Restrictive Lung Diseases - Interstitial Pulmonary Fibrosis. Pathology, Clinical, Tests, Treatment

Рет қаралды 113,937

6 жыл бұрын

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This video presents the introduction to restrictive lung diseases. We will discuss:
Definition
Types
Extrapulmonary restrictive lung diseases
* Obesity
* Scoliosis
Pulmonary parenchymal restrictive lung diseases
* Idiopathic
* Autoimmune
* Granulomatous (Wagner's granulomatosis, Sarcoidosis)
* Occupational (pneumoconiosis, silicosis, asbestosis, coal, etc.)
* Other irritants
* Chronic infections (Tuberculosis)
Neuromuscular restrictive lung diseases
* Myasthenia gravis
* Diaphragm issues
* Polio
Cellular events/pathogenesis
* Damaged Type I Pneumocytes
* Hypertrophy of Type II Pneumocytes
* Irritated epithelium
* Irritated macrophages
* Apoptosis of epithelium
* Tissue damage leading to local inflammation and lung destruction/scaring.
* Neutrophils releasing cytokines, proteases, tumor growth factors (TGF)
* Macrophages releasing transforming growth factor beta, tumor necrosis factor (TNF), platelet activation factor.
* Fibroblasts overactivity resulting in more extracellular matrix and hardening.
* Epithelial-mesenchymal transformation.
* Smooth muscle proliferation.
* Respiratory interface thickening. Disrupted gaseous exchange.
Clinical:
Dry hacking cough
* Dyspnea
* Hypoxia
* Respiratory alkalosis
* Late inspiratory crackles
Abnormal chest X-Ray
* Reduced volume in chest X-Ray
* Lower lobes show more involvement and the reason why.
* Right heart failure/cor pulmonale
Lung Function Changes
* FEV1/FVC ratio increases above 80% (normal or above normal)
Treatment
* Anti-inflammatory (may not be very effective)
* TGF Beta-blockers
* Oxygen
* Lung transplant ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

Пікірлер: 94

@irinarakovicprivatepractice 6 жыл бұрын

Well done! It's so much fun to listen to you! Thank you!

@grntara78 5 жыл бұрын

Wow....you are the only one....who can make restrictive lung diseases understandable...thanks a lot for the lecture.

@thivz6630 5 жыл бұрын

This was an amazing lecture! Thank you sir 😊

@ayudiahmayasari1182 5 жыл бұрын

Finally i can understand..bravo.good explaining

@kishwarbanotelar3282 6 жыл бұрын

I have never saw the teacher like you .. You are so great..if these type of teachers teach in my college I will definitely become a doctor one day..thank you so much mobeen sir..

@DrBeenMedicalLectures 6 жыл бұрын

I am glad that lectures are valuable. Check out tons of more lectures on drbeen.com.

@claudeanurudha7907 3 жыл бұрын

Great lecture.Very educational and clear.Thank you.

@muskandeshwal9299 3 жыл бұрын

Such an amazing lecture......very conceptual ......thank you so much❤️❤️

@cmikewilson 6 жыл бұрын

This was helpful. Thanks.

@helean1344 3 жыл бұрын

This is so great ,thank you so much

@vinitasolanki3218 3 жыл бұрын

Thanks a lot sir... Keep it up... Your videos are very helpful

@motocephalic 3 жыл бұрын

very good presentation, reminds me of respiratory school.

@tenderprecious 3 жыл бұрын

Thank you for your work 💓

@m-HamzaQayyum 4 жыл бұрын

Sir, I think decrease CO2 from blood to cause build up CO2 in blood and hence Respiratory acidosis will develop not alkalosis. Plz correct me if I'm wrong

@blessedcharles2279 3 жыл бұрын

Good lecture God bless you

@mairakhan8586 6 жыл бұрын

great lectr,thanku sir.

@khamikos1 6 жыл бұрын

excellent.you are a great teacher. keep it up. thanks fromGreece

@DrBeenMedicalLectures 6 жыл бұрын

My pleasure. We got tons of content on drbeen.com. Check it out.

