The Bioluminescent Gaming PC
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By genetically modifying some E. Coli we make a PC glow. Really.
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MUSIC CREDIT
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Intro: Laszlo - Supernova
Video Link: • [Electro] - Laszlo - S...
iTunes Download Link: itunes.apple.com/us/album/sup...
Artist Link: / laszlomusic
Outro: Approaching Nirvana - Sugar High
Video Link: • Sugar High - Approachi...
Listen on Spotify: spoti.fi/UxWkUw
Artist Link: / approachingnirvana
Intro animation by MBarek Abdelwassaa / mbarek_abdel
Monitor And Keyboard by vadimmihalkevich / CC BY 4.0 geni.us/PgGWp
Mechanical RGB Keyboard by BigBrotherECE / CC BY 4.0 geni.us/mj6pHk4
Mouse Gamer free Model By Oscar Creativo / CC BY 4.0 geni.us/Ps3XfE
CHAPTERS
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0:00 - Say hello to the Angler Fish
0:37 - War Thunder
0:50 - LTT Intro
0:58 - What is Bioluminescence
2:04 - Intro to Genetic Engineering
3:15 - Biotechnology, cooking show style
4:51 - Linus playing with E. Coli
5:44 - Test tube glowing
7:15 - Purification feat. His-Tag
8:30 - Glow #2
10:56 - Filling the loop
13:42 - The Bioluminescent Gaming PC
14:23 - What this is actually used for
16:22 - War Thunder again!
17:06 - Outro
@AYgameZ 2 жыл бұрын
Fireflies: *look what he has to do to mimic a fraction of our power*
@kyzinga266 2 жыл бұрын
I grant u my chuckle
@Nxrreshh_ 2 жыл бұрын
😂😂😂
@Nxrreshh_ 2 жыл бұрын
@@kyzinga266 🤣
@kingchauvinthehate7030 2 жыл бұрын
look what they need*
@jon4715 2 жыл бұрын
Great comment, and true. I've read this before, where?
@stephenjeremy5985 2 жыл бұрын
Ive never thought that the day would come where Linus explains DNA translation and PCR to us
@filleswe91 2 жыл бұрын
Yeah, usually it's been all about PCMR and RDNA talk instead.
@EhmJB 2 жыл бұрын
Just wait until the "Installing the Intel Cognicyte i59 BioCPU" video he releases in 2063. It's gene splicing all the way down.
@georgejosifidis 2 жыл бұрын
He just relayed the information like a parrot making noises
@maciejjabonski833 2 жыл бұрын
Technically, he explained TRANSCRIPTION, not translation (geneticist here). Transcription - DNA -> RNA Translation RNA -> Protein
@TheIceThorn 2 жыл бұрын
@@maciejjabonski833 it's a quesiton that bohers me since very long... but since dna "evolved" from RNA, now it came to be? An error of transcription? Ther might be some sort of bacteria that has reverse rhybosomes which reverses the reaction and forms new DNA instead of RNA? yeah, i've already tried to find th e answer by myself or I wouldn't be asking, i swear.
@ajmatt 2 жыл бұрын
As a molecular biologist I can die peacefully now listening to Linus's voice explaining cloning and bacterial transformation.
@TheBatracho 2 жыл бұрын
Dude, same here, molecular biologist here and PC fan who never expected hearing Linus talk about His tags lol
@farhannajme7542 2 жыл бұрын
Samee as a marine microbiologist Linus gave a pretty good lecture there.
@showjjumper 2 жыл бұрын
But cut the part where he drops the eppendorf pipette 😭😭😭
@johnkaba2593 2 жыл бұрын
@@showjjumper This is where I died inside
@Winter_huntsman 2 жыл бұрын
About to graduate with a microbiology degree in a few weeks and completely agree. It’s so neat hearing him talk about lab techniques that I learned in classes and performed in labs so much.
@mumble3535 2 жыл бұрын
"Yeah, I have this massive algae bloom in my tank at the moment" "Damn dude, are the fish okay?" "What? Nah dude, my rgb algae has really come into its own and its looking sick" I support this kind of bio engineering
@spamreciever4208 Жыл бұрын
I wanna live in the CyberPunk future where I can have a bloom of pet bio-engineered bioluminescent bacteria in my computer full time.
@TheHookUp 2 жыл бұрын
I taught AP Biology for 15 years it's sad how much better your animations are than anything teachers get access to with a textbook. This is totally not a dig because I loved the video, but If I was still in the classroom I'd 100% use this video with my students to be able to go over the hand wavy parts and have them find the couple of inaccurate/incomplete sections of the process. Science Linus gets at least a B+.
@volklii 2 жыл бұрын
kzfaq.info/get/bejne/pcujlqVhs9_Jmn0.html
@StripesOO7 2 жыл бұрын
Exakly my thoughts with a bachelor in Biology (bachelor-thesis in genetic) . Beautiful animations that are 100x better than every old textbook but some parts are either missing or slightly wrong. But nevertheless accurate enough to be understandable and having an educational effekt on the „average“ viewer. 👍
@majsstenen 2 жыл бұрын
Just make sure to correct it first, that DNA repair animation ain't right :3 // Biotech engineer
@reyanak9818 2 жыл бұрын
@@StripesOO7 You need a bachelors degree in spelling
@Kitulous 2 жыл бұрын
@@reyanak9818 don't need to be a douche in the comments. Maybe they're German, that's how they spell "effect" and the languages are pretty similar enough to mix up the words.
