It took courage to call out Dr. Sinclair, a perceived “giant” in the anti-aging field. Thank you

this is why I subscribe to the Dr Stanfield channel. He has no fear reporting current studies bringing the largest of youTube whales or nutritional sacred cows into question... including his own past recommendations! He DOES let the facts "get in the way"; how admirable and edifying.

Although the ITP did consult with Sinclair, you didn't address the fact that they just gave the resveratrol to the mice in food without mixing it with fat. As Sinclair said, in their own studies giving it to the mice in regular food without fat didn't extend lifespan.

Your honesty and bravery on challenging such established beliefs have made me a loyal follower of your content. I already appreciated your passion for health, but now I also admire your tenacity as well.

The way you caught Dr Sinclair in that lie was pretty great. Thanks for calling this out and bringing it to our attention. I will have a hard time taking him seriously now.

Highly appreciated that u make a video on this controversial topic.

I really love the technical level at which you pitch your videos. Simply explained, but not dumbed down. Thank you!

Thank you Dr. Brad for going through the research papers and podcast to provide an updated information on resveratrol.

Perhaps your best video yet ( I hadn’t seen your earlier video on Resveratrol). I have been taking Resveratrol for years and now I feel like a fool that has been duped. Thank you for the enlightenment. Keep up the good work.

I have researched this myself as well and as someone who really WANTS to trust Dr. Sinclair and appreciates his mantra of aging as a disease it pains to say I agree that his lab is far too biased, invested and perhaps even invented to push this flawed narrative. I appreciate your follow up on this.

This was an outstanding review. A lot of people have wasted a lot of money taking resveratrol for over a decade or more.

Thank you for always being on top of research. Love your videos. Very informative.

thanks Dr Brad. you really help the community anti-aging. You have the courage to face the real facts.

Resveratrol was the perfect excuse to drink more wine. The masses loved it.

Thank you...that was eye-opening, and I'm glad you went there. Keep up the excellent work of evaluating research!

Thank you so much Dr. Stanfield for digging deeper and explaining further your opionion! 🥰

Thank you for your explanation of the studies. You have covered this topic very well. Your video about Resveratrol before this one, is why I stopped taking Resveratrol. I had been taking it for at least 8 yrs and I'm glad I found your channel. Thank you very much Dr. Standield.

I have been taking Resveratrol since November 2021. My anxiety disappeared and I slept much better - that was he first thing I noticed. Then my energy levels increased - my body seemed to start craving exercise. I don’t think I am imagining any of this. I have noticed no side effects so far.

Beautiful. Thank you for all your hard work Dr. Stanfield. Absolutely wonderful investigation. Bravo.

Thanks a lot for this video - planted a seed of healthy suspicion in me. I'm so happy KZfaq's algorithm suggested this to me even I needed to dig quite deep into the suggestions.

Very well done doc. We need more of this about supplements and disease. Tanks a lot.

One of the best videos from Dr. Stanfield I've seen. Thank you. I love this channel.

Thanks for keeping it real. Haven’t visited in a few months but really enjoy your channel.

