The Clotting Cascade EXPLAINED!

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ICU Advantage

ICU Advantage

Күн бұрын

Discussing the complex clotting cascade. 📝 Free Quiz: adv.icu/3Px3yXI
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When bleeding is present, our blood needs to transform from a liquid to a gel in an attempt to slow and stop the bleeding. This process of hemostasis is a complex one and the most complex part of this is what we refer to as the clotting cascade. The cascade allows the rapid conversion of Fibrinogen to Fibrin, a crucial component to forming a stable clot. The cascade involves multiple steps and enlists multiple helpers to "cascade" into a large volume of fibrin. We have both the Intrinsic and Extrinsic Pathways that both feed into the Common Pathway and result in clot formation.
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0:00 Intro
1:32 Hemostasis
4:51 The Cascade
12:46 Extrinsic Pathway
14:33 Intrinsic Pathway
16:53 Entire Cascade
19:29 Wrap up
#ICUAdvantage #ClottingCascade #Hemostasis

Пікірлер: 82
@ICUAdvantage
@ICUAdvantage Жыл бұрын
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@ilonaspeicher760
@ilonaspeicher760 Жыл бұрын
@t1g3r2009
@t1g3r2009 Жыл бұрын
As a Clinical Hematology Professor, I approve! Love your videos!!!
@ICUAdvantage
@ICUAdvantage Жыл бұрын
Awesome! So cool to hear this. Thanks so much Luis and glad you enjoy them.
@ivantarandovskiy4765
@ivantarandovskiy4765 Жыл бұрын
You really approve that calcium is needed for conversion of fibrinogen to fibrin? And that platelet phospholipids are not needed for prothrombinase formation?
@fredoxychannel923
@fredoxychannel923 Жыл бұрын
I don't know why school teachers can't explain vividly and briefly like this. Thank you man. Keep up the good work 👏 🙌 👍 👌 💪
@ICUAdvantage
@ICUAdvantage Жыл бұрын
Thanks so much for that. Really glad I was able to convey the info so it made sense.
@malikasha
@malikasha Жыл бұрын
U mean medical schools?:)
@fredoxychannel923
@fredoxychannel923 Жыл бұрын
@@malikasha yes med school,.all my doctor teachers know is to make med school a hell life.
@malikasha
@malikasha Жыл бұрын
@@fredoxychannel923 haha I see, dont give up
@nygeek6471
@nygeek6471 Жыл бұрын
Because they don’t actually know it
@josetrujillo738
@josetrujillo738 Ай бұрын
You are exceptionally well spoken: you speak very clear and explain very nicely.
@josetrujillo738
@josetrujillo738 Ай бұрын
It is very desirable.
@michaelmoyer1865
@michaelmoyer1865 Жыл бұрын
“All bleeding stops eventually”, is my favorite one liner
@ICUAdvantage
@ICUAdvantage Жыл бұрын
Haha yes and it’s so true!
@annatendai6809
@annatendai6809 14 сағат бұрын
Very well simplified and understood 😊
@christinafurneri9699
@christinafurneri9699 Жыл бұрын
Some tips to help remember : PT = tennis (played inside) = intrinsic pathway versus aPTT = table tennis (ping-pong, played outside) = extrinsic pathway Common pathway = 10, 5, 2, 1 = like $ currency Intrinsic = numbers 8 through 12 (except 10) Thank you so much ICU Advantage! You have greatly helped this pharmacist prep for hospital residency!
@ICUAdvantage
@ICUAdvantage Жыл бұрын
Thanks for sharing that! I really like the currency part! And you are very welcome. Truly happy to know I'm able to help!
@bonniehuang8696
@bonniehuang8696 Жыл бұрын
Forgive my ignorance, but I thought tennis is played outside and table tennis is played inside?
@christinafurneri9699
@christinafurneri9699 Жыл бұрын
@@bonniehuang8696 oops! True, I meant the opposite :(
@ObiomaFlorence-dp7js
@ObiomaFlorence-dp7js Күн бұрын
Thanks for teaching Really understood everything 😊
@igorbesel4910
@igorbesel4910 Жыл бұрын
I am also teaching from time to time and really can´t get my mind wrapped around this cascade. Great Job wrapping this thing up.
@ICUAdvantage
@ICUAdvantage Жыл бұрын
Nice! Happy to help Igor!
@parkerphelps5202
@parkerphelps5202 Жыл бұрын
Thanks so much for making this video! I was just looking into learning more about this topic the other day. I definitely have a better understanding of it now
@lobarita
@lobarita Жыл бұрын
Watched and read many things trying to understand this, and this video was what put it all together for me.
@senioracademia1947
@senioracademia1947 27 күн бұрын
Woah, clear and concise thank you!
@hannahmacababbad5195
@hannahmacababbad5195 Жыл бұрын
I particularly enjoyed this presentation!
@Flying.thomson
@Flying.thomson 10 күн бұрын
Thank you very much sir for this valuable information!!
@waseemahmed6990
@waseemahmed6990 Жыл бұрын
Very logical and good explanation, thanks
@RdGdGW
@RdGdGW Жыл бұрын
I absolutely love your lectures.
@ICUAdvantage
@ICUAdvantage Жыл бұрын
Thank you so much Rose!
@emekaanikwo8282
@emekaanikwo8282 3 ай бұрын
This is awesome.❤ Thanks a lot