@Julian-og3ps 2 жыл бұрын
That moment where he turned on the pump was legitimetely the coolest thing I've seen in years. Made me feel like a kid going to one of these places that let you do supervised science experiments again.
@shadowpenguin3482 2 жыл бұрын
12:45 for anyone who wants to rewatch it
@fantasticparrot602 2 жыл бұрын
@@shadowpenguin3482 a bit later actually for the when he turns on the pump 13:51
@markj9860 2 жыл бұрын
I much preferred the part where he started pouring the bacteria into the spherical reservoir, that slow blue spill down the sphere is just gorgeous. But yes, this few minute segment is one of the greatest things I've seen in this channel.
@solarbirdyz 2 жыл бұрын
@@markj9860 YES YES YES that was AMAZING. It literally looked like an SFX shot but was real.
@FlyingPenguino 2 жыл бұрын
"Oh god" - Alex
@pedroguincho6580 2 жыл бұрын
Easiest like of my whole life, It’s amazing seeing Linus combining my two most loved subjects, biochemistry professionally and Tech as an hobby. What impressed me the most was how clear Linus’s explanation was of such a complex topic. Well done guys, you really outdone yourselves with this one!
@MoChuang343 2 жыл бұрын
What kind of biochemistry do you do?
@filleswe91 2 жыл бұрын
More scientifically broken down videos like this please! I didn't feel like an idiot and I enjoyed the science lesson. Not just because it was Linus. Fun project, LMG!
@filleswe91 2 жыл бұрын
@Phoenix Trinity what?
@crumpybird4281 2 жыл бұрын
@@filleswe91 what?
@pranaygohel4630 2 жыл бұрын
"Tech Tip: Don't get E. Coli" Yeah, that would be a good idea.
@BrianTeague00 2 жыл бұрын
Bioengineer here: The strain used in the lab is quite different from the one that makes you sick! You could drink a culture of it, and it might give you a belly-ache, but not much else.
@furkell 2 жыл бұрын
Not exactly tech, but a good tip nonetheless
@rwhite9994 2 жыл бұрын
E. Coli is natural in nature and most all of us have it somewhere at any given time. The kind that makes us sick, or takes over is different. That e coli is as safe.
@Giangero21 2 жыл бұрын
what the ..... i don't think this is a coincidence
@emilie6466 2 жыл бұрын
@@DemeDemetreEscherichia Coli
@PetePeteRepeat 2 жыл бұрын
Linus, get your team to do some research and create an LTT Lab Coat, with elastic sleeve cuffs, and quick-release snap buttons... as a Chemist, I would 100% buy one
@hellowill 2 жыл бұрын
Reminds me of his older videos, around 2013, when he would wear a lab coat for PC builds
@Aviyara 2 жыл бұрын
Quick-release snap buttons, three pockets (with the pen subdivision on the chest pocket) and in-garment "cable management" loops for threading wired earphones. Forget buy them, I'd preorder them and pay up front.
@volklii 2 жыл бұрын
kzfaq.info/get/bejne/pcujlqVhs9_Jmn0.html
@Jeffmylife 2 жыл бұрын
As not a chemist, I also would 100 percent buy one
@ron200088 2 жыл бұрын
Now that they have the technology, they could also create their own brand of bioluminescent "RGB" coolant. ;)
@sullychow4123 2 жыл бұрын
Never expected LTT to go all Thought Emporium but love it. More of this whenever you guys can please.
@Cobyc5150 2 жыл бұрын
I want more science lectures from linus, he's surprisingly really good at explaining everything. He uses some very easy to understand examples.
@bigboij3027 2 жыл бұрын
The magic of writers
@damustermann 2 жыл бұрын
Linus DNA tips - really cool that you guys go into a lot of detail about the background of this.
@_yuri 2 жыл бұрын
amd RDNA
@MrSerella 2 жыл бұрын
@@_yuri RDNAvidia
@jonathanmoelester448 2 жыл бұрын
@@MrSerella GeForce RX 3090 XT
@ln1721 2 жыл бұрын
this is just upgraded RGB and i love it
@gliderman9302 2 жыл бұрын
Ikr? But it adds style points tho
@basil127 2 жыл бұрын
eco friendly rgb
@brodyenli 2 жыл бұрын
More like upgraded B
@subboytris8946 2 жыл бұрын
RGB 2.0 HAS BEEN RELEASED
@paulgray1318 2 жыл бұрын
We're just getting used to 4 wire RGB controller's and now they want to add DNA controllers - in the 60's you made your own colours :).
@SnifferSock 2 жыл бұрын
2 things: This is sick. The mixing effect is good enough to replace CGI.
@MiddleofKnowhere 2 жыл бұрын
Please keep spotlighting initiatives like this with sustainable and environmentally friendly products. The tech industry is probably one of the most wasteful from materials for the actual product to the packaging (all that plastic!). It's something that ought to change and some companies have been doing better I've noticed.
@matiastripaldi406 2 жыл бұрын
Am I actually seeing PCR, recombinant protein expression and bacterial culture in an LTT video? Is this a dream? I study biotech so this is my bread and butter, never thought you guys would venture into it. Amazing work!