Dear Brad First of all, I’m a big fan and appreciate your publications and critical analysis very much. Without having a medical background, I heavily rely on content like yours to define my personal (longevity) supplement stack. My comment is a summary of an opinion I gathered from a friend at Biolytica and I would love to hear your response, as we don’t think you are covering the story of Resveratrol as objective as it could (and probably should) be - concluding “There’s no human data of health benefits with resveratrol” and “There’s human evidence of harm”. Most of the supporting studies and anecdotal references to podcasts you mention are dated 2008-2013ish. Doing a pubmed search for “RSV and SIRT1”, filtered to only “Human RCTs”, deliver numerous studies that used RSV doses between 150mg and 500mg. The 3rd study (Kitada et al) used Piceatannol not RSV. They were all published 2017-2020 (which is noteworthy since these are far better human RCTs than your quotes which are many in vitro and they are all older studies). Hoseini A, Namazi G, Farrokhian A, Reiner Ž, Aghadavod E, Bahmani F, Asemi Z. The effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease. Food Funct. 2019 Sep 1;10(9):6042-6051. doi: 10.1039/c9fo01075k. Epub 2019 Sep 5. PMID: 31486447. Beijers RJ, Gosker HR, Sanders KJ, de Theije C, Kelders M, Clarke G, Cryan JF, van den Borst B, Schols AM. Resveratrol and metabolic health in COPD: A proof-of-concept randomized controlled trial. Clin Nutr. 2020 Oct;39(10):2989-2997. doi: 10.1016/j.clnu.2020.01.002. Epub 2020 Jan 13. PMID: 31996311. Kawamura K, Fukumura S, Nikaido K, Tachi N, Kozuka N, Seino T, Hatakeyama K, Mori M, Ito YM, Takami A, Hinotsu S, Kuno A, Kawasaki Y, Horio Y, Tsutsumi H. Resveratrol improves motor function in patients with muscular dystrophies: an open-label, single-arm, phase IIa study. Sci Rep. 2020 Nov 25;10(1):20585. doi: 10.1038/s41598-020-77197-6. PMID: 33239684; PMCID: PMC7688653. Kitada M, Ogura Y, Maruki-Uchida H, Sai M, Suzuki T, Kanasaki K, Hara Y, Seto H, Kuroshima Y, Monno I, Koya D. The Effect of Piceatannol from Passion Fruit (Passiflora edulis) Seeds on Metabolic Health in Humans. Nutrients. 2017 Oct 18;9(10):1142. doi: 10.3390/nu9101142. PMID: 29057795; PMCID: PMC5691758. Asghari S, Asghari-Jafarabadi M, Somi MH, Ghavami SM, Rafraf M. Comparison of Calorie-Restricted Diet and Resveratrol Supplementation on Anthropometric Indices, Metabolic Parameters, and Serum Sirtuin-1 Levels in Patients With Nonalcoholic Fatty Liver Disease: A Randomized Controlled Clinical Trial. J Am Coll Nutr. 2018 Mar-Apr;37(3):223-233. doi: 10.1080/07315724.2017.1392264. Epub 2018 Jan 9. PMID: 29313746. Batista-Jorge GC, Barcala-Jorge AS, Silveira MF, Lelis DF, Andrade JMO, de Paula AMB, Guimarães ALS, Santos SHS. Oral resveratrol supplementation improves Metabolic Syndrome features in obese patients submitted to a lifestyle-changing program. Life Sci. 2020 Sep 1;256:117962. doi: 10.1016/j.lfs.2020.117962. Epub 2020 Jun 11. PMID: 32534040. There are 4 more RCTs that are relevant… cited below: Zemel MB. Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span. J Med Food. 2020 Nov;23(11):1129-1135. doi: 10.1089/jmf.2020.0105. Epub 2020 Aug 4. PMID: 32758058. This one was promising - combo lower dose RSV, leucine and NAD+ precursors incl NMN. Like most of the promising RCTs, this one showed benefit in subjects with MetS or obesity, subjects all had some imbalance. This one compared normal and slightly overweight subjects - some promising results, some not: Roggerio A, Strunz CMC, Pacanaro AP, Leal DP, Takada JY, Avakian SD, Mansur AP. Gene Expression of Sirtuin-1 and Endogenous Secretory Receptor for Advanced Glycation End Products in Healthy and Slightly Overweight Subjects after Caloric Restriction and Resveratrol Administration. Nutrients. 2018 Jul 21;10(7):937. doi: 10.3390/nu10070937. PMID: 30037068; PMCID: PMC6073749. Another “promising” RCT: Bo S, Togliatto G, Gambino R, Ponzo V, Lombardo G, Rosato R, Cassader M, Brizzi MF. Impact of sirtuin-1 expression on H3K56 acetylation and oxidative stress: a double-blind randomized controlled trial with resveratrol supplementation. Acta Diabetol. 2018 Apr;55(4):331-340. doi: 10.1007/s00592-017-1097-4. Epub 2018 Jan 12. PMID: 29330620; PMCID: PMC5851693. Based on the available data we have to question your research objectivity in this very case. It is long known that RSV and many other mild pro-oxidants increase genes to upregulate production of enzymes that have powerful red-ox, inflammation modulation value through the process of hormesis. Context is critical - and nutrigenomic supplementation must be tested in human clinical trials not petrie dishes. The hormesis issue explains why healthy people might not benefit and why adding 2 xeno-hormetic effects like RSV and exercise might result in too great a pro-oxidant effect (especially more athletic/higher intensity exercise). I don’t try to support or protect any opinion or claim made by David Sinclair. I just try to understand the function and benefits of Resveratrol for myself and my surrounding. Best, Pascal

Great video Brad. Thanks for this excellent review of why resveratrol is actually... less then useless. I had been putting off taking it because of some concerns I had, and this is the first time I have seen those concerns deeply addressed.

Great video, thanks so much for digging through the science and bringing much needed truth to the public!

