PSMA Scans & Pluvicto (lutetium-177) in 2022 | Geoffrey Johnson, MD, PhD

PSMA Scans & Pluvicto (lutetium-177) in 2022 | Geoffrey Johnson, MD, PhD | PCRI Conference 2022

Рет қаралды 49,220

Жыл бұрын

Geoffrey Johnson, MD, Ph.D., is a radiologist specializing in nuclear medicine at the Mayo Clinic in Rochester, Minnesota. Here, he discusses PET/CT scans and new "theranostics" treatments for prostate cancer, including the newly approved "Pluvicto" (lutetium-177). Theranostics is a combination of "therapy" and "diagnostics". It refers to the fact that the same radiotracer used for the PET scan ("PSMA" in the case of Pluvicto) is used to guide injectible radioactive particles to the sites of disease. View Dr. Johnson's faculty page here: www.mayoclinic.org/biographie...
Get the full conference experience here: pcri.org/2022-conference
Watch Day 1 of the 2022 September Conference here: • Day 1 | PSMA PET, Acti...
Day 1 features the following lectures & Q&A sessions:
"PSMA PET, Theranostics, SPECT, and the Road Ahead in Prostate Cancer" by Geoffrey Johnson, MD, Ph.D
"Improving Quality of Life: ED, Incontinence, and More" by Jeffrey Brady, MD, FACS
"Active Surveillance Update 2022" by Laurence Klotz, CM, MD
Watch Day 2 of the 2022 September Conference here: • Day 2 | Advanced Treat...
Day 2 features the following lectures and Q&A sessions:
"2022 Hot Topics in Advanced Prostate Cancer" by Evan Yu, MD
"DIY Combat Manual for Beating Prostate Cancer" by Eugene Kwon, MD
"Conference Wrap Up" with Mark Moyad, MD, MPH, and Mark Scholz, MD
Don’t know your stage? Take the quiz: Visit www.prostatecancerstaging.org
To learn more about prostate cancer visit www.pcri.org
Sign up for our newsletter here to receive the latest updates on prostate cancer and the PCRI: pcri.org/join
Who we are:
The Prostate Cancer Research Institute (PCRI) is a 501(c)(3) not-for-profit organization that is dedicated to helping you research your treatment options. We understand that you have many questions, and we can help you find the answers that are specific to your case. All of our resources are designed by a multidisciplinary team of advocates and expert physicians, for patients. We believe that by educating yourself about the disease, you will have more productive interactions with your medical professionals and receive better individualized care. Feel free to explore our website at pcri.org or contact our free helpline with any questions that you have at pcri.org/helpline. Our Federal Tax ID # is 95-4617875 and qualifies for maximum charitable gift deductions by individual donors.
The information on the Prostate Cancer Research Institute's KZfaq channel is provided with the understanding that the Institute is not engaged in rendering medical advice or recommendation. The information provided in these videos should not replace consultations with qualified health care professionals to meet your individual medical needs.
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Пікірлер: 73

@tomswoverland Жыл бұрын

Had my first PSMA scan the beginning of February at Mayo. The good news is I don’t need pluvicto yet. Did see 2 small possible spots but no treatment needed. Not bad for some one who started out with Gleason 8 and a 93 PSA score. Over 3 years of different treatments. Thanks Mayo. Keep up the good work. 😁

@peterklus Жыл бұрын

Utterly fascinating! The advances in this field give all of us cancer patients hope.

@cyrillekounde8395 3 ай бұрын

Explaining complex things in a simple manner is an art. You have mastered it Dr . Johnson!

@tinghong8809 Жыл бұрын

What a great talk! Thank you for standing with patients suffering from prostate cancer!

@davidlee8551 Жыл бұрын

Thank you for your work & the update.

@TMCMR Жыл бұрын

Great presentation. I’m waiting for my radiation results after my PSMA PET SCANS. I had 5 high dose treatments and I supposed to wait 8!weeks.

@garykliewer2097 Жыл бұрын

Excellent presentation, best on the topic. A PSMA PET scan from UCSF shows I am the poster-child candidate for Pluvicto, so we'll see. As for all of us, it's about living long enough to take advantage of the next new therapy - this talk maps that future out very well.

@MyCousinGrandpa Жыл бұрын

An excellent presentation, thank you!

@bbally1754 Жыл бұрын

Thank you, outstanding presentation

@14BRIANBOY Жыл бұрын

Excellent presentation. Brought it down the level of the average person with a college level understanding. Sounds like technology is improving rapidly. I was diagnosed with PCa 9 yrs ago. Progression was slow for 9 yrs. Then PSA suddenly went to 39. CT/MRI/PSMA showed no METs. Was treated with IMRT at Stanford U. Will have 3 month PSA test this week. Hope for results to show declining PSA. But, it's good to know there are other treatments in the pipeline, in case PCa rebounds.

@luketimber4679 Жыл бұрын

Brian -How are you doing now? Hope well. Got a PSA of 10 and seeing a urologist today.

@meganote Жыл бұрын

Thank you! Very good presentation.