@mycosys 2 жыл бұрын
likely the most culture we'll ever get on an LTT video ;)
@goldcd 2 жыл бұрын
You are - and I liked it!
@luxbio 2 жыл бұрын
so glad you liked it! what area of biotech are you studying?
@FranciscoTC 2 жыл бұрын
As a med student who loves tech, this definitely tickled my pickle
@matiastripaldi406 2 жыл бұрын
@@luxbio well i'm in 3rd year of university (out of 5). my uni is mostly geared towards research work (which is what I'm interested in) but it also prepares you for if you decide to go into industry (such as producing insuline for diabetes patient en masse with genetically modified E coli). After i graduate i'll probably go into research hopefully in something health or human biology related, there's a bunch of really interesting stuff popping up. Most of my professors are researchers too so they tell you about the work they're doing and it just sounds awesome to work in. But tbh molecular biology in general fascinates me so i'd be happy to work in any lab (with bacteria or eukaryotes) as long as it's not plants haha, plants are incredible but kinda boring
@ThisIsTechToday 2 жыл бұрын
If only science class was this exciting when I was in grade school, lol
@doggoonus1414 2 жыл бұрын
kzfaq.info/get/bejne/fpNyqLuUlp7KgX0.html
@desmanbotts4244 2 жыл бұрын
Thats crazy because I learn about rna and dna last school year.
@dadsfriendlyrobotcompany 2 жыл бұрын
@@desmanbotts4244 it gets even crazier. I got my degree in genetics and genomics
@experimental0000 2 жыл бұрын
Little show called Bill Nye the Science Guy
@markscheuerman7962 2 жыл бұрын
What grade school is going to be able to afford pcr equipment?
@CsTvInc 2 жыл бұрын
truthfully, I love it when they head out and meet up with companies with cool ideas and goals. these are some of the best type of videos
@thecomfyshirt 2 жыл бұрын
It SO beautiful!!!! I wish it was practical to actually have on of these. This is why I love LTT. Today I learned about chemistry on a PC building channel. What a great vid!
@NathansWargames 2 жыл бұрын
Linus, we need a legit LTT Lab Coat for when we're doing computer "science" like this.
@simplybloxxed 2 жыл бұрын
the amount of ads here though
@xanthosjason9530 2 жыл бұрын
Bioluminescent bacteria: *exist* Linus: "slap that sh*t in a computer!"
@hojiry490 2 жыл бұрын
@Sahara Gurun no.
@leonardtao4457 2 жыл бұрын
Next step: RGB bacteria
@jessterbal 2 жыл бұрын
Great collaboration, please do more like this!!!! Thanks!!!
@bkrc123 2 жыл бұрын
Thank you for giving nyoka labs recognition. Will be following their progress.
@YeahRightMCD 2 жыл бұрын
A whole video on environmentalism-meets-technology? Keep em coming, big guy.
@pdabrowski4831 2 жыл бұрын
Linus already has more going on in the environmentalism space than most tech reviewers/creators, there's been a good amount of highlighting sustainable packaging in their unboxings and his recent serious investment in the right-to-repair campaign with Framework Laptops shows a commitment to the future.
@YeahRightMCD 2 жыл бұрын
@@pdabrowski4831 You're not kidding. Most tech content creators realistically don't do enough to push the efficiency side of progress, as much as the *RAW POWER* side of the coin. P.s. A+ power move investment on framework. Right to repair, and Wu Tang, are for the children. P.p.s. #$_& a full landfill *throws up fake gang sign thing, or whatever*
@volklii 2 жыл бұрын
kzfaq.info/get/bejne/pcujlqVhs9_Jmn0.html
@HattertheThird 2 жыл бұрын
This PC lures in gamers with its pretty lights to prey on their free time
@kristycyw Жыл бұрын
That was an impressive summary of DNA transcription, translation, RNA transcriptomics, PCR and genetic engineering
@thekraken8him 2 жыл бұрын
This has got to be the most interesting PC build I've ever seen. What a creative idea, and great execution. The Techquickie style explanation of the DNA reactions was an excellent touch. Also, 9:47 should be the thumbnail for this video.
@lecuyermarcandre 2 жыл бұрын
As an immuno and microbiologist, this is by far the best content ltt could have produced. Great vulgarisation of the scientific principle behind it as well. I would like twice if I could.
@dkofkloveeqisgreat6123 2 жыл бұрын
virologist and molecular biologist here, this might help some begin to understand how mRNA vaccines work as well. Tip of an iceberg but a start. other than that is there a version of these products that has both molecules stable before and after binding that can reveresed by say the application of heat. so in the cool part of the loop they bind and emit light but on the addition of heat dissacociate ( pass through heat block over chip), rinse repeat. i guess it depends on how stable the protein or capable of refolding after the techicaly heat denaturing. awesome work either way and shows molecular biology/ bio chemistry off well, in way lots can see and understand. ahh beer and now i cant stop thinking grr
@thanhvinhle2893 2 жыл бұрын
Linus holding biology chemicals. Everyone: nervous sweating
@kemalardaayar 2 жыл бұрын
conspiracy theorists: oh shit L virus is coming!
@clydemasterson1129 2 жыл бұрын
Next week: Can Linus power a gaming PC with a Tesla Coil???