Excellent work, Dr. Brad. I have noticed that since starting resveratrol, my workouts have suffered - through it all in the garbage after hearing this.

Excellent investigative reporting Brad. Over the years so many folks were skeptical about resveratrol because both the grape growers and wine makers were heavily funding countless studies and issuing plethoric press releases. Andrew Weil, MD mocked it all decades ago.

This is incredibly helpful. When you first debunked the life extending effects of Resveratrol, I tossed my pills. I stopped taking Basis, which is a product with NAD that includes Resveratrol in the formulation (replaced it with Lipo NMN from AlivebyScience). The last thing I need is to blunt the effects of exercise at my age. I greatly appreciate your in depth reviews of these papers. It saves so much time!

Thanks for the in-depth details. Keep up the excellent work!

Wow…Dr Brad! Excellent critical review and analysis on the latest research available on Resveratrol benefits!!! You are a HERO in the anti-aging community!!!

Thank you as always for a very informative video. Please keep us posted about the latest research on NR, NMN, Niacin, TMG .. Basically your supplement stack. Many thanks.

This study was performed to investigate the effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD). This randomized, double-blind, placebo-controlled trial was performed with 56 patients having T2DM and CHD. The patients were randomly divided into two groups to receive either 500 mg resveratrol per day (n = 28) or placebo (n = 28) for 4 weeks. Resveratrol reduced fasting glucose (β-10.04 mg dL-1; 95% CI, -18.23, -1.86; P = 0.01), insulin (β-1.09 μIU mL-1; 95% CI, -1.93, -0.24; P = 0.01) and insulin resistance (β-0.48; 95% CI, -0.76, -0.21; P = 0.001) and significantly increased insulin sensitivity (β 0.006; 95% CI, 0.001, 0.01; P = 0.02) when compared with the placebo. Resveratrol also significantly increased HDL-cholesterol levels (β 3.38 mg dL-1; 95% CI, 1.72, 5.05; P < 0.001) and significantly decreased the total-/HDL-cholesterol ratio (β-0.36; 95% CI, -0.59, -0.13; P = 0.002) when compared with the placebo. Additionally, resveratrol caused a significant increase in total antioxidant capacity (TAC) (β 58.88 mmol L-1; 95% CI, 17.33, 100.44; P = 0.006) and a significant reduction in malondialdehyde (MDA) levels (β-0.21 μmol L-1; 95% CI, -0.41, -0.005; P = 0.04) when compared with the placebo. Resveratrol upregulated PPAR-γ (P = 0.01) and sirtuin 1 (SIRT1) (P = 0.01) in the peripheral blood mononuclear cells (PBMCs) of T2DM patients with CHD. Resveratrol supplementation did not have any effect on inflammatory markers. Four-week supplementation of resveratrol in patients with T2DM and CHD had beneficial effects on glycemic control, HDL-cholesterol levels, the total-/HDL-cholesterol ratio, TAC and MDA levels. Resveratrol also upregulated PPAR-γ and SIRT1 in the PBMCs of T2DM patients with CHD.

Thank you so much for clarifying this for the general public!

Awesome work on this summary, thank you!!

Glad I found your channel as I’ve just been introduced to this stuff. Interesting about the Resveratrol absorption issue and normal food because I heard Sinclair say recently, and I think this may be his “work around” to validate it, that it is best to pair it with intermittent fasting and taken every second day not every day. Standing on its own you think great, ok, that’s the protocol . But hearing it now in light of what you’ve found makes me see it in a very different light.

Dr. Stanfield is now my go to guy for information on supplements and longevity. I used to follow Sinclair, but now have deleted all of his videos. Thank you Dr. Stanfield for being transparent, admitting when your wrong, and reporting the facts. Thank you!

Wow! Thank you, Dr. Stanfield. I watched both video's and am very impressed with your reporting on this topic. Please keep up the great work!

Your facts based approached is compelling, persuasive and empowering. I appreciate your work. Thanks Brad.

I'm under the impression that the original resveratrol study used extra virgin olive oil as a carrier and it turned out to be synergistic and vital to it's effect. Subsequent studies did not use extra virgin olive oil and didn't get the same results.

Thank you for this video. Sharing negative but balanced data on the popularized interventions in the "alternative" health space are very hard to find. This is a most valuable video!

Wow! This was an extremely thorough report. It saves us a lot of money on our supplements stack, for sure! Thank you! I've taken it off and on through the years but I never felt any differently and so, for the money, I didn't continue taking it. It's not cheap.

