Kyle Gillette is an absolute boss and such a valuable wealth of knowledge who shares information in way that is easy to digest and understand and peaks fascination. Thank you for hosting Dr. Gillette, and thank you Dr. Gillette for sharing so much science with us! Keep it up guys.

Looks to me like the safety profile of semaglutide is better than the safety profile of obesity.

I had a gastric sleeve in 2016 and was very successful. I had a lower bmi so I went to Mexico for the surgery. So glad I did the service was incredible. Fast forward to 2020. I actually did not regain in 2020. It happened towards the end of 2021 and slowly kept up. I just turned 50 so lots of that was menopause related. I was having serious hot flashes unless I was fasting. The hot flashes vanished with fasting. During this period of time it became incredibly difficult to take the weight off even with whole foods. I've been a Thomas folkower for the past 7 years so I had nailed my diet and knew what worked. I started a semaglutide compound as a self pay August 10th, 2022 and it was miraculous. I am planning to take this forever at a maintenance dose. It also has increased my memory ten fold. I feel unstoppable. My body composition also changed for the better in a way weight-loss and exercise did not give me in the past. My doctor said he only has success stories.

Thank you thank you ! So relieved that you are open to talking with someone like thjs Dr about this big subject. So many questions answered today. I fight uphill with my weight and believe this is just one tool that can help so many people. Love your channel

Good info. I have an incredible amount of info on this. Real quick summary. Retired bodybuilder at the pro level that still trains. Developed Type 2 from multiple reasons. Brutal getting my A1C down. Couldn’t get past 9 with insulin and a solid diet. Started trulicity and it got it down into the 5s. Doc was in shock. My resting pulse started to be higher, so we switched after a year to Rybelsus. My A1C is floating in the low 6s now. Trulicity definitely worked for A1C. Body fat is probably around 12 percent. I eat a bit more don’t like getting too lean for my training. Joints hurt at my age from the weights if too lean. 2 years on this now. Hope this helps some people.

I’ve been on Mounjaro for about 4 months now…I’ve lost 26 lbs. up to that I had tried it all. Keto even stopped working for weight loss for me. It’s strange because I stalled on MJ, but stopped working out and started loosing again. It’s just not black and white for everyone. This med has taken away entirely my sweet tooth. I don’t want wine anymore, and it has stopped the food noise in my head. I literally don’t think about food anymore. I’m thankful for this medication.

I have been waiting on you to produce this video on Semaglutide!! 🙌

Great interview/video Thomas and Dr. Gillette very interesting I enjoyed learning more 👍

Dang your video quality is super sharp & clear

I started Ozempic over a year ago to bring down my blood sugar. My A1C came down (from 11 to 7) but I didn’t lose any weight. Once they bumped me up to 1mg injection, I started losing a modest amount of weight but what DID happen was I lost so much muscle mass, I was basically a limp noodle and had to go through physical therapy to get some muscle back. No one told me I had to eat more protein. Or Ihad to work out more. Walking isn’t cutting it.

I love this man. So good at explaining mechanisms and facts.

Great video. Very helpful. Thank you!

I love my doctor for working to get me on this. She knows how much I I've been trying. Pre 2021 I did excellent and keto was my answer!!! But I've been slacking my keto since being hospitalized. Covid. They didn't exactly support ketogenic diet during my stay so I was without a single healthy fat to eat.

Very interesting Thomas, you should do more of these with the Doc.

Super informative! Thank you so much!

I’ve been on semiglutide for 12 weeks. I’ve lost 30lbs and it’s come off pretty slow and steady. I loved wine, drank it all the time at least one glass a night. Once I started taking semiglutide I couldn’t even sip on it anymore. It helped me to be sober for 10 weeks. That was the best part of taking this. I’m going to stop for a while, I’ll see what happens. I’m hoping all the good habits I pick up help me to continue.

Great discussion.

EXCELLENT video!! Thank you

Today I really gained some good knowledge my doctor prescribed Ozempic and I was afraid to use it be since you explained everything you made it easy to get started thank you Dr. Kyle Gillette and Thomas DeLauer.

This is so helpful...thanks!