@cyber_hacker 2 жыл бұрын
@@kemalardaayar are you talking about that L-vid-2021 (aka. Linus video 2021)
@kemalardaayar 2 жыл бұрын
@@cyber_hacker oh
@zerumsum1640 2 жыл бұрын
even though i knew it'd be lab bacteria that are (relatively) harmless, I still cringed when he said it was e-coli. We get examples all the time of why Linus is a bad guy to pass dangerous/fragile things.
@DrivenKeys Жыл бұрын
Perfect reservoir for this, and great camerawork. Absolutely amazing developments. Keep making these videos.
@rusinsr 2 жыл бұрын
Love these sorts of videos! Really interesting and different from the usual stuff :D
@EclipsaMyrtenaster 2 жыл бұрын
"Haha. I made you guys watch a Science lecture disguised as a computer video." That ticks off two things on my list.
@argon552 2 жыл бұрын
As a microbiologist that specializes in bioinformatics, this was one of the best colabs and video that LTT ever produced. Well done guys
@StripesOO7 2 жыл бұрын
Nice to see someone else doing the same thing. I am still studying but switched after my bachelor thesis in molecular biology/genetics to bioinformatics as my master 😅👋
@argon552 2 жыл бұрын
@@StripesOO7 in that case cheers 🤘
@carnotit 2 жыл бұрын
this vid is awesome! congratulations linus for bringing such great content.
@zen1647 2 жыл бұрын
Bloody amazing video. Loved it!
@thethoughtemporium 2 жыл бұрын
Nyoka's stuff is so cool. I've seen their stuff go by a lot in the various bio groups. It's a neat idea for sure, though hard to say if they'll be successful. Don't get me wrong, the idea is clever, but scaling biotech is really really hard. Take it from someone literally trying to scale up a lab scale biotech project to industrial scale. It's very much non-trivial, even if the idea is very simple. Also the claim you can drink it is mega sus. And they will need a huge amount of certification that there is no contamination of the live genetically modified organisms in the liquid or it would be a felony to dump it down the sink. The EPA would be furious. And if it's just a lysed ecoli suspension it'll always smell awful. So ya, they've got some stuff to address. Also, I really hope those were "stunt" pipettes, cause those are expensive and dropping them like that will wreck them. Edit: They replied and clarified that they've already addressed all this, and this was just the demo version, so nvm I guess. Glad they're further along than I realized! Never gonna complain about more cool biotech companies doing cool stuff.
@timfallonphd3085 2 жыл бұрын
Yep, I totally agree on the difficulty of implementation of bioluminescence! Biology is a whole different ballgame from tech, as you well know! And yeah, dropping the pipettes not ideal but in my experience not too bad. Every biologist should know how to calibrate / validate their pipettes & do it whenever they have a suspicious fall like this.
@ScreenNameLmao 2 жыл бұрын
My fav biotech youtuber in linus comments? Is this a crossover episode
@thethoughtemporium 2 жыл бұрын
After what I just spent on pipettes, there's no way I'd throw them around like that. But that's just me. I do have a cheap chinese set though that are specifically for shots like that where you want to joke around. But I film bio stuff all the time. I assume for them the publicity of this video outweighs concerns about pipette calibration though, so w.e. To each their own.
@timfallonphd3085 2 жыл бұрын
@@thethoughtemporium Not to worry, I'm sure Linus is working on a follow up video about calibration of that dropped pipette right now! Right Linus?? Linus? Haha but more seriously: people get all up in arms about mistreating instruments - either pipettes, or things several orders of magnitude more expensive like LC-MS instruments. IMO, minor mistreatment and yes occasionally breaking them is part of the natural learning process, so my philosophy is scientists should be comfortable with pushing the envelope, potentially breaking things, & evaluating when they need to be fixed & how to fix things, and not be afraid if they did break something to ask for help. I can understand in self supported research that changes the equation a bit as each dollar available is more precious due to the limited funding sources, but at least in science education I lean towards the response being "that's okay, let's see what happened". Or at least that is what I tell myself to feel better about when I accidentally drop my pipettes :)
@matiastripaldi406 2 жыл бұрын
@@thethoughtemporium i thought the same, was really surprised to see the team handling expensive lab equipment. But i guess they're within budget
@marcosmedia7463 2 жыл бұрын
Linus: We make PC that glow War Thunder: This is worth a sponsor
@tomasalmeida2940 2 жыл бұрын
Nah but is a minor detail
@haydenw8691 2 жыл бұрын
Good thing you can block sponsors now. Makes the videos much better.
@acrythm8316 2 жыл бұрын
Wow. This looks amazing, love the video man!
@Swordsmanjan 2 жыл бұрын
As a biochemist working in enzymology I truly enjoyed this episode. Great job everyone, both for the entertaining content and the high degree of scientific accuracy. Seeing educational content like this is great!
@fireaza 2 жыл бұрын
It was very brave of the staff to hand Linus their expensive scientific equipment to hold, knowing what might happen.
@ikonikian475 2 жыл бұрын
How is it brave? He's rich. He breaks it he buys it lol
@zatoichi188 2 жыл бұрын
PCR machine ain't that expensive, and once you have the actual engineered organism you can you usually produce buckets of it for pennies. The expensive bit is the actual engineering.
