жыл бұрын
And BOOM!!!! That's how I understood DNA replication!!!
@boscokimbawala1053 Жыл бұрын
Thank proff Devi .....am really enjoy your session
@TKenziefied 3 ай бұрын
thank you so much, i am so grateful for this video. Explanations are perfect.
@mustafafarhati9882 7 жыл бұрын
You just made this shenegan simple.
@Dunger974 Жыл бұрын
Watching this before my AP bio exam today
@The_end_of_the_f_world Жыл бұрын
I'm confused ! isn't it always 5' to 3' direction ? In some videos I heard that DNA polymerase can only move in the (5' → 3') .
@ProfessorDaveExplains Жыл бұрын
direction of motion along template and direction of synthesis are complementary
@memunaissah823 Жыл бұрын
You’re a life saver Professor Dave..
@dustinkim303 Жыл бұрын
best DNA replication video!
@dafidtaylor 7 жыл бұрын
great refresher vid, great name
@DyanaBunnyPhD 2 жыл бұрын
From Professor to Professor 👉🏼 you are great !!!
@savinas.577 2 жыл бұрын
Thank you very much for this lecture! But isn't it, that the direction is from 5' to 3' and not the other way around? At least that is what Amboss states.
@ProfessorDaveExplains 2 жыл бұрын
Watch that section again and listen carefully.
@linoswater Жыл бұрын
you are truly God sent Prof. Dave
@josiahkingmwabunga3476 4 ай бұрын
very much well explained
@Ben-kl8do Жыл бұрын
Not sure if nitpicky or not but it could help to clarify that DNA polymerase III/I are those used in prokaryotes. I remember in high school still using the terms generically but I believe DNA pol-alpha/delta are the current standards for eukaryotes?
@akinyemihafsat3699 2 жыл бұрын
Wow! I love the lecture. Thank you Prof
@LullubiKURD 7 жыл бұрын
Thank you.
@damerababu1476 5 жыл бұрын
Easy understanding explanation
@anjaliiiraaa1 6 жыл бұрын
Thank you so much sir.... It really helped✌️👌
@tylergoh2287 3 жыл бұрын
I love u Prof. Dave , u made it simpler
@pradeepajayanetti7500 3 жыл бұрын
This video is perfect thanks a lot sir.
@ayushijain8671 7 жыл бұрын
Well explained. Thanks!
@alderamin1402 2 жыл бұрын
Amazing explanation
@kimia1664 5 жыл бұрын
I got more than I asked for! A lot of these stuff aren’t part of my textbook but I don’t care. I’ve always wanted to learn this anyway.
@bow2myia 6 жыл бұрын
Can you explain the difference between DNA pol 1 and pol 3 a little more? I'm not getting it
@vidyabhushan4381 6 жыл бұрын
Awesome description!!!!
@darkday661 Жыл бұрын
Professor why the one strand is continuous and the other one is discontinue??
@Sciencegurukul108 6 жыл бұрын
Nice explanation..
@onefriendlyduck7768 10 ай бұрын
Thank you, Dave!
@pratapsarkar9693 2 жыл бұрын
Great video... But did you forget SSBPs??
@AndriCloud 8 ай бұрын
one moment of silence for appreciating the complex administration of life
@sunehrikiran5638 6 жыл бұрын
great as always .
@desyjo5547 3 жыл бұрын
Does DNA polymerase III only work on leading strand ? Does DNA polymerase I also work on leading strand to replace RNA nucleotide into DNA nucleotide ?
@tobywang9679 4 жыл бұрын
Are DNA polymerases I and III in prokaryotic cells? What are the DNA polymerases in our cells(eukaryotic)?
@bestofplay3110 6 жыл бұрын
He looks like Jesus Christ
@kristianbell9044 5 жыл бұрын
Because he is Jesus Christ
@RuhabDabeer 5 жыл бұрын
@@kristianbell9044 of Science
@kingalexanderia3365 5 жыл бұрын
Did u met Jesus before ?
@goldielox2382 5 жыл бұрын
Lol, I didn't think that specifically but, I did wonder if he is Jewish. He looks Jewish.
@RandomPerson-pi9cu 4 жыл бұрын
Don't be ridiculous. Jesus Christ looks like Professor Dave.
@kierancrouse3167 6 ай бұрын
This helps a lot
@mdrayhanuddin4350 2 жыл бұрын
Correction : A new DNA is always synthesized in the 5'➤3' direction!!
@ProfessorDaveExplains 2 жыл бұрын
Yes, so the polymerase moves along the template strand 3' to 5', as I said.
@ganeshmath717 3 жыл бұрын
Why RNA primer is used in DNA replication sir??plz reply
@coursechawer5296 7 жыл бұрын
you mean even brain cells a being replace as we grow
@ProfessorDaveExplains 7 жыл бұрын
actually not those! a few types divide very slowly or not at all. i have biology tutorials coming out soon that talk about this!
@saniyyaahussain9936 4 жыл бұрын
Yes it's because they lack centrosomes right?....but then how do they replicate initially...I mean from zygote to the number we have today.....or is it kind of like rbc where they have stem cells (forgive me if what I asked is stupid😅...I am pretty sure we don't have stem cells for neurons)
@madampawsy1903 3 жыл бұрын
@@saniyyaahussain9936 I think if I remember correctly neutrons get replaced after years but it’s just the components inside the cells that get replaced
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