Thanks for exposing the real data and information!Much appreciated.

Thank you Dr. Brad. It’s amazing how all the data is there but can still be hidden. Your research is so helpful.

Thanks again doc for the timely update on resveratrol. You are a beacon of hope in the medical field.

Thank you so much for this. It was very timely for me as I was getting ready to add resveratrol to my vitamin regimen. I appreciate you so much. And I am so disappointed in David Sinclair. I watched your other video of him blocking you. Very troubling. I thought science was about learning and challenging each other. Keep doing what you're doing. I appreciate you!

Thank you Dr. Brad for looking out for us and taking the motto of do no harm. There are always agendas associated with resources that the public doesn't always see, thank you for showing us the information. Thank you for your ethics in really helping people.

Since I can’t read scientific papers, I’m in a weak position to decide which brilliant scientist is right when they don’t agree.

The thing that really bothers me is Sinclair flat out lying about not being consulted on these studies that show RSV does nothing to extend life. He just lies about it and hopes no one will actually look into it. That is not the first time he has lied about such things. This person cannot be trusted, he is simply not a quality source of information.

you have earned my subscription with this one video. never heard this other side of the argument regarding resveratrol.

Thanks Brad for this good of a summary.

The power of the peer reviewed system is a beautiful thing.

Excellent review presenting all the relevant studies on resveratrol. Thank you 🙏. Certainly GLK wouldn’t have walked away from a billion dollar investment if they had hopes of it showing any positive effects on longevity. This video sure hasn’t helped your chances of getting Dr Sinclair on your show but your viewers appreciate your insights and integrity.

Thanks for your dedication Dr Brad. This is great information. Just, threw my resveratrol down the toilet.

I watch both your channels, you and Sinclair, I'm so glad we have another expert opinion on this! Thank you!!!

Sinclair says over and over that Riz Verital must be taken with fat and NMN should be taken with it. He quotes resveratrol is the pedal on the car, and nmn Is the gas could you please speak about that

Wow, you've made some very good observations. Just shows once again that you cant blindly trust no one.

Thank you for your diligent work and the significant fact you shared. Please keep working on these longevity endeavors.

EXCELLENT Report Dr. Brad............. excellent!

Really appreciate the painstaking and updated research you do and keep us informed…..it’s so important to understand the volatile nature of new researches .

So... where do I buy "Fluorescent Dye" pills?

Good overview, thx for spending time to create it 👍

Excellent service. Excellent information. Appreciate you acknowledged you also were taken for a loop with the information and faulty research. 👍😒

I understand Dr Brad Stanfield's genuine interest in having enough clarity on this Resveratrol issue, but in order to understand one set of data and be able to compare it to another set of data we need to make sure they are in the same context. I believe that the information presented is incomplete. It does not mention the context in which these tests were carried out and whether they are the same ones that Dr. David Sinclair mentions... that everything is due to scientific rigor.

Could it be that once you sold your “Resveratrol research” company for 720M, you may then be tempted to do anything possible to continue make it look efficient..

Stunning presentation! Excellent work!!!

You did a fabulous job on this video. I am grateful for your efforts at informing people like me.

Quite a thorough, amazing, and convincing video. I've been taking resveratrol for a while, and I've got a new bottle ready to go, but it's going in the trash. With supplements (or even with medicines for that matter) there isn't always research to show their effectiveness, or in cases like this one, researchers are motivated to show certain results, not to find some objective "truth." I'm especially curious to see if my cholesterol will improve after I quit, and if I will see more effects from exercise. If new research ever comes out that reverses the conclusions here, I would consider taking it again, but until that day, you've convinced me to ditch it. Thank you -- this was clearly a lot of work to put together.

Mind blowing! Worked in the supplement industry and wondered why the wonder nutrient virtually disappeared. Incredible story thanks

Excellent investigation. Thank you.

Thanks for this concise coverage. You rock!

Sinclair's calm delivery and elegant speech certainly won me over on resveratrol. Thank you for exposing the science that was already there to show the guy is no longer scientifically motivated.

Well my father has memory problems and we have given him resveratrol and it has made a great difference in his memory and ability to function. According to the research out of Australia resveratrol reverses brain aging by 10 years. Let's wait to hear David Sinclair's response lets not be too hasty.

Thank you Dr. Stanfield. Thank for your courage and integrity.

Excellent review and video.Highly relevant information these days. Thank you very much !!

This is sad especially for an ex-scientist such as myself. When I was in science I never tried to lie about my results. The results weren't there. I failed and left science for good. But that's life.