@highping5137 2 жыл бұрын
@@ikonikian475 do you know how much money it takes to make a business he probably only has 50% more money than the averege person so he would be broke if he broke one
@Jawad.1 2 жыл бұрын
Nothing 'might have happened'. Linus knows what he does. He's one of the most intelligent and responsible people I've ever seen.
@joetownsend6325 2 жыл бұрын
@@highping5137 he has a business and assets, to say he would be broke because he loses the money in his pockets is patently false. It simply means he can't buy a new car until next week.
@DerekMorrelli 2 жыл бұрын
Having a bachelors in biology and a masters in chemistry, this is possibly my favorite video I've seen from LMG. Great job at explaining the scientific process, pretty much as simplified as you can get and still describing the process accurately. You've just made RGB obsolete!
@WendtKyle 2 жыл бұрын
This and the Framework laptop video from a day or two ago are a new and really awesome direction for this channel.
@FriendBe 2 жыл бұрын
This is pretty amazing ngl. The applications for something like this has me pretty excited for the future.
@okabehakaze6416 2 жыл бұрын
As a molecular biologist that builds computers as a hobby, I just wanna say this build looks awesome
@ninjashuriken 2 жыл бұрын
fkn mad scientists
@pauliewalnuts2527 2 жыл бұрын
Why don't you do something similar?
@mindgame112 2 жыл бұрын
As someone wo used to work in Molecular Biology: Linus dropping the pipet: SHIT now you need to recalibrate it...
@mayanksoni2399 2 жыл бұрын
forget recalibration, my lab ones would just shatter and break
@MitgliedT5 2 жыл бұрын
If we broke a pipette in the lab, we had to go to the professor and pay for a new one ourselves, depending on the situation.
@arksy8703 2 жыл бұрын
@BIG ASS you will never be a real woman, 48% yourself
@Spork0 2 жыл бұрын
@@arksy8703 its a robot btw. not a real person
@ilodabomb 2 жыл бұрын
Dropped so many pipettes in my life... recalibated a whopping number of 0 pipettes 😄
@nihouma11 2 жыл бұрын
This looks so cool, have to watch later, but keep up the amazing videos!
@keithvassallo 2 жыл бұрын
This was one of the best and most interesting LTT videos I’ve seen in a long time! Well done and give us more!
@optillian4182 2 жыл бұрын
Linus really woke up one day and said "hmm yes I'm gonna put glowing germs in a computer".
@optillian4182 2 жыл бұрын
@CHIYOKO Begone, bot.
@yknx4 2 жыл бұрын
He is running out of new things to put into computers
@DVMJon 2 жыл бұрын
I LoL'd literally. When I realized Linus was giving an actual lecture in polymerase chain reaction (PCR) 😂
@Grocel512 2 жыл бұрын
Linus next week: "Let's overclock and water cool a PCR machine." **shows live Covid-19 samples** "This will be our benchmark!"
@Auroric 2 жыл бұрын
This is so rad! Stoked to see Nyoka getting some good exposure, would love to this take off
@luxbio 2 жыл бұрын
Thanks Auroric! How had you heard of us??
@dkursada 2 жыл бұрын
It was such a fun episode, legit props for the explanation w/ great animations! As someone long time PC enthusiast who's just started studying biotechnology, this video is such an eye opener for me, for the bioluminescent gaming PC is such a cool demonstration of what happens when you bring knowledge of two seemingly distinct subjects together with a fun idea or two. What you do doesn't always have to be practical. A PC with glowing water cooling is just plain awesome. It's good getting to know Nyoka Design Labs folk, too. They're doing awesome work with reusable and longer-lifespan material! p.s: Linus Biotech Tips lol, I could get used to this. Would be such a fun channel
@occasionalglory5261 2 жыл бұрын
Linus: "Traditional glow sticks are full of toxic material." Me: *Starts having flashbacks to cutting open glow sticks and smearing it on my face as a kid*
@willy.c 2 жыл бұрын
I remember well biting into one and having the liquid shit in my mouth to scare my friends...p
@aarontimm 2 жыл бұрын
bruh WHAT
@hpsmash77 2 жыл бұрын
tf!!!
@Soosss 2 жыл бұрын
i used to bite into them like an idiot
@t_y8274 2 жыл бұрын
One part carcinogen, one part high concentration peroxide. Yum!
@20quid 2 жыл бұрын
I love how he's holding a model of a tardigrade when he's explaining how they get the genetics from a crustacean and put it in a bacteria, neither of which are tardigrades.
@Kuli24000 2 жыл бұрын
Nervous laugh.... yeah that.
@la24dogg21 2 жыл бұрын
Lmao I knew I would learn form someone here
@paigewhitehead2157 2 жыл бұрын
yeah we didn’t have a model of those on hand! We brought our tardigrade in the hopes it would make it on screen - it was hand made by someone on our team 😆
@benezzy 2 жыл бұрын
I was waiting to see when the tardigrade Linus was holding was gonna be talked and it just never happened lol😂
@tomrl6674 2 жыл бұрын
@@paigewhitehead2157 tardigrades are pretty cute
@AD-de2sl Жыл бұрын
love the fact that you give great ideas a chance on your channel ! :)
@yolog37 2 жыл бұрын
Awesome video! I learned a lot!
