Mechanisms of DNA Damage and Repair

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Professor Dave Explains

Professor Dave Explains

Күн бұрын

Remember how the Ninja Turtles came to be? Yes you do. It was the ooze! A radioactive ooze that mutated their DNA in just the right way to give them the ability to walk upright, talk, and do ninjutsu. Now, I'm as a big a Turtle fan as they come (Donatello is my main man) but this is a highly inaccurate way to portray mutation. Let's learn about the real ways that your DNA can become damaged, and the strategies nature has developed to combat these risks.
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Пікірлер: 254
@maria1239876
@maria1239876 3 жыл бұрын
I like the preschool vibes i get from the background while I'm learning stuff in my junior year of college :D it makes me feel all warm and fuzzy.
@daniellewilson8527
@daniellewilson8527 3 жыл бұрын
Imagine how smart preschoolers would be by watching this
@noblevenom2858
@noblevenom2858 9 ай бұрын
@@daniellewilson8527nah preschoolers are pretty dumb. They can’t do shit
@dr.bibaswan
@dr.bibaswan 3 ай бұрын
Correct. We are all little kids deep inside. Our official age may be 20 - 30 but we love the vibes of age 2-3 😇
@personalacc4352
@personalacc4352 6 жыл бұрын
"Now that we are sufficiently terrified of genetic mutations" 😂
@sroydetroy6404
@sroydetroy6404 3 жыл бұрын
Where did he say this lol?
@memoryloop5816
@memoryloop5816 3 жыл бұрын
@@sroydetroy6404 5:39
@anusphoorthi9anuradha968
@anusphoorthi9anuradha968 2 жыл бұрын
Àyy
@ComandaKronikk
@ComandaKronikk 6 жыл бұрын
Dude thanks for getting directly to the point and not fluffing about like so many other youtube videos. U just feed me facts that I CRAVE!!! Professor Dave 4 prime minister 2019
@Youssef-zo3ls
@Youssef-zo3ls 5 жыл бұрын
Paris Coroneos exactly! He gets directly to the point
@BishoujoMegami
@BishoujoMegami 2 жыл бұрын
Professor Dave, I'm still using your videos at Uni😂 They are so helpful. My genetics lectures are really confusing so far but this is helping consolidate my understanding. Genetics was always my week point in biology🙏🏾
@alaazein7147
@alaazein7147 2 жыл бұрын
Me too
@geetugupta7244
@geetugupta7244 Жыл бұрын
I don't even have to take biology next year, but I'm forced to learn it this year ...stupid school rules...😭😭
@hamzazaqut1315
@hamzazaqut1315 Жыл бұрын
It seems spelling is your “week” point too.
@BishoujoMegami
@BishoujoMegami Жыл бұрын
@hamzazaqut1315 omg, you need to quit your day job and become a stand up comic... you'd be a millionaire...
@Eagles883
@Eagles883 2 ай бұрын
@@hamzazaqut1315you’re harsh, I was thinking to myself “I’m not going to correct it.”
@EpicSelenium34
@EpicSelenium34 6 жыл бұрын
Thank you professor...another fabulous video. I like how you go deep down into the molecular structures of the mutant amino acids and the pyrimidine dimers (and other such things) instead of just glossing over them. Getting to the chemistry at the heart of what we observe makes the learning experience so much more intuitive!
@mirarizqah
@mirarizqah 7 жыл бұрын
This video is great. easy to understand and have a very clear explanation! I love it
@MrLaTEchno
@MrLaTEchno 5 жыл бұрын
For a layman like me this series is fairly easy to follow and understand. I am therefore very grateful and hope to be able to use your work here on Y-T a lot. Greetzzz from Holland [sorry for my bad grammar]
@iluvbeef11
@iluvbeef11 5 жыл бұрын
hey professor dave. great video! your graphics really illustrate concepts that I've been struggling to grasp since high school. this is honestly the best explanation of mutations I've ever seen. I do have one thing I wanna clarify tho. so in the frame shift mutations, it was one whole base pair that you had deleted. let's say you showed an insertion. would it be an insertion of a whole base pair? or could you have an insertion of a nucleotide on one strand but not on the other strand opposite to that added nucleotide? let me know if my question is confusing lol I'd be happy to rephrase it as best as I can
@ProfessorDaveExplains
@ProfessorDaveExplains 5 жыл бұрын
ooh that's a good question! you know i'm not too sure, i'll have to look into that
@iluvbeef11
@iluvbeef11 5 жыл бұрын
@@ProfessorDaveExplains awesome, lemme know when ya know! and thanks again for the great vids
@furkaan346
@furkaan346 5 жыл бұрын
Dave, I suggest you first present a summarized outline using a flowchart classifying different mutations and its subtypes. This way it'll be easier to grasp and make notes at the same time. I suggest you apply it to other videos too
@yikotao
@yikotao 7 жыл бұрын
He knows all about science stuff and he is professor dave explains. This song is like gangnam style. I only watched several videos and start singing when I was cooking my dinner!
