The brain and obesity | The Royal Society

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The brain and obesity | The Royal Society

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The Croonian Medal and Lecture 2022 given by Sir Stephen O'Rahilly FMedSci FRS and Professor Sadaf Farooqi FMedSci FRS.
#obesity #weight #health #food
Globally, over 1 billion people are overweight or obese. Obesity and its complications are associated with significant morbidity and mortality due to type 2 diabetes, cardiovascular disease and some forms of cancer. While the widespread availability of high calorie, palatable food and physical inactivity are major environmental drivers of the rise in prevalence of obesity, heritable factors play a substantial role in influencing a person’s propensity to gain weight (or not), within an obesogenic environment.
In this lecture, Professors O’Rahilly and Farooqi will discuss how the identification of genes and the pathways they regulate has highlighted the fundamental role of the brain in modulating eating behaviour and body weight. They will discuss how studies of the leptin-melanocortin pathway have provided a mechanistic framework for understanding how body weight is regulated in humans, how energy status is coupled to reproduction and growth and how disruption of these neural mechanisms causes obesity. They will also discuss the impact of this work on societal perceptions of obesity and how targeting these mechanisms has provided new treatments for people with severe obesity.
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Пікірлер: 38

@Stop-and-listen 2 жыл бұрын

Extremely informative. I will be contacting the GOOS for further information on BBS.

@christopherscobie 2 жыл бұрын

Lets have a two week lockdown, sorry two year panic/global pandemic mania over obesity, it kills a lot of people everywhere. worse that a virus i'd say.. Great talk, much obliged, so interesting.

@applegal3058 Жыл бұрын

In my extended family, women who have a larger waist and smaller hips have diabetes, and ones that have larger hips and smaller waists have none. Thank goodness I didn't inherit a small hips and bigger belly from my mom. I got the Hooper hips...from the ancestors who had big arses in our family lol The only down side is to find pants that fit properly in both hips and waist. Genetics definitely has some role in our body size and predisposes people to different diseases. In saying that, I'd be obese if I didn't control my food or exercise. I used to be obese many years ago caused by mental and physical issues. Thankfully I have knowledge about human health and am financially able to afford healthy food, and have the time to cook at home and exercise.

@selenaclarke 2 жыл бұрын

Wonderful Video, thank you

@royalsociety 2 жыл бұрын

Glad you enjoyed it

@voidisyinyangvoidisyinyang885 2 жыл бұрын

fascinating that obesity is inheritable!

@maxwelldillon4805 2 жыл бұрын

Fantastic work. You already know that there will be some people who will outright deny these findings and stick to their ridiculous ideas of 'free choice'. Oh well, I guess they're determined to be that way. I wonder about the mechanisms underpinning their stubborn science denial...

@maxwelldillon4805 2 жыл бұрын

@@ggrthemostgodless8713 For the most part, fat people don't want to be fat. It's like saying "genetics gives cancer patients an excuse for their tumours". There is a minority of fat people who celebrate their being overweight - but I don't think they're really causing problems for people.

@maxwelldillon4805 2 жыл бұрын

@@ggrthemostgodless8713 I don't think it's an excuse as if they're getting away with something, because they're not cheating anyone by remaining fat, only they really suffer from it. I do think many are concerned with their health, although yes priorities do vary. I think it's ok if people have different motivations for achieving the same goal. Personally I think it's important to achieve one's needs of intimacy (assuming one has any such desires), so I don't see that motivation as being trivial.

@ggrthemostgodless8713 2 жыл бұрын

@@maxwelldillon4805 Oooooookkkkk, you win. Who said anything about "cheating"?? Or "getting away with something"? Did you read my response well?? Jesus!!

@maxwelldillon4805 2 жыл бұрын

@@ggrthemostgodless8713 I thought that's what you were suggesting when you said it could be used by fat people to stop trying

@funkymunky6349 Жыл бұрын

is obesity inheritable by 40-70%? Because i have found other sources in the web which says it is inherited by maximum of 5% ?

@rezalayeghi3442 2 жыл бұрын

The genteman, one of the speakers may be great idea that he looks at BMI . please

@applegal3058 Жыл бұрын

You must he fun to be around... f 🤦‍♀️

@Exodus26.13Pi 2 жыл бұрын

I ate like an American and got to 400. Now I eat like a wealthy peasant in the 1800s minus the sugar.

@TheDavidlloydjones 2 жыл бұрын

And...?

@SvengelskaBlondie 2 жыл бұрын

@@TheDavidlloydjones He forgot that peasants in the 1800's didn't have computers or access to the internet. Also ignore the oxymoron of "wealthy peasant". "a poor smallholder or agricultural labourer of low social status (chiefly in historical use or with reference to subsistence farming in poorer countries)."

@rowanscmorien4761 2 жыл бұрын

Start at 1:46

@rowanscmorien4761 2 жыл бұрын

In fact, that is just the introduction. If you want less context, start at 6:06.

@wobblybobengland 2 жыл бұрын

@@rowanscmorien4761 And it's goodnight from him

@rowanscmorien4761 2 жыл бұрын

@@wobblybobengland is that a two Ronnie's reference?

@TheDavidlloydjones 2 жыл бұрын

At 12:09 there is a reference to "gavage feeding,"* I think it is. I don't know the term. I'm not sure what the word is or how it's speled, so I went back and looked, twice, at the written captions. It's not there. Whoever typed up the dot-srt file didn't know what the word was, so they simply left it out. I.e. they took the money but they didn't do the work. This is shameful. Somebody should be fired. Somebody else should be fired, get the work done, and replace the file here on KZfaq. * Apparently the word is "gavage." It means feeding through a tube. If I can look it up, the person paid to do the job could have done so, too.

@NerdPirateRadio 2 жыл бұрын

Listen to pronunciation. (guh-VAZH) A way of giving medicines and liquids, including liquid foods, through a small tube placed through the nose or mouth into the stomach or small intestine.

@LesliePajuelo 2 жыл бұрын

It's either auto-generated or some gig worker was paid pennies per minute. So chill with the "fire all the people" for a resource which is being provided for free. Both the video and the transcript is free for you to watch. @.@

@rezalayeghi3442 2 жыл бұрын

The main cause of obesity is Insulin Resistance. The cause of it is the SAD diet which encourage carb diet. Please have a look at Dr. Jason Fungs's work and Ketgenic diet plus fasting. I hope you will come up with great new finding.

@ondrej1893 Жыл бұрын

Dunning-Kruger identified.

@churblefurbles 2 жыл бұрын

Less drugs, more Jason Fung.

@overtsaceie 2 жыл бұрын

Very informative but it is hard to understand an old man repetitive speaking

@danielrodgers3002 2 жыл бұрын

Congrats, sounds like in another 40 years you guys will discover that if humans eat Real food and exercise then they won't get fat and sick.

@rowanscmorien4761 2 жыл бұрын

It's untrue. Eating whole foods and exercising improves health and reduces the chance of getting sick, but people can still have excess body fat and all manner of illness while doing those things. Smoking increases the risk of lung cancer but nonsmokers can absolutely get it. Ultraprocessed food increases the risk of obesity and diabetes but these conditions existed before ultraprocessed food. Exercise is great and important and reduces the risk of myriad health problems but it won't make anyone not get sick. The reason I'm stressing this so hard is because I'm sick of people making blanket statements about various interpretations of healthy diets or healthy lifestyles being claimed to prevent illness, when that is in fact the magical thinking of people who a) don't understand chance and risk and b) just desperately want to believe there is a set of rules they can follow and they will be safe and in control.