As usual... GREAT and CURRENT content Thomas!... Well done. Data driven and not theatrical like all the other Sema You Tube videos. 👍 ... Also a Data Proven Benefit that you did not discuss is the positive impact on those patients using a Sema that are addicted to numerous mental addictions... Alcohol, and Opioids most common... but also other. VERY Smart discussion. Thanks

I’ve been on Mounjaro three months and lost 23 lbs. My blood sugar is much better. During this third month I’ve noticed I’ve lost cravings for foods even that I used to love. I feel full a long time after I eat. The draw back is that while I’ve always been very regular with bowl movements I sometimes go several days before having one which can make you feel bloated, etc. I take a scoop of fiber every morning and I’ve included a tbsp of Miralax, plus increasing my water which seems to be helping with regularity. I work out lifting weights with a little cardio five days a week now as well. I’m really excited about getting healthy and this medication has really helped.

Thank you for covering this, My Dr just started me on wegovy because im 325 and i really want to get to 200 but the weight loss is really kicking my butt.

Apple cider vinegar mandatory for stomach issues 2 or 3 x a day, completely zero SWEET tooth , down 26 lbs- I’ve never had satiety in my life until my first shot.

I've been on mounjaro since January 17th, at the 7.5 mg level right now. Im doing intermittent fasting eating window 11-3. I eat mostly fiber plant based foods with low sodium. The mounjaro is fantastic at taking the food chatter out of my head. Down 30 pounds. I think it's a fantastic drug for people who have struggled trying everything else. The word "game changer" is a perfect word..

Thomas DeLauer has been one of those individuals that I have come to trust when it comes to nutrition and wellness. I am interested on getting started on Tirzepatide and have been watching a lot of other videos and none of them are as complete as this one is. This information is priceless. Dr. Gillette provides in this 26 minutes video more information than I have been able to obtain in hours of watching other professionals and aficionados on this matter. Way to go @ThomasDeLauer! Please continue to bring this type of information to us, I bet that I am not the only one who sees you as the BOMB DIGGITY GURU of wellness! Thank you, Thank you, Thank you!

I'm on Semaglutidefor about a month now and am just on the .25 dose. 15 pounds down. I had a few days of nausea from the first two injections but none since. I'm going up to .5 next week. I've made my schedule for the gym, incorporating new diet strategies as well even though I wasn't bad in the first place, but I find that things that I did enjoy, I can't go near now. If I can hit my goal I plan on staying on it for a year to two to really make some lifestyle changes stick, then ease off and see what happens. I also have lipedema, and to my once very athletic and active self, it's an insult. I'm finding that very few people know or understand the condition or give more than a nod to it unless they actually struggle with it themselves.

Thanks for this video. My doctor just prescribed this medication to help me with these last 50lbs that just will not go anywhere despite exercise, diet etc.

Loved last question. Borderline prediabetic. On two meds that cause high blood sugar and diabetes. But no negotiable. CGM and glucometer. Underweight by dexa. But docs suggest semaglutide for stabilization of arterial plaque. Weighing risks and benefits.

Thank you. ❤

Thank you Thomas! I was just put on Ozempic and was wondering exactly what you said, will this be forever? Great info.

I’ve been on it for a month, and it’s doing exactly what I need. IMO it should be used as a tool towards lifestyle changes. I had no idea how bad my cravings(food noise) was until it was gone. Now I feel like I can focus on getting healthy vs combating myself

i like to increase GLP-1 long term with the right fiber. a cabbage soup with added ground meet works best for me so far. an oatmeal also works but comes with a lot of carbs too. i stumbled upon a broccoli soup recipe that contains wheat bran too which has an insane amount of fiber. i have to try that as well. but regarding the cabbage soup i also like the effect on PYY additionally to GLP-1 which lowers hunger a lot

I was prescribed Ozempic when I was diagnosed as type 2 diabetic. It made me sick with nausea and stomach pain. I quit after 2 injections of the lowest dose and did not lose bodyfat. I went lo carb, lost 57 lbs, normalized my blood sugar from a1c 11.8 to 5.3, lowered triglycerides, normalized fatty liver, reversed kidney failure.

I take it for weight loss. Most people I know take it for weightloss only. It’s been fabulous. No nausea. I do get fatigue. My doses were increased slowly and I don’t plan on getting off it as i see obesity as a chronic illness that requires long term treatment.

I’ve been on semaglutide for 3 weeks now and love it! I’ve gone from 186 lbs to 178 lbs.