@tomservo5007
@tomservo5007 5 жыл бұрын
cooking and singing will increase dna mutations. good luck.
@jwh5505
@jwh5505 4 жыл бұрын
just keep on cooking
@thebigtricky9156
@thebigtricky9156 3 жыл бұрын
Overtly, I find it annoying, but each to their own.
@VinodGupta-hj8hu
@VinodGupta-hj8hu 5 ай бұрын
thank you, Professor Dave your explanations make me learn more. Thank you for producing this videos.
@napojusticeramothokoane5536
@napojusticeramothokoane5536 4 жыл бұрын
Thank you Prof. um thinking, I may as well stop paying my school fees and start paying R5.00 per month for joining your channel, this feels great
@MyMorghy
@MyMorghy 6 жыл бұрын
Thank you so much Professor Dave I have an exam of Genetics this Tuesday and you have explained me about half of the themes of the exam in 11 minutes. Fantastic
@Surgtari
@Surgtari 7 жыл бұрын
thank you jesu.. I mean prof. Dave this was beyond mind blowing
@patricksarama4963
@patricksarama4963 3 жыл бұрын
Don’t be shy, call him biology Jesus
@ravikumarkommareddy3723
@ravikumarkommareddy3723 7 жыл бұрын
Easy to understand and informative. Thank you very much. Great job
@lezanibrahim8327
@lezanibrahim8327 2 жыл бұрын
You saved my life by this video ,thank you
@e.c.2215
@e.c.2215 4 жыл бұрын
Thank you for all your tutorials! From Chemistry to Bio they all have the exact content that I need.
@alwaysambitious
@alwaysambitious 6 жыл бұрын
I love how clearly you talk! great Videos
@nesrineemira6381
@nesrineemira6381 3 жыл бұрын
sir u are a life saver..and that intro sends ...
@renkei7596
@renkei7596 3 жыл бұрын
Love your videos to sum up what i learned in biochem :) But could you do a video about molecular cloning and PCR?
@GurpreetSingh-jr8kk
@GurpreetSingh-jr8kk 8 жыл бұрын
U r fabulous professor ..... u teach better than my teachers in my tutions.... Lots of love from INDIA
@reemsjourney9070
@reemsjourney9070 3 жыл бұрын
Thank you prof Dave, you made me survive my journey in premed 🙏❤️
@DanyalLaghari7
@DanyalLaghari7 8 ай бұрын
your videos are still being used after 7 years. Thanks
@samlynn7681
@samlynn7681 9 ай бұрын
Thank you so much! I couldn't understand mismatch or NER for the life of me for the entire semester. I really needed this explanation for my exam tomorrow!!
@TheAnnie121
@TheAnnie121 4 жыл бұрын
....am I the only one who ALWAYS sings the intro, even though this channel has been accompanying me since my Senior year? :D
@reginadaka2335
@reginadaka2335 4 жыл бұрын
No u ain't the only one..
@fathimashahabudeen3477
@fathimashahabudeen3477 3 жыл бұрын
This video is great now u are my professor.. it’s easy to understand yr videos so simple and made with dedication and love 💕
@molecularunity
@molecularunity 4 жыл бұрын
Another great vid and, as always, total clarity. Thank you.
@OneWithTheOcean
@OneWithTheOcean 7 жыл бұрын
Very informative, Thank you!
@jwh5505
@jwh5505 4 жыл бұрын
if this video is that informative to you, i recommend you not to take ap biology
@iseegoodandbad6758
@iseegoodandbad6758 2 жыл бұрын
I love Dave so much!! The best teacher so far!!