@mullokakkarin 2 жыл бұрын
I actually really appreciate as ex Lab worker, that once in a while you make science videos. We actually need more people to get people interested in the science topic and also influencers to put more emphasis on importance of science... I believe that even those 'once in a while videos' can cause some changes for better in that field. (Believe me or not but scientists are in many cases underpaid, and they do not want to invest more than 10-15 years of gaining knowledge to not earn enough to live like a human)
@TheKeKApex 2 жыл бұрын
imagine if we put the ability to regrow limbs in humans, how many amputee's we can help alone. along with other things that can be cured with designer viruses. it's wild it's even a debate to keep pushing on this.
@volklii 2 жыл бұрын
kzfaq.info/get/bejne/pcujlqVhs9_Jmn0.html
@wobblysauce 2 жыл бұрын
While YT is good and all, more people in Science is not a bad thing.
@joosts4085 2 жыл бұрын
These videos are such an amazing lesson in disguise. The amount of people that now know about this that otherwise wouldn't hear about this for months or years is amazing and will hopefully boost this kind of research.
@timfallonphd3085 2 жыл бұрын
I totally agree. The type of reach this video has is incredible! Millions of people learning about bioluminescence! So great!
@Haskellerz 2 жыл бұрын
LTT in 2030, we are gaming on the latest Ryzen 90000 bacteria processor attached to 1000 TB permanent DNA storage
@TheBackyardChemist 2 жыл бұрын
@@Haskellerz DNA tape drive. Retains data integrity for 10 000 years at -80 °C.
@mirrorsandstuff 2 жыл бұрын
This is one of the neatest projects the LTT team have come up with recently and I really hope whoever led the project's research is proud of themselves. The organic chemistry was well explained and the level of detail was at the right level whilst still being engaging.
@shriramvenu Жыл бұрын
this was a really entertaining and educational video. keep it up guys!
@Verlisify 2 жыл бұрын
Ok this is one of the coolest things I have ever seen and exactly what I imagined the future would be like
@botted1193 2 жыл бұрын
deez
@an456pop3 2 жыл бұрын
nutz
@LightningSquad 2 жыл бұрын
I uploaded my Face Reveal...
@raulll95 2 жыл бұрын
Just think having the Bioluminescent liquid inside the PC and having the Glow paint on the PC case - kzfaq.info/get/bejne/j8V_fK5jrqjViHk.html . The effects from TRON movie are not far from having day to day near us
@Denofu 2 жыл бұрын
cringe
@benjaminkocsis2983 2 жыл бұрын
As a researcher in a microbiology lab, I am so happy LTT made this video. He did a pretty good job of explaining pcr in lamens terms. I didnt expect to see the wonders of microbiology shared by a tech channel but I am very glad they did.
@volklii 2 жыл бұрын
kzfaq.info/get/bejne/pcujlqVhs9_Jmn0.html
@radspiderjackson 2 жыл бұрын
cool intro breakdown, i didnt have to skip thru to the good stuff
@SparklySpencer 2 жыл бұрын
This was a fantastic video, and I hope you have more like this in the future
@DrNarf 2 жыл бұрын
LTT, you're laying the groundwork for producing better, higher quality, educational videos than McGraw-Hill when it comes to Biochemistry. If you need someone with an MS in Biochem, lmk because, yeah. Awesome work. We need more content like this. I already enjoy your "tech longer". Go full send. Keep at it, bro.
@Ulandos 2 жыл бұрын
7:12, Linus deciding whether or not he's holding a condom or E.Coli
@trailfork7815 2 жыл бұрын
I'm still bothered that it looked like a used condom
@pepkin88 2 жыл бұрын
linus sex tips
@randomblock1_ 2 жыл бұрын
4:52
@adityadivine 2 жыл бұрын
Me who never got a chance to use it. Ahh life sucks
@106640guy 2 жыл бұрын
COOOOM
@fishingtherapy5959 2 жыл бұрын
Idk how I missed this video. I watch nearly everything you guys do. My apologies you waited on my view for so long. Great content! I was tickled pink
@MakDemonik 2 жыл бұрын
As a student of Biotechnology I have to say you did a great job of simply yet effectively explaining the whole process of cloning genetic material via the PCR method and how the entire bioluminescence process works. (You could have just mentioned that each cycle gives you orders of magnitude more material - doubling it every time - than just having "more" in general) Loved the video.
@zackriehl8079 2 жыл бұрын
"I will not be making any *AHEM* unscheduled visits to the bathroom." - Linus. This implies the existence of SCHEDULED bathroom visits. Hmmmmm
@sphrcl. 2 жыл бұрын
Bro someone copied this exact comment word for word and they got a lot more likes than you because they have a check mark next to their name
@zackriehl8079 2 жыл бұрын
@@sphrcl. oh well. As long as I'm the og, I don't care.
@stefa4013 2 жыл бұрын
I mean on work days I have set times I go to the bathroom so yeah you can totally schedule them
@cubeventure 2 жыл бұрын
@@zackriehl8079 i respect that you don’t care
@clared5812 2 жыл бұрын
@@sphrcl. why does it matter, internet points are completely meaningless
@FranciscoTC 2 жыл бұрын
If you want to do this at home you'll only need: *200 dollar variable volume pipette*
@timfallonphd3085 2 жыл бұрын
There is always Ebay :) Rather than a variable volume pipette, a standard medicine dropper, releases about 20 to 50 microliters per drop - more than enough accuracy to do this type of experiment at home.