@prashantj50 6 жыл бұрын

Nice job sir , specially fev1 ,about restrictive lung disease have more elastic

@thandimtshali3465 3 жыл бұрын

Thank you for this 🙏

@paulwang7765 5 жыл бұрын

you're a god ! appreciate this so much :)

@ayudiahmayasari1182 5 жыл бұрын

Nice ..thanks

@gins8781 4 жыл бұрын

A comprehensive explanation.

@DrBeenMedicalLectures 4 жыл бұрын

Thank you!

@kellyjoplin3153 4 жыл бұрын

Excellent

@maleeshajayasundara6318 3 жыл бұрын

Thank you very much.

@PrabhatKumar-mu1nr 6 жыл бұрын

Nice Lecture, Thank You Sir.!

@DrBeenMedicalLectures 6 жыл бұрын

My pleasure.

@dr.faizanali4770 4 жыл бұрын

Sir .. as co2 cant go outside during exchange , how it cause alkalosis ? There must be acidosis

@harikrishna70 5 жыл бұрын

thanks sir we want more lecturere s from you plzzzzzzzzzzzzzz

@mohammedumarfarooqui6373 4 жыл бұрын

You are awesome sir

@AsadUllah-wp8hn 3 жыл бұрын

Increase CO2 pressure suppose to cause Respiratory Acidosis rather than Alkalosis BTW nice explanation Sir

@gunabharathi3152 6 жыл бұрын

Sir... Would u take respiratory failure lectures???

@sanjusingh8124 3 жыл бұрын

Thank you so much sir 🙏

@fatimaemad7402 4 жыл бұрын

Sir , you said the irritant will cause apoptosis of epithelium then you said that pneumocyte type ii will be hypertrophied and thus making more pneumocytes type i so where the apotopsis exactly occurs?

@jindijulie105 5 жыл бұрын

THANK YOU SO MUCH !

@DrBeenMedicalLectures 5 жыл бұрын

You are very welcome.

@sindook6085 4 жыл бұрын

Amazing teacher. Masterhood at display. Great teachers are are always Purposeful.

@DrBeenMedicalLectures 4 жыл бұрын

Thank you dear!

@paulvijith2732 5 жыл бұрын

Thank you sir

@kushaltarafder6425 3 жыл бұрын

Thank you sir😊

@drshivamtomar511 3 жыл бұрын

At 15:58 you said elevated co2 in blood cause respiratory alkalosis... I think its cause respiratory acidosis..

@jamalsayed8828 4 жыл бұрын

Sir I need your all lecture where to get those ?

@muzaffarshah9319 6 жыл бұрын

Top class

@anildutta2750 5 жыл бұрын

thnx a lot sir😊😊😊😊

@srirambhardwaj2343 3 жыл бұрын

Thank.you.so.much.sir.

@MuntazerAyyed 3 жыл бұрын

Great ❤️

@iambikash6596 4 жыл бұрын

Thank you sir ....i wish if only i would get a lecturer like you

@user-jj1nm4sx6w 6 жыл бұрын

wouldn't the increasing of co2 pressure in the blood cause acidosis not alkalosis ? . thank you for the lecture

@cristinavanloon8028 5 жыл бұрын

yes it would cause respiratory acidosis! the lecture is great though.

@ramnathyaduwanshi9579 3 жыл бұрын

Sir please upload complete lecture on COPD 🙏🙏🙏🙏

@zareenakhan1536 4 жыл бұрын

Sir whyy respiratory alkalosis occurs if co2 cant go out there should be respiratory acidosis????

@shery123love 6 жыл бұрын

great lecture sir !

@Vd.Krishna 5 жыл бұрын

Tq so much

@usmleislife3396 6 жыл бұрын

grt lecture sir.... sir plz make vedio on general pharmacology which is highly tested in usmle..