@bhagmeister Жыл бұрын

Fantastic presentation; Fantastic progress in the detection and treatment of prostate cancer. I was diagnosed in 2007 and the medical science - thank god - has improved substantially. Thank you all!

@pratibhasingh1123 8 ай бұрын

What is the response now sir about your prostate cancer

@bhagmeister 7 ай бұрын

@@pratibhasingh1123 At present, my PSA & Testosterone are beginning to climb slowly after nearly two years of being off hormone blockade. The blockade had been successful is burying my PSA below detection for many years but my MedOnc & I agree that it’s not IF but WHEN my body will develop a resistance. With the advent of the PSMA scanning technique we’re hopeful to locate the location(s) of my cancer in order to hit it with a membrane targeted chemotherapy. I’ve had this scan earlier without any detection. We’re waiting for a larger expression of PSA to reattempt.

@barrie888 Жыл бұрын

tks for the great talk Doc you are very very generous with your knowledge

@miltondavis8842 Жыл бұрын

Thanks. In two days I get my third Pluvicto infusion. It is working according to PSA and the way I feel, and lymph Mets diminishing in my neck

@utot0210 Жыл бұрын

I will have my first treatment 1/12/23 Of pluvicto infusion and pretty exited about it but my PSA now is rising and at this point is 12.5 from 11 what do you feel after your treatment?

@jeffyoung1396 Жыл бұрын

Mine not working after three infusions

@tomswoverland Жыл бұрын

I’m headed to Mayo for my first psma scan after more than 3 years of treatments mostly at Mayo. Now that I qualify for the scan the quicker they find the stuff the longer I can keep going. Thanks for explaining all this.

@model.train.railway. Жыл бұрын

Excellent. Thankyou

@tomsimpson7994 Жыл бұрын

Thanks for helping us. I have PC, your information will help guide me.

@billyjohnson9166 Жыл бұрын

Geoffrey your a genius. You would be my choice in a doctor

@robgerety 10 ай бұрын

Good lord. Such smart people. Amazing stuff.

@jimjohngirard Жыл бұрын

Informative and eye opening presentation. As one who is going to receive a PSMA scan for prostate cancer, I love the explanations......thank you so much.

@luketimber4679 Жыл бұрын

When are you getting your PSMA scan? I have mine this Wednesday in Long Island NY What about you?

@jimjohngirard Жыл бұрын

Luke, the wait is tough. I have mine on the 21st and meet with the radiologist on the 24th. I live in Boise, Idaho and just 6 months ago I would have had to fly to San Francisco for the PET scan, but now they have one here. I'm hoping the cancer is limited to the prostate and not anywhere else in my body....probably you too. Fingers crossed. Maybe we could stay in touch...All the best to you on your scan....I'll be thinking of you.

@luketimber4679 Жыл бұрын

@@jimjohngirard Yes, I will be thinking of you. Lets stay in touch. What is your PSA score btw? Mine it 10.85. I have a metal hip which messed up my MRI results

@luketimber4679 Жыл бұрын

@@jimjohngirard I live in NYC btw

@jimjohngirard Жыл бұрын

Luke, my pathology report came back like this.... Gleason 3+4=7, Group 2, PSA 3.31, small tumor only in right apex. Low risk intermediate. My MRI found a PIRADs 4 lesion, "Clinically Significant Disease Likely", yet when the biopsy was complete, the PIRADS 4 lesion was benign tissue, but the systematic needle biopsy found a small tumor in the right apex. The MRI missed the cancer all together. Urologist says not life threatening and wouldn't do surgery....so I'm waiting on the PET scan results to then meet with the radiologist to determine the proper course of action. Let's stay in touch....and keep each other positive....all the best....Jim G.

@jaimevelazquez7624 8 ай бұрын

I was diagnosed in 2022 and my doc is already thinking of switching me to Pluvicto. I am honestly terrified, now knowing that after a few months cancer will come back with Pluvicto.

@robertmonroe3678 Жыл бұрын

Any chance the PSMA PET CT Scan can determine if Prostate Cancer cells have left the prostrate and moved to nearby tissue? As in local v regional Prostate cancer staging. A KEY issue in initial staging. And a KEY determiner of curative treatment modalities. Of course there are other applications for the PSMA PET CT Scan (including recurrence and distant spread and radiotherapies).

@vycuraci Жыл бұрын

this is cool

@kiheidude Жыл бұрын

Wouldn’t it be better to go ahead and get a PSMA PET/CT scan if you have an elevated PSA and positive DRE, rather than getting the traditional biopsy first? Given the risks involved with the biopsy and the accuracy of the PMSA PET scan, it seems it would be advisable to just get the PMSA PET scan to get a more accurate decision whether you have prostate cancer?

@utot0210 Жыл бұрын

that makes sense, if they can see cancer cell on MRI or PSMA PET SCAN, go ahead and sap it with protons , that takes care of that bad boy , no side effects and you can start your life again🤣

@kiheidude Жыл бұрын

@@utot0210 I recently had an elevated PSA, positive DRE (for nodules), and doctor wanted to do a traditional biopsy. I insisted on getting the 3T MRI over his objections. The 3T MRI came back negative for cancer, much to the doctor’s surprise. I was spared the risks and after effects of the biopsy. He did share with me that there is a more advance urine test they can do where they massage the prostate digitally, then you collect the first couple tablespoons of urine. The urine sample is then tested for the presence of cancer cells. You have to be an advocate for your own health and do your research.

