Remyelination research in Multiple Sclerosis

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Remyelination research in Multiple Sclerosis

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The Multiple Sclerosis Trust

Күн бұрын

Пікірлер: 14

@donjerrard9370 3 жыл бұрын

It’s very good to hear that there is research into remylination and very encouraging to MS sufferers like myself

@ilostsomethingonce 3 жыл бұрын

Wow this is so fascinating. I think MS research deserves way more recognition, the progress just in the past couple years is amazing.

@DavidRivera-mr6pi Жыл бұрын

gives me hope for my future years of life to see MS isn't being forgotten about

@__Wanderer Жыл бұрын

had severe ON and haven't recovered after 6 months - I am considering doing a combination of fasting and taking clemastine for a couple months (the fasting to mimic metformin) combined with exercise to boost Treg - I can't wait another 2-4 years to maybe get some results. The research is fantastic and I am amazed at the ingenuity and dedication of everyone involved, but to a patient these results are still painfully slow. Surprised there is not a broader interest in remyelination as this would surely be beneficial to anyone over the age of 60 - perhaps assist in general cognitive decline for everyone not just people with MS. Thank you MS Trust + Dr. Nick, great interview. :)

@davidtrindle6473 2 жыл бұрын

Interesting. Gold was used in treating Rhematoid arthritis. Perhaps there’s a connection to MS

@BernardAsagai 4 ай бұрын

Would like to join.

@BernardAsagai 4 ай бұрын

Is there a study?

@genogeno1234 2 жыл бұрын

Any research into cheap treatments for remyelination using Lion's Mane mushrooms? Animals have responded well and have shown regrowth of myelin, correct? Oh that's right...there isn't any big money like $125,000 per person per year in that kind of treatment. Never mind.

@bobbivolz5849 2 жыл бұрын

Do you know of any Clinical Studies for my son with Cerebral LEUKODYSTROPHY?

@mstrust 2 жыл бұрын

We are a multiple sclerosis charity and so this is outside of our area of knowledge. It may be worth contacting the MLD Support Association UK www.mldsupportuk.org.uk/ who support people affected by metachromatic leukodystrophy and will know what research is happening. You can also find a list of recent and current trials around the world on the Clinical Trials website at clinicaltrials.gov/ct2/results?cond=Cerebral+LEUKODYSTROPHY

@vojkostar 2 жыл бұрын

anything new on metformin/clemastine trials ?

@mstrust 2 жыл бұрын

The start of the study was delayed by the pandemic, but the first of the 50 people they are aiming to enroll started on the study in April 2022 (multiplesclerosisnewstoday.com/news-posts/2022/04/26/clinical-trial-enrollment-metformin-clemastine-myelin-repair-multiple-sclerosis/) The treatment will last 24 weeks, and the intention is to have gathered all the data by October 2023. There's a little bit more about the trial on the Cambridge University website at www-neurosciences.medschl.cam.ac.uk/jones-coles-group/ccmr2-a-trial-of-metormin-and-clemastine-as-remyelinating-drugs-in-ms/ and also on the ClinicalTrials site at clinicaltrials.gov/ct2/show/NCT05131828 (this latter includes the eligibility criteria)

@novicailic6361 Жыл бұрын

this research has been terminated due to numerous adverse effects

@mstrust Жыл бұрын

An update of the five treatments mentioned in the video (as of December 2022): Bexarotene - the video explains why this drug wasn't taken beyond the completion of the initial trial due to is side effects, though the research did indicate that remyelination is possible - www.mstrust.org.uk/a-z/bexarotene Anti-lingo-1 (Opicinumab) - this trial was discontinued, not because of side effects but because the drug wasn't proving any more effective than placebo - www.mstrust.org.uk/a-z/opicinumab-anti-lingo-1-biib033 Nanocrystalline Gold - these trials are still ongoing, with results possibly appearing in 2023 - clinicaltrials.gov/ct2/show/NCT03993171 Clemastine/metformin - the Cambridge trial was further delayed by Covid but began recruiting participants in March 2022. It will be running throughout 2023, with results possibly in 2024 - www-neurosciences.medschl.cam.ac.uk/jones-coles-group/ccmr2-a-trial-of-metormin-and-clemastine-as-remyelinating-drugs-in-ms/