Thank you Thomas for this information

I had a partial hysterectomy i was keto for a long time even went Alittle higher on my carbs but still lower carb. And I was so stuck for a long time Ozempic here and down another 42lbs im thankful for it. I was truly stuck even eating healthy. I haven't changed anything and losing again. Other then smaller portions

Great talk! I had VSG in 2015. Gained all weight plus more back. Hit near 400 pounds. Started using Compound Tirzepatide 7/1. I am down 70 pounds and finally starting to feel better. This medication is saving my life. The food noise is just about gone. It's still there but is able to handled. I do high protein, pretty low carb. Stay away from bread and sugar, sodas, etc. It's all working. I also gave quite a cardiac problems and I've had no problem. There are great studies on the benefits of glp1's and cardiac health protection. Also liver health. I wish the drs would also promote compound pharmacies. Some of us have insurance that will not cover name brand so we have to go the route of tele health and compounding pharmacies. Just get with a good company.

Hey, Thomas, thanks for the great video and info! I do have a question though about using semiglutide while on keto - so I recently got my lab results back and they show I have insulin resistance, I am yet to discuss those with my endocrinologist, but I believe they are keen to prescribe semiglutide drugs to help stimulate insulin production. I am on a keto + intermittent fasting regime for 3 weeks now (starting weight was 264 lbs, down to 249 lbs now) and I do wish to use GLP1 as a kickstart and lose 40-50 lbs before devoting entirely to keto/healthy style of eating and exercise. Do you think a moderate keto is suitable while on semaglutide? I couldn't quite understand what Dr. Gillet's opinion was on that. Thanks in advance! ❤ PS - I was on keto back in 2018 and was able to lose 80 lbs in 4 months and I sustained 180 lbs for a year, but then i had to deal with depression, covid19, broken leg, pneumonia, etc, and I regained my weight again 😢 I gave birth for the second time in November last year and I was at my heaviest after breastfeeding my son for 5 months, so it's high time I get a grip and take care of myself. Gosh, it's extremely hard to admit that. Anyway, sorry for the long comment. Expecting your advice! 😊

Would glp-1 agonist be helpful to those with Non Alcoholic Fatty Liver NAFLD? Are there protective or negative effects on the liver when using these types of medications? What mechanisms are involved when insulin resistant or diabetics with NAFLD use glp-1 antagonists?

My doctor told me that I should start to consider surgery. My blood pressure was high and normally between 138 and 148 regularly. I have heard a lot of people would rebound after the surgeries so I wanted to fix my mentality before even thinking about surgery. I signed up for noom and it was not doing it for me but it gave me a lot of info about low calorie and high volume eating. I kept that in mind when I made the decision to start on Mounjaro. In January I started at 498lbs, I was not taking it seriously at first eating whatever I wanted. After a month and 10lbs lost I saw a glimmer of hope. I thought if I lost so much just eating what I wanted, what would happen if I took it seriously. I watched a lot of Huberman lab and it inspired me to change my life style, I took his advice on a lot of things and started doing intermittent fasting. After 30lbs on fasting I was hooked. In the past month I have been doing a lot of research on keto and although I still eat carbs I keep it low carb and high volume and if its keto friendly food or meal I just go with that. Once my hunger started going away I was able to move my fasting from 12 hours a day to 14 and right now between 16 and 18 hours. I started exercising 3 to 4 times a week and upped my protein but I was staying around the same weight for a month. I finally broke that wall after I reduced my protein. I keep my calorie intake below 1600 calories. I am currently at 430LBS and honestly I cannot be thankful enough for Mounjaro. I am also thankful for the information I have learned from Thomas DeLauer and Andrew Huberman.

I've been on Monjarou for the last 9 months and am down 101 lbs so far. A lot of the weight loss was fat but I also lost a significant amount of lean mass. When I went off of Monjarou for 3 months (due to a shortage - unavailable at every local pharmacy) I regained about 16 lbs over a 3 month period. The weight loss resumed the moment I went back on the drug. I dont know if this helps anyone else but I did Carnivore / Keto for the first 60 lbs, and 1300 calories a day for the second 40.