@lyfandeth Жыл бұрын

I suspect that it does make sense, but you'd find the insurers wouldn't pay for it and the scanning bill would be a huge cash expense.

@mperloe Жыл бұрын

As ADT may increase the expression of PSMA, might ADT serve as a sensitizer to Lu177 perhaps over non-prostate source of PSMA.

@billdavis3957 Жыл бұрын

PET scans are very expensive so insurance requires biopsies first, then CAT scans, then MRI scans, then finally PET scans. MRI is the most cost effective.

@andrew8919 Жыл бұрын

At 42:50 with a great response, which sounds great, why do most have cancer come back?

@kipanderson1479 Жыл бұрын

What is the cpt code for a PSMA pet scan? I want to verify acceptance by my insurance. And find skilled treatment centers. Thank you. PSA 25, MRI Pirad= 5

@gshenaut Жыл бұрын

Interesting talk. I'm wondering if there are any non-radioactive molecules that would bind to psma and could be used to transport powerful nonradioactive chemotherapies directly to cancer cells and kill them.

@mperloe Жыл бұрын

Personalized medicine through whole genome analysis may identify specific points in the genesis or progression of cancer that might be targeted. Research has offered clues as to tumors ability to progress to the castrate resistant phase. Unfortunately in the age of private equity funded medicine we are being forced to accept one size fits all medicine. It is my hope that comprehensive genomic analysis and artificial intelligence will enable patients to receive the most effective choice for them.

@kamalsh6123 Жыл бұрын

I had a small suspicious patch seen on an MpMRI in Transition zone of the prostate. The PSMA PET scan report shows "patchy PSMA expression" in Transition Zone and nothing elsewhere. I have confirmed bacterial prostatitis as per the Semen culture report (done multiple times). What does this suggest? Does the patchy PSMA expression indicate cancer or is it only bacterial prostatitis? If it is cancer, does patchy expression of PSMA mean only a benign or slow growing cancer ?

@cafireman Жыл бұрын

Great informative Video! Did anyone provide contact or an email to reach Dr. Johnson?

@1royalpalm Жыл бұрын

Has actinium (225Ac-PSMA-617) been FDA approved like Pluvicto (lutetium-177) as therapy for metastatic prostate cancer?

@dfb1976 Жыл бұрын

Not as yet

@salsamink 5 ай бұрын

Wonderful info! Alpha treatment seems promising. Any update on that?

@CW89134 2 ай бұрын

Dr. Johnson - My husband has had a Prostate cancer recurrence 17 years after treatment with proton radiation. He had a PSMA PET scan in March 2024 that showed uptake in the prostate and 6th lateral rib. We are not sure that the radiologist interpreted the results properly. Can I have the slides sent to you?

@jeanlittlejohn1280 Жыл бұрын

Gosh !

@MrConan89 Жыл бұрын

Can anyone answer this........if PSMA-PET scan is so accurate, is there any need for an old style biopsy first? I have the money to pay for it so no problem for me with an insurer.

@perfectly22smith38 10 ай бұрын

They can’t grade the cancer with the pmsa is the problem

@venkatnelluri7750 Жыл бұрын

Radical prostractomy done on 28.10.2017. Now PSA increases gradually from 0.002 to 0.5 now. PSMA pet scan done on 01.10.2022. No symptoms of cancer. Why PSA increases.

@RH-xd3nx Жыл бұрын

Did they check to see if cancer is in the blood..if it's not on organs. Also there is a small percentage of men that psma pet scans don't work on..not being negative sir just precautions

@jabster58 3 ай бұрын

The saddest thing I learned today was that cancer cames back in 40 percent of the people treated with radiation or prostate removal...can anyone cheer me up with better news?

@clintcarter 6 ай бұрын

🙏💪👌

@jb66young Жыл бұрын

How can i reach you?

@bobankr Жыл бұрын

As a Gleason 4+3 holder whose disease metatastized 4 years after prostatectomy, I am looking for a way to reduce ADT time to 3 months during radiotherapy and the new PSMA Pet scan seems right on target. This new scan allows for a more wait and see approach.

@gvet47 8 ай бұрын

When first told I had prostate cancer I was told to get my afairs in order. Told it was alreadyvin many lymph nodes and tumorvon lower spine. Gave me hormone shots that first day. WhyvI let them was crazy! Told it might extend my life but byva day or what? Now just changing me into a woman!!!! Larger breast, small testicles and penis. Terriblecsweats that last for hours and live with a towel on my chest and wraped on my head as I have never been socked so much. Impossible to function day to day Cancer doctor does not even set up appointments or follow cancer with scans. Am I just to die? Palliative nurse at least helps with pain meds. Visiting home nurse justcsay tobgobon hospice. What a non careing desease to have. Turn 76 on Nov 22, 2023. And live alone with no family.