@belgacem_mehdi
@belgacem_mehdi 4 ай бұрын
A question : 2:27 you said if the mutation happen outside the gene it does not cause any thing But we know that there many gene that are regulated and activated and deactivated by portions of DNA outside the gene ( epigenic )
@henrynyirongo8761
@henrynyirongo8761 4 жыл бұрын
Professor Dave is one of the very few that take time to respond to the various comments😊
@econguyph
@econguyph 4 жыл бұрын
*you helped me in biochem class thank you professor I think thank you isn't enough so grateful ❤️*
@annestricker6917
@annestricker6917 Жыл бұрын
Thanks! Great presentation, much appreciated!
@mohammedjobarafadlallah6144
@mohammedjobarafadlallah6144 3 жыл бұрын
شرح ظريف وممتع بالتوفيق وللامام دومااا
@arovana82
@arovana82 6 жыл бұрын
Very good explanation! Thank you!
@yusuphajallow5646
@yusuphajallow5646 4 жыл бұрын
thank you Professor its well explained indeed
@Godessa9shrek
@Godessa9shrek Жыл бұрын
"Now that we are sufficiently terrified of genetic mutations...", lol...a laugh I needed while late night studying. Thanks!
@christopherreed2694
@christopherreed2694 2 жыл бұрын
Thank you Dave for taking 🙏 the time it is appreciated much 👍
@breadbread8759
@breadbread8759 3 жыл бұрын
This video was tooo good! so perfect!! Thank you!!
@nileflower9181
@nileflower9181 3 жыл бұрын
you're information is very useful
@4everanjan
@4everanjan 9 ай бұрын
Fantastic !!! really helpful
@omaimah7366
@omaimah7366 5 жыл бұрын
thanks.. you explain it so clearly
@citysbandaid
@citysbandaid 6 жыл бұрын
Dave thanks so much for the videos ! Your lectures are complete and easy to understand. :)
@dannyfreeman2302
@dannyfreeman2302 8 ай бұрын
so great this is awesome information thank you dave
@raqimafarhad7745
@raqimafarhad7745 9 ай бұрын
Very clear and concise 👍
@roxannemacasinag761
@roxannemacasinag761 4 жыл бұрын
Thank you Prof! My Go To Guy! I’ve been passing my subjs, partly bc of u! And correctly answering activity sheets because of u! THANK U SO MUCH!
@joedart1465
@joedart1465 3 жыл бұрын
Nice job Dave.
@MrMagic-bl3ew
@MrMagic-bl3ew 5 жыл бұрын
lol aced my genetics final by watching these videos... didn't go a single day to class loooool
@klutz3955
@klutz3955 4 жыл бұрын
College or high school?
@joshmemarrynagdey1639
@joshmemarrynagdey1639 Жыл бұрын
It's very nice helpful. Thank you
@ProfessorFrydman
@ProfessorFrydman Ай бұрын
Hi Professor Dave! I'm an atheist from Brazil and I wonder how could such a complex mechanism exists without an inteligent mind to project this. I know the answer is very complex. Do you have any content about the origins of this part of biochemistry? It's well related to the origins of life, right? I just love your videos, thanks a lot for them!
@ProfessorDaveExplains
@ProfessorDaveExplains Ай бұрын
check my content debunking james tour
@purkinje4248
@purkinje4248 9 ай бұрын
As a medical student, I appreciate you, sir. You're amazing. God sent u to teach us medical contents
@mymonamkeess6516
@mymonamkeess6516 6 жыл бұрын
Thanks for the wonderful explain ♡ I loved the song at beginning ^_^
@henrydennis2199
@henrydennis2199 2 жыл бұрын
@ 5:39 Dave: Now that we are sufficiently terrified of genetic mutation.... Me: guuuuuuyyyy!!!😂😂
@johnbates3567
@johnbates3567 6 жыл бұрын
This is excellent Dave, thank you!
@jayasriramani6718
@jayasriramani6718 6 жыл бұрын
John Bates
@jeannensantos4296
@jeannensantos4296 3 жыл бұрын
brilliant. everything I needed in one video clearly explained
@sciencenerd7639
@sciencenerd7639 2 жыл бұрын
very good information, thanks so much
@geraldwise335
@geraldwise335 2 жыл бұрын
wow amazing proff Dave
@Lalita_Chevaliere_108
@Lalita_Chevaliere_108 6 жыл бұрын
Thank you, Professor! Does this mean that if you avoid sunlight, you will be healthier? Say if you just go in the morning sun for a few minutes, and then stay inside all the time? Or do we need sunlight so much that we can't avoid it, though it comes at a price?