@dianachen4986
@dianachen4986 Жыл бұрын
thanks it really helped!!!
@kenirole2433
@kenirole2433 Жыл бұрын
Incredibly easy to follow lesson... thank you
@ICUAdvantage
@ICUAdvantage Жыл бұрын
So great to hear this Ken!
@rolandrojas8473
@rolandrojas8473 Ай бұрын
Great lecture
@doc.asifali
@doc.asifali 7 ай бұрын
Thank you so much sir.❤
@dgmnhn2098
@dgmnhn2098 Жыл бұрын
Thanks !
@cezarzagorneanu5905
@cezarzagorneanu5905 Жыл бұрын
Loved it. Thank you so much 😊
@ICUAdvantage
@ICUAdvantage Жыл бұрын
Glad to hear it!
@faithbolding4597
@faithbolding4597 Жыл бұрын
Love your videos!! Thank you!
@ICUAdvantage
@ICUAdvantage Жыл бұрын
Thank you Faith! ❤️
@abesha9928
@abesha9928 Жыл бұрын
Thank you
@medicalchalupa9928
@medicalchalupa9928 Жыл бұрын
Started scribing in a heme/onc clinic and this video is gonna help a ton
@ICUAdvantage
@ICUAdvantage Жыл бұрын
Glad you liked it!
@collin4555
@collin4555 Жыл бұрын
Very helpful in developing my understanding of my factor VII deficiency hemophilia on a mechanistic level
@fatimahassan8043
@fatimahassan8043 Ай бұрын
Thank you sir 😢
@MariAngelical23
@MariAngelical23 Жыл бұрын
I finally understand this!! 😊 🙏 thank you so much!!
@ICUAdvantage
@ICUAdvantage Жыл бұрын
Woohoo!! Happy to help!
@MariAngelical23
@MariAngelical23 Жыл бұрын
Your the best !
@MrM49901
@MrM49901 Жыл бұрын
Thabk you so much! This helps very very much!
@ICUAdvantage
@ICUAdvantage Жыл бұрын
Glad it helped!
@hersheygo7931
@hersheygo7931 Жыл бұрын
thank you so much!
@ICUAdvantage
@ICUAdvantage Жыл бұрын
You’re welcome!
@kevinmills8617
@kevinmills8617 8 ай бұрын
This is excellent, from a University College London Professor of biochemistry, I also approve.
@melissarainchild
@melissarainchild Жыл бұрын
thanks for explaining something pretty complex...
@ICUAdvantage
@ICUAdvantage Жыл бұрын
You’re welcome and glad I was able to do so in a way that made sense!
@shubhangikamble3177
@shubhangikamble3177 4 ай бұрын
Thank you ❤❤❤❤
@ICUAdvantage
@ICUAdvantage 4 ай бұрын
You're welcome 😊
@bahiachibi895
@bahiachibi895 10 ай бұрын
🤩thanks
@safnasagar988
@safnasagar988 4 ай бұрын
Pretty complicated but explained well❤
@ICUAdvantage
@ICUAdvantage 4 ай бұрын
Great to hear! And yes, it is quite complicated!
@MrBogombo
@MrBogombo Жыл бұрын
One question, with txa it stops the process of fibrinolysis by binding with plasminogen. Why during a massive hemorrhage is the body trying to breakdown its own clots? Something I could never understand. Great videos!!
@ivantarandovskiy4765
@ivantarandovskiy4765 Жыл бұрын
Coagulation is much faster than fibrinolysis. Normally, the clot is being lysed after the vessel is regenerated. In massive hemorrhages fibrinolysis does not play big role
@elishevajoseph5301
@elishevajoseph5301 Жыл бұрын
Hello! love your videos I've been struggling with this topic for a long time. So thank you! I just have a quick (and rather dumb) question: When you were explaining the intrinsic pathway you said activated factor 12 and 11 activate factor 7 which activates the extrinsic pathway, but you drew the arrow from activated factor 9. Which one is it?😅🙈
@ICUAdvantage
@ICUAdvantage Жыл бұрын
Ahh this was my bad! It took me a minute to try and make sense of what was being asked, but once I realized my mistake it all makes sense now. I did draw it correctly, but I completely misread IX as 11 instead of 9. It is activated 9 that activates 7, along with many others. Sorry for the confusion!
@elishevajoseph5301
@elishevajoseph5301 Жыл бұрын
@@ICUAdvantage Thank you so much!!!
@rashmeechavan8745
@rashmeechavan8745 2 ай бұрын
@michaelburatovich3199
@michaelburatovich3199 Жыл бұрын
Every time I teach this pathway, I run out of blackboard space.
@ICUAdvantage
@ICUAdvantage Жыл бұрын
Hahaha I could see that!
@DavidTiptonJr
@DavidTiptonJr Жыл бұрын
My head hurts 😂
@ICUAdvantage
@ICUAdvantage Жыл бұрын
Hahaha yeaaahhh...... this will do that!
@thepalettewhispererasmr1227
@thepalettewhispererasmr1227 Жыл бұрын
Holy craps...that's why EDDIE WATSON is the GOAT. Complex indeed
@mikelestala7382
@mikelestala7382 6 ай бұрын
Notes?
@HOOPSZ4LYF
@HOOPSZ4LYF Жыл бұрын
Where can I find the notes please??? ❤
@ICUAdvantage
@ICUAdvantage Жыл бұрын
Hey Larysa! First off, thanks so much for your support! Unfortunately KZfaq doesn't make it very clear. If you go to the main "ICU Advantage" KZfaq page, then at the top look for "Community" and that is where you will find the link to the notes and the current months password. Let me know if you have any issues and feel free to shoot me an email if you still do! Thank you! -Eddie
@shreyansh_sdu_9362
@shreyansh_sdu_9362 11 ай бұрын
Flabbergasted
@lobarita
@lobarita Жыл бұрын
Thanks !!!!!
@ICUAdvantage
@ICUAdvantage Жыл бұрын
Yw!!
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