@shamimakhanam261 5 жыл бұрын

Amazing

@ishwaryapatil3429 5 жыл бұрын

Awesome ur

@dharmrajmaurya605 4 жыл бұрын

thank you so much

@DrBeenMedicalLectures 4 жыл бұрын

Your are very welcome.

@yasirhasnat9795 4 жыл бұрын

Thank you so much sir

@DrBeenMedicalLectures 4 жыл бұрын

Very welcome!

@dutarnab 4 жыл бұрын

Sir, why do we usually have tremors of rib casge for patients with Idiopathy interstitial fibrosis or lung disease.

@muskandeshwal9299 3 жыл бұрын

Sir please make a video on wbc disorders.....🥺🥺

@shrutikshirsagar4537 6 жыл бұрын

1st you said transforming growth facter then after some time tumour growth factor.....

@mustaquenadaf18 4 жыл бұрын

@15:52 it should be respiratory acidosis not alkalosis

@drabhishekparihar 4 жыл бұрын

Sir Is this resp alkalosis Or resp acidosis?

@arjunharikumar9040 4 жыл бұрын

If sarcoidosis is a restrictive lung disease then why does it show a different kind of pathology

@raghavsoni717 5 жыл бұрын

Bestttt

@deepankarkaushik6384 5 жыл бұрын

Can you tell what to do in ild last stage

@triargotube 4 жыл бұрын

Grupo de HP no facebook facebook.com/groups/683424751844146/

@freedomuk9418 4 жыл бұрын

Hi pls give some advice they told me I've got ristrictive lung I dont smoke am so stressted as dont know what's happening to me pls help any advice

@triargotube 4 жыл бұрын

Grupo de HP no facebook facebook.com/groups/683424751844146/

@clintchimbangu2476 5 жыл бұрын

Good lecturer , but I thought increase in carbon dioxide pressure would cause metabolic acidosis, ..

@fatimaemad7402 4 жыл бұрын

Respiratory acidosis

@drhumzaashrafsial6500 3 жыл бұрын

Exactly

@abhisek241288 6 жыл бұрын

around 16 minutes mark I guess that should be respiratory acidosis.

@geraldhoskins1506 6 жыл бұрын

I agree with DrAbhisek Nanda - the increased interstitium thickness initially results in a localized acidosis due to the inability for CO2 to diffuse and leave the blood vessel. It isn't until there is a response from the patient (in which they would be breathing more deeply or more rapidly) that there is the potential for hyperventilation... However, hypercapnia is the primary driver for breathing - once that is resolved, the hypoxemia may not be sufficient enough to justify breathing as deeply/rapidly. Instead, the patient will feel tired, but generally more comfortable than symptoms associated with hypercarbia, so I posit to you that there will continue to be a compensated respiratory acidosis until late-stage processes in the disease occur.

@9032290952 5 жыл бұрын

yes even great teachers make mistakes

@dr.priyankaganglani895 5 жыл бұрын

it would b acidosis!!

@rogodanelena2721 5 жыл бұрын

i think it's correct alkalosis because co2+h20=h2co3 which is a normal compensatory mechanism of the body. So if co2 increases, also h2co3 increases so it gives alkalosis

@rogodanelena2721 5 жыл бұрын

this happens over time. initially the body develops acidosis, but as time goes by, the kidneys start to produce more bicarbonate to compensate the acidosis, so finally we have alkalosis.

@champion8912 4 жыл бұрын

why cracles

@debbieautry-skubik6594 4 жыл бұрын

I'm not a teacher or student but I do have Restrictive Airway Disease at 32% and Chronic Obstructive Pulmonary Disease at 52% pluse Asthma which were caused by a Ventilator I was on while in my long Coma. I NEVER smoked one day in my Life. I am 62 years old and very ANGRY cause I was healthy all my LIFE until 3 years ago! How does this happen?

@jayantclasses3089 4 жыл бұрын

Sir, my father is suffering from "cronic I L D", and he is near about 70. Doctor has told that 60% of the lungs has been ruptured. I want to ask that, is it curable or not ? This very disease caused due to infection.