@ProfessorDaveExplains
@ProfessorDaveExplains 6 жыл бұрын
well you need some! but excessive exposure increases the risk of skin cancer certainly. sunscreen!
@Lalita_Chevaliere_108
@Lalita_Chevaliere_108 6 жыл бұрын
Thank you! I'll remember that ;)
@jasonl4237
@jasonl4237 3 жыл бұрын
@@ProfessorDaveExplains What sunscreen type/spf should I choose? Do I need to apply sunscreen to all skin areas (face, neck, hands, arms, legs) exposed to sunlight or only the face? How long should I stay in the sun each day to be healthy? Thanks.
@camilasousa5853
@camilasousa5853 3 жыл бұрын
Thank you so much!! I was really looking for a class like this
@TutunChanda
@TutunChanda 5 жыл бұрын
Awesome video proffessor
@witty_me
@witty_me 6 жыл бұрын
Thanks, Professor, for explaining it.
@skynabendera7854
@skynabendera7854 Жыл бұрын
Super helpful
@jacobguenette273
@jacobguenette273 3 жыл бұрын
Dude I understand everything so well now. Thanks!
@maschinenraum
@maschinenraum 5 жыл бұрын
sunscreen is only good for preventing a serious sun burn. but beside that i do not use sun screen because it reduces the vitamin d level in the body. and with a high vitamin d level there is maybe more DNA repair going on.
@TupeDavid
@TupeDavid 5 жыл бұрын
This video is great. easy to understand and have a very informative.
@windyanissarecita
@windyanissarecita 6 жыл бұрын
omg very helpful.. im a big fan
@kylahughes4171
@kylahughes4171 2 жыл бұрын
Thank you Professor
@maryamsediqi3625
@maryamsediqi3625 3 жыл бұрын
Many thanks, was great explanation.
@themillennialpa
@themillennialpa 4 жыл бұрын
I love you PROFESSOR DAVE!!!
@abdullahhelal5413
@abdullahhelal5413 4 жыл бұрын
Dave sir you r great!
@ThePhoenixstar88
@ThePhoenixstar88 Жыл бұрын
He always makes me smile if he pops up while I’m scrolling by lol ☺️
@duolchol3262
@duolchol3262 5 жыл бұрын
the greater teacher ever
@holden2966
@holden2966 5 жыл бұрын
Thanks Dave
@The-Anonymous.
@The-Anonymous. 3 жыл бұрын
Here for 0:09
@abidemitoluwaniosho5571
@abidemitoluwaniosho5571 6 жыл бұрын
THANKS MAN, THIS WAS Helpful
@raoulfulgos8536
@raoulfulgos8536 6 жыл бұрын
Nice job, would love a homologous and nonhomologous recombination video if you have it in you
@maavaishno2198
@maavaishno2198 4 жыл бұрын
AWESOME EXPLANATION
@zollingerellison1998
@zollingerellison1998 7 жыл бұрын
thank you,professor👍
@bumblebee434
@bumblebee434 3 жыл бұрын
Thank you sir ❤️
@abdullahhelal5413
@abdullahhelal5413 4 жыл бұрын
Informative video.
@radhikabiraj5243
@radhikabiraj5243 3 жыл бұрын
U r amazing sir.....lots of love from india.....ur videos boost my knowledge🤗🙏🙏
@user-pr1st5rh9r
@user-pr1st5rh9r 3 ай бұрын
that binding of oxidized guanine with A happens when during repair or replication as there should be C there initially ?
@floppy8568
@floppy8568 5 ай бұрын
Deletion or insertion reminds me of a situation of a program I'm thinking of codons as instructions here when an opcode is read as an operand and vice versa In computers this gets fixed quickly since instructions aren't stored in a constant amount of bytes, could be one with "NOP" (0x00), could be 2 or even three. but genetic code is stored in a constant amount of nucleotides: 3, so this never gets fixed. Nonsense mutations gotten from that i like to think as 0xFF in the operand being read as the halt instruction
@mapuliclavery9883
@mapuliclavery9883 6 жыл бұрын
Very nice professor
@AR-rf9hc
@AR-rf9hc 6 жыл бұрын
Thank you professor
@divyatiwari4990
@divyatiwari4990 4 жыл бұрын
Sir please start lecture on animal physiology subject.