I took ozempic samples that my Dr. gave me for one month (and it was even low dose .5) I’ve been 6’ 310 borderline type 2 my entire life. I’ve always worked out an hour five days a week. I’m a home builder so I do heavy physical labor all day. I’ve had high blood pressure for 10 years. After 1 month I lost 28 pounds, nearly quit drinking alcohol (no desire), had no desire to eat junk food or snack at convenience stores, portion control came naturally, my cardio workout ease and intensity improved over 25%, my blood pressure dropped from 170/95 to 119/76, and I felt better than I ever have in my entire life. My Dr. Was thrilled and gave me an ozempic prescription and said we will now try quitting the blood pressure meds and keep working out. Then my insurance company (Avera Health…. Also the medical provider) said I cannot have any Ozempic. 🤬🤬🤬😡. I guess since the insurance company is also the medical provider they know they need fat unhealthy people with heart problems to make a profit. So I guess I’m not one of the chosen who gets the privilege of health treatment.

Been doing Semiglutide for 2 months. H1 has come down .1 a week. 10 pounds down. It works for me. But, I'm also doing IF for 20 hours a day, also.

Can GLP 1A or tirzepatide be used as a first line of treatment for T2D? Can one of these be used instead of metformin?

Clarity please Thomas DeLauer : I am taking Viktosa injection for weight loss. Week 1 I was taking (1st recommended) 0.6 dose : I lost 2.7 kgs Amazing. Week 2 - I am taking 1.2 dose as recommended but have not lost weight. I eat low carb (last 10 years) , healthy eating (LC veges protein), I am not hungry, I feel light headed taking injections, (my blood pressure is fine, no meds). I am in calorie deficit, gym 3 times a week, 67. 5’3”. 75 kgs ideal 60 kgs. I track my ketones with Acetrack monitor and am in light ketosis most of the time (I believe I am fat adapted), I get higher readings when I work out hard. Question: should I go back to original dose? Or continue increasing next week to 1.8 (as prescribed?)

This was a very good video so far. Im looking at the semaglutide peptide. I was morbidly obese but with keto, intermittent fasting, and creatine monohydrate +HMB and weight training, im down to 182 pounds from 260 in 6 months. But I am knocking on a 6 packs abs front door right now and I'm wondering if a month of ozempic is the key to the city and final boss for me while pushing 110% at the gym. 😅

I am at the 4th month mark of Semiglutide (the generic made in a compound pharmacy and nit takrn from the Ozempic inventory). I lost 19 pounds from 232 to 211 so far. I am 5 8 so another 50 pounds to go. I am doing this through my functioal medicine doctor ( Forum Health clinics). Paid a bit more at my first visit and after that 400 dollars for each vile (lasts for 2 to 3 months)./i have health coaches visit that suports with food choises and also with thendisage going slowly up.

Lol Dr. Kyle Gillett is the one that prescribed me semaglutide over a year ago and it was already expensive back then. Now that it’s hitting mainstream media, I can’t even imagine how much it’ll cost now. Good thing I got it early.

Super important question by Thomas 12:10👏👏

Are there natural glp1s? It may not be same dosage but anything that helps give a bit of a edge if you are tracking calories and exercising regularly to stay/lean out ‘a little’

This guy is very smart and knowledgeable.

Would this help if you have had your Gallbladder removed ? I find it so hard keep my weight down now. Keto has been the best but it hard do on a physical job that I have.

At 50, I found myself being 30-40 lbs overweight. I have been thin my entire life and couldn’t stand the extra weight. I eat super healthy. Don’t even go out to restaurants because of the bad oils they use. I was so depressed and frustrated. I lost 5 lbs with the first shot of generic semaglutide. 3lbs the 2nd week. It has helped me with cravings. I am feeling hopeful now. I have insulin resistance and nothing helped me lose weight. This is a miracle. I am eating more protein every 2-4 hours, VERY Small portions,like two egg whites, or 3 slices of turkey and ipI feel full. Also, I increased my water intake to half of my body weight.

This guy was my doc at Marek Health. He was awesome. Sad that he left.

Took it for three weeks. Migraine every week, and constipation to the point I was in pain. But my wife does amazing on her.

Love this what about the person who does everything Right and nothing works . Menopause is a big deal is this good To Do ?

