Rapamycin Protocol | Dosing, Benefits & Side Effects from 4 Experts In the Field

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Rapamycin Protocol | Dosing, Benefits & Side Effects from 4 Experts In the Field

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Күн бұрын

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Here we have clips from experts with experience of rapamycin, personal, as clinician prescribing it and as researchers, talking about the best dose, timing, benefits and side effects. You can watch the original videos of the interview for more details in each case.
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Dr Matt Kaeberlein • Rapamycin Update What ...
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#rapamycin #healthspan #longevity

Пікірлер: 25

@ModernHealthspan Ай бұрын

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@sebek12345 29 күн бұрын

🎯 Key points for quick navigation: 00:15 *📊 A study collected data on off-label rapamycin use, including both users and non-users.* 01:52 *🔬 The study was based on self-reported data from participants, not verified by medical records.* 04:52 *😮 Mouth sores were the only statistically significant side effect reported more frequently by rapamycin users.* 06:28 *🧠 Interestingly, anxiety and depression were reported less frequently in rapamycin users.* 07:52 *🦠 Continuous rapamycin use was associated with less severe COVID-19 infections and fewer long COVID symptoms.* 10:38 *💊 The most common rapamycin dose reported was 6 mg once a week orally.* 12:27 *⚠️ Rapamycin is not recommended for pregnant women, children, teenagers, or young adults.* 14:11 *🩸 Blood tests for sirolimus levels are recommended to ensure proper dosing and absorption.* 17:39 *🔄 Intermittent rapamycin use is preferred to avoid significant immune system suppression.* 21:28 *🍊 Grapefruit juice may slow down rapamycin metabolism, potentially increasing blood levels.* 23:16 *⏱️ Rapamycin dosing is typically once a week, with doses ranging from 1 to 6 mg.* 23:42 *🔄 Some users take rapamycin every other week with a doubled dose, alternating with metformin.* 24:26 *⏳ The concept of "five half-lives" is used to determine dosing frequency for rapamycin.* 25:18 *🛑 High doses of rapamycin interfere with mTOR2 assembly by competing for binding sites.* 25:45 *🔬 In transplant medicine, continuous rapamycin use suppresses mTOR2 to prevent organ rejection.* 27:10 *🐢 For anti-aging purposes, it's recommended to start with low doses (1-2 mg) and slowly increase over time.* 28:32 *💊 Personal experience: Starting at 1 mg every two weeks, gradually increased to 4 mg.* 29:09 *😖 Side effects experienced at 4 mg: hives and severe gum/tooth pain for several days.* 30:04 *🔬 Rapamycin affects mitochondrial function, iron, and copper metabolism, which could explain some side effects.* 30:46 *🐁 Mouse studies show about 10% improvement with rapamycin, but human results may vary due to different metabolic factors.* Made with HARPA AI

@olyav5819 Ай бұрын

Great interview.

@ModernHealthspan Ай бұрын

Hi thanks Olya!

@michael-qp9xd Ай бұрын

Hi Richard - very good videos here. I see in comment section you mention to try. I am about your age (I’m late 60s) and think too very healthy like you. Been for last 40 yrs running 20 miles a wk, exercise with heavy weights 4 days wk, BMI at 20, take no meds, eat no processed foods, all blood markers (~50 tested) in ideal range - so very thankful, lucky and fortunate. A few medical researchers i follow - mention if older and very healthy maybe no benefit by taking the once wk rapamycin and maybe some negative side effects. So just hard to determine if to start and not fully known maybe for another several yrs. Good if one was 30 could wait but in late 60s when all known could be too late. Think still I’ll wait another yr to decide as maybe little more info to help with decision. Thanks all efforts here with video updates you do each wk.

@ModernHealthspan Ай бұрын

Hi Michael, thanks for sharing. Your protocol looks excellent! I have not started rapamycin yet, but am thinking about it. If we are doing the right things, does it help? According to the observational paper by Dr Kaeberlein there were few side effects and it seemed to improve general health. (www.ncbi.nlm.nih.gov/pmc/articles/PMC10187519/) . I think it is like Dr Cohen says, you need to think about what value it would give you and see if you see that.