@zechsta28 2 жыл бұрын
you could use a thin straw as long as you make a good estimate on the volume. a bikewheel as centrifuge, and pots and pans with different temp water in them for the thermalcycler (Its gone take a while though getting your sample from pot to pot 40+ times)
@timfallonphd3085 2 жыл бұрын
@@zechsta28 Yep! I think there are lots of ways to make this work at home, without the "professional" equipment, just have to get a bit creative. After all, biologists in the 1800 - early 1900s had pretty crude tools but were able to figure out a huge amount of stuff!
@kehrnal 2 жыл бұрын
Also if you used the centrifuge he showed, you'd be spinning small amounts of that culture all day long... Not 10 min
@adamengelhart5159 2 жыл бұрын
At least the column is only five cents? Oh, wait. I think I might have that confused with something else. :-/
@jerbearnone2012 2 жыл бұрын
I'd love more content like this!
@alexandernieto1265 2 жыл бұрын
Great video! I enjoyed it!!
@MrWestonO 2 жыл бұрын
"Alex, you had ONE JOB." *proceeds to list 5 jobs* Edit: yes guys i know this was a joke but its still funny
@Tosti_bakker 2 жыл бұрын
I think that was the joke
@duatchol7710 2 жыл бұрын
I’m completely lost as to whether you got the joke or not, lost in internet translation I guess
@MrWestonO 2 жыл бұрын
@@Tosti_bakker well ye
@MrWestonO 2 жыл бұрын
@@duatchol7710 i did
@devinou-programmationtechn9979 2 жыл бұрын
Linus : "Minor details like our sponsor : war thunder ..." War Thunder : "Am I a joke to you ?"
@zUnderscore 2 жыл бұрын
tbh war thunder is a joke
@jora9655 2 жыл бұрын
I absolutely adore how you give us the background knowledge to understand how bioluminescence works and even how the gene manipulation involved functions. You're a tech channel, but you have such a broad horizon. Love it!
@madhazza64 2 жыл бұрын
I really enjoyed this! I love science, Linus delivers things so well and I honestly wasn’t bothered at all that computers were hardly involved. I’d super appreciate more videos of this style thrown into the regular mix more often ☺️☺️
@jordanm2984 2 жыл бұрын
As a biology undergraduate and a PC enthusiast, this is one of the coolest videos you guys have released!
@Aepus 2 жыл бұрын
That pipette technique tho
@DamnCyrus 2 жыл бұрын
That shot of the reservoir lighting up was so fucking good, hope those people get the work done to make the bio-luminescence usable in the future
@dontaskiwasbored2008 2 жыл бұрын
This is wildly out of scope for this channel and I love it.
@kehnxii Жыл бұрын
This is the first time I have ever seen this pop up on recs and I love it
@floofthefops 2 жыл бұрын
Am I the only one that absolutely loves when Linus goes to explore what other companies are doing? These videos are always very cool and usually talk about stuff I would never hear about otherwise. The episode about quantum computing was absolutely fascinating to me.
@Slinder14 2 жыл бұрын
We did a bioluminescence experiment in my bio lab a few years ago. To me it’s one of the coolest things in nature, and bringing it to a pc is amazing. Awesome video
@doggoonus1414 2 жыл бұрын
cool r6 clip ---> kzfaq.info/get/bejne/fpNyqLuUlp7KgX0.html
@luxbio 2 жыл бұрын
we so agree. what kind of experiment did you use bioluminescence for?
@andresleon-vargas3603 2 жыл бұрын
This was awesome. Great job explaining the science, not an easy task. I'm studying bioengineering in school right now and find this type of content particularly interesting and fun.
@nolanmanning3749 2 жыл бұрын
I love this and hope it takes off to reach multiple millions of views! Would love to see more demo type videos
@TechDove 2 жыл бұрын
My PC glowed once too, when my power supply shorted and caught on fire. Much cooler looking than this, but far more dangerous and expensive 1/10 do not recommend
@johanesrafael9679 2 жыл бұрын
Wow, power supply AND arc welding machine in 1 package! Now that's the deal of the year 😂
@TechDove 2 жыл бұрын
@@johanesrafael9679 hell yeah! I got so much done that the fire department came to congratulate me
@karine3126 2 жыл бұрын
AISURU.TOKYO/mizumi/?[🤤] (◍•ᴗ•◍)✧*。18 year and over KZfaq: This is fime Someone: Says "heck" KZfaq: Be gone #однако #я #люблю #таких #рыбаков #Интересно #забавно #девушка #смешная #垃圾
@karine3126 2 жыл бұрын
AISURU.TOKYO/mizumi/?[🤤] (◍•ᴗ•◍)✧*。18 year and over KZfaq: This is fime Someone: Says "heck" KZfaq: Be gone #однако #я #люблю #таких #рыбаков #Интересно #забавно #девушка #смешная #垃圾
@Telhias 2 жыл бұрын
My PC glowed too! There was a fault in the power supply and it sent so much current to my graphics card, that it melted glowing red hot. Don't cheap out on power supply guys. The money saved on it was not worth that GPU.
@balintmajor5416 2 жыл бұрын
Linus speaks like he knows what is he speaking about, he is a very good actor.