Just started.. life battle..so hopeful

What if someone has Lymphoma, no gall bladder, NAFLD, Insulin Resistance, and Type 2 Diabetes? Would that person be a good candidate? (BMI 30)

My mother just had to get her gallbladder taken out and has been very sick with constant vomiting. She's been taking Ozempic strictly for weight loss as she's not a diabetic. I was suspicious the semaglutide might be responsible for her cholecystitis and after watching this video I'm definitely leaning towards that.

I accidentally agreed to take this. After 2 successful months on Carnivore diet, I was doing very well. Now my success is attributed to Semaglutide, but not my effort. When I have used it up, have I learned the skill sets to control my weight? It is expensive, so I guess I'll use it up and hope that my eating and exercise habits are favorable to maintaining the weight loss.

What is this appetite suppressant raulseed? I can’t find any information on it anywhere?

I think there is a very strong case for semaglutide for bulimics/binge eaters. I have been bulimic for 10 years and the smallest dose of semaglutide really heped free me from my cravings. Shame I have had to get it "off label" since I am not overweight.

So if a Dr is suggesting to take a GLP1 and you have IBS-D, does that mean you shouldn't take it due to the IBS-D?

Buddy knows his stuff and was great. Did you give him a coffee? Seems like he had a long day to get there.

Can you have autophagy while on a GLP-1?

What about bioavailability of say Ozempic vs Rybelsus?

Starting to think my arms are too small

Can you take semaglutide with injectible fast and long acting insulin? Semaglutide is giving me constipation.

I have Diabetes 2 as well and was prescribed Trulicity two weeks ago-- the lowest dose for six weeks and then my doctor and I will review and increase the dose if needed. I believe in being your own advocate in medical care, and my doctor agrees and welcomes it. He also teaches other doctors at the University of North Carolina - Chapel Hill. While I usually monitor my diabetes by diet, diet slone has not been enough the past year or so. It's been going up. My A1C hit 7.1 (plus the fact that I recently hit 300lbs) and my doctor thought this might be a good solution-- two birds, one stone. Two weeks in, I'm feeling better; have lost 10 lbs; removed certain carbohydrates, added sugars, and processed foods from my diet; started walking more (I'm nearly 51 with arthritis in my knees and back, so... baby steps are STILL progress; I hope/plan to work up to 10k steps a day), and am starting Variable Resistance Training (X3 Bar) this week. Plus, I'm watching Thomas' and a few others (Will Tennyson, Stan Browney, Sean Nalewanyj, Doctor Mike, Dr. Boz) for fitness and nutritional information to make better food choices, aim for better overall health. Would I call my diet Keto-esque? I dunno. I'm focusing more on protein, good fats, and less carbs... natural, not overly-processed foods. I don't know how to go full Keto yet; still learning. Being disabled, limited income, I can't toss out / donate everything in my pantry and fridge. I have to be able to eat and replenish my pantries with better food choices. But being on Trulicity and feeling better.... I'm hopeful. I was starting to forget what that felt like.

so what are better appetite suppressers for people with “normal” body fat%?

In 3 weeks I have lost 10 pounds. Very happy with the results. Don't eat after 5PM. And I'm not hungry during the evening.

14:23- what is the supplement mentioned called something like “Raolsy”? Does anyone know?

How do you see bimagrumab being of benefit with Semaglutide?.

Been taking ozempic for years T2 diabetes works great Past 2 years added keto works well with it Much better results blood sugar control I was never overweight Run about 115 lbs to 120 But a1c has come down to 5.1 5.4

I need a transcript of your discussion. I have Long Covid with extreme inflammation. I gained 50 plus pounds after 3 bouts with covid and have not been able to lose 1 pound.

I just started taking Wegovy for weight loss because I gained 25 pounds over 9 months as a side effect of another medication I am taking. Despite all my efforts with exercise and diet the weight just keeps rising. I’m wondering if there are other people on semiglutides out there who are battling weight loss caused by another med. I’d love to hear your experience.

I was just diagnosed with Type 2. This is NASTY stuff -- I had to quit after 6 weeks on the lowest dose. It made me simultaneously weak, nauseous, dizzy, and constipated! I am currently bedridden waiting for this med to wear off.

This might also work for alcohol cravings/binge drinking? Sugar…

I've been taking Trulicity for my type 2 diabetes and I went on a 3-day fast so I can reset my body but at the same time I stopped taking trulicity and jardiance that was prescribed by my endocrinologist. I'm on my fourth week of not taking Trulicity and the constipation and diarrhea is worse now than it was when I was on it. I'm wanting to know how long does this go for with the GI issues? My goal is to get off these medications by changing my diet. All these medications are just bad because they always have some other side effect

What was the supplements he said to shut down thr appetite with? He says it at 14:18, I can’t quite understand the name.