I looked into resveratrol studies and accepted that life extension and nootropic claims were unsubstantiated, but decided to take it because of a noted reduction of TMAO, but that's completely negated by raising cholesterol, and blunting the benefit of exercise is unacceptable. Buh bye resveratrol.

Thank you for cutting through the noise around this supplement.

Thank you for being thorough ❤

I love your channel and I really appreciate your manner and willingness to explain these things. You are saving lives. At the same time, I have a question that I really want your insight on. What I want to ask is important but it will take me a minute to unpack - please bear with me. I recall David Sinclair stating in an interview that studies involving resveratrol routinely store it at regular temperatures instead of keeping it refrigerated, and he said the researchers aren't respecting the molecule in the way they treat it - and he said resveratrol can actually be harmful if allowed to go bad (if I remember correctly). If he is right about that (for sake of argument) could it be possible that it makes a difference? I remember reading in a book about oils by Udo Erasmus that the story behind snake oil salesmen might be more complicated than people think. Because, it was derived from a chinese water snake that has higher levels of omega-3 than salmon - but omega-3 goes rancid if not stored properly and can actually be harmful if rancid. So, it's possible that fresh snake oil was actually relieving inflammation but when bottled and carried from town to town in the hot sun, it went rancid - losing its benefit. Interesting, huh? Then, as science progressed, but before the discovery of omega-3 having anti-inflammatory benefits, snake oil developed a reputation for being a con, as scientists said essentially that we were beyond these superstitious ideas and that oil is just oil, there's nothing special about it.

Would love to see you interview Sinclair for his response. He always says “I will always tell the truth.” I have trusted him unwaveringly. What is the truth???

Your work on this is excellent. You helped fill the gaps for me.

Very good review of the history of the product. I am sure you spent hundreds of hours to prepare us this summary.

After watching most of your videos the only thing that stands true for extending your life is eat in moderation, eat healthy, and exercise. I've dropped almost every supplement because of your videos. I appreciate your channel. Thanks so much.

I use Resverotrol and it has increased my exercise endurance ..when I don't take it I feel flat ...it must be taken with fat ..I take mine with yogurt. It definately works.

WOW what an eye opener! ..thank you Dr. Stanfield!

Thank you doctor Brad for bringing us the news. The good as well as the bad.

As someone who's made personal investments that didn't pan out, I know what the argument would be. As a consumer who would rather not buy expensive tablets that do worse than nothing, I say thanks and wish you continued success with your regular career!

It is sad that scientists and business people have to re-learn the same lessons they’ve learned before. For example, sunk costs should not, under almost any circumstance, influence future investments. Also, separate your personal identity from what you are studying or investing in. Its tale is as old as science itself and as old as business itself. Just the latest iteration.

Great update on Resveratrol thanks 🙏

Thank you so much for that! It is again an object lesson in how extremely difficult it is, being just a human being, to truly objectively select and look at data - wanting or not based on what we prefer as an outcome. I'm now glad that I took Resveratrol only for a short time and didn't waste more money on it. Two different serums with Resveratrol had irritated my skin and noone could tell me if taking it systemically would trigger inflammation inside as well, so I chose the safe way and stopped it. It was about the same time when you switched over to Pterostilbene anyway.

I never took it for extended life span once I found out that olive oil has an order of magnitude more of it. Something was very odd about that fact.

Ha- I am halfway through my first bottle of resveratrol, so this seems like a good time to stop, thanks so much! At my advanced age I assume any further level of replicative stress is something to do without. Looking up recipes for spinach Greek yogurt dip now.

Thank you for your service to the medical community and the public! This is what we need! Thank you for putting the truth out there.

This is important stuff. Thank you!

In David Sinclair podcast this week he was still talking about resveratrol as a proven anti ager

Great video. It conflicts with my initial belief and warrants change. It's nice when published data presented in a clear way can change your mind. Science is not perfect. It’s often misused; it’s only a tool, but it’s the best tool we have. Self-correcting, ever changing, applicable to everything: with this tool, we vanquish the impossible - Carl Sagan

Great video. The supporting documentation was great, I can tell it must have taken quite a while to put all this together. Would love to see deep dives like this on the NAD booster molecules. I feel foolish giving so much credence to the Harvard brand; it made me feel safe and I did not do enough due diligence of my own. Thank you.

Thank you Dr. Brad. Your search for truth is a light in the fog.

All of that and still the ITP didn't give it to the mice mixed into fat. Unbelievable!