@Emma_madison 2 жыл бұрын
Well it all about putting up a show
@vk.7165 2 жыл бұрын
This was one of the most interesting videos in a while, really fun and informative, and also gives a shoutout to hard working scientists. If you can, do more of things like this :)
@MoChuang343 2 жыл бұрын
This is a long comment/suggestion. But I hope you read the whole thing. Using luciferase, luciferin, ATP, and O2 to catalyze an enzymatic luminescence reaction inherently runs into the problem of running out of substrate which then requires refilling the loop with more substrate as you mentioned. The glow stick company needs to use the luciferase system since no additional ingredients are required other than the ones already provided in the stick. But for a PC, you can take advantage of one key ingredient that is already present in any self-respecting gaming PC, RGB light. I would suggest using fluorescent proteins which can absorb specific colors of light and then emit a longer wavelength color light. The most famous is probably green fluorescent protein (GFP). If you filled your loop with GFP, it would look like a dull yellow-green fluid. But once you turn on the blue RGB in your PC, that blue light will get absorbed and then be emitted as a visibly green glow. This glow would be recharged every time the GFP solution encounters blue light from the various RGB lights in your PC along the loop. I have no idea exactly how this would look, but you could play with the proximity of RGB sources to the GFP loop to see if that affects the intensity of the glow. And you could use different RGB effects like strobing to see how that changes the glow of the GFP as it absorbs light unevenly and flows through the loop. You might be able to make a pulsating wave pattern. Or the least exciting would be that the blue RGB in the case simply bleeds all over the place and the entire loop lights up uniformly regardless of what RGB effects you try. EDIT!!! I just thought of another ingredient a PC has...heat! You could tag the GFP to a liquid-liquid phase separating protein. These proteins form droplets like oil under certain conditions, one of which is temperature. Thus you could have this glowing green liquid that mixes well at high temperatures but demixes into droplets at cooler temperatures. So you could observe the relative temperature of your coolant in the loop...or an 80C CPU block will just denature everything it touches...
@user-cv3ph9bh9r 2 жыл бұрын
I think you could even get a work around to the GFP being thermally stable when it touch a cpu blocl. According to a study by Ishii et al., "Study of the thermal stability of GFP in glucose parental formulations" in 2007, you should be able to have GFP fluroesce even up to 100C in the right conditions. so it could not denature, or denature more slowly as it lights up!
@muhammadanwaril6872 2 жыл бұрын
keep it coming, Linus. environment-friend techs, repairable techs, things will eventually get better. hopefully.
@eisenklad 2 жыл бұрын
Linus should get Solar and possibly Wind power on his home
@spongerglory 2 жыл бұрын
The whole Anglerfish bit in the beginning won a “like” from me!
@timfallonphd3085 2 жыл бұрын
Fun fact! The type of bioluminescence (in terms of the luciferase and luciferin) is different from both the types linus showed here: Firefly (yellowish green glow) and the Marine copepod Gaussia (blue glow)
@kwerboom 2 жыл бұрын
Cool and informative video. This is interesting technology. The in depth explanation of the science behind the technology was informative and appreciated.
@aceofspades3763 2 жыл бұрын
W video. Honestly, this is the COOLEST thing I have seen in years. I want to rewatch it over and over lmao
@jackgotgamez 2 жыл бұрын
I bet with a lot of those “glow sticks” and the luminescence you could actually make yourself a diy glow in the dark lightsaber from Star Wars.
@oMega-sm1eg 2 жыл бұрын
Then it will be pretty heavy since it's filled with water, and not retractable of course. Now some excellent-looking lightsabers already exist using diffusion of a beam of LED light to light up the entire retractable blade.
@nickthemage2052 2 жыл бұрын
I feel like LEDs, a toggle switch, and a sanded plastic tube (to make it opaque) would be lighter and far cheaper lol
@oMega-sm1eg 2 жыл бұрын
@@nickthemage2052 Yes, that's what cheap sabers are, a LED strip in the middle and plastic outside. It's not retractable though, thus not a true lightsaber but a fluorescent lamp with color, attached to a handle
@nickthemage2052 2 жыл бұрын
@@oMega-sm1eg yes I’m aware.
@tywer1297 2 жыл бұрын
*gets safety glasses last* “safety first, ladies and gentlemen”
@mattjc 2 жыл бұрын
Proceeds to roll up sleeves and leave labcoat unbottoned, leaving the most likely areas of exposure unprotected
@wagonet 2 жыл бұрын
Now this is unique content. Loved it
@TilmanBaumann 2 жыл бұрын
That's the quality computer content I can't here for nice work
@mohidwaseem7997 2 жыл бұрын
Its amazing when professionals from two different walks come together to do something fun.... Like linus us so excited during the chemistry part and the people there are all serious and want to get it to work, then as soon as the PC comes in Linus goes serious 'lets let it run for the air bubbles' mode and the team there is all excited. Just a wholesome and lovely collab
@errhka 2 жыл бұрын
This is one of the raddest videos you've ever done. As a former biochem major the explanation was excellent and the chemistry was awesome to see.
@MarcusBS 2 жыл бұрын
thank you for this! its fun to learn, and i want a ocean computer with some thing like this!
@becomealex 2 жыл бұрын
I'm barely one-third of the way to the video and this is the best video I Feel you've ever produced! I'm loving the whole science aspect of this and I'm really looking forward to the science lab! Congratulations on all your success! Continue being excellent and may the Everlasting Computer Gods be with you through all your endeavors!
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