I had try everything in the book I exercise 6 days a week eat a clean diet I'm 5'1 173 pounds I been stuck on the same weight for months I started semaglutide with b12 and finally I started loosing weight again my first week 2 pounds I don't have much to go 28 pounds also I'm 56 years old so it makes it harder hopefully ill reach my goal weight by my 57 birthday April 22

I'm on Wegovy. I'm on the 1.0 dose. My only side effect has been some acid reflux. I've lost around 20 pounds. Was 380, now 359. I feel a lot better already. I feel very full the first two days after a dose and then my appetite comes back slowly till my next dose. It feels like a miracle drug.

What Appetit suppressed was Dr Gillett referring to?

Type two is super easy to reverse with diet and correct protocols, so why would we use Semaglutide for Type 2 diabetes with all the risks?

Informative video. Thanks. But how is this different from just normal caloric restricting diet ? If all this does is suppressing appetite

I really needed this info - thank you!!! 🫛😃

Low glucose causes hepatic lipolysis and also an ~increase~ in SHBG as opposed to what you are saying here regarding insulin. Of course high glucose increases insulin. The low carb diet will be the former though.

Intermittent Fasting seeks to lower insulin levels to stop the body from storing fat. But GLP1s stimulate the pancreas to increase insulin 2 or 3 times. How can both work for weight loss of they do the opposite?

What was the name of the appetite suppressant that he mentioned? I heard Rousin but nothing with that name came up.

Dr mentioned a natural appetite suppressant but I don’t know how to spell it & the transcription stops prior. Sounds like Realci?

Diabetic Type2 65yrs old Did loose weight on it ladt year I'm in Australia When it wasn't available last yr Due to over demand All tht horrible fluid loss of sleep Loss of energy I'm back on it & find it easier to control my eating Intermittent fasting coming of carbhydrates suger for long long periods Of time🦄🦋🦄

“We ga veey “ 😂 that’s when I shut it off

Hey man, question. Massive weight loss via diet restriction has been shown to create havoc on the body's hormones - drop in insulin, cortisol spikes, spikes in SHGB, decreased sex hormones, etc...all of which can affect skin health, hair loss etc. Lots of negative short term affects of severe diets. My question is: has semaglutide bypassed these negative hormone affects? If so, this might be a huge benefit instead of severe dieting.

I take issue, at least for myself; I’m taking Mounjaro specifically to treat my type 2 diabetes, which I’ve had for 30 years. I’d been struggling more than ever before trying to keep my BG levels down, and my hbA1c levels were at the highest they’d ever been. So, my Dr. informed me about Mounjaro & prescribed it for me. The $$ has been extremely high as my insurance has not covered anything toward this prescription, so it’s been strictly out-of-pocket cost for me. Also, the people taking these types of medication off label for weight loss have also caused shortages and I’ve had difficulty filling the prescriptions because of this. There is currently a shortage of the 7.5 strength, and this is not expected to be alleviated by the manufacturer, Eli Lily, for several month out. This is really frustrating and aggravating to me!! So, please acknowledge that this is a valid medication for use with Type 2 diabetics. I’m on my 4th month now, and my labs have already improved greatly. I’ll find out my most recent A1C tomorrow!

I love macadamia and pecan mix, it's helped me to lost another 20lbs in 30 days, and I eat them raw, thank you. #ThomasDelauer you rock Sir!

Can I take this semaglutide with my TRT ?

So what is the bottom line answer to the question of how I can insure I do not gain the weight back. I got totally lost in all the science talk. Sounds like he was saying we will still need a drug for appetite control. I have been on keto for 3 years and stuck because I was eating too much dirty keto. Switched to carnivore 1 month before getting on semiglutide. Now loosing at a faster rate but really concerned that I am spending all this money and will just gain the weight back even on carnivore I have been tired more than usual and struggle to get in my 2 miles a day slow walk in I am 70 years old and despise exercise and especially hate loud gyms so revving up exercise is not an option

Good info, Dr.Kyle seems super tired 🥱