thank you for not just waving your hand and saying the action potential "jumps" over the myelin sheaths

Its my first time that i understand saltatory conduction... Just by word BOOST 👏👏 THANK YOU 😄

This is the best explanation of sultatory conduction I've ever had. Thank you.

Dissipate Dissipate ... BOOST! Great explanation!

I've taken 3 different biology courses and struggled with all of them. This- this sir makes PERFECT sense. Thank you!

Finally, a video that uses logic that is simple to understand

Wow I loved this , never understood the concept of current jumping .

the best saltatory conduction explanation

Just one thing to correct in the video. The signal travels faster because the myelin sheets acts a s a capacitor. In other words, once an action potential is triggered at one node it provokes a rearrragment of the electric charges in the capacitor (myellin). The change in charge distribution is immediately transmitted to the other end as a change of voltage and triggers a new action potential at the downward node. View it as electrostatic charges on a plastic rod. If we change the charge at one end of the rod the charges readjust almost automatically at the other end without having any electrical current flowing through the rod. It is as if all charges are welded together. If the myelin sheet is destroyed, (like in multiple sclerosis) then the voltage spread electrotonically within the neuron and gradually decrease in amplitude over distance to a point where no action potentials can be triggered at the downward node. This later process is much slower.

OMG this was the best explanation. Thank you so much.

Thank you so much for this video. Clear and Easy explanation! THE BEST EVER!!!

Thank you so much!!!! I couldn’t picture all these in my head just by reading the book.

Thanks! This was a very helpful video. Props!

It's just funny how you posted this on New Year's Eve :) I call this "DETERMINATION" !!! Thanks for the explanation. It is awesome!

the most amazing and well explained neuron conduction video i've seen

you make things so easy and clear to understand. thank you so much!

Thank you so much for taking the time to do these videos! Happy new year! :)

his explanation is so much good

THANK YOU! I finally understood the concept. Well done Sir.

thank you! this video make my studying easier.

Man, this video is simply awesome ❤️❤️

Thank you so much!!!

Thank you brother , I got cleared my concept ,which was lagging from 2 years ,thanks,lol

It helped me a lot. thank u

thanks so much for explaning

No one else can explain in such a simpler language. Good job #KHANACADEMY

THANK GOD FOR KHAN ACADEMY

perfect 👌

Thank you great video and explanation

Thank you mate great work

Happy New Year

Thankyou sir

i can not thank you enough :)

Amaxing

Thanks!!!

Very helpful

thank you sir

Great

No proper explanation in high school nor during med school. The phenomenon was described, Not the mechanism. Thank you for lighting a bulb in my brain!

since weeks i search for a explanation of this...yours makes a lot of sense but what actually boosts the signal?

thank you! I am going to have my exam on 14/1 and this is very helpful!!!!!!

Well done. Many videos here on KZfaq claim ion movement causes the adjacent depolarization rather than electrotonic spread - which would preclude saltatory conduction altogether.

5:08-5:39 That doesnt seem right. The Velocity at which the current propagates doesnt have anything to do with the leekage of charge now does it. Its only the amount of charge Transporter that goes down right?

Sal the goat

thank you so much. Now I love this chapter!! :D

Man you're good

I might be wrong about this, but you seem to imply that the point in saltatory conduction is simply the boosting of the action potential *within the axon*. From what I've understood, saltatory conduction happens when the opening of a sodium gate at the axon hillock/node of Ranvier (point A) causes a change in voltage polarity at the next node of Ranvier (point B) due to an inrush of sodium ions from outside the myelin sheath at point A. This leads to a lower ionic density at point B (the sodium is "sucked in" at point A), which in turn opens the sodium gates at point B etc, where the same thing happens all over again from B to C, C to D etc. This signal propagates down all the way to the end of the myelin sheath to the axon terminal. In other words, saltatory conduction happens *outside* the myelinated axon. You give the example of a signal booster to explain it and granted, there is an element of that. However, as I understand it, a more accurate metaphor would be following: Imagine a department store on Black Friday, which is situated in a long building that has hundreds of front doors. The store is so popular that it is besieged by its customers, who want to get in and who are waiting at every front door. The employees are freaked out and want to go home, but the crowd outside will rush in if they open any of the doors. One of the employees decides to risk it and opens door 1, which results in the crowd barging in. However, the crowd at door 2 thins out because everybody's trying to get in through door 1, so the employee at door 2 opens his door and tries to escape. The crowd notices him and rushes through door 2 as well. The employee at door 3 notices the crowd thinning in front of his door and does the same thing, etc. etc. So, saltatory conduction in this metaphor would be the employees noticing the crowd thinning in front of their door and opening it. To continue with the metaphor, the crowds rushing in does result in more people in the building (i.e. boosting the signal), but the actual saltatory element happens _outside_ the building, as crowds rush from one open door to the next. To summarize, the actual definition of saltatory conduction is the sequential opening of voltage-gated sodium and potassium channels due to changes in ionic density outside the myelinated axon. This does result in the action potential being boosted within the axon, but that's a _result_ of saltatory conduction, not saltatory conduction in itself.

I've really appreciated this video, thank you. Just a question: when the electrotonic current generates, shouldn't it go in both directions (forward and backward)? I mean, as said in the previous lecture, electrotonic signal generates when sodium - during action potential - goes inside the cell, repelling other positive charges. But what inibits the charges to go in both directions, "left and right", and so creating a sequence of action potential in both directions?

Thumbs up

Wow

Than you, made it easy.

I found this thing very similar to linear particle accelerator. Anyone out there who feels the same way?

Which pen tab he used for writing??

How long does it take the nervous impulse to travel from one node of Ranvier to the next? I need answer to this Q please😭🥺

The comparison with the insulated copper wire isn't correct.

Who else is watching this today?its super easy ..20th may 2022

🙏🏻

Good explanation but really having trouble getting past the constant stuttering and repeating every 3 or 4 words three or four times before moving on to the next half dozen words and repeating them a couple times before moving on and so on... by the time a sentence is finished I can't remember what was being explained... maybe if there was a prewritten script or something...

John Mayer is that you?

I literally thought the ions were physically jumping thats how its explained in the book 🤣

who is this guy b ro i should know more about him about now khan academy this khan academy my butt

SALtatory KHANduction

Yep, all of this happened by pure chance. 😜

Can you replace my teacher? hahah