@stefanallard3084 Ай бұрын

It was very intresting to hear the guy from the trim trail explaining mtor is needed for thymus function.. being on rapa constantly will slow cell growth and also repair it seems like, even tho the studies show it increase repair thrue autophagy, yet people on it get slow healing from scars/get infections and so on. Wich would indicate a weaker body. Extended fast that on paper do the same as rapa, repair skin n stretch marks, kills off infections, cure cellulite n so on - so fasting really seems supperior

@ModernHealthspan Ай бұрын

Hi Stefan, thanks for the comment. I would agree with Dr Fahy, it is about balance and cycling between growth and clean up modes. Fasting is good, but there does seem to be more people (Dr Peter Attia for example) coming out against it for older people because of the danger of lean tissue loss.

@stefanallard3084 Ай бұрын

@@ModernHealthspan dident he find out that lifting weights during the fast helped with alot of the loss? I see alot of people look more musclar even post a fast, prob due to the hgh increase. I will try vibration therapy during the fast to activate autophagy alot more Btw you should read the book from the american health expert paul bragg i belive, the guy that sells the apple cider vinegar, his book on fasting is incredible

@tylermoore4429 Ай бұрын

I agree with Dr. Cohen. If you are already doing a lot of longevity interventions (even aspirin is an inhibitor of mTOR), maybe rapamycin does not add much value. I will also note that Dr. Blagosklonny, who first brought rapa as longevity medicine to the world's attention is now struggling with cancer despite his long-term rapa use.

@stefanallard3084 Ай бұрын

@@tylermoore4429 he took the clot shot, got cancer soon the after as many others

@ModernHealthspan Ай бұрын

Hi Tyler, thanks for sharing. I am also unsure, if you do the "right things" how much supplements can add. In principal we would all get a baseline of some sort, then take the supplement for 3 months and remeasure. But this is resource intensive. I did not know about Dr Blagosklonny having cancer. I wish him the best.

@user-qe6bl1lb7u Ай бұрын

It is tasteless to disclose Dr B's medical condition in an argument against Rapamycin. If you were a physician such a move would be considered highly unethical. 😂

@rayyu8538 Ай бұрын

Good summary, tks Richard.

@ModernHealthspan Ай бұрын

Hi Ray, thanks!

@jamescondron8266 Ай бұрын

I would suggest you investigate the recent revelations regarding the new data regarding the irregular fatty acid C15:0. I suspect you will be interested.

@karlbabaji Ай бұрын

As noted, taking with grapefruit juice and a fatty meal can make the Rapa far more bioavailable. I like this efficiency and cost savings as you can't just buy rap at the corner store. But the question is does potentiating it with grapefruit juice extend the half life? I was taking 3mg weekly Rapamycin 4-12 hours after juicing a whole pomelo (which is basically a grapefruit) and after a few weeks suffered an infected anti-biotic resistant staff infected abscess. Coindidence? Maybe but hard to know. Wondering if the grapefruit crowd might be better off doing longer intervals to clear the system? Interested to know if anyone had tested levels over time with the grapefruit method. I'll also note that studies have shown that different variations of Pomelo have shown to produce different levels of the As noted, taking with grapefruit juice and a fatty meal can make the Rapa far more bioavailable. I like this efficiency and cost savings as you can't just buy rap at the corner store. But the question is does potentiating it with grapefruit juice extend the half life? I was taking 3mg weekly Rapamycin 4-12 hours after juicing a whole pomelo (which is basically a grapefruit) and after a few weeks suffered an infected anti-biotic resistant staff infected abscess. Coindidence? Maybe but hard to know. Wondering if the grapefruit crowd might be better off doing longer intervals to clear the system? I know that taking Pomelo/Grapefruit can be quite variable in effects both from variations in the fruits themselves, method of administration and individual responses to it

@jhonsmiths7559 Ай бұрын

Can you take other supplements with rapamycin - and how long after the rapa dose, the others can be taken

@sergey9986 Ай бұрын

This stuff is way to expensive for how long it extends longevity.

@smedleyjefferson1450 Ай бұрын

Re: Dr Pelton: I didn't know that hay rapamycin was fat-soluble.

@ModernHealthspan Ай бұрын

Hi Smedley, thanks for pointing that out. That is a good point. I have just done some investigation and it is not soluble in water, but I see no mention of it being soluble in fat, rather there is some solubility in ethanol and propylene glycol.

@rogerreich2721 Ай бұрын

what was the name of the Blood test for Rapa??? Test Test Test....

@Peterdoran33 Ай бұрын

Sirolimus

@ModernHealthspan Ай бұрын

Hi Roger, thanks for the question. I don't think that Dr Pelton mentioned that name but I find a test here labtestsonline.org.uk/tests/sirolimus (in the UK) which is called sirolimus (the brand name for a rapamycin product).