@ProfessorDaveExplains
@ProfessorDaveExplains 4 жыл бұрын
zoology tutorials are coming next year!
@divyatiwari4990
@divyatiwari4990 4 жыл бұрын
@@ProfessorDaveExplains thank you sir.
@whisperingsage
@whisperingsage 4 жыл бұрын
One big cause of gene damage is minerals and vitamin deficiencies. Too bad he left that one out. Weston Price did work in showing vitamin A deficiencies cause lack of eye development in pigs and puppies, there are pictures of this in his free online book, Nutrition and Physical Degeneration. He also showed where soil mineral deficiencies caused double faced calves and partial absorption of a twin which showed as calves with extra limbs. He even showed where calcium and Magnesium deficient soils caused proud upright horns of an ox to gradually fall when he was moved to an area of poor soil. These are things that are preventable, by supplementation, and soil supplementation. So it's sad that more isn't done in this area as it's an easy and usually cheap fix. Dolomite has calcium and magnesium, much needed by the soil for good crop production (ideal soil needs 68% calcium and 12-20% magnesium) and limestone has calcium and 60 trace minerals (found in the soils of the centenarian cultures) (soilminerals dot com). A"simple" magnesium deficiency can cause multiple illnesses and maladies including death. William Albrecht was the father of soil minerals. He discovered this and helped this farm resolve their high mortality rate. Also missing was a discussion of fetal alcohol and tylenol, and smoking and any number of drugs taken in pregnancy. There is enormous chance of damage in pregnancy when ingesting these things. So easy to prevent.
@docmaker-italy
@docmaker-italy 6 жыл бұрын
Bravissimo, molto belli i tuoi video, thumbs up!
@fredcalledbygod
@fredcalledbygod 2 жыл бұрын
Very good teacher👌🏿👍🏿
@sarahward5974
@sarahward5974 3 жыл бұрын
Really great thank you!
@prembhattarai7365
@prembhattarai7365 2 жыл бұрын
you're genius. thanks for saving my life
@Phoenix-np1iu
@Phoenix-np1iu 3 ай бұрын
is the polymerase used dna polymerase iii? I can never remember which polymerase is which
@RandomNooby
@RandomNooby 4 жыл бұрын
One of the greatest mysteries of modern science, is how does Dave have such a derpy haircut and yet manage to ooze cool from every fiber of his being?
@thebigtricky9156
@thebigtricky9156 3 жыл бұрын
Most likely his knowledge of his area of expertise and indeed the subject of the content, I think he uses that to stimulate people's interest and become and thus become charismatic.
@AyushPramanik
@AyushPramanik 6 жыл бұрын
Could you gimme the details regarding the repairing enzymes? I mean, not all of them. But the main ones.
@ipanemasalinas
@ipanemasalinas 2 жыл бұрын
ily dave 💖
@myazed1
@myazed1 5 жыл бұрын
can the silent mutation make any phenotypic, effect ?
@ProfessorDaveExplains
@ProfessorDaveExplains 5 жыл бұрын
they shouldn't, no.
@myazed1
@myazed1 5 жыл бұрын
@@ProfessorDaveExplains silent mutation can happen in non codon mutation, right? and the non codon can be affect gene expression by up and down promoter mutation , is this not considered phenotype effect ?
@ProfessorDaveExplains
@ProfessorDaveExplains 5 жыл бұрын
well that's not what's implied by a silent mutation, it implies it is within a codon, but certainly mutations can occur within a promoter as well, which could potentially be devastating.
@Kanyovu
@Kanyovu Жыл бұрын
"who knows"
@MONGTRAN11
@MONGTRAN11 7 жыл бұрын
Mutations are classified by heredity or environment factors ?
@ProfessorDaveExplains
@ProfessorDaveExplains 7 жыл бұрын
i think typically by the mechanism of repair as i've done here, but you can certainly classify them by the means you've mentioned as well. i'm not too familiar!
@geetugupta7244
@geetugupta7244 Жыл бұрын
Really urgent doubt : Are cytosine and cytobine the same ?
@nikokallio8650
@nikokallio8650 Жыл бұрын
It´s very calming that he talks like for baby to me, after being on lectures where you have 20 seconds time for one dia while professor is speaking,,, to read and understand one dia takes 2 minutes and to listen and understand professor takes another 2 minutes which end up you learning nothing and just skip the lectures and try to find what the hell are we supposed to learn and